EuRBPDB

Description

Ensembl ID: ENSG00000146701 (Gene tree)
Gene ID: 4191
Gene Symbol: MDH2
Alias: N
Full Name: malate dehydrogenase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 19,490 bases
Position: chr7:76,048,019-76,067,508
Accession: 6971
RBP type: non-canonical RBP
Summary: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23672475	Differentially expressed proteins in the skin mucus of Atlantic cod (Gadus morhua) upon natural infection with Vibrio anguillarum.	BMC Vet Res	2013 May 14	Rajan B	doi: 10.1186/1746-6148-9-103.
28433711	MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition.	Biochim Biophys Acta Mol Basis Dis	2017 Jun	Chen YH	doi: 10.1016/j.bbadis.2017.04.018

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000424167	MDH2-202	681	-	-	- (aa)	-	-
ENST00000490105	MDH2-207	569	-	-	- (aa)	-	-
ENST00000461665	MDH2-206	551	-	-	- (aa)	-	-
ENST00000443006	MDH2-204	2020	-	ENSP00000416929	231 (aa)	-	G3XAL0
ENST00000315758	MDH2-201	2209	-	ENSP00000327070	338 (aa)	-	P40926
ENST00000461263	MDH2-205	648	-	ENSP00000475583	28 (aa)	-	U3KQ63
ENST00000432020	MDH2-203	1548	-	ENSP00000408649	296 (aa)	-	P40926
ENST00000492663	MDH2-208	546	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa00270	Cysteine and methionine metabolism	KEGG
hsa00620	Pyruvate metabolism	KEGG
hsa00630	Glyoxylate and dicarboxylate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000146701	Emotions	7.82e-005	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000146701	MDH2	99	58.079	WBGene00003162	mdh-2	96	57.622	Caenorhabditis_elegans
ENSG00000146701	MDH2	99	59.760	FBgn0262559	Mdh2	99	59.760	Drosophila_melanogaster
ENSG00000146701	MDH2	100	94.970	ENSMUSG00000019179	Mdh2	100	94.970	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	16740313.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0006099	tricarboxylic acid cycle	-	TAS	Process
GO:0006107	oxaloacetate metabolic process	-	IEA	Process
GO:0006108	malate metabolic process	16740313.	IDA	Process
GO:0006108	malate metabolic process	6576816.	IMP	Process
GO:0006475	internal protein amino acid acetylation	20167786.	IDA	Process
GO:0006734	NADH metabolic process	-	IEA	Process
GO:0009060	aerobic respiration	27989324.	IDA	Process
GO:0016020	membrane	-	IEA	Component
GO:0030060	L-malate dehydrogenase activity	16740313.27989324.	IDA	Function
GO:0030060	L-malate dehydrogenase activity	6576816.	IMP	Function
GO:0043621	protein self-association	-	IEA	Function
GO:0046554	malate dehydrogenase (NADP+) activity	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component