EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000147586 (Gene tree)
Gene ID: 28957
Gene Symbol: MRPS28
Alias: MRP-S28|HSPC007|MRPS35
Full Name: mitochondrial ribosomal protein S28
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 111,573 bases
Position: chr8:79,918,717-80,030,289
Accession: 14513
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000428050	MRP-S35	PF10246.9	2.1e-52	1	1
ENSP00000276585	MRP-S35	PF10246.9	2.8e-52	1	1
ENSP00000428744	MRP-S35	PF10246.9	6e-49	1	1
ENSP00000428880	MRP-S35	PF10246.9	1.9e-45	1	1
ENSP00000430401	MRP-S35	PF10246.9	3.1e-43	1	1
ENSP00000427846	MRP-S35	PF10246.9	1.9e-31	1	1
ENSP00000476135	MRP-S35	PF10246.9	8.6e-25	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000518271	MRPS28-202	487	-	ENSP00000427846	162 (aa)	-	H7C5V3
ENST00000518371	MRPS28-203	783	-	ENSP00000476135	83 (aa)	-	U3KQQ8
ENST00000519120	MRPS28-204	403	-	ENSP00000428744	103 (aa)	-	E5RGC7
ENST00000521434	MRPS28-207	585	-	ENSP00000428880	125 (aa)	-	E5RFH3
ENST00000520946	MRPS28-206	411	-	ENSP00000430401	108 (aa)	-	E5RK86
ENST00000521605	MRPS28-208	437	-	ENSP00000427965	86 (aa)	-	E5RFT8
ENST00000276585	MRPS28-201	850	-	ENSP00000276585	187 (aa)	-	Q9Y2Q9
ENST00000522987	MRPS28-209	487	-	-	- (aa)	-	-
ENST00000519386	MRPS28-205	555	-	ENSP00000428050	143 (aa)	-	H0YAT2

Gene Model

Click here to download ENSG00000147586's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147586's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000147586	MRPS28	100	63.889	ENSAPOG00000007350	mrps28	90	63.889	Acanthochromis_polyacanthus
ENSG00000147586	MRPS28	99	92.157	ENSAMEG00000017516	MRPS28	100	89.565	Ailuropoda_melanoleuca
ENSG00000147586	MRPS28	97	68.000	ENSACIG00000007839	mrps28	82	56.849	Amphilophus_citrinellus
ENSG00000147586	MRPS28	97	69.000	ENSAOCG00000000705	mrps28	100	51.613	Amphiprion_ocellaris
ENSG00000147586	MRPS28	97	69.000	ENSAPEG00000016051	mrps28	83	58.219	Amphiprion_percula
ENSG00000147586	MRPS28	96	72.727	ENSATEG00000015295	mrps28	74	65.185	Anabas_testudineus
ENSG00000147586	MRPS28	97	83.000	ENSAPLG00000005666	MRPS28	100	82.243	Anas_platyrhynchos
ENSG00000147586	MRPS28	97	62.000	ENSACLG00000003892	mrps28	90	61.538	Astatotilapia_calliptera
ENSG00000147586	MRPS28	97	73.000	ENSAMXG00000026324	mrps28	71	66.917	Astyanax_mexicanus
ENSG00000147586	MRPS28	98	94.059	ENSBTAG00000001302	MRPS28	99	85.027	Bos_taurus
ENSG00000147586	MRPS28	85	48.864	WBGene00012830	mrps-28	65	43.750	Caenorhabditis_elegans
ENSG00000147586	MRPS28	95	94.898	ENSCAFG00000008393	MRPS28	100	81.215	Canis_familiaris
ENSG00000147586	MRPS28	95	94.898	ENSCAFG00020017987	MRPS28	100	81.215	Canis_lupus_dingo
ENSG00000147586	MRPS28	100	92.233	ENSCHIG00000018727	MRPS28	100	83.511	Capra_hircus
ENSG00000147586	MRPS28	100	79.612	ENSTSYG00000031343	-	100	73.262	Carlito_syrichta
ENSG00000147586	MRPS28	94	64.706	ENSTSYG00000013531	-	100	79.389	Carlito_syrichta
ENSG00000147586	MRPS28	99	83.333	ENSCAPG00000006948	-	95	82.857	Cavia_aperea
ENSG00000147586	MRPS28	99	84.314	ENSCPOG00000031885	-	95	83.810	Cavia_porcellus
