EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000146909 (Gene tree)
Gene ID: 64434
Gene Symbol: NOM1
Alias: SGD1|PPP1R113|C7orf3
Full Name: nucleolar protein with MIF4G domain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 23,460 bases
Position: chr7:156,949,723-156,973,182
Accession: 13244
RBP type: canonical RBP
Summary: Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000275820	MA3	PF02847.17	2.4e-23	1	1
ENSP00000275820	MIF4G	PF02854.19	4.8e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21576267	Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex.	Genes Dev	2011 May 15	Alexandrov A	doi: 10.1101/gad.2045411.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000472491	NOM1-204	593	-	-	- (aa)	-	-
ENST00000485661	NOM1-206	486	-	-	- (aa)	-	-
ENST00000489850	NOM1-208	559	-	-	- (aa)	-	-
ENST00000469271	NOM1-203	1209	-	-	- (aa)	-	-
ENST00000475176	NOM1-205	714	-	-	- (aa)	-	-
ENST00000486131	NOM1-207	997	-	-	- (aa)	-	-
ENST00000460332	NOM1-202	706	-	-	- (aa)	-	-
ENST00000275820	NOM1-201	6077	-	ENSP00000275820	860 (aa)	-	Q5C9Z4

Gene Model

Click here to download ENSG00000146909's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000146909	Stroke	9.0039250E-004	19369658

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000146909's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000146909	NOM1	61	69.905	ENSAPOG00000012073	nom1	97	55.205	Acanthochromis_polyacanthus
ENSG00000146909	NOM1	84	76.374	ENSAMEG00000001412	NOM1	95	77.616	Ailuropoda_melanoleuca
ENSG00000146909	NOM1	83	70.577	ENSACIG00000018050	nom1	69	68.624	Amphilophus_citrinellus
ENSG00000146909	NOM1	60	69.231	ENSAOCG00000006229	nom1	98	54.035	Amphiprion_ocellaris
ENSG00000146909	NOM1	60	69.423	ENSAPEG00000015994	nom1	98	54.279	Amphiprion_percula
ENSG00000146909	NOM1	80	60.781	ENSATEG00000005405	nom1	98	54.513	Anabas_testudineus
ENSG00000146909	NOM1	77	64.750	ENSAPLG00000006585	NOM1	99	63.623	Anas_platyrhynchos
ENSG00000146909	NOM1	81	61.141	ENSACAG00000011192	NOM1	97	56.911	Anolis_carolinensis
ENSG00000146909	NOM1	84	59.010	ENSACLG00000000033	nom1	98	53.418	Astatotilapia_calliptera
ENSG00000146909	NOM1	61	65.649	ENSAMXG00000041486	nom1	63	63.752	Astyanax_mexicanus
ENSG00000146909	NOM1	95	70.182	ENSBTAG00000016435	NOM1	100	69.666	Bos_taurus
ENSG00000146909	NOM1	100	87.963	ENSCJAG00000004336	NOM1	100	88.079	Callithrix_jacchus
ENSG00000146909	NOM1	55	63.655	ENSCAFG00000029845	-	100	61.896	Canis_familiaris
ENSG00000146909	NOM1	96	74.101	ENSCAFG00020005121	NOM1	100	72.841	Canis_lupus_dingo
ENSG00000146909	NOM1	95	70.195	ENSCHIG00000020102	NOM1	100	69.222	Capra_hircus
ENSG00000146909	NOM1	95	82.906	ENSTSYG00000000227	NOM1	100	81.206	Carlito_syrichta
ENSG00000146909	NOM1	61	85.468	ENSCAPG00000016273	NOM1	100	85.468	Cavia_aperea
ENSG00000146909	NOM1	95	70.863	ENSCPOG00000025538	NOM1	96	69.102	Cavia_porcellus
ENSG00000146909	NOM1	92	94.340	ENSCCAG00000014944	NOM1	100	94.944	Cebus_capucinus
