EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000146453 (Gene tree)
Gene ID: 154197
Gene Symbol: PNLDC1
Alias: FLJ40240|dJ195P10.2
Full Name: PARN like, ribonuclease domain containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 20,456 bases
Position: chr6:159,800,249-159,820,704
Accession: 21185
RBP type: canonical RBP
Summary: (PARN Like, Ribonuclease Domain Containing 1) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is PARN.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000376007	CAF1	PF04857.20	3.7e-79	1	1
ENSP00000476448	CAF1	PF04857.20	8.7e-72	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000609334	PNLDC1-203	571	-	-	- (aa)	-	-
ENST00000610273	PNLDC1-207	1940	XM_011535491	ENSP00000476448	520 (aa)	XP_011533793	Q8NA58
ENST00000275275	PNLDC1-201	1921	-	ENSP00000275275	39 (aa)	-	V9GYA0
ENST00000610041	PNLDC1-205	965	-	ENSP00000476769	39 (aa)	-	V9GYA0
ENST00000609658	PNLDC1-204	475	-	-	- (aa)	-	-
ENST00000610048	PNLDC1-206	578	-	ENSP00000476544	39 (aa)	-	V9GYA0
ENST00000392167	PNLDC1-202	1816	XM_017010312	ENSP00000376007	531 (aa)	XP_016865801	Q8NA58

Gene Model

Click here to download ENSG00000146453's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000146453	Waist-Hip Ratio	8.5180000E-005	-
ENSG00000146453	Waist-Hip Ratio	7.8980000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000146453's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000146453	PNLDC1	99	86.932	ENSAMEG00000015371	PNLDC1	99	86.932	Ailuropoda_melanoleuca
ENSG00000146453	PNLDC1	99	58.046	ENSAPLG00000007014	PNLDC1	99	58.046	Anas_platyrhynchos
ENSG00000146453	PNLDC1	100	59.962	ENSACAG00000013667	PNLDC1	100	59.962	Anolis_carolinensis
ENSG00000146453	PNLDC1	83	30.043	ENSACAG00000004973	PARN	69	30.043	Anolis_carolinensis
ENSG00000146453	PNLDC1	99	93.019	ENSANAG00000034713	PNLDC1	100	92.955	Aotus_nancymaae
ENSG00000146453	PNLDC1	99	85.851	ENSBTAG00000015166	PNLDC1	99	86.042	Bos_taurus
ENSG00000146453	PNLDC1	99	92.830	ENSCJAG00000011865	PNLDC1	99	93.083	Callithrix_jacchus
ENSG00000146453	PNLDC1	99	87.925	ENSCAFG00000000740	PNLDC1	99	87.925	Canis_familiaris
ENSG00000146453	PNLDC1	99	86.064	ENSCAFG00020017742	PNLDC1	99	86.064	Canis_lupus_dingo
ENSG00000146453	PNLDC1	99	85.472	ENSCHIG00000003141	PNLDC1	99	85.472	Capra_hircus
ENSG00000146453	PNLDC1	99	90.377	ENSTSYG00000005606	PNLDC1	99	90.377	Carlito_syrichta
ENSG00000146453	PNLDC1	99	61.509	ENSCAPG00000011893	PNLDC1	99	61.509	Cavia_aperea
ENSG00000146453	PNLDC1	99	78.719	ENSCPOG00000019565	PNLDC1	99	78.719	Cavia_porcellus
ENSG00000146453	PNLDC1	99	94.151	ENSCCAG00000026232	PNLDC1	99	94.151	Cebus_capucinus
ENSG00000146453	PNLDC1	99	96.415	ENSCATG00000033196	PNLDC1	99	96.415	Cercocebus_atys