ENSG00000147586	MRPS28	100	92.233	ENSCCAG00000022534	MRPS28	100	88.000	Cebus_capucinus
ENSG00000147586	MRPS28	93	89.583	ENSCLAG00000003227	-	95	85.714	Chinchilla_lanigera
ENSG00000147586	MRPS28	99	90.196	ENSCHOG00000004885	MRPS28	100	80.749	Choloepus_hoffmanni
ENSG00000147586	MRPS28	97	82.000	ENSCPBG00000007206	MRPS28	59	79.661	Chrysemys_picta_bellii
ENSG00000147586	MRPS28	99	89.216	ENSCGRG00001018741	Mrps28	100	75.936	Cricetulus_griseus_chok1gshd
ENSG00000147586	MRPS28	99	87.255	ENSCGRG00000018208	Mrps28	99	86.957	Cricetulus_griseus_crigri
ENSG00000147586	MRPS28	92	68.421	ENSCSEG00000020947	mrps28	97	67.961	Cynoglossus_semilaevis
ENSG00000147586	MRPS28	94	56.701	ENSCVAG00000007159	mrps28	97	50.000	Cyprinodon_variegatus
ENSG00000147586	MRPS28	91	75.532	ENSDARG00000041538	mrps28	98	53.672	Danio_rerio
ENSG00000147586	MRPS28	100	88.350	ENSDNOG00000017379	-	60	78.495	Dasypus_novemcinctus
ENSG00000147586	MRPS28	99	84.314	ENSDORG00000002762	Mrps28	100	75.936	Dipodomys_ordii
ENSG00000147586	MRPS28	87	54.444	FBgn0034361	mRpS28	69	44.928	Drosophila_melanogaster
ENSG00000147586	MRPS28	89	72.826	ENSEBUG00000010846	mrps28	75	63.359	Eptatretus_burgeri
ENSG00000147586	MRPS28	98	94.059	ENSEASG00005020574	MRPS28	100	83.511	Equus_asinus_asinus
ENSG00000147586	MRPS28	96	66.452	ENSECAG00000036837	-	80	81.343	Equus_caballus
ENSG00000147586	MRPS28	96	66.452	ENSECAG00000030797	-	83	81.343	Equus_caballus
ENSG00000147586	MRPS28	98	95.050	ENSECAG00000015430	MRPS28	100	83.511	Equus_caballus
ENSG00000147586	MRPS28	98	57.065	ENSEEUG00000013471	MRPS28	99	57.065	Erinaceus_europaeus
ENSG00000147586	MRPS28	73	44.538	ENSELUG00000023151	mrps28	51	64.384	Esox_lucius
ENSG00000147586	MRPS28	99	93.137	ENSFCAG00000032510	MRPS28	100	84.492	Felis_catus
ENSG00000147586	MRPS28	97	80.000	ENSFALG00000008608	MRPS28	98	71.318	Ficedula_albicollis
ENSG00000147586	MRPS28	100	83.495	ENSFDAG00000013634	MRPS28	97	75.401	Fukomys_damarensis
ENSG00000147586	MRPS28	96	58.654	ENSFHEG00000006233	mrps28	93	52.066	Fundulus_heteroclitus
ENSG00000147586	MRPS28	96	59.596	ENSGAFG00000014759	mrps28	98	44.920	Gambusia_affinis
ENSG00000147586	MRPS28	100	69.903	ENSGACG00000019939	mrps28	78	58.389	Gasterosteus_aculeatus
ENSG00000147586	MRPS28	97	81.000	ENSGAGG00000025904	MRPS28	69	78.814	Gopherus_agassizii
ENSG00000147586	MRPS28	97	62.000	ENSHBUG00000014315	mrps28	100	53.659	Haplochromis_burtoni
ENSG00000147586	MRPS28	100	86.408	ENSHGLG00000009986	MRPS28	81	80.214	Heterocephalus_glaber_female
ENSG00000147586	MRPS28	100	86.408	ENSHGLG00100019258	MRPS28	81	80.214	Heterocephalus_glaber_male
ENSG00000147586	MRPS28	86	65.556	ENSHCOG00000011561	mrps28	73	54.545	Hippocampus_comes
ENSG00000147586	MRPS28	96	71.717	ENSIPUG00000012566	mrps28	77	61.538	Ictalurus_punctatus
ENSG00000147586	MRPS28	95	67.532	ENSSTOG00000015179	MRPS28	100	84.091	Ictidomys_tridecemlineatus
ENSG00000147586	MRPS28	94	58.170	ENSJJAG00000023759	Mrps28	84	63.190	Jaculus_jaculus
ENSG00000147586	MRPS28	94	75.258	ENSKMAG00000006636	mrps28	88	53.552	Kryptolebias_marmoratus
