EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000147065 (Gene tree)
Gene ID: 4478
Gene Symbol: MSN
Alias: N
Full Name: moesin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 153,555 bases
Position: chrX:65,588,377-65,741,931
Accession: 7373
RBP type: non-canonical RBP
Summary: Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10385389	Estrogen receptor regulation of the Na+/H+ exchange regulatory factor.	Endocrinology	1999 Jul	Ediger TR	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000360270	MSN-201	3944	XM_005262269	ENSP00000353408	577 (aa)	XP_005262326	P26038
ENST00000447323	MSN-204	382	-	-	- (aa)	-	-
ENST00000609205	MSN-205	1761	-	-	- (aa)	-	-
ENST00000439474	MSN-203	539	-	-	- (aa)	-	-
ENST00000609672	MSN-206	568	-	ENSP00000477441	103 (aa)	-	V9GZ54
ENST00000429601	MSN-202	487	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000147065's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05162	Measles	KEGG
hsa05205	Proteoglycans in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000147065	Macular Degeneration	8.857014E-6	-
ENSG00000147065	Macular Degeneration	5.41248E-6	-
ENSG00000147065	Macular Degeneration	8.857014E-6	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000147065	rs143755874	X	65639521	A	Male-pattern baldness	28196072	NR unit decrease	0.1862	Orphanet_79364

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147065's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000147065	MSN	100	88.350	ENSG00000137710	RDX	100	89.655	Homo_sapiens
ENSG00000147065	MSN	100	86.408	ENSG00000092820	EZR	100	73.038	Homo_sapiens
ENSG00000147065	MSN	100	99.029	ENSMUSG00000031207	Msn	100	98.614	Mus_musculus
ENSG00000147065	MSN	100	88.350	ENSMUSG00000032050	Rdx	93	89.532	Mus_musculus
ENSG00000147065	MSN	100	85.437	ENSMUSG00000052397	Ezr	100	72.572	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001771	immunological synapse formation	27405666.	IDA	Process
GO:0001931	uropod	-	IEA	Component
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0003779	actin binding	-	IEA	Function
GO:0005102	signaling receptor binding	15819698.	IPI	Function
GO:0005200	structural constituent of cytoskeleton	1924289.	TAS	Function
GO:0005515	protein binding	7844168.9430655.10806479.15020681.16938849.17046996.18586956.20642453.21044950.21148287.22363216.22952686.23241358.23855374.24351927.24695735.24794857.24904275.25009464.26824392.27357661.	IPI	Function
GO:0005615	extracellular space	16502470.	HDA	Component
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005737	cytoplasm	16791210.	HDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	16130169.	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005902	microvillus	12082081.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	21282464.	IDA	Component
GO:0007010	cytoskeleton organization	-	IEA	Process
GO:0007159	leukocyte cell-cell adhesion	12082081.	IEP	Process
GO:0008360	regulation of cell shape	24862762.	IMP	Process
GO:0008361	regulation of cell size	24862762.	IMP	Process
GO:0008361	regulation of cell size	22467863.	IMP	Process
GO:0009986	cell surface	15922359.	IDA	Component
GO:0010628	positive regulation of gene expression	23264465.	IGI	Process
GO:0016323	basolateral plasma membrane	-	IEA	Component
GO:0016324	apical plasma membrane	24862762.	IDA	Component