ENSG00000146453	PNLDC1	99	83.962	ENSCLAG00000003228	PNLDC1	99	83.962	Chinchilla_lanigera
ENSG00000146453	PNLDC1	99	95.393	ENSCSAG00000012478	PNLDC1	99	95.393	Chlorocebus_sabaeus
ENSG00000146453	PNLDC1	96	65.430	ENSCPBG00000004050	PNLDC1	100	65.430	Chrysemys_picta_bellii
ENSG00000146453	PNLDC1	99	95.183	ENSCANG00000043076	PNLDC1	99	95.183	Colobus_angolensis_palliatus
ENSG00000146453	PNLDC1	99	66.038	ENSCGRG00001011981	-	99	66.038	Cricetulus_griseus_chok1gshd
ENSG00000146453	PNLDC1	99	81.321	ENSCGRG00001007470	-	99	81.321	Cricetulus_griseus_chok1gshd
ENSG00000146453	PNLDC1	99	81.321	ENSCGRG00000010221	-	99	81.321	Cricetulus_griseus_crigri
ENSG00000146453	PNLDC1	99	68.113	ENSCGRG00000003103	-	99	68.113	Cricetulus_griseus_crigri
ENSG00000146453	PNLDC1	99	86.174	ENSDNOG00000013709	PNLDC1	99	86.174	Dasypus_novemcinctus
ENSG00000146453	PNLDC1	99	79.550	ENSDORG00000011517	Pnldc1	99	86.901	Dipodomys_ordii
ENSG00000146453	PNLDC1	93	76.543	ENSETEG00000007587	PNLDC1	98	76.543	Echinops_telfairi
ENSG00000146453	PNLDC1	99	79.926	ENSEASG00005019029	PNLDC1	99	79.926	Equus_asinus_asinus
ENSG00000146453	PNLDC1	99	88.302	ENSECAG00000012898	PNLDC1	99	88.302	Equus_caballus
ENSG00000146453	PNLDC1	69	81.250	ENSEEUG00000005717	-	86	81.250	Erinaceus_europaeus
ENSG00000146453	PNLDC1	99	88.068	ENSFCAG00000002848	PNLDC1	99	88.068	Felis_catus
ENSG00000146453	PNLDC1	96	57.455	ENSFALG00000012081	PNLDC1	99	57.455	Ficedula_albicollis
ENSG00000146453	PNLDC1	99	84.499	ENSFDAG00000021334	PNLDC1	99	84.499	Fukomys_damarensis
ENSG00000146453	PNLDC1	79	58.670	ENSGALG00000011624	PNLDC1	82	58.670	Gallus_gallus
ENSG00000146453	PNLDC1	99	66.408	ENSGAGG00000015276	PNLDC1	100	67.355	Gopherus_agassizii
ENSG00000146453	PNLDC1	99	99.245	ENSGGOG00000014077	PNLDC1	99	99.245	Gorilla_gorilla
ENSG00000146453	PNLDC1	99	84.906	ENSHGLG00000006889	PNLDC1	99	84.906	Heterocephalus_glaber_female
ENSG00000146453	PNLDC1	99	84.906	ENSHGLG00100018275	PNLDC1	99	84.906	Heterocephalus_glaber_male
ENSG00000146453	PNLDC1	99	88.658	ENSSTOG00000005595	PNLDC1	99	88.658	Ictidomys_tridecemlineatus
ENSG00000146453	PNLDC1	99	80.266	ENSJJAG00000009937	Pnldc1	99	80.266	Jaculus_jaculus
ENSG00000146453	PNLDC1	59	85.397	ENSLAFG00000030189	PNLDC1	92	85.397	Loxodonta_africana
ENSG00000146453	PNLDC1	99	96.415	ENSMFAG00000041296	PNLDC1	99	96.415	Macaca_fascicularis
ENSG00000146453	PNLDC1	99	96.415	ENSMMUG00000004181	PNLDC1	99	96.415	Macaca_mulatta
ENSG00000146453	PNLDC1	99	96.226	ENSMNEG00000034271	PNLDC1	99	96.226	Macaca_nemestrina
ENSG00000146453	PNLDC1	99	92.830	ENSMLEG00000044059	PNLDC1	99	92.830	Mandrillus_leucophaeus
ENSG00000146453	PNLDC1	98	58.743	ENSMGAG00000012470	PNLDC1	97	58.743	Meleagris_gallopavo
