EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000147162 (Gene tree)
Gene ID: 8473
Gene Symbol: OGT
Alias: O-GLCNAC|HRNT1|MGC22921|FLJ23071|OGT1
Full Name: O-linked N-acetylglucosamine (GlcNAc) transferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 42,836 bases
Position: chrX:71,533,062-71,575,897
Accession: 8127
RBP type: non-canonical RBP
Summary: This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000466181	OGT-207	421	-	-	- (aa)	-	-
ENST00000373701	OGT-201	3310	-	ENSP00000362805	1036 (aa)	-	O15294
ENST00000488174	OGT-210	7243	-	-	- (aa)	-	-
ENST00000474633	OGT-209	564	-	-	- (aa)	-	-
ENST00000472270	OGT-208	689	-	-	- (aa)	-	-
ENST00000373719	OGT-202	5461	XM_017029908	ENSP00000362824	1046 (aa)	XP_016885397	O15294
ENST00000498566	OGT-211	601	-	-	- (aa)	-	-
ENST00000455587	OGT-204	632	-	-	- (aa)	-	-
ENST00000459760	OGT-205	541	-	-	- (aa)	-	-
ENST00000444774	OGT-203	556	-	ENSP00000399729	156 (aa)	-	C9JZL3
ENST00000462638	OGT-206	400	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000147162's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00514	Other types of O-glycan biosynthesis	KEGG
hsa04931	Insulin resistance	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147162's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000123	histone acetyltransferase complex	20018852.	IDA	Component
GO:0005515	protein binding	12150998.12670868.16189514.17882263.20200153.21285374.21295698.22923583.23088713.23222540.23353889.23629655.24474760.24995978.25416956.25419848.26678539.27505673.27705803.	IPI	Function
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	18288188.	IDA	Function
GO:0005634	nucleus	21285374.26678539.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	21285374.	IDA	Component
GO:0005886	plasma membrane	18288188.	IDA	Component
GO:0006110	regulation of glycolytic process	22923583.	IDA	Process
GO:0006111	regulation of gluconeogenesis	-	ISS	Process
GO:0006357	regulation of transcription by RNA polymerase II	26678539.	IMP	Process
GO:0006493	protein O-linked glycosylation	21240259.21285374.22923583.23222540.23352454.24474760.	IDA	Process
GO:0006493	protein O-linked glycosylation	23353889.	IMP	Process
GO:0006915	apoptotic process	20824293.	IDA	Process
GO:0007165	signal transduction	9083067.	TAS	Process
GO:0007584	response to nutrient	9083068.	TAS	Process
GO:0008375	acetylglucosaminyltransferase activity	9083068.	TAS	Function
GO:0016032	viral process	-	IEA	Process
GO:0016262	protein N-acetylglucosaminyltransferase activity	21240259.21285374.22923583.23222540.23352454.23353889.24474760.	IDA	Function
GO:0016262	protein N-acetylglucosaminyltransferase activity	26678539.	IMP	Function
GO:0016485	protein processing	28584052.	IMP	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0031397	negative regulation of protein ubiquitination	26678539.	IMP	Process
GO:0031397	negative regulation of protein ubiquitination	-	ISS	Process
GO:0031966	mitochondrial membrane	-	IEA	Component
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	26678539.	IMP	Process