ENSG00000147586	MRPS28	97	76.000	ENSLACG00000014702	MRPS28	69	69.697	Latimeria_chalumnae
ENSG00000147586	MRPS28	97	77.000	ENSLOCG00000017359	mrps28	73	65.957	Lepisosteus_oculatus
ENSG00000147586	MRPS28	86	76.404	ENSMAMG00000017782	mrps28	83	75.000	Mastacembelus_armatus
ENSG00000147586	MRPS28	97	62.000	ENSMZEG00005010529	-	90	61.538	Maylandia_zebra
ENSG00000147586	MRPS28	97	62.000	ENSMZEG00005014997	mrps28	90	61.538	Maylandia_zebra
ENSG00000147586	MRPS28	96	81.818	ENSMGAG00000011622	MRPS28	100	81.731	Meleagris_gallopavo
ENSG00000147586	MRPS28	99	90.196	ENSMAUG00000009465	Mrps28	100	76.471	Mesocricetus_auratus
ENSG00000147586	MRPS28	100	91.262	ENSMICG00000044873	MRPS28	100	84.492	Microcebus_murinus
ENSG00000147586	MRPS28	99	90.196	ENSMOCG00000021930	Mrps28	100	77.005	Microtus_ochrogaster
ENSG00000147586	MRPS28	91	60.204	ENSMMOG00000018438	mrps28	53	60.204	Mola_mola
ENSG00000147586	MRPS28	97	84.000	ENSMODG00000006621	MRPS28	97	70.330	Monodelphis_domestica
ENSG00000147586	MRPS28	99	72.549	ENSMALG00000006494	mrps28	88	69.828	Monopterus_albus
ENSG00000147586	MRPS28	99	87.255	MGP_CAROLIEiJ_G0024833	Mrps28	100	73.797	Mus_caroli
ENSG00000147586	MRPS28	99	86.275	ENSMUSG00000040269	Mrps28	100	73.262	Mus_musculus
ENSG00000147586	MRPS28	99	87.255	MGP_PahariEiJ_G0026281	Mrps28	100	71.658	Mus_pahari
ENSG00000147586	MRPS28	99	86.275	MGP_SPRETEiJ_G0025763	Mrps28	100	73.262	Mus_spretus
ENSG00000147586	MRPS28	99	95.098	ENSMPUG00000001853	MRPS28	100	83.957	Mustela_putorius_furo
ENSG00000147586	MRPS28	98	88.119	ENSMLUG00000015175	MRPS28	100	77.540	Myotis_lucifugus
ENSG00000147586	MRPS28	99	84.314	ENSNGAG00000000216	Mrps28	100	75.401	Nannospalax_galili
ENSG00000147586	MRPS28	86	69.663	ENSNBRG00000021393	mrps28	78	54.015	Neolamprologus_brichardi
ENSG00000147586	MRPS28	98	84.158	ENSMEUG00000007676	MRPS28	100	72.131	Notamacropus_eugenii
ENSG00000147586	MRPS28	99	89.216	ENSODEG00000005701	MRPS28	97	80.874	Octodon_degus
ENSG00000147586	MRPS28	97	63.000	ENSONIG00000020758	mrps28	78	54.015	Oreochromis_niloticus
ENSG00000147586	MRPS28	99	94.118	ENSOCUG00000000867	MRPS28	100	81.921	Oryctolagus_cuniculus
ENSG00000147586	MRPS28	97	66.000	ENSORLG00000026843	mrps28	80	55.944	Oryzias_latipes
ENSG00000147586	MRPS28	97	67.000	ENSORLG00020022089	mrps28	80	56.643	Oryzias_latipes_hni
ENSG00000147586	MRPS28	97	60.000	ENSOMEG00000008250	mrps28	76	54.478	Oryzias_melastigma
ENSG00000147586	MRPS28	98	90.099	ENSOGAG00000016599	MRPS28	100	85.027	Otolemur_garnettii
ENSG00000147586	MRPS28	99	94.118	ENSPPRG00000009220	MRPS28	100	85.027	Panthera_pardus
ENSG00000147586	MRPS28	99	93.137	ENSPTIG00000019934	MRPS28	100	84.492	Panthera_tigris_altaica
ENSG00000147586	MRPS28	97	74.000	ENSPKIG00000022304	mrps28	94	69.492	Paramormyrops_kingsleyae
ENSG00000147586	MRPS28	90	64.516	ENSPMGG00000008007	-	94	47.191	Periophthalmus_magnuspinnatus
ENSG00000147586	MRPS28	99	86.275	ENSPEMG00000012338	Mrps28	100	74.332	Peromyscus_maniculatus_bairdii
ENSG00000147586	MRPS28	97	74.000	ENSPMAG00000002015	mrps28	92	74.757	Petromyzon_marinus