ENSG00000146453	PNLDC1	99	66.917	ENSMAUG00000012298	Pnldc1	100	66.917	Mesocricetus_auratus
ENSG00000146453	PNLDC1	99	88.491	ENSMICG00000008021	PNLDC1	99	88.491	Microcebus_murinus
ENSG00000146453	PNLDC1	99	85.902	ENSMOCG00000014287	Pnldc1	99	85.902	Microtus_ochrogaster
ENSG00000146453	PNLDC1	99	75.614	ENSMODG00000007420	PNLDC1	99	75.614	Monodelphis_domestica
ENSG00000146453	PNLDC1	99	85.985	MGP_CAROLIEiJ_G0021045	Pnldc1	99	85.985	Mus_caroli
ENSG00000146453	PNLDC1	99	85.985	ENSMUSG00000073460	Pnldc1	100	88.571	Mus_musculus
ENSG00000146453	PNLDC1	99	86.200	MGP_PahariEiJ_G0023361	Pnldc1	99	86.200	Mus_pahari
ENSG00000146453	PNLDC1	99	85.795	MGP_SPRETEiJ_G0021975	Pnldc1	99	85.795	Mus_spretus
ENSG00000146453	PNLDC1	99	86.792	ENSMPUG00000004920	PNLDC1	99	86.792	Mustela_putorius_furo
ENSG00000146453	PNLDC1	99	86.415	ENSMLUG00000000747	PNLDC1	99	86.415	Myotis_lucifugus
ENSG00000146453	PNLDC1	99	87.358	ENSNGAG00000017714	Pnldc1	99	87.358	Nannospalax_galili
ENSG00000146453	PNLDC1	99	96.532	ENSNLEG00000011282	PNLDC1	99	96.532	Nomascus_leucogenys
ENSG00000146453	PNLDC1	55	66.667	ENSMEUG00000014042	-	100	66.667	Notamacropus_eugenii
ENSG00000146453	PNLDC1	62	63.438	ENSMEUG00000011926	-	64	63.438	Notamacropus_eugenii
ENSG00000146453	PNLDC1	79	86.364	ENSOPRG00000003813	PNLDC1	79	86.364	Ochotona_princeps
ENSG00000146453	PNLDC1	99	83.932	ENSODEG00000008047	PNLDC1	99	83.932	Octodon_degus
ENSG00000146453	PNLDC1	99	57.170	ENSOANG00000012199	PNLDC1	99	59.434	Ornithorhynchus_anatinus
ENSG00000146453	PNLDC1	99	86.742	ENSOCUG00000013867	PNLDC1	99	86.742	Oryctolagus_cuniculus
ENSG00000146453	PNLDC1	99	89.603	ENSOGAG00000007331	PNLDC1	100	89.603	Otolemur_garnettii
ENSG00000146453	PNLDC1	99	85.660	ENSOARG00000004585	PNLDC1	99	85.660	Ovis_aries
ENSG00000146453	PNLDC1	99	98.868	ENSPPAG00000026651	PNLDC1	99	98.868	Pan_paniscus
ENSG00000146453	PNLDC1	99	88.068	ENSPPRG00000012854	PNLDC1	99	88.068	Panthera_pardus
ENSG00000146453	PNLDC1	97	86.056	ENSPTIG00000011501	PNLDC1	99	83.619	Panthera_tigris_altaica
ENSG00000146453	PNLDC1	99	98.868	ENSPTRG00000018762	PNLDC1	99	98.868	Pan_troglodytes
ENSG00000146453	PNLDC1	99	96.604	ENSPANG00000022009	PNLDC1	99	96.604	Papio_anubis
ENSG00000146453	PNLDC1	62	56.000	ENSPSIG00000011419	PNLDC1	99	56.000	Pelodiscus_sinensis
ENSG00000146453	PNLDC1	99	86.553	ENSPEMG00000016301	Pnldc1	99	86.553	Peromyscus_maniculatus_bairdii
ENSG00000146453	PNLDC1	86	30.629	ENSPMAG00000003956	parn	90	30.832	Petromyzon_marinus
ENSG00000146453	PNLDC1	84	76.538	ENSPCIG00000023412	PNLDC1	100	76.538	Phascolarctos_cinereus
ENSG00000146453	PNLDC1	99	90.584	ENSPPYG00000017148	PNLDC1	99	90.584	Pongo_abelii
