EuRBPDB

Description

Ensembl ID: ENSG00000146247 (Gene tree)
Gene ID: 55023
Gene Symbol: PHIP
Alias: ndrp|FLJ20705|DCAF14|BRWD2|WDR11
Full Name: pleckstrin homology domain interacting protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 143,876 bases
Position: chr6:78,934,419-79,078,294
Accession: 15673
RBP type: non-canonical RBP
Summary: This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000275034	PHIP-201	10460	XM_005248729	ENSP00000275034	1821 (aa)	XP_005248786	Q8WWQ0
ENST00000479165	PHIP-202	5694	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000146247	rs12208915	6	78993018	A	Left atrial antero-posterior diameter	28394258	[0.019-0.045] unit decrease	0.0319	EFO_0008205
ENSG00000146247	rs10943605	6	78945760	A	Diastolic blood pressure	27618448	[0.1-0.22] unit increase	0.16	EFO_0006336
ENSG00000146247	rs10943605	6	78945760	A	Mean arterial pressure	27618448	[0.13-0.31] unit increase	0.21725878	EFO_0006340
ENSG00000146247	rs10455120	6	79070050	T	Self-reported math ability	30038396	[0.0073-0.0155] unit increase	0.0114	EFO_0004875
ENSG00000146247	rs9343861	6	79035151	A	Self-reported math ability (MTAG)	30038396	[0.0083-0.0153] unit decrease	0.0118	EFO_0004875
ENSG00000146247	rs10455120	6	79070050	T	Highest math class taken (MTAG)	30038396	[0.0093-0.0163] unit increase	0.0128	EFO_0004875
ENSG00000146247	rs6454092	6	78992255	G	Systolic blood pressure	30578418	[0.16-0.29] mmHg increase	0.2277	EFO_0006335
ENSG00000146247	rs2050663	6	79043677	T	Diastolic blood pressure	27841878	unit decrease	0.174	EFO_0006336
ENSG00000146247	rs2050663	6	79043677	T	Systolic blood pressure	27841878	unit decrease	0.229	EFO_0006335

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000146247	PHIP	100	94.893	ENSMUSG00000032253	Phip	100	99.444	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001932	regulation of protein phosphorylation	-	ISS	Process
GO:0005158	insulin receptor binding	11018022.	NAS	Function
GO:0005515	protein binding	11018022.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0007010	cytoskeleton organization	21873635.	IBA	Process
GO:0007010	cytoskeleton organization	21834987.	IMP	Process
GO:0008284	positive regulation of cell proliferation	-	ISS	Process
GO:0008286	insulin receptor signaling pathway	11018022.	NAS	Process
GO:0008360	regulation of cell shape	21873635.	IBA	Process
GO:0022604	regulation of cell morphogenesis	21834987.	IMP	Process
GO:0043066	negative regulation of apoptotic process	-	ISS	Process
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	-	ISS	Process
GO:0045840	positive regulation of mitotic nuclear division	-	ISS	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	17636024.	IDA	Process
GO:0070577	lysine-acetylated histone binding	22464331.	IDA	Function
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	17636024.	IDA	Process