ENSG00000147586	MRPS28	97	84.000	ENSPCIG00000026795	MRPS28	98	71.429	Phascolarctos_cinereus
ENSG00000147586	MRPS28	92	62.105	ENSPFOG00000020828	mrps28	82	53.378	Poecilia_formosa
ENSG00000147586	MRPS28	92	62.105	ENSPLAG00000005387	mrps28	82	53.378	Poecilia_latipinna
ENSG00000147586	MRPS28	83	68.235	ENSPMEG00000022332	mrps28	77	58.647	Poecilia_mexicana
ENSG00000147586	MRPS28	92	62.105	ENSPREG00000005690	mrps28	83	53.378	Poecilia_reticulata
ENSG00000147586	MRPS28	100	96.117	ENSPPYG00000018694	MRPS28	100	93.048	Pongo_abelii
ENSG00000147586	MRPS28	99	89.216	ENSPCAG00000000404	MRPS28	100	88.793	Procavia_capensis
ENSG00000147586	MRPS28	99	93.137	ENSPCOG00000003866	MRPS28	100	87.701	Propithecus_coquereli
ENSG00000147586	MRPS28	98	93.069	ENSPVAG00000007815	MRPS28	98	83.607	Pteropus_vampyrus
ENSG00000147586	MRPS28	97	62.000	ENSPNYG00000016499	mrps28	90	61.538	Pundamilia_nyererei
ENSG00000147586	MRPS28	97	74.000	ENSPNAG00000018621	mrps28	80	61.184	Pygocentrus_nattereri
ENSG00000147586	MRPS28	98	89.109	ENSRNOG00000032630	Mrps28	99	72.727	Rattus_norvegicus
ENSG00000147586	MRPS28	100	89.320	ENSSBOG00000028198	MRPS28	100	87.701	Saimiri_boliviensis_boliviensis
ENSG00000147586	MRPS28	98	71.287	ENSSFOG00015004723	mrps28	77	57.862	Scleropages_formosus
ENSG00000147586	MRPS28	95	67.347	ENSSMAG00000021042	mrps28	76	59.701	Scophthalmus_maximus
ENSG00000147586	MRPS28	91	72.340	ENSSDUG00000021722	mrps28	91	54.268	Seriola_dumerili
ENSG00000147586	MRPS28	51	65.217	ENSSLDG00000003091	-	62	54.217	Seriola_lalandi_dorsalis
ENSG00000147586	MRPS28	87	73.333	ENSSLDG00000013261	mrps28	71	62.121	Seriola_lalandi_dorsalis
ENSG00000147586	MRPS28	100	86.408	ENSSARG00000007429	MRPS28	99	72.727	Sorex_araneus
ENSG00000147586	MRPS28	97	73.000	ENSSPUG00000017502	MRPS28	72	69.421	Sphenodon_punctatus
ENSG00000147586	MRPS28	97	65.000	ENSSPAG00000003194	mrps28	82	56.164	Stegastes_partitus
ENSG00000147586	MRPS28	100	91.262	ENSSSCG00000037782	MRPS28	100	84.574	Sus_scrofa
ENSG00000147586	MRPS28	85	70.455	ENSTRUG00000012758	mrps28	69	60.465	Takifugu_rubripes
ENSG00000147586	MRPS28	99	89.216	ENSTBEG00000010380	MRPS28	100	81.283	Tupaia_belangeri
ENSG00000147586	MRPS28	98	92.079	ENSTTRG00000000087	MRPS28	100	81.283	Tursiops_truncatus
ENSG00000147586	MRPS28	99	95.098	ENSUAMG00000018127	MRPS28	100	83.422	Ursus_americanus
ENSG00000147586	MRPS28	99	95.098	ENSUMAG00000014927	MRPS28	100	83.422	Ursus_maritimus
ENSG00000147586	MRPS28	99	93.137	ENSVPAG00000000652	MRPS28	100	85.027	Vicugna_pacos
ENSG00000147586	MRPS28	95	94.898	ENSVVUG00000000384	MRPS28	100	81.667	Vulpes_vulpes
ENSG00000147586	MRPS28	83	68.605	ENSXCOG00000015251	mrps28	69	58.209	Xiphophorus_couchianus
ENSG00000147586	MRPS28	76	73.077	ENSXMAG00000008774	mrps28	66	57.018	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	21873635.	IBA	Component
GO:0005763	mitochondrial small ribosomal subunit	10938081.	TAS	Component
GO:0008150	biological_process	-	ND	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process