ENSG00000146453	PNLDC1	99	76.705	ENSPCAG00000014169	PNLDC1	99	76.705	Procavia_capensis
ENSG00000146453	PNLDC1	99	89.245	ENSPCOG00000025722	PNLDC1	99	89.245	Propithecus_coquereli
ENSG00000146453	PNLDC1	73	89.870	ENSPVAG00000005325	PNLDC1	73	89.870	Pteropus_vampyrus
ENSG00000146453	PNLDC1	99	85.985	ENSRNOG00000023140	Pnldc1	100	86.250	Rattus_norvegicus
ENSG00000146453	PNLDC1	99	96.415	ENSRBIG00000033806	PNLDC1	99	96.415	Rhinopithecus_bieti
ENSG00000146453	PNLDC1	99	95.761	ENSRROG00000043919	PNLDC1	99	95.761	Rhinopithecus_roxellana
ENSG00000146453	PNLDC1	99	94.151	ENSSBOG00000019135	PNLDC1	99	94.151	Saimiri_boliviensis_boliviensis
ENSG00000146453	PNLDC1	99	76.163	ENSSHAG00000015192	PNLDC1	99	76.163	Sarcophilus_harrisii
ENSG00000146453	PNLDC1	55	65.398	ENSSPUG00000004627	PNLDC1	99	66.071	Sphenodon_punctatus
ENSG00000146453	PNLDC1	98	86.444	ENSSSCG00000004046	PNLDC1	99	86.444	Sus_scrofa
ENSG00000146453	PNLDC1	93	58.557	ENSTGUG00000011418	PNLDC1	99	58.557	Taeniopygia_guttata
ENSG00000146453	PNLDC1	99	77.043	ENSTBEG00000009131	PNLDC1	99	77.043	Tupaia_belangeri
ENSG00000146453	PNLDC1	73	83.117	ENSTTRG00000010409	PNLDC1	72	83.117	Tursiops_truncatus
ENSG00000146453	PNLDC1	99	75.000	ENSUAMG00000015783	PNLDC1	99	75.000	Ursus_americanus
ENSG00000146453	PNLDC1	97	80.196	ENSUMAG00000011903	PNLDC1	99	80.196	Ursus_maritimus
ENSG00000146453	PNLDC1	96	88.650	ENSVVUG00000006586	PNLDC1	99	87.860	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	21873635.	IBA	Function
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	IEA	Process
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	21873635.	IBA	Process
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	27515512.	IDA	Process
GO:0001825	blastocyst formation	-	IEA	Process
GO:0003723	RNA binding	-	IEA	Function
GO:0004535	poly(A)-specific ribonuclease activity	21873635.	IBA	Function
GO:0004535	poly(A)-specific ribonuclease activity	27515512.	IDA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	27515512.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	159800756	Missense_Mutation	novel	F10V	0.39
BLCA	chr6	159816582	Missense_Mutation	NA	F356C	0.28	CAF1
BLCA	chr6	159819071	Silent	novel	V450V	0.53
BLCA	chr6	159816009	Missense_Mutation	novel	H335D	0.29	CAF1
BLCA	chr6	159811736	Silent	novel	L286L	0.32
BLCA	chr6	159804000	Missense_Mutation	novel	P84R	0.21	CAF1
BLCA	chr6	159818570	Silent	rs545678739	P380P	0.34
BLCA	chr6	159811754	Missense_Mutation	novel	D292N	0.09	CAF1
BLCA	chr6	159804053	Nonsense_Mutation	NA	Q102*	0.34	CAF1
BLCA	chr6	159800791	Silent	rs185464452	T21T	0.55
BLCA	chr6	159819024	Missense_Mutation	rs145458684	E435K	0.58
BLCA	chr6	159809124	Missense_Mutation	novel	S239Y	0.5	CAF1