GO:0032868	response to insulin	18288188.	IDA	Process
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0032991	protein-containing complex	26678539.	IDA	Component
GO:0035020	regulation of Rac protein signal transduction	18288188.	IDA	Process
GO:0042995	cell projection	-	IEA	Component
GO:0043981	histone H4-K5 acetylation	20018852.	IDA	Process
GO:0043982	histone H4-K8 acetylation	20018852.	IDA	Process
GO:0043984	histone H4-K16 acetylation	20018852.	IDA	Process
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	20018852.	IDA	Function
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	20018852.	IDA	Function
GO:0045862	positive regulation of proteolysis	21285374.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	23222540.23353889.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	23352454.	IMP	Process
GO:0046626	regulation of insulin receptor signaling pathway	18288188.	IDA	Process
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	20018852.	IDA	Function
GO:0048015	phosphatidylinositol-mediated signaling	18288188.	IDA	Process
GO:0061087	positive regulation of histone H3-K27 methylation	24474760.	IMP	Process
GO:0080182	histone H3-K4 trimethylation	23353889.	IMP	Process
GO:0097363	protein O-GlcNAc transferase activity	23777819.28584052.	IMP	Function
GO:0097363	protein O-GlcNAc transferase activity	-	ISS	Function
GO:0120162	positive regulation of cold-induced thermogenesis	28637651.	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28347804	O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress.	J Hepatol	2017 Aug	Xu W	doi: 10.1016/j.jhep.2017.03.017
21567137	Gene expression of O-GlcNAc cycling enzymes in human breast cancers.	Clin Exp Med	2012 Mar	Krzelak A	doi: 10.1007/s10238-011-0138-5
29556021	A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies.	Leukemia	2018 Jun	Inoue D	doi: 10.1038/s41375-018-0083-3
22384635	Expression of genes encoding for enzymes associated with O-GlcNAcylation in endometrial carcinomas: clinicopathologic correlations.	Ginekol Pol	2012 Jan	Krzelak A	-
20190804	Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.	Oncogene	2010 May 13	Caldwell SA	doi: 10.1038/onc.2010.41
28455227	Suppression of OGT by microRNA24 reduces FOXA1 stability and prevents breast cancer cells invasion.	Biochem Biophys Res Commun	2017 Jun 3	Liu Y	doi: 10.1016/j.bbrc.2017.04.135
27331873	O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes.	Oncotarget	2016 Jul 12	Kim M	doi: 10.18632/oncotarget.10112.
28929346	O-GlcNAc-Dependent Regulation of Progesterone Receptor Function in Breast Cancer.	Horm Cancer	2018 Feb	Trinca GM	doi: 10.1007/s12672-017-0310-9
23720054	O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells.	Cancer Res	2013 Aug 15	Itkonen HM	doi: 10.1158/0008-5472.CAN-13-0549
25773598	Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT.	Mol Cell	2015 Apr 2	Yang Y	doi: 10.1016/j.molcel.2015.01.038
23642195	O-GlcNAc cycling: a link between metabolism and chronic disease.	Annu Rev Nutr	2013	Bond MR	doi: 10.1146/annurev-nutr-071812-161240