ENSG00000146909	NOM1	84	74.064	ENSCLAG00000000267	NOM1	80	75.585	Chinchilla_lanigera
ENSG00000146909	NOM1	70	76.415	ENSCPBG00000018215	NOM1	82	76.415	Chrysemys_picta_bellii
ENSG00000146909	NOM1	61	42.430	ENSCING00000005248	-	70	42.430	Ciona_intestinalis
ENSG00000146909	NOM1	62	94.925	ENSCANG00000041984	NOM1	91	94.925	Colobus_angolensis_palliatus
ENSG00000146909	NOM1	95	71.653	ENSCGRG00001020293	Nom1	98	70.273	Cricetulus_griseus_chok1gshd
ENSG00000146909	NOM1	62	86.415	ENSCGRG00000005405	Nom1	99	86.415	Cricetulus_griseus_crigri
ENSG00000146909	NOM1	75	59.565	ENSCSEG00000000932	nom1	63	65.377	Cynoglossus_semilaevis
ENSG00000146909	NOM1	97	54.567	ENSCVAG00000007562	nom1	97	54.545	Cyprinodon_variegatus
ENSG00000146909	NOM1	80	59.855	ENSDARG00000060027	nom1	99	67.983	Danio_rerio
ENSG00000146909	NOM1	65	70.228	ENSDORG00000015682	Nom1	98	67.288	Dipodomys_ordii
ENSG00000146909	NOM1	60	39.179	FBgn0035336	CG9004	62	39.139	Drosophila_melanogaster
ENSG00000146909	NOM1	92	71.226	ENSETEG00000003104	NOM1	95	60.120	Echinops_telfairi
ENSG00000146909	NOM1	50	51.157	ENSEBUG00000010077	nom1	95	51.157	Eptatretus_burgeri
ENSG00000146909	NOM1	79	82.991	ENSEASG00005001489	NOM1	100	75.344	Equus_asinus_asinus
ENSG00000146909	NOM1	79	81.621	ENSECAG00000007596	NOM1	94	74.429	Equus_caballus
ENSG00000146909	NOM1	61	67.803	ENSELUG00000006266	nom1	81	58.650	Esox_lucius
ENSG00000146909	NOM1	96	73.519	ENSFCAG00000006467	NOM1	100	72.917	Felis_catus
ENSG00000146909	NOM1	80	64.416	ENSFALG00000006904	NOM1	97	64.483	Ficedula_albicollis
ENSG00000146909	NOM1	96	72.575	ENSFDAG00000016241	NOM1	98	72.705	Fukomys_damarensis
ENSG00000146909	NOM1	95	55.286	ENSFHEG00000015974	nom1	97	54.557	Fundulus_heteroclitus
ENSG00000146909	NOM1	80	56.250	ENSGMOG00000005129	nom1	70	63.686	Gadus_morhua
ENSG00000146909	NOM1	99	57.840	ENSGALG00000006437	NOM1	60	72.553	Gallus_gallus
ENSG00000146909	NOM1	63	66.300	ENSGAFG00000003211	nom1	97	54.612	Gambusia_affinis
ENSG00000146909	NOM1	79	67.965	ENSGAGG00000014347	NOM1	64	76.604	Gopherus_agassizii
ENSG00000146909	NOM1	99	96.973	ENSGGOG00000010920	NOM1	92	96.973	Gorilla_gorilla
ENSG00000146909	NOM1	83	58.783	ENSHBUG00000014616	nom1	98	53.232	Haplochromis_burtoni
ENSG00000146909	NOM1	96	73.728	ENSHGLG00000007392	NOM1	97	73.540	Heterocephalus_glaber_female
ENSG00000146909	NOM1	83	87.342	ENSHGLG00100014407	NOM1	96	87.342	Heterocephalus_glaber_male
ENSG00000146909	NOM1	64	62.909	ENSIPUG00000013980	nom1	94	53.226	Ictalurus_punctatus
ENSG00000146909	NOM1	66	84.886	ENSSTOG00000031736	NOM1	98	85.080	Ictidomys_tridecemlineatus
ENSG00000146909	NOM1	57	88.344	ENSJJAG00000011716	Nom1	99	88.344	Jaculus_jaculus
ENSG00000146909	NOM1	80	64.132	ENSLACG00000011777	NOM1	98	57.455	Latimeria_chalumnae
ENSG00000146909	NOM1	95	56.348	ENSLOCG00000012452	nom1	99	53.882	Lepisosteus_oculatus
ENSG00000146909	NOM1	96	68.630	ENSLAFG00000007119	NOM1	98	67.918	Loxodonta_africana
ENSG00000146909	NOM1	100	89.480	ENSMMUG00000039033	NOM1	100	89.480	Macaca_mulatta