BLCA	chr6	159801155	Missense_Mutation	novel	Q48H	0.15	CAF1
BRCA	chr6	159819050	Missense_Mutation	NA	Q443H	0.21
BRCA	chr6	159820537	3'UTR	rs780220019		0.38
BRCA	chr6	159801176	Silent	NA	V55V	0.13
BRCA	chr6	159818634	Nonsense_Mutation	rs760549447	R402*	0.12
BRCA	chr6	159811750	Silent	NA	L290L	0.57
BRCA	chr6	159819002	Silent	NA	V427V	0.26
BRCA	chr6	159819269	Silent	NA	L472L	0.4
CESC	chr6	159801146	Missense_Mutation	NA	K45N	0.1	CAF1
CESC	chr6	159819076	Missense_Mutation	rs143586629	R452Q	0.19
CESC	chr6	159820578	3'UTR	novel		0.08
CESC	chr6	159820580	3'UTR	novel		0.09
CESC	chr6	159800727	5'UTR	rs779595258		0.43
CESC	chr6	159809141	Silent	novel	L245L	0.43
CESC	chr6	159808798	Silent	NA	T196T	0.21
CESC	chr6	159800362	5'UTR	novel		0.45
CESC	chr6	159818982	Missense_Mutation	novel	P421S	0.18
CESC	chr6	159816024	Missense_Mutation	novel	E340Q	0.58	CAF1
CHOL	chr6	159819007	Missense_Mutation	novel	R429M	0.41
COAD	chr6	159800753	Frame_Shift_Del	NA	*F10Lfs9**	0.61
COAD	chr6	159800331	5'UTR	novel		0.34
COAD	chr6	159800293	5'UTR	novel		0.2
COAD	chr6	159813639	Silent	NA	V315V	0.41
COAD	chr6	159818635	Missense_Mutation	NA	R402Q	0.36
COAD	chr6	159800753	Frame_Shift_Del	NA	*F10Lfs9**	0.37
COAD	chr6	159820489	Missense_Mutation	novel	A512V	0.39
COAD	chr6	159800790	Missense_Mutation	NA	T21M	0.32	CAF1
COAD	chr6	159818571	Missense_Mutation	rs202013209	E381K	0.24
COAD	chr6	159803287	Silent	rs760064049	S64S	0.11
COAD	chr6	159806032	Missense_Mutation	NA	W160R	0.13	CAF1
COAD	chr6	159819013	Missense_Mutation	rs375974775	P431L	0.27
COAD	chr6	159817153	Splice_Site	NA	X375_splice	0.21
COAD	chr6	159801150	Missense_Mutation	novel	R47C	0.33	CAF1
COAD	chr6	159813633	Silent	rs767842736	S313S	0.17
COAD	chr6	159800742	Missense_Mutation	rs763629906	R5Q	0.21
COAD	chr6	159819024	Missense_Mutation	rs145458684	E435K	0.23
COAD	chr6	159800379	5'UTR	novel		0.05
COAD	chr6	159800292	5'UTR	novel		0.36
COAD	chr6	159803963	Splice_Site	NA	X72_splice	0.11
GBM	chr6	159819011	Nonsense_Mutation	NA	W430*	0.35
GBM	chr6	159804606	Missense_Mutation	rs745935275	D133N	0.3	CAF1
GBM	chr6	159820567	3'UTR	rs747351757		0.05
GBM	chr6	159804043	Silent	novel	A98A	0.13
GBM	chr6	159819336	Missense_Mutation	rs138386704	V495I	0.25
GBM	chr6	159804002	Missense_Mutation	rs748393092	T85A	0.45	CAF1
HNSC	chr6	159801114	Missense_Mutation	novel	L35V	0.05	CAF1
HNSC	chr6	159820525	3'UTR	rs373154516		0.13
HNSC	chr6	159811712	Missense_Mutation	novel	Q278K	0.08	CAF1
HNSC	chr6	159811713	Missense_Mutation	novel	Q278L	0.08	CAF1
HNSC	chr6	159804606	Missense_Mutation	rs745935275	D133N	0.11	CAF1
HNSC	chr6	159801146	Missense_Mutation	NA	K45N	0.04	CAF1
KIRP	chr6	159818597	Silent	rs146349877	D389D	0.2
