EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000147677 (Gene tree)
Gene ID: 8667
Gene Symbol: EIF3H
Alias: eIF3-gamma|eIF3-p40|eIF3h|EIF3S3
Full Name: eukaryotic translation initiation factor 3 subunit H
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 124,796 bases
Position: chr8:116,642,130-116,766,925
Accession: 3273
RBP type: non-canonical RBP
Summary: (Eukaryotic Translation Initiation Factor 3 Subunit H) is a Protein Coding gene. Diseases associated with EIF3H include Trichorhinophalangeal Syndrome, Type I and Trichorhinophalangeal Syndrome, Type Ii. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity. An important paralog of this gene is COPS5.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9341143	Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.	J Biol Chem	1997 Oct 24	Asano K	-
20816988	Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit.	J Mol Biol	2010 Oct 22	Cai Q	doi: 10.1016/j.jmb.2010.07.054

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000517974	EIF3H-202	594	-	-	- (aa)	-	-
ENST00000522453	EIF3H-210	518	-	ENSP00000428885	170 (aa)	-	E5RFH0
ENST00000611080	EIF3H-212	1265	-	ENSP00000482724	349 (aa)	-	A0A087WZK9
ENST00000518034	EIF3H-203	1047	-	-	- (aa)	-	-
ENST00000520289	EIF3H-207	855	-	-	- (aa)	-	-
ENST00000276682	EIF3H-201	2041	-	ENSP00000276682	366 (aa)	-	B3KS98
ENST00000518949	EIF3H-204	843	-	ENSP00000428195	244 (aa)	-	E5RJT0
ENST00000520813	EIF3H-208	562	-	ENSP00000427908	97 (aa)	-	E5RFW7
ENST00000519046	EIF3H-206	488	-	ENSP00000430926	46 (aa)	-	E5RHC7
ENST00000521861	EIF3H-209	3959	-	ENSP00000429931	352 (aa)	-	O15372
ENST00000522800	EIF3H-211	635	-	ENSP00000429884	56 (aa)	-	E5RH59
ENST00000518995	EIF3H-205	731	-	ENSP00000428669	235 (aa)	-	E5RGU4

Gene Model

Click here to download ENSG00000147677's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa05162	Measles	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000147677	Cholesterol, HDL	1.2431066840602E-7	17903299
ENSG00000147677	Triglycerides	9.54e-005	-
ENSG00000147677	Triglycerides	9.54e-005	-
ENSG00000147677	Body Mass Index	6E-6	25673413

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000147677	rs17811450	8	116729674	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147677's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000147677	EIF3H	89	39.941	WBGene00001231	eif-3.H	92	39.349	Caenorhabditis_elegans
ENSG00000147677	EIF3H	94	45.152	FBgn0022023	eIF3h	93	46.372	Drosophila_melanogaster
ENSG00000147677	EIF3H	100	97.159	ENSMUSG00000022312	Eif3h	100	97.159	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001732	formation of cytoplasmic translation initiation complex	-	IEA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	17322308.18599441.	IC	Function
GO:0003743	translation initiation factor activity	17581632.25849773.	IDA	Function
GO:0005515	protein binding	12812986.16189514.17043677.18599441.18628297.19060904.19615732.19748344.22190034.23623729.26100019.	IPI	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005852	eukaryotic translation initiation factor 3 complex	21873635.	IBA	Component
GO:0005852	eukaryotic translation initiation factor 3 complex	17322308.17581632.18599441.25849773.	IDA	Component
GO:0006413	translational initiation	17322308.18599441.	IC	Process
GO:0006413	translational initiation	17581632.	IDA	Process
GO:0006413	translational initiation	-	TAS	Process
GO:0006446	regulation of translational initiation	9341143.	TAS	Process
GO:0006508	proteolysis	-	IEA	Process
GO:0008237	metallopeptidase activity	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016282	eukaryotic 43S preinitiation complex	21873635.	IBA	Component
GO:0033290	eukaryotic 48S preinitiation complex	-	IEA	Component
GO:0042788	polysomal ribosome	21873635.	IBA	Component
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30060823	Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation.	Tissue Cell	2018 Aug	Wang X	doi: 10.1016/j.tice.2018.05.006
30022709	The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.	Biosci Biotechnol Biochem	2018 Oct	Yu G	doi: 10.1080/09168451.2018.1484271
24148822	A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.	Carcinogenesis	2014 Mar	Mahmood SF	doi: 10.1093/carcin/bgt351
20862326	Allelic variation at the 8q23.3 colorectal cancer risk locus functions as a cis-acting regulator of EIF3H.	PLoS Genet	2010 Sep 16	Pittman AM	doi: 10.1371/journal.pgen.1001126.
16652384	Overexpression of EIF3S3 promotes cancer cell growth.	Prostate	2006 Aug 1	Savinainen KJ	-
14997205	Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer.	Br J Cancer	2004 Mar 8	Savinainen KJ	-
11733359	Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer.	Am J Pathol	2001 Dec	Saramki O	-
30232453	mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.	Nature	2018 Sep	Choe J	doi: 10.1038/s41586-018-0538-8