GO:0019899	enzyme binding	15922359.	IPI	Function
GO:0019901	protein kinase binding	19255442.	IPI	Function
GO:0022612	gland morphogenesis	24862762.	IMP	Process
GO:0022614	membrane to membrane docking	12082081.	IEP	Process
GO:0030175	filopodium	12082081.24065547.	IDA	Component
GO:0031143	pseudopodium	24065547.	IDA	Component
GO:0031528	microvillus membrane	-	IEA	Component
GO:0031982	vesicle	19190083.	HDA	Component
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0042098	T cell proliferation	27405666.	IDA	Process
GO:0045177	apical part of cell	12082081.	IDA	Component
GO:0045198	establishment of epithelial cell apical/basal polarity	24862762.	IMP	Process
GO:0048471	perinuclear region of cytoplasm	24862762.	IDA	Component
GO:0050839	cell adhesion molecule binding	12082081.	IPI	Function
GO:0050900	leukocyte migration	12082081.	IEP	Process
GO:0061028	establishment of endothelial barrier	23264465.	IGI	Process
GO:0070062	extracellular exosome	12519789.19056867.19199708.20458337.21362503.23533145.	HDA	Component
GO:0070489	T cell aggregation	27405666.	IDA	Process
GO:0071394	cellular response to testosterone stimulus	24065547.	IDA	Process
GO:0071437	invadopodium	25486435.	IDA	Component
GO:0071803	positive regulation of podosome assembly	-	IEA	Process
GO:0071944	cell periphery	22291017.	IDA	Component
GO:0072562	blood microparticle	22516433.	HDA	Component
GO:0072678	T cell migration	27405666.	IDA	Process
GO:1902115	regulation of organelle assembly	21148287.	IGI	Process
GO:1902966	positive regulation of protein localization to early endosome	21148287.	IGI	Process
GO:1903364	positive regulation of cellular protein catabolic process	21148287.	IGI	Process
GO:2000401	regulation of lymphocyte migration	19255442.	IMP	Process
GO:2000643	positive regulation of early endosome to late endosome transport	21148287.	IGI	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21352885	ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.	Biochimie	2011 May	Ou-Yang M	doi: 10.1016/j.biochi.2011.01.017
22266319	Tumor suppressive microRNA-133a regulates novel targets: moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma.	Biochem Biophys Res Commun	2012 Feb 10	Kinoshita T	doi: 10.1016/j.bbrc.2012.01.030
28624994	Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.	Clin Exp Metastasis	2017 Jun	Bartova M	doi: 10.1007/s10585-017-9853-y
27793041	CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.	Oncotarget	2016 Nov 29	Riecken LB	doi: 10.18632/oncotarget.12919.
29715096	Moesin Involvement in Oral Carcinogenesis of the Lower Lip.	Anticancer Res	2018 May	Assao A	-
24891603	Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.	J Cell Biol	2014 Jun 9	Beaty BT	doi: 10.1083/jcb.201312046
22439598	Differential expression of moesin in breast cancers and its implication in epithelial-mesenchymal transition.	Histopathology	2012 Jul	Wang CC	doi: 10.1111/j.1365-2559.2012.04204.x
20429915	Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade.	BMC Cancer	2010 Apr 29	He M	doi: 10.1186/1471-2407-10-170.
23420497	ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.	Cell Oncol (Dordr)	2013 Jun	Halon A	doi: 10.1007/s13402-013-0125-9
19152423	Proteomic profiling in pancreatic cancer with and without lymph node metastasis.	Int J Cancer	2009 Apr 1	Cui Y	doi: 10.1002/ijc.24163.