ENSG00000146909	NOM1	62	95.669	ENSMLEG00000037062	NOM1	100	95.669	Mandrillus_leucophaeus
ENSG00000146909	NOM1	95	54.632	ENSMAMG00000004118	nom1	65	65.580	Mastacembelus_armatus
ENSG00000146909	NOM1	85	58.209	ENSMZEG00005000384	nom1	97	53.318	Maylandia_zebra
ENSG00000146909	NOM1	81	62.640	ENSMGAG00000005051	NOM1	79	71.271	Meleagris_gallopavo
ENSG00000146909	NOM1	98	73.325	ENSMAUG00000017988	Nom1	97	71.972	Mesocricetus_auratus
ENSG00000146909	NOM1	100	79.443	ENSMICG00000017531	NOM1	100	80.765	Microcebus_murinus
ENSG00000146909	NOM1	97	74.435	ENSMOCG00000015962	Nom1	96	74.940	Microtus_ochrogaster
ENSG00000146909	NOM1	95	51.490	ENSMMOG00000004419	nom1	66	62.143	Mola_mola
ENSG00000146909	NOM1	98	67.364	ENSMODG00000005177	NOM1	99	68.446	Monodelphis_domestica
ENSG00000146909	NOM1	90	55.290	ENSMALG00000008800	nom1	97	53.662	Monopterus_albus
ENSG00000146909	NOM1	97	71.731	MGP_CAROLIEiJ_G0027043	Nom1	95	71.172	Mus_caroli
ENSG00000146909	NOM1	97	73.790	ENSMUSG00000001569	Nom1	95	71.192	Mus_musculus
ENSG00000146909	NOM1	97	73.934	MGP_SPRETEiJ_G0028039	Nom1	95	71.243	Mus_spretus
ENSG00000146909	NOM1	79	72.741	ENSMPUG00000009745	NOM1	99	72.741	Mustela_putorius_furo
ENSG00000146909	NOM1	73	76.266	ENSMLUG00000009129	NOM1	88	85.206	Myotis_lucifugus
ENSG00000146909	NOM1	85	58.480	ENSNBRG00000016429	nom1	99	66.184	Neolamprologus_brichardi
ENSG00000146909	NOM1	100	91.792	ENSNLEG00000000238	NOM1	100	92.370	Nomascus_leucogenys
ENSG00000146909	NOM1	86	67.033	ENSMEUG00000001108	NOM1	86	67.033	Notamacropus_eugenii
ENSG00000146909	NOM1	90	67.391	ENSOPRG00000014676	NOM1	90	67.391	Ochotona_princeps
ENSG00000146909	NOM1	79	76.778	ENSODEG00000009399	NOM1	97	76.343	Octodon_degus
ENSG00000146909	NOM1	84	58.735	ENSONIG00000005958	nom1	86	61.257	Oreochromis_niloticus
ENSG00000146909	NOM1	54	80.087	ENSOANG00000006139	-	97	80.087	Ornithorhynchus_anatinus
ENSG00000146909	NOM1	96	79.904	ENSOCUG00000004071	-	100	79.398	Oryctolagus_cuniculus
ENSG00000146909	NOM1	94	52.330	ENSORLG00000010541	nom1	98	53.118	Oryzias_latipes
ENSG00000146909	NOM1	79	58.874	ENSORLG00020010789	nom1	90	58.120	Oryzias_latipes_hni
ENSG00000146909	NOM1	94	53.121	ENSORLG00015010475	nom1	98	53.245	Oryzias_latipes_hsok
ENSG00000146909	NOM1	94	53.650	ENSOMEG00000004219	nom1	97	53.373	Oryzias_melastigma
ENSG00000146909	NOM1	68	85.495	ENSOGAG00000001124	NOM1	92	87.544	Otolemur_garnettii
ENSG00000146909	NOM1	85	72.605	ENSOARG00000007261	NOM1	92	73.792	Ovis_aries
ENSG00000146909	NOM1	100	97.791	ENSPPAG00000041374	NOM1	100	97.791	Pan_paniscus
ENSG00000146909	NOM1	79	78.020	ENSPTIG00000013532	NOM1	93	78.020	Panthera_tigris_altaica
ENSG00000146909	NOM1	100	97.558	ENSPTRG00000019917	NOM1	100	97.558	Pan_troglodytes
ENSG00000146909	NOM1	100	92.361	ENSPANG00000007605	NOM1	100	92.361	Papio_anubis
ENSG00000146909	NOM1	96	51.748	ENSPKIG00000005825	nom1	97	50.959	Paramormyrops_kingsleyae
ENSG00000146909	NOM1	63	75.691	ENSPSIG00000017848	NOM1	89	75.691	Pelodiscus_sinensis
ENSG00000146909	NOM1	82	60.475	ENSPMGG00000002577	nom1	67	67.582	Periophthalmus_magnuspinnatus