22783592	Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.	Clin Lab	2012	Rozanski W	-
26397041	Silencing β-linked N-acetylglucosamine transferase induces apoptosis in human gastric cancer cells through PUMA and caspase-3 pathways.	Oncol Rep	2015 Dec	Wen T	doi: 10.3892/or.2015.4276
22275356	Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis.	J Biol Chem	2012 Mar 30	Lynch TP	doi: 10.1074/jbc.M111.302547
30106436	Decreasing O-GlcNAcylation affects the malignant transformation of MCF-7 cells via Hsp27 expression and its O-GlcNAc modification.	Oncol Rep	2018 Oct	Netsirisawan P	doi: 10.3892/or.2018.6617
30453909	Suppressed OGT expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer.	BMC Cancer	2018 Nov 20	Wang L	doi: 10.1186/s12885-018-5033-y.
29059153	Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.	Oncogene	2018 Feb 15	Sodi VL	doi: 10.1038/onc.2017.395

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	71557014	Missense_Mutation	novel	D410V	0.43
BLCA	chrX	71555267	Missense_Mutation	NA	Y269C	0.47
BLCA	chrX	71564603	Splice_Region	NA	I813I	0.43
BLCA	chrX	71557255	Missense_Mutation	novel	D461H	1
BLCA	chrX	71567523	Silent	NA	S871S	0.31
BLCA	chrX	71544582	Missense_Mutation	NA	R160C	0.25
BLCA	chrX	71564620	Missense_Mutation	NA	T819I	0.53
BLCA	chrX	71563326	Splice_Region	novel		0.42
BRCA	chrX	71557264	Missense_Mutation	novel	D464N	0.31
BRCA	chrX	71554510	Splice_Region	novel		0.35
BRCA	chrX	71567611	Missense_Mutation	novel	I901V	0.06
BRCA	chrX	71529923	5'Flank	novel		0.4
BRCA	chrX	71563213	In_Frame_Del	novel	D746_L748del	0.36
BRCA	chrX	71557073	Missense_Mutation	NA	D430N	0.2
BRCA	chrX	71557514	Missense_Mutation	novel	Y482N	0.3
BRCA	chrX	71568011	Missense_Mutation	novel	R954L	0.9
BRCA	chrX	71544827	Intron	novel		0.26
BRCA	chrX	71529901	5'Flank	NA		0.27
BRCA	chrX	71567688	Silent	rs762597748	L926L	0.33
BRCA	chrX	71561868	Missense_Mutation	novel	E649Q	0.13
BRCA	chrX	71530122	5'Flank	novel		0.11
BRCA	chrX	71555370	Silent	novel	L303L	0.05
BRCA	chrX	71554551	Missense_Mutation	novel	I229M	0.13
BRCA	chrX	71537888	Missense_Mutation	NA	S93L	0.25
BRCA	chrX	71556071	Missense_Mutation	rs267606503	R348C	0.08
BRCA	chrX	71559276	Missense_Mutation	novel	L538I	0.09
BRCA	chrX	71547932	Missense_Mutation	rs778629433	T186M	0.38
BRCA	chrX	71547570	Intron	novel		0.28
BRCA	chrX	71529914	5'Flank	novel		0.38
CESC	chrX	71559425	Splice_Region	NA	E587E	0.22
CESC	chrX	71564619	Missense_Mutation	NA	T819P	0.39
CESC	chrX	71574304	3'UTR	novel		0.29
CESC	chrX	71574829	3'UTR	novel		0.51
CESC	chrX	71568010	Nonsense_Mutation	NA	R954*	0.23
CESC	chrX	71563446	Missense_Mutation	novel	I795V	0.35
CESC	chrX	71574683	3'UTR	novel		0.42
CESC	chrX	71575782	3'UTR	novel		0.38
CESC	chrX	71575290	3'UTR	novel		0.16
CESC	chrX	71574122	3'UTR	novel		0.37
CESC	chrX	71574844	3'UTR	novel		0.13
CESC	chrX	71557264	Missense_Mutation	NA	D464H	0.57
CESC	chrX	71568011	Missense_Mutation	NA	R954P	0.2
CESC	chrX	71530028	5'Flank	novel		0.2
COAD	chrX	71557653	Missense_Mutation	NA	G528D	0.37
COAD	chrX	71530290	5'Flank	novel		0.3