24037528	MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways.	Oncogene	2014 Jul 31	Li X	doi: 10.1038/onc.2013.370
26209696	Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.	FASEB J	2015 Nov	Adada MM	doi: 10.1096/fj.15-274340
27130522	Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and Paxillin.	Mol Cell Endocrinol	2016 Jul 15	Sanchez AM	doi: 10.1016/j.mce.2016.04.021
28933253	The role of p53-microRNA 200-Moesin axis in invasion and drug resistance of breast cancer cells.	Tumour Biol	2017 Sep	Alam F	doi: 10.1177/1010428317714634.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chrX	65729450	Missense_Mutation	rs765836962	D69N	0.37
BLCA	chrX	65739830	Silent	rs763920638	K557K	0.39
BLCA	chrX	65739875	Silent	rs756544101	D572D	0.29
BRCA	chrX	65738972	Splice_Region	NA	A449A	0.16
BRCA	chrX	65739837	Missense_Mutation	NA	R560C	0.16
BRCA	chrX	65729544	Missense_Mutation	rs770945316	R100H	0.5
BRCA	chrX	65731865	Silent	novel	K193K	0.03
BRCA	chrX	65731188	Splice_Region	novel	L183L	0.04
BRCA	chrX	65737276	Missense_Mutation	NA	E397K	0.35
BRCA	chrX	65739162	Nonsense_Mutation	novel	E513*	0.11
BRCA	chrX	65739798	Nonsense_Mutation	novel	E547*	0.03
BRCA	chrX	65739132	Missense_Mutation	NA	R503C	0.51
BRCA	chrX	65736869	Missense_Mutation	novel	E345G	0.32
BRCA	chrX	65735326	Missense_Mutation	NA	M285I	0.32
CESC	chrX	65667822	5'UTR	novel		0.31
CESC	chrX	65739926	3'UTR	novel		0.06
CESC	chrX	65729543	Missense_Mutation	rs746950857	R100C	0.36
CESC	chrX	65740006	3'UTR	novel		0.06
CESC	chrX	65733239	Missense_Mutation	novel	D252H	0.12
CESC	chrX	65731155	Silent	novel	I172I	0.44
CESC	chrX	65738577	Missense_Mutation	rs371555667	R435Q	0.32
CESC	chrX	65729567	Missense_Mutation	novel	E108K	0.31
CESC	chrX	65735306	Missense_Mutation	rs778459733	R279W	0.11
CESC	chrX	65737191	Missense_Mutation	novel	Q368H	0.24
CESC	chrX	65739012	Silent	novel	L463L	0.47
CESC	chrX	65739998	3'UTR	novel		0.35
CESC	chrX	65733253	Silent	NA	V256V	0.2
CESC	chrX	65731961	Silent	novel	L225L	0.1
CESC	chrX	65729585	Missense_Mutation	NA	D114N	0.28
CESC	chrX	65740154	3'UTR	novel		0.27
CHOL	chrX	65739099	Missense_Mutation	novel	A492T	0.46
COAD	chrX	65735356	Frame_Shift_Ins	NA	*P297Afs2**	0.34
COAD	chrX	65729600	Missense_Mutation	NA	P119T	0.19
COAD	chrX	65735349	Missense_Mutation	novel	R293H	0.42
COAD	chrX	65667721	5'UTR	novel		0.25
COAD	chrX	65731175	Missense_Mutation	NA	H179R	0.27
COAD	chrX	65729515	Silent	NA	S90S	0.61
COAD	chrX	65738527	Splice_Region	NA	A418A	0.38
COAD	chrX	65739147	Missense_Mutation	NA	R508C	0.44
COAD	chrX	65739133	Missense_Mutation	NA	R503H	0.51
COAD	chrX	65735296	Silent	NA	R275R	0.63
COAD	chrX	65667749	5'UTR	novel		0.77
COAD	chrX	65739964	3'UTR	novel		0.18
COAD	chrX	65736836	Missense_Mutation	NA	E334G	0.59