ENSG00000146909	NOM1	95	72.674	ENSPEMG00000024180	Nom1	97	72.497	Peromyscus_maniculatus_bairdii
ENSG00000146909	NOM1	99	66.304	ENSPCIG00000027941	NOM1	94	68.161	Phascolarctos_cinereus
ENSG00000146909	NOM1	60	68.654	ENSPFOG00000015771	nom1	98	54.502	Poecilia_formosa
ENSG00000146909	NOM1	60	68.654	ENSPLAG00000007856	nom1	97	54.710	Poecilia_latipinna
ENSG00000146909	NOM1	60	68.269	ENSPMEG00000014155	nom1	98	54.382	Poecilia_mexicana
ENSG00000146909	NOM1	97	54.427	ENSPREG00000008850	nom1	97	54.458	Poecilia_reticulata
ENSG00000146909	NOM1	100	90.592	ENSPPYG00000018222	NOM1	100	90.592	Pongo_abelii
ENSG00000146909	NOM1	91	66.369	ENSPCAG00000000440	NOM1	96	67.057	Procavia_capensis
ENSG00000146909	NOM1	62	88.136	ENSPCOG00000015222	NOM1	100	88.136	Propithecus_coquereli
ENSG00000146909	NOM1	100	74.682	ENSPVAG00000014760	NOM1	100	73.958	Pteropus_vampyrus
ENSG00000146909	NOM1	85	57.938	ENSPNYG00000006975	nom1	97	66.790	Pundamilia_nyererei
ENSG00000146909	NOM1	95	68.313	ENSRNOG00000048969	AABR07059041.1	99	66.667	Rattus_norvegicus
ENSG00000146909	NOM1	100	91.773	ENSRBIG00000037042	NOM1	100	91.773	Rhinopithecus_bieti
ENSG00000146909	NOM1	100	91.541	ENSRROG00000037293	NOM1	100	91.541	Rhinopithecus_roxellana
ENSG00000146909	NOM1	85	71.070	ENSSHAG00000017998	-	98	72.294	Sarcophilus_harrisii
ENSG00000146909	NOM1	60	64.717	ENSSHAG00000002835	-	99	75.912	Sarcophilus_harrisii
ENSG00000146909	NOM1	56	65.768	ENSSFOG00015003196	nom1	99	65.768	Scleropages_formosus
ENSG00000146909	NOM1	95	53.684	ENSSMAG00000011047	nom1	98	54.481	Scophthalmus_maximus
ENSG00000146909	NOM1	80	59.833	ENSSDUG00000006834	nom1	97	54.306	Seriola_dumerili
ENSG00000146909	NOM1	80	60.649	ENSSLDG00000021812	nom1	64	67.279	Seriola_lalandi_dorsalis
ENSG00000146909	NOM1	83	56.510	ENSSPUG00000002556	NOM1	97	62.804	Sphenodon_punctatus
ENSG00000146909	NOM1	60	70.192	ENSSPAG00000000953	nom1	64	67.273	Stegastes_partitus
ENSG00000146909	NOM1	84	63.438	ENSTGUG00000000702	-	97	64.422	Taeniopygia_guttata
ENSG00000146909	NOM1	95	54.137	ENSTRUG00000010239	nom1	98	54.556	Takifugu_rubripes
ENSG00000146909	NOM1	95	53.976	ENSTNIG00000012783	nom1	99	53.442	Tetraodon_nigroviridis
ENSG00000146909	NOM1	98	74.473	ENSTTRG00000009691	NOM1	97	75.091	Tursiops_truncatus
ENSG00000146909	NOM1	96	74.347	ENSUAMG00000025450	NOM1	100	72.260	Ursus_americanus
ENSG00000146909	NOM1	85	76.478	ENSUMAG00000014275	NOM1	95	78.070	Ursus_maritimus
ENSG00000146909	NOM1	96	72.760	ENSVVUG00000002608	NOM1	100	71.510	Vulpes_vulpes
ENSG00000146909	NOM1	97	54.737	ENSXETG00000021611	nom1	92	71.552	Xenopus_tropicalis
ENSG00000146909	NOM1	95	55.193	ENSXMAG00000002451	nom1	97	54.940	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	17965019.21576267.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	15715967.17965019.	IDA	Component
GO:0008150	biological_process	-	ND	Process
GO:0042274	ribosomal small subunit biogenesis	21873635.	IBA	Process
GO:0048820	hair follicle maturation	-	IEA	Process