COAD	chrX	71562948	Silent	rs770630335	S693S	0.36
COAD	chrX	71555953	Splice_Site	novel	X309_splice	0.54
COAD	chrX	71573633	Missense_Mutation	NA	R994C	0.8
COAD	chrX	71557653	Missense_Mutation	NA	G528D	0.32
COAD	chrX	71555284	Missense_Mutation	novel	I275V	0.21
COAD	chrX	71544591	Missense_Mutation	novel	L163M	0.11
COAD	chrX	71567554	Nonsense_Mutation	novel	G882*	0.34
COAD	chrX	71573919	3'UTR	novel		0.36
COAD	chrX	71567557	Missense_Mutation	NA	E883Q	0.14
COAD	chrX	71562882	Silent	rs148161543	A671A	0.32
COAD	chrX	71568106	Missense_Mutation	novel	D986H	0.6
COAD	chrX	71533199	5'UTR	novel		0.24
COAD	chrX	71538046	Frame_Shift_Ins	novel	*Y146Sfs38**	0.08
COAD	chrX	71563351	Missense_Mutation	novel	D763G	0.26
ESCA	chrX	71575790	3'UTR	novel		0.71
ESCA	chrX	71567509	Missense_Mutation	novel	R867C	0.7
ESCA	chrX	71529786	5'Flank	novel		0.4
ESCA	chrX	71563189	Silent	novel	L736L	0.14
GBM	chrX	71544653	Intron	novel		0.11
GBM	chrX	71561858	Silent	rs773916315	G645G	0.43
GBM	chrX	71568058	Missense_Mutation	novel	A970P	0.3
GBM	chrX	71561835	Missense_Mutation	novel	N638Y	0.1
GBM	chrX	71538018	Frame_Shift_Ins	novel	*G137Wfs2**	0.09
GBM	chrX	71559314	Silent	novel	K550K	0.07
GBM	chrX	71562898	Missense_Mutation	novel	I677V	0.11
GBM	chrX	71563471	Missense_Mutation	novel	S803N	0.15
GBM	chrX	71547977	Frame_Shift_Del	novel	F201*	0.03
GBM	chrX	71557657	Missense_Mutation	NA	N529K	0.29
HNSC	chrX	71547836	Intron	NA		0.26
HNSC	chrX	71567676	Silent	novel	L922L	0.64
HNSC	chrX	71557041	Missense_Mutation	novel	T419M	0.14
HNSC	chrX	71568030	Silent	novel	L960L	0.13
HNSC	chrX	71567505	Silent	novel	L865L	0.31
HNSC	chrX	71556971	Missense_Mutation	novel	D396N	0.61
HNSC	chrX	71555232	Missense_Mutation	novel	N257K	0.2
KIRC	chrX	71564691	Missense_Mutation	NA	V843I	0.35
KIRC	chrX	71536244	Missense_Mutation	NA	G35V	0.56
KIRP	chrX	71536330	Missense_Mutation	novel	I64L	0.58
KIRP	chrX	71562881	Missense_Mutation	NA	A671V	0.23
LGG	chrX	71557106	Splice_Site	NA	X440_splice	0.15
LGG	chrX	71547963	Missense_Mutation	rs200109331	N196K	0.87
LGG	chrX	71537960	Missense_Mutation	NA	R117H	0.13
LGG	chrX	71563331	Missense_Mutation	novel	M756I	0.43
LGG	chrX	71563396	Missense_Mutation	novel	P778L	0.07
LGG	chrX	71573777	Missense_Mutation	NA	V1042I	0.25
LGG	chrX	71564691	Missense_Mutation	NA	V843L	0.28
LIHC	chrX	71555241	Silent	novel	V260V	0.75
LUAD	chrX	71563144	Missense_Mutation	novel	I721M	0.49
LUAD	chrX	71564659	Missense_Mutation	NA	R832L	0.62
LUAD	chrX	71555225	Missense_Mutation	novel	S255I	0.51
LUAD	chrX	71562957	Missense_Mutation	novel	L696F	0.09
LUAD	chrX	71556088	Silent	novel	A353A	0.06
LUAD	chrX	71556089	Frame_Shift_Ins	novel	*L354Sfs34**	0.06
LUAD	chrX	71562940	Missense_Mutation	NA	Q691K	0.27
LUAD	chrX	71561860	Missense_Mutation	novel	A646D	0.17
LUAD	chrX	71547938	Missense_Mutation	novel	P188R	0.22
LUAD	chrX	71557199	Nonsense_Mutation	novel	S442*	0.38
LUAD	chrX	71556955	Silent	novel	I390I	0.32
LUAD	chrX	71559594	Missense_Mutation	NA	C590S	0.35
LUAD	chrX	71563347	Missense_Mutation	rs760156553	G762R	0.25
LUAD	chrX	71544619	Missense_Mutation	novel	R172H	0.18
