EuRBPDB

Ensembl ID

ENSG00000147604 (Gene tree)

Gene ID

6129

Gene Symbol

RPL7

Alias

humL7-1|L7

Full Name

ribosomal protein L7

Gene Type

protein_coding

Species

Homo_sapiens

Status

confidence

Strand

Minus strand

Length

5,523 bases

Position

chr8:73,290,267-73,295,789

Accession

10363

RBP type

canonical RBP

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]