COAD	chrX	65731175	Missense_Mutation	novel	H179L	0.07
COAD	chrX	65735353	Silent	novel	R294R	0.07
COAD	chrX	65735272	Silent	NA	F267F	0.28
DLBC	chrX	65735402	Nonsense_Mutation	novel	E311*	0.72
DLBC	chrX	65731150	Missense_Mutation	novel	R171W	0.09
ESCA	chrX	65729626	Silent	novel	S127S	0.79
ESCA	chrX	65739837	Missense_Mutation	NA	R560C	0.41
ESCA	chrX	65735410	Missense_Mutation	novel	K313N	0.74
GBM	chrX	65733245	Missense_Mutation	novel	K254Q	0.2
GBM	chrX	65738577	Missense_Mutation	rs371555667	R435Q	0.94
GBM	chrX	65729670	Missense_Mutation	NA	H142R	0.89
HNSC	chrX	65739842	Missense_Mutation	novel	Q561H	0.5
HNSC	chrX	65737310	Missense_Mutation	novel	R408L	0.23
HNSC	chrX	65739728	Splice_Site	novel	X524_splice	0.79
KIRC	chrX	65739759	Missense_Mutation	NA	D534Y	0.06
KIRC	chrX	65739840	Nonsense_Mutation	NA	Q561*	0.13
KIRC	chrX	65739133	Missense_Mutation	NA	R503H	0.2
KIRP	chrX	65716896	Missense_Mutation	NA	D31H	0.17
LGG	chrX	65667716	5'UTR	novel		0.43
LGG	chrX	65727871	Missense_Mutation	novel	T52A	0.48
LIHC	chrX	65737309	Missense_Mutation	rs748200741	R408W	0.14
LUAD	chrX	65738531	Missense_Mutation	NA	E420Q	0.25
LUAD	chrX	65729514	Missense_Mutation	novel	S90Y	0.08
LUAD	chrX	65735326	Missense_Mutation	novel	M285I	0.67
LUAD	chrX	65729438	Missense_Mutation	NA	V65L	0.15
LUAD	chrX	65729605	Silent	novel	E120E	0.2
LUAD	chrX	65739093	Missense_Mutation	NA	A490P	0.47
LUAD	chrX	65739926	3'UTR	novel		0.06
LUAD	chrX	65739792	Missense_Mutation	novel	H545N	0.19
LUAD	chrX	65737182	Frame_Shift_Del	novel	*E366Kfs59**	0.32
LUAD	chrX	65735327	Missense_Mutation	NA	G286W	0.79
LUSC	chrX	65736855	Silent	novel	I340I	0.71
LUSC	chrX	65731158	Missense_Mutation	NA	Q173H	0.47
LUSC	chrX	65739754	Missense_Mutation	NA	A532D	0.51
LUSC	chrX	65731950	Missense_Mutation	novel	A222S	0.48
LUSC	chrX	65737333	Missense_Mutation	NA	Q416E	0.24
LUSC	chrX	65731845	Missense_Mutation	novel	A187P	0.07
LUSC	chrX	65738586	Missense_Mutation	novel	K438M	0.13
LUSC	chrX	65729507	Missense_Mutation	NA	D88H	0.55
LUSC	chrX	65739138	Missense_Mutation	novel	E505K	0.22
OV	chrX	65739086	In_Frame_Del	NA	E489_A490del	0.45
OV	chrX	65667794	5'UTR	novel		0.45
OV	chrX	65733219	Missense_Mutation	novel	I245T	0.08
PCPG	chrX	65731888	Missense_Mutation	rs761463986	Y201C	0.21
PRAD	chrX	65729580	Missense_Mutation	NA	N112T	0.56
READ	chrX	65731875	Missense_Mutation	NA	D197Y	0.17
SARC	chrX	65740122	3'UTR	novel		0.43
SKCM	chrX	65737243	Missense_Mutation	NA	A386T	0.45
SKCM	chrX	65737307	Missense_Mutation	novel	S407F	0.37
SKCM	chrX	65729501	Missense_Mutation	novel	P86S	0.32
SKCM	chrX	65737305	Silent	NA	A406A	0.16
SKCM	chrX	65739876	Missense_Mutation	NA	E573K	0.31
SKCM	chrX	65733220	Silent	NA	I245I	0.39
SKCM	chrX	65739767	Silent	NA	S536S	0.51
SKCM	chrX	65735278	Silent	NA	F269F	0.67