LUAD	chrX	71561818	Missense_Mutation	novel	G632V	0.25
LUAD	chrX	71562970	Missense_Mutation	novel	H701Y	0.28
LUAD	chrX	71544685	Intron	novel		0.31
LUAD	chrX	71554510	Splice_Region	novel		0.17
LUAD	chrX	71567557	Missense_Mutation	NA	E883Q	0.26
LUAD	chrX	71559677	Frame_Shift_Del	novel		0.28
LUAD	chrX	71564705	Silent	novel	F847F	0.4
LUAD	chrX	71573678	Missense_Mutation	novel	T1009A	0.56
LUAD	chrX	71563195	Silent	NA	G738G	0.42
LUAD	chrX	71567668	Missense_Mutation	NA	V920I	0.45
LUAD	chrX	71567653	Missense_Mutation	novel	G915C	0.12
LUAD	chrX	71536281	Silent	novel	L47L	0.13
LUAD	chrX	71547960	Silent	NA	S195S	0.07
LUAD	chrX	71555207	Missense_Mutation	NA	L249H	0.14
LUAD	chrX	71538016	Missense_Mutation	novel	A136T	0.07
LUSC	chrX	71556031	Silent	novel	A334A	0.11
LUSC	chrX	71537888	Missense_Mutation	NA	S93L	0.17
LUSC	chrX	71557667	Missense_Mutation	NA	D533H	0.34
LUSC	chrX	71537897	Missense_Mutation	novel	G96E	0.27
LUSC	chrX	71554579	Missense_Mutation	NA	R239C	0.43
LUSC	chrX	71563231	Missense_Mutation	novel	D750E	0.15
LUSC	chrX	71567510	Missense_Mutation	novel	R867H	0.1
LUSC	chrX	71561829	Missense_Mutation	novel	L636I	0.15
LUSC	chrX	71563445	Missense_Mutation	novel	Q794H	0.12
LUSC	chrX	71564754	Splice_Site	NA	X863_splice	0.25
LUSC	chrX	71559593	Missense_Mutation	novel	F589L	0.46
LUSC	chrX	71573751	Missense_Mutation	novel	P1033H	0.22
LUSC	chrX	71530189	5'Flank	novel		0.75
LUSC	chrX	71567656	Nonsense_Mutation	novel	Q916*	0.18
OV	chrX	71557235	Missense_Mutation	NA	T454K	0.27
OV	chrX	71529742	5'Flank	novel		0.36
OV	chrX	71538071	Missense_Mutation	novel	P154L	0.06
OV	chrX	71557495	Splice_Region	novel	I475I	0.05
OV	chrX	71567551	Missense_Mutation	novel	V881L	0.1
OV	chrX	71548004	Missense_Mutation	novel	A210V	0.06
OV	chrX	71563145	Missense_Mutation	novel	D722N	0.04
PAAD	chrX	71537960	Missense_Mutation	NA	R117H	0.42
PAAD	chrX	71557243	Missense_Mutation	novel	K457E	0.15
PCPG	chrX	71536272	Silent	novel	C44C	0.43
PCPG	chrX	71548006	Missense_Mutation	novel	I211V	0.73
READ	chrX	71568042	Silent	novel	G964G	0.09
READ	chrX	71530262	5'Flank	novel		0.43
READ	chrX	71562952	Missense_Mutation	NA	K695E	0.13
READ	chrX	71556027	Missense_Mutation	NA	L333P	0.67
READ	chrX	71561897	Missense_Mutation	NA	I658M	0.17
SARC	chrX	71567502	Splice_Region	novel	I864I	0.08
SARC	chrX	71555280	Silent	novel	G273G	0.78
SARC	chrX	71567718	Silent	novel	V936V	0.5
SARC	chrX	71567719	Missense_Mutation	novel	L937F	0.48
SARC	chrX	71573910	3'UTR	novel		0.5
SKCM	chrX	71573747	Missense_Mutation	novel	K1032E	0.32
SKCM	chrX	71561840	Missense_Mutation	NA	M639I	0.21
SKCM	chrX	71564612	Silent	NA	K816K	0.35
SKCM	chrX	71544582	Missense_Mutation	NA	R160C	0.2
SKCM	chrX	71567733	Silent	NA	T941T	0.6
SKCM	chrX	71563426	Missense_Mutation	NA	E788G	0.88
SKCM	chrX	71556095	Splice_Site	novel	X355_splice	0.51
SKCM	chrX	71547818	Intron	novel		0.96
SKCM	chrX	71559366	Missense_Mutation	NA	H568Y	0.22
SKCM	chrX	71556005	Missense_Mutation	NA	H326Y	0.17
SKCM	chrX	71561858	Silent	rs773916315	G645G	0.69
SKCM	chrX	71547852	Intron	novel		0.51