LGG	chr6	159820531	3'UTR	novel		0.34
LGG	chr6	159816570	Missense_Mutation	NA	A352V	0.38	CAF1
LIHC	chr6	159816012	Missense_Mutation	NA	A336S	0.25	CAF1
LIHC	chr6	159819256	Missense_Mutation	rs778909851	A468V	0.44
LUAD	chr6	159816586	Silent	novel	L357L	0.14
LUAD	chr6	159805993	Frame_Shift_Del	novel	*D148Tfs6**	0.08	CAF1
LUAD	chr6	159816570	Missense_Mutation	NA	A352E	0.4	CAF1
LUAD	chr6	159808798	Silent	NA	T196T	0.38
LUAD	chr6	159819113	Missense_Mutation	novel	K464N	0.13
LUAD	chr6	159817127	Missense_Mutation	novel	H367R	0.15
LUAD	chr6	159820490	Silent	novel	A512A	0.55
LUAD	chr6	159820490	Silent	rs144377714	A512A	0.18
LUAD	chr6	159813657	Splice_Site	NA	X321_splice	0.12
LUAD	chr6	159804087	Missense_Mutation	novel	K113M	0.36	CAF1
LUSC	chr6	159816571	Silent	novel	A352A	0.3
LUSC	chr6	159819024	Missense_Mutation	novel	E435Q	0.05
LUSC	chr6	159816570	Missense_Mutation	NA	A352V	0.18	CAF1
LUSC	chr6	159820457	Silent	novel	V501V	0.11
LUSC	chr6	159816571	Silent	rs367855452	A352A	0.3
LUSC	chr6	159819026	Missense_Mutation	NA	E435D	0.15
LUSC	chr6	159819302	Silent	novel	I483I	0.43
LUSC	chr6	159816026	Silent	novel	E340E	0.27
LUSC	chr6	159801141	Silent	novel	L44L	0.09
OV	chr6	159817120	Missense_Mutation	novel	V365L	0.11
OV	chr6	159803282	Missense_Mutation	novel	F63V	0.25	CAF1
OV	chr6	159818970	Missense_Mutation	NA	S417C	0.81
OV	chr6	159819281	Silent	NA	R476R	0.33
OV	chr6	159801180	Missense_Mutation	novel	Q57E	0.08	CAF1
PAAD	chr6	159804085	Silent	novel	N112N	0.05
PAAD	chr6	159817124	Missense_Mutation	novel	A366V	0.1
PRAD	chr6	159803979	Missense_Mutation	rs370436669	S77F	0.37	CAF1
PRAD	chr6	159800682	5'UTR	rs772443431		0.42
READ	chr6	159800379	5'UTR	novel		0.27
READ	chr6	159809045	Missense_Mutation	rs746765267	R213C	0.59	CAF1
READ	chr6	159809045	Missense_Mutation	rs746765267	R213C	0.24	CAF1
READ	chr6	159819279	Missense_Mutation	rs764324481	R476W	0.34
READ	chr6	159810064	Missense_Mutation	NA	H263Q	0.22	CAF1
READ	chr6	159803993	Missense_Mutation	rs138958903	L82F	0.42	CAF1
READ	chr6	159804633	Missense_Mutation	rs769175302	R142C	0.43	CAF1
READ	chr6	159811708	Silent	rs181607194	Y276Y	0.39
READ	chr6	159819054	Missense_Mutation	NA	L445I	0.51
READ	chr6	159820585	3'UTR	rs551122980		0.48
READ	chr6	159809054	Missense_Mutation	NA	L216V	0.46	CAF1
SARC	chr6	159818654	Splice_Region	rs142457687	I408I	0.23
SKCM	chr6	159803992	Nonsense_Mutation	novel	Y81*	0.06	CAF1
SKCM	chr6	159818967	Missense_Mutation	rs759936192	P416S	0.2
SKCM	chr6	159818575	Missense_Mutation	novel	S382L	0.33
SKCM	chr6	159809091	Missense_Mutation	novel	K228T	0.32	CAF1
SKCM	chr6	159818982	Missense_Mutation	novel	P421S	0.3
SKCM	chr6	159819351	Nonsense_Mutation	novel	Q500*	0.72