STAD	chrX	65667794	5'UTR	novel		0.2
STAD	chrX	65729515	Silent	NA	S90S	0.37
STAD	chrX	65729543	Missense_Mutation	rs746950857	R100C	0.18
STAD	chrX	65667855	Splice_Site	NA	X4_splice	0.19
STAD	chrX	65737209	Missense_Mutation	NA	E374D	0.63
STAD	chrX	65735348	Missense_Mutation	NA	R293C	0.44
STAD	chrX	65716827	Missense_Mutation	rs759664613	R8C	0.74
STAD	chrX	65739180	Missense_Mutation	NA	Q519K	0.84
STAD	chrX	65731967	Silent	NA	I227I	0.08
STAD	chrX	65737195	Missense_Mutation	rs761864712	R370C	0.28
STAD	chrX	65739933	3'UTR	novel		0.33
STAD	chrX	65733269	Frame_Shift_Del	novel	*A264Pfs42**	0.12
STAD	chrX	65729606	Missense_Mutation	NA	T121A	0.68
STAD	chrX	65716889	Missense_Mutation	novel	Q28H	0.29
STAD	chrX	65727877	Missense_Mutation	NA	G54S	0.12
STAD	chrX	65739837	Missense_Mutation	NA	R560C	0.08
UCEC	chrX	65729661	Missense_Mutation	NA	K139T	0.27
UCEC	chrX	65739808	Missense_Mutation	NA	R550Q	0.32
UCEC	chrX	65727843	Silent	novel	V42V	0.13
UCEC	chrX	65731899	Missense_Mutation	novel	Y205D	0.33
UCEC	chrX	65735348	Missense_Mutation	NA	R293C	0.13
UCEC	chrX	65739817	Missense_Mutation	novel	R553Q	0.34
UCEC	chrX	65735316	Missense_Mutation	rs771845314	A282V	0.35
UCEC	chrX	65667787	5'UTR	novel		0.3
UCEC	chrX	65735322	Missense_Mutation	novel	C284Y	0.13
UCEC	chrX	65741364	3'UTR	novel		0.17
UCEC	chrX	65736885	Missense_Mutation	rs182327269	R350S	0.34
UCEC	chrX	65739056	Missense_Mutation	novel	E477D	0.46
UCEC	chrX	65735415	Missense_Mutation	novel	Q315L	0.48
UCEC	chrX	65737330	Nonsense_Mutation	novel	E415*	0.34
UCEC	chrX	65736837	Missense_Mutation	novel	E334D	0.14
UCEC	chrX	65741572	3'UTR	novel		0.08
UCEC	chrX	65731119	Missense_Mutation	NA	Q160H	0.19
UCEC	chrX	65731906	Missense_Mutation	NA	S207N	0.17
UCEC	chrX	65737181	Frame_Shift_Ins	novel	*E366Gfs60**	0.14
UCEC	chrX	65727835	Missense_Mutation	NA	R40G	0.39
UCEC	chrX	65727842	Missense_Mutation	NA	V42A	0.48
UCEC	chrX	65741621	3'UTR	novel		0.48
UCEC	chrX	65731875	Missense_Mutation	NA	D197Y	0.13
UCEC	chrX	65731178	Missense_Mutation	rs373340100	R180H	0.33
UCEC	chrX	65731958	Silent	novel	G224G	0.1
UCEC	chrX	65667757	5'UTR	novel		0.3
UCEC	chrX	65737264	Missense_Mutation	novel	R393C	0.16
UCEC	chrX	65667814	5'UTR	novel		0.36
UCEC	chrX	65737238	Missense_Mutation	novel	S384N	0.39
UCEC	chrX	65729445	Missense_Mutation	novel	A67V	0.31
UCEC	chrX	65737196	Missense_Mutation	rs767712102	R370H	0.31
UCEC	chrX	65729546	Silent	novel	L101L	0.35
UCEC	chrX	65737309	Missense_Mutation	rs748200741	R408W	0.38
UCEC	chrX	65740014	3'UTR	novel		0.39
UCEC	chrX	65735272	Silent	NA	F267F	0.43
UCEC	chrX	65737196	Missense_Mutation	rs767712102	R370H	0.33
UCEC	chrX	65738581	Missense_Mutation	novel	Q436H	0.17
UCEC	chrX	65739108	Missense_Mutation	novel	R495W	0.21
UCEC	chrX	65729626	Silent	novel	S127S	0.38