SKCM	chrX	71538028	Missense_Mutation	novel	E140Q	0.87
SKCM	chrX	71564670	Missense_Mutation	NA	G836R	0.9
SKCM	chrX	71548001	Missense_Mutation	novel	L209P	0.73
SKCM	chrX	71567629	Missense_Mutation	NA	P907S	0.93
SKCM	chrX	71562907	Missense_Mutation	NA	D680N	0.36
SKCM	chrX	71567593	Silent	rs748622645	L895L	0.27
SKCM	chrX	71563006	Missense_Mutation	NA	P713S	0.65
SKCM	chrX	71559610	Missense_Mutation	NA	P595L	0.28
STAD	chrX	71557572	Missense_Mutation	novel	R501K	0.55
STAD	chrX	71562975	Frame_Shift_Del	NA	*F704Lfs12**	0.09
STAD	chrX	71538004	Missense_Mutation	NA	A132T	0.22
STAD	chrX	71547939	Silent	rs764536052	P188P	0.18
STAD	chrX	71563155	Missense_Mutation	novel	S725F	0.33
STAD	chrX	71555245	Missense_Mutation	novel	H262Y	0.13
STAD	chrX	71547987	Silent	NA	Q204Q	0.08
STAD	chrX	71547827	Intron	novel		0.77
STAD	chrX	71567540	Missense_Mutation	NA	R877H	0.24
STAD	chrX	71567611	Frame_Shift_Ins	novel	*S903Ffs6**	0.23
STAD	chrX	71547773	Intron	novel		0.47
STAD	chrX	71562975	Frame_Shift_Del	NA	*F704Lfs12**	0.13
STAD	chrX	71547827	Intron	novel		0.22
STAD	chrX	71559333	Missense_Mutation	rs759414360	R557C	0.44
TGCT	chrX	71573712	Missense_Mutation	novel	Y1020C	0.19
THCA	chrX	71537969	Missense_Mutation	novel	P120L	0.03
THCA	chrX	71537969	Missense_Mutation	novel	P120L	0.04
THCA	chrX	71563215	Frame_Shift_Del	novel	*L745Hfs4**	0.04
THYM	chrX	71568035	Missense_Mutation	novel	C962Y	0.17
THYM	chrX	71567740	Missense_Mutation	novel	V944L	0.07
UCEC	chrX	71544650	Intron	novel		0.31
UCEC	chrX	71538047	Missense_Mutation	NA	Y146C	0.36
UCEC	chrX	71557038	Missense_Mutation	NA	Y418C	0.38
UCEC	chrX	71533199	5'UTR	novel		0.17
UCEC	chrX	71547899	Splice_Region	novel		0.26
UCEC	chrX	71559418	Missense_Mutation	novel	K585T	0.23
UCEC	chrX	71573809	3'UTR	novel		0.17
UCEC	chrX	71575248	3'UTR	novel		0.32
UCEC	chrX	71556072	Missense_Mutation	novel	R348H	0.08
UCEC	chrX	71567557	Nonsense_Mutation	NA	E883*	0.38
UCEC	chrX	71537902	Missense_Mutation	novel	V98M	0.42
UCEC	chrX	71574295	3'UTR	novel		0.19
UCEC	chrX	71556080	Missense_Mutation	NA	R351C	0.36
UCEC	chrX	71544764	Intron	novel		0.13
UCEC	chrX	71561863	Missense_Mutation	NA	R647Q	0.48
UCEC	chrX	71564603	Splice_Region	NA	I813I	0.42
UCEC	chrX	71533155	5'UTR	novel		0.43
UCEC	chrX	71538049	Missense_Mutation	rs368768611	V147I	0.41
UCEC	chrX	71573633	Missense_Mutation	NA	R994C	0.44
UCEC	chrX	71574147	3'UTR	novel		0.3
UCEC	chrX	71547846	Intron	novel		0.3
UCEC	chrX	71574197	3'UTR	novel		0.28
UCEC	chrX	71573831	3'UTR	novel		0.51
UCEC	chrX	71555237	Missense_Mutation	NA	A259V	0.11
UCEC	chrX	71561847	Missense_Mutation	NA	Y642H	0.17
UCEC	chrX	71573870	3'UTR	novel		0.17
UCEC	chrX	71559333	Missense_Mutation	rs759414360	R557C	0.4
UCEC	chrX	71547683	Intron	novel		0.38
UCEC	chrX	71544751	Intron	novel		0.19
UCEC	chrX	71556033	Missense_Mutation	NA	N335T	0.16
UCEC	chrX	71533232	5'UTR	novel		0.31
UCEC	chrX	71533324	Missense_Mutation	novel	A9T	0.09
UCEC	chrX	71554580	Missense_Mutation	NA	R239H	0.24
UCEC	chrX	71556992	Missense_Mutation	novel	N403D	0.15
UCEC	chrX	71561863	Missense_Mutation	NA	R647Q	0.38