SKCM	chr6	159818640	Missense_Mutation	rs570714361	G404R	0.14
SKCM	chr6	159819267	Silent	NA	L472L	0.39
SKCM	chr6	159800695	5'UTR	rs762387295		0.48
SKCM	chr6	159804619	Missense_Mutation	novel	G137E	0.43	CAF1
SKCM	chr6	159808808	Missense_Mutation	NA	D200N	0.53	CAF1
SKCM	chr6	159808750	Silent	NA	A180A	0.37
SKCM	chr6	159818579	Silent	NA	S383S	0.18
SKCM	chr6	159809117	Missense_Mutation	novel	G237S	0.1	CAF1
SKCM	chr6	159819288	Missense_Mutation	novel	P479S	0.12
SKCM	chr6	159804611	Silent	novel	I134I	0.27
SKCM	chr6	159819350	Splice_Region	NA	L499L	0.43
SKCM	chr6	159818633	Silent	novel	I401I	0.11
SKCM	chr6	159800726	5'UTR	novel		0.48
SKCM	chr6	159800818	Silent	NA	P30P	0.12
SKCM	chr6	159819120	Missense_Mutation	novel	D467N	0.45
SKCM	chr6	159818964	Missense_Mutation	NA	Y415N	0.37
SKCM	chr6	159813613	Missense_Mutation	novel	P307S	0.29	CAF1
SKCM	chr6	159813614	Missense_Mutation	rs781459190	P307L	0.29	CAF1
SKCM	chr6	159819266	Silent	NA	I471I	0.23
STAD	chr6	159806052	Silent	NA	E166E	0.28
STAD	chr6	159800799	Missense_Mutation	NA	R24H	0.12	CAF1
STAD	chr6	159818639	Silent	rs139683511	A403A	0.1
STAD	chr6	159819075	Nonsense_Mutation	rs200629089	R452*	0.1
STAD	chr6	159800733	Missense_Mutation	NA	F2Y	0.09
STAD	chr6	159809129	Frame_Shift_Del	novel	*F242Sfs5**	0.22	CAF1
STAD	chr6	159800753	Frame_Shift_Del	NA	*F10Lfs9**	0.29
STAD	chr6	159803970	Missense_Mutation	NA	I74R	0.38	CAF1
STAD	chr6	159804006	Missense_Mutation	rs772224007	T86M	0.07	CAF1
STAD	chr6	159806029	Missense_Mutation	rs780297384	R159W	0.35	CAF1
STAD	chr6	159819311	Nonsense_Mutation	novel	Y486*	0.07
STAD	chr6	159800741	Nonsense_Mutation	rs140968331	R5*	0.29
THCA	chr6	159804026	Missense_Mutation	NA	E93Q	0.36	CAF1
UCEC	chr6	159809046	Missense_Mutation	rs750811678	R213H	0.21	CAF1
UCEC	chr6	159803989	Missense_Mutation	novel	F80L	0.31	CAF1
UCEC	chr6	159809045	Missense_Mutation	rs746765267	R213C	0.28	CAF1
UCEC	chr6	159810037	Silent	NA	G254G	0.2
UCEC	chr6	159808797	Missense_Mutation	rs758831751	T196M	0.33	CAF1
UCEC	chr6	159818638	Missense_Mutation	rs766167072	A403V	0.39
UCEC	chr6	159818999	Silent	rs775284378	S426S	0.21
UCEC	chr6	159820507	Missense_Mutation	novel	S518F	0.39
UCEC	chr6	159803999	Missense_Mutation	novel	P84T	0.24	CAF1
UCEC	chr6	159804566	Silent	novel	I119I	0.2
UCEC	chr6	159819324	Missense_Mutation	novel	H491Y	0.35
UCEC	chr6	159813633	Silent	rs767842736	S313S	0.53
UCEC	chr6	159818598	Missense_Mutation	rs190950900	V390M	0.24
UCEC	chr6	159819092	Missense_Mutation	NA	Q457H	0.12
UCEC	chr6	159800822	Nonsense_Mutation	NA	Q32*	0.47	CAF1
UCEC	chr6	159800319	5'UTR	novel		0.54
UCEC	chr6	159800723	5'UTR	novel		0.49
UCEC	chr6	159809046	Missense_Mutation	rs750811678	R213H	0.26	CAF1