UCEC	chrX	65736822	Silent	novel	K329K	0.52
UCEC	chrX	65741440	3'UTR	novel		0.51
UCEC	chrX	65735354	Missense_Mutation	novel	R295S	0.43
UCEC	chrX	65741435	3'UTR	novel		0.33
UCEC	chrX	65739807	Nonsense_Mutation	NA	R550*	0.53
UCEC	chrX	65739848	Silent	NA	R563R	0.53
UCEC	chrX	65667849	Missense_Mutation	novel	K3T	0.18
UCEC	chrX	65735348	Missense_Mutation	NA	R293C	0.14
UCEC	chrX	65736828	Missense_Mutation	novel	E331D	0.18
UCEC	chrX	65737250	Missense_Mutation	novel	K388T	0.33
UCEC	chrX	65739034	Missense_Mutation	novel	P470H	0.27
UCEC	chrX	65741604	3'UTR	novel		0.38
UCEC	chrX	65737264	Missense_Mutation	novel	R393C	0.59
UCEC	chrX	65740040	3'UTR	novel		0.45
UCEC	chrX	65737186	Nonsense_Mutation	novel	E367*	0.3
UCEC	chrX	65739806	Missense_Mutation	novel	M549I	0.3
UCEC	chrX	65737229	Missense_Mutation	rs368873074	R381H	0.39
UCEC	chrX	65739876	Missense_Mutation	NA	E573K	0.26
UCEC	chrX	65735307	Missense_Mutation	rs747717262	R279Q	0.17
UCEC	chrX	65667836	5'UTR	novel		0.51
UCEC	chrX	65739830	Missense_Mutation	novel	K557N	0.38
UCEC	chrX	65741465	3'UTR	novel		0.51
UCEC	chrX	65738577	Missense_Mutation	NA	R435L	0.18
UCEC	chrX	65729590	Missense_Mutation	novel	I115M	0.24
UCEC	chrX	65739108	Missense_Mutation	novel	R495W	0.24
UCEC	chrX	65741482	3'UTR	novel		0.17
UCEC	chrX	65735355	Missense_Mutation	NA	R295H	0.31
UCEC	chrX	65739081	Missense_Mutation	novel	N486D	0.3
UCEC	chrX	65739936	3'UTR	novel		0.23
UCEC	chrX	65729672	Missense_Mutation	novel	K143E	0.15
UCEC	chrX	65741644	3'UTR	novel		0.55
UCEC	chrX	65741794	3'UTR	novel		0.08
UCEC	chrX	65740219	3'UTR	novel		0.33
UCEC	chrX	65729581	Silent	NA	N112N	0.42
UCEC	chrX	65667757	5'UTR	novel		0.21
UCEC	chrX	65727849	Missense_Mutation	novel	F44L	0.39
UCEC	chrX	65741728	3'UTR	novel		0.29
UCEC	chrX	65737240	Missense_Mutation	NA	E385K	0.29
UCEC	chrX	65739864	Missense_Mutation	novel	Q569E	0.33
UCEC	chrX	65740136	3'UTR	novel		0.75
UCEC	chrX	65736916	Missense_Mutation	rs767686320	A361T	0.4
UCEC	chrX	65731177	Missense_Mutation	NA	R180C	0.35
UCEC	chrX	65731967	Silent	NA	I227I	0.29
UCEC	chrX	65740111	3'UTR	novel		0.21
UCEC	chrX	65739966	3'UTR	novel		0.38
UCS	chrX	65667757	5'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LGG	AMP	0.076	0.00022256
PRAD	AMP	0.0142	0.020479
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00031	Kaplan-Meier Survival Analysis
STAD	0.016	Kaplan-Meier Survival Analysis
SARC	0.032	Kaplan-Meier Survival Analysis
MESO	0.0062	Kaplan-Meier Survival Analysis
ACC	0.024	Kaplan-Meier Survival Analysis
LUSC	0.0037	Kaplan-Meier Survival Analysis
KIRP	0.0041	Kaplan-Meier Survival Analysis
PAAD	0.0027	Kaplan-Meier Survival Analysis
LAML	0.00089	Kaplan-Meier Survival Analysis
GBM	0.017	Kaplan-Meier Survival Analysis
LIHC	0.014	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742