UCEC	chrX	71563389	Missense_Mutation	novel	V776I	0.17
UCEC	chrX	71574320	3'UTR	novel		0.49
UCEC	chrX	71573799	3'UTR	novel		0.14
UCEC	chrX	71574229	3'UTR	novel		0.37
UCEC	chrX	71544583	Missense_Mutation	novel	R160H	0.34
UCEC	chrX	71554591	Missense_Mutation	novel	R243G	0.32
UCEC	chrX	71557041	Missense_Mutation	novel	T419M	0.24
UCEC	chrX	71563396	Missense_Mutation	novel	P778H	0.21
UCEC	chrX	71573828	3'UTR	novel		0.38
UCEC	chrX	71575017	3'UTR	novel		0.23
UCEC	chrX	71528683	5'Flank	novel		0.43
UCEC	chrX	71547766	Intron	novel		0.3
UCEC	chrX	71555355	Silent	novel	N298N	0.3
UCEC	chrX	71575677	3'UTR	novel		0.45
UCEC	chrX	71575052	3'UTR	novel		0.33
UCEC	chrX	71547529	Intron	novel		0.21
UCEC	chrX	71529797	5'Flank	rs758060768		0.35
UCEC	chrX	71544650	Intron	novel		0.5
UCEC	chrX	71547939	Silent	rs764536052	P188P	0.46
UCEC	chrX	71563428	Missense_Mutation	novel	M789L	0.36
UCEC	chrX	71573685	Missense_Mutation	novel	Q1011P	0.51
UCEC	chrX	71575762	3'UTR	novel		0.45
UCEC	chrX	71530197	5'Flank	novel		0.38
UCEC	chrX	71533082	5'Flank	novel		0.52
UCEC	chrX	71533234	5'UTR	novel		0.55
UCEC	chrX	71537915	Missense_Mutation	novel	R102I	0.19
UCEC	chrX	71575782	3'UTR	novel		0.41
UCEC	chrX	71555202	Silent	NA	A247A	0.41
UCEC	chrX	71559600	Missense_Mutation	novel	A592T	0.1
UCEC	chrX	71574147	3'UTR	novel		0.41
UCEC	chrX	71533101	5'UTR	novel		0.42
UCEC	chrX	71544804	Intron	novel		0.54
UCEC	chrX	71530111	5'Flank	novel		0.19
UCEC	chrX	71574004	3'UTR	novel		0.26
UCEC	chrX	71574207	3'UTR	novel		0.46
UCEC	chrX	71574490	3'UTR	novel		0.48
UCEC	chrX	71575325	3'UTR	novel		0.31
UCEC	chrX	71575662	3'UTR	novel		0.38
UCEC	chrX	71575791	3'UTR	novel		0.4
UCEC	chrX	71547973	Missense_Mutation	novel	V200F	0.23
UCEC	chrX	71575010	3'UTR	novel		0.38
UCEC	chrX	71574638	3'UTR	novel		0.14
UCEC	chrX	71548014	Missense_Mutation	novel	H213Q	0.08
UCEC	chrX	71556029	Missense_Mutation	novel	A334T	0.08
UCEC	chrX	71559418	Missense_Mutation	novel	K585R	0.15
UCEC	chrX	71567557	Nonsense_Mutation	NA	E883*	0.25
UCEC	chrX	71573633	Missense_Mutation	NA	R994C	0.15
UCEC	chrX	71575666	3'UTR	rs191878713		0.15
UCEC	chrX	71574147	3'UTR	novel		0.61
UCEC	chrX	71533327	Missense_Mutation	novel	D10N	0.39
UCEC	chrX	71536346	Missense_Mutation	novel	R69Q	0.17
UCEC	chrX	71537948	Missense_Mutation	rs377762466	R113Q	0.33
UCEC	chrX	71555319	Silent	novel	I286I	0.34
UCEC	chrX	71564650	Missense_Mutation	novel	V829A	0.3
UCEC	chrX	71575248	3'UTR	novel		0.48
UCEC	chrX	71575799	3'UTR	novel		0.21
UCEC	chrX	71557237	Missense_Mutation	novel	A455T	0.48
UCEC	chrX	71564638	Missense_Mutation	rs186760930	R825H	0.47
UCEC	chrX	71567503	Missense_Mutation	novel	L865M	0.45
UCEC	chrX	71567624	Missense_Mutation	novel	V905D	0.46
UCEC	chrX	71536258	Missense_Mutation	novel	A40T	0.27
UCEC	chrX	71537981	Missense_Mutation	novel	D124A	0.33
UCEC	chrX	71556071	Missense_Mutation	rs267606503	R348C	0.52
UCEC	chrX	71557046	Missense_Mutation	novel	A421T	0.12
UCEC	chrX	71561863	Missense_Mutation	NA	R647Q	0.42
UCEC	chrX	71575666	3'UTR	rs191878713		0.55
UCEC	chrX	71567628	Silent	NA	A906A	0.46