UCEC	chr6	159819271	Missense_Mutation	NA	K473T	0.3
UCEC	chr6	159808770	Missense_Mutation	novel	L187P	0.2	CAF1
UCEC	chr6	159820537	3'UTR	rs780220019		0.16
UCEC	chr6	159818654	Splice_Region	rs142457687	I408I	0.4
UCEC	chr6	159801130	Missense_Mutation	novel	S40L	0.35	CAF1
UCEC	chr6	159804633	Missense_Mutation	rs769175302	R142S	0.39	CAF1
UCEC	chr6	159820585	3'UTR	rs551122980		0.27
UCEC	chr6	159803306	Missense_Mutation	novel	N71H	0.41	CAF1
UCEC	chr6	159801151	Missense_Mutation	novel	R47H	0.28	CAF1
UCEC	chr6	159813624	Silent	novel	S310S	0.49
UCEC	chr6	159818571	Missense_Mutation	rs202013209	E381K	0.56
UCEC	chr6	159800753	Frame_Shift_Del	NA	*F10Lfs9**	0.44
UCEC	chr6	159800680	5'UTR	novel		0.3
UCEC	chr6	159800331	5'UTR	novel		0.72
UCEC	chr6	159800279	5'UTR	novel		0.25
UCEC	chr6	159800280	5'UTR	novel		0.35
UCEC	chr6	159803275	Silent	novel	L60L	0.47
UCEC	chr6	159804016	Missense_Mutation	novel	I89M	0.32	CAF1
UCEC	chr6	159809038	Silent	novel	K210K	0.44
UCEC	chr6	159813623	Missense_Mutation	rs763815098	S310L	0.46	CAF1
UCEC	chr6	159817122	Silent	novel	V365V	0.18
UCEC	chr6	159800734	Missense_Mutation	novel	F2L	0.34
UCEC	chr6	159811780	Silent	novel	I300I	0.39
UCEC	chr6	159803277	Missense_Mutation	novel	S61Y	0.35	CAF1
UCEC	chr6	159806068	Missense_Mutation	novel	L172I	0.49	CAF1
UCEC	chr6	159811762	Missense_Mutation	novel	K294N	0.32	CAF1
UCEC	chr6	159801169	Missense_Mutation	novel	F53C	0.09	CAF1
UCEC	chr6	159804611	Silent	novel	I134I	0.12
UCEC	chr6	159819054	Missense_Mutation	novel	L445F	0.28
UCEC	chr6	159820497	Missense_Mutation	novel	L515I	0.38
UCEC	chr6	159819016	Missense_Mutation	novel	G432E	0.32
UCEC	chr6	159804598	Missense_Mutation	novel	I130S	0.05	CAF1
UCEC	chr6	159800727	5'UTR	rs779595258		0.3
UCEC	chr6	159805988	Missense_Mutation	rs200077469	P145L	0.56	CAF1
UCEC	chr6	159809116	Missense_Mutation	rs777438960	R236S	0.31	CAF1
UCEC	chr6	159818655	Splice_Site	rs771497671	X408_splice	0.37
UCEC	chr6	159816571	Silent	rs367855452	A352A	0.37
UCS	chr6	159819054	Missense_Mutation	novel	L445F	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3652	0.00027473
CESC	DEL	0.2881	9.8477e-05
KIRC	DEL	0.2462	7.439e-11
KIRP	DEL	0.1042	0.054498
LGG	DEL	0.1442	0.0054594
MESO	DEL	0.4023	0.0023534
PAAD	DEL	0.375	0.11274
SKCM	DEL	0.5477	1.5442e-06
TGCT	DEL	0.0933	0.0031874
THYM	DEL	0.1382	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00032	Kaplan-Meier Survival Analysis
MESO	0.017	Kaplan-Meier Survival Analysis
HNSC	0.043	Kaplan-Meier Survival Analysis
SKCM	0.04	Kaplan-Meier Survival Analysis
BRCA	0.037	Kaplan-Meier Survival Analysis
COAD	0.02	Kaplan-Meier Survival Analysis
UCEC	0.0039	Kaplan-Meier Survival Analysis
GBM	0.0064	Kaplan-Meier Survival Analysis