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	116648875	Missense_Mutation	novel	M253I	0.3
BRCA	chr8	116755807	5'UTR	novel		0.09
BRCA	chr8	116644876	3'UTR	novel		0.92
BRCA	chr8	116755669	Silent	novel	G43G	0.08
BRCA	chr8	116644945	3'UTR	novel		0.18
CESC	chr8	116658727	Intron	novel		0.4
CESC	chr8	116646485	Missense_Mutation	rs765673805	S316L	0.39
CESC	chr8	116755697	Missense_Mutation	NA	S34L	0.37
CHOL	chr8	116755754	Missense_Mutation	novel	S15Y	0.38
CHOL	chr8	116755755	Missense_Mutation	novel	S15T	0.35
COAD	chr8	116658768	Intron	novel		0.25
COAD	chr8	116648868	Missense_Mutation	novel	D256N	0.08
COAD	chr8	116755791	Missense_Mutation	novel	S3P	0.28
COAD	chr8	116658783	Intron	novel		0.11
COAD	chr8	116657225	Frame_Shift_Del	novel	*S183Pfs5**	0.05
COAD	chr8	116646586	Silent	NA	Q282Q	0.15
COAD	chr8	116646547	Silent	rs770749973	P295P	0.21
COAD	chr8	116755713	Missense_Mutation	novel	G29C	0.11
ESCA	chr8	116646547	Silent	rs770749973	P295P	0.33
GBM	chr8	116658956	Missense_Mutation	NA	R105Q	0.05
GBM	chr8	116755771	Silent	novel	G9G	0.13
GBM	chr8	116726088	Missense_Mutation	NA	E73K	0.4
GBM	chr8	116646497	Missense_Mutation	novel	A312V	0.1
HNSC	chr8	116655882	Silent	novel	K227K	0.24
HNSC	chr8	116656002	Missense_Mutation	NA	L187F	0.21
HNSC	chr8	116646520	Silent	novel	L304L	0.13
HNSC	chr8	116658820	Silent	novel	L150L	0.17
HNSC	chr8	116646547	Silent	novel	P295P	0.23
KIRP	chr8	116648912	Missense_Mutation	NA	K241T	0.25
LIHC	chr8	116658701	Intron	novel		0.14
LIHC	chr8	116646595	Silent	NA	Q279Q	0.4
LIHC	chr8	116655890	Missense_Mutation	rs755682334	A225S	0.36
LIHC	chr8	116658964	Missense_Mutation	novel	E102D	0.14
LUAD	chr8	116646502	Silent	NA	P310P	0.22
LUAD	chr8	116658914	Missense_Mutation	novel	W119S	0.5
LUAD	chr8	116658852	Missense_Mutation	NA	Y140N	0.08
LUAD	chr8	116755782	Nonsense_Mutation	novel	E6*	0.36
LUAD	chr8	116755783	Silent	novel	K5K	0.36
LUSC	chr8	116726163	Missense_Mutation	novel	K48E	0.13
LUSC	chr8	116657280	Silent	NA	L164L	0.36
LUSC	chr8	116658878	Missense_Mutation	NA	R131L	0.41
LUSC	chr8	116657239	Missense_Mutation	novel	K178R	0.38
LUSC	chr8	116655914	Frame_Shift_Del	novel	*E217Nfs30**	0.21
LUSC	chr8	116655915	Missense_Mutation	rs754971614	W216C	0.21
OV	chr8	116658757	Intron	novel		0.14
PAAD	chr8	116655968	Missense_Mutation	novel	E199K	0.09
READ	chr8	116658930	Missense_Mutation	rs367787019	H114Y	0.2
READ	chr8	116657237	Nonsense_Mutation	NA	E179*	0.04
READ	chr8	116658956	Missense_Mutation	NA	R105Q	0.05
READ	chr8	116648824	Silent	NA	Q270Q	0.1
SKCM	chr8	116755821	5'UTR	rs199623419		0.3
SKCM	chr8	116646565	In_Frame_Del	novel	Q283_Q289del	0.24
SKCM	chr8	116755817	5'UTR	rs74344182		0.48
SKCM	chr8	116644941	3'UTR	novel		0.37
SKCM	chr8	116755817	5'UTR	rs74344182		0.29
SKCM	chr8	116755790	Missense_Mutation	NA	S3F	0.23
SKCM	chr8	116646604	Splice_Site	NA	X277_splice	0.27
SKCM	chr8	116645066	Silent	rs771805150	F333F	0.43
SKCM	chr8	116646600	Nonsense_Mutation	novel	Q278*	0.38
STAD	chr8	116646577	Silent	NA	N285N	0.23
STAD	chr8	116646509	Missense_Mutation	rs200534489	P308L	0.35
STAD	chr8	116658647	Intron	novel		0.3
STAD	chr8	116646505	Silent	novel	Q309Q	0.08
STAD	chr8	116646533	Missense_Mutation	NA	D300V	0.08
STAD	chr8	116658957	Missense_Mutation	NA	R105W	0.21
STAD	chr8	116644966	3'UTR	novel		0.37
STAD	chr8	116658862	Silent	NA	S136S	0.13
STAD	chr8	116658785	Intron	novel		0.14
STAD	chr8	116657225	Frame_Shift_Del	novel	*S183Pfs5**	0.21
UCEC	chr8	116648907	Missense_Mutation	novel	L243I	0.03
UCEC	chr8	116655853	Splice_Region	novel		0.21
UCEC	chr8	116655930	Silent	novel	I211I	0.09
UCEC	chr8	116726058	Missense_Mutation	novel	P83T	0.05
UCEC	chr8	116655904	Missense_Mutation	novel	K220T	0.4
UCEC	chr8	116658754	Intron	novel		0.29
UCEC	chr8	116755723	Silent	novel	G25