UCEC	chrX	71538071	Missense_Mutation	novel	P154H	0.08
UCEC	chrX	71559418	Missense_Mutation	novel	K585R	0.11
UCEC	chrX	71547886	Intron	novel		0.15
UCEC	chrX	71574177	3'UTR	novel		0.12
UCEC	chrX	71574638	3'UTR	novel		0.9
UCEC	chrX	71529797	5'Flank	rs758060768		0.33
UCEC	chrX	71529912	5'Flank	novel		0.2
UCEC	chrX	71547741	Intron	novel		0.27
UCEC	chrX	71536189	Missense_Mutation	NA	R17C	0.28
UCEC	chrX	71554580	Missense_Mutation	NA	R239H	0.05
UCEC	chrX	71557042	Silent	novel	T419T	0.07
UCEC	chrX	71555356	Missense_Mutation	novel	L299I	0.23
UCEC	chrX	71563017	Missense_Mutation	novel	K716N	0.58
UCEC	chrX	71574424	3'UTR	novel		0.13
UCEC	chrX	71544687	Intron	novel		0.39
UCEC	chrX	71567662	Missense_Mutation	novel	A918T	0.31
UCEC	chrX	71536246	Missense_Mutation	NA	D36Y	0.39
UCEC	chrX	71547939	Silent	rs764536052	P188P	0.42
UCEC	chrX	71573761	Missense_Mutation	novel	M1036I	0.07
UCEC	chrX	71563381	Missense_Mutation	NA	N773I	0.39
UCEC	chrX	71562951	Silent	NA	E694E	0.25
UCEC	chrX	71574487	3'UTR	novel		0.79
UCEC	chrX	71562975	Frame_Shift_Del	NA	*F704Lfs12**	0.48
UCEC	chrX	71556071	Missense_Mutation	rs267606503	R348C	0.2
UCEC	chrX	71563129	Splice_Site	NA	X717_splice	0.37
UCEC	chrX	71573965	3'UTR	novel		0.41
UCEC	chrX	71559410	Silent	NA	N582N	0.27
UCEC	chrX	71547724	Intron	novel		0.24
UCEC	chrX	71547939	Silent	rs764536052	P188P	0.37
UCEC	chrX	71559611	Silent	novel	P595P	0.37
UCEC	chrX	71575547	3'UTR	novel		0.61
UCEC	chrX	71575783	3'UTR	novel		0.51
UCEC	chrX	71568064	Missense_Mutation	novel	N972H	0.38
UCEC	chrX	71547694	Intron	novel		0.21
UCEC	chrX	71564659	Missense_Mutation	novel	R832H	0.09
UCEC	chrX	71537835	In_Frame_Del	novel	H76_L87del	0.19
UCEC	chrX	71547727	Intron	novel		0.47
UCEC	chrX	71575454	3'UTR	novel		0.33
UCEC	chrX	71533082	5'Flank	novel		0.3
UCEC	chrX	71555344	Missense_Mutation	novel	A295T	0.45
UCEC	chrX	71555993	Silent	novel	L322L	0.36
UCEC	chrX	71561872	Missense_Mutation	novel	L650R	0.3
UCEC	chrX	71567732	Missense_Mutation	novel	T941I	0.1
UCEC	chrX	71568089	Missense_Mutation	novel	A980V	0.42
UCEC	chrX	71573667	Missense_Mutation	novel	P1005L	0.4
UCEC	chrX	71574239	3'UTR	novel		0.44
UCEC	chrX	71574891	3'UTR	novel		0.33
UCEC	chrX	71575782	3'UTR	novel		0.36
UCEC	chrX	71574911	3'UTR	novel		0.07
UCS	chrX	71564670	Missense_Mutation	NA	G836R	0.45
UCS	chrX	71538049	Missense_Mutation	rs368768611	V147I	0.42
UCS	chrX	71573633	Missense_Mutation	NA	R994C	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.043	Kaplan-Meier Survival Analysis
SARC	0.034	Kaplan-Meier Survival Analysis
MESO	0.0013	Kaplan-Meier Survival Analysis
HNSC	0.0066	Kaplan-Meier Survival Analysis
SKCM	0.00055	Kaplan-Meier Survival Analysis
PRAD	0.03	Kaplan-Meier Survival Analysis
ESCA	0.024	Kaplan-Meier Survival Analysis
KIRP	0.023	Kaplan-Meier Survival Analysis
PCPG	0.048	Kaplan-Meier Survival Analysis
BLCA	0.00011	Kaplan-Meier Survival Analysis
KICH	0.034	Kaplan-Meier Survival Analysis
UCEC	0.006	Kaplan-Meier Survival Analysis
GBM	0.022	Kaplan-Meier Survival Analysis
LUAD	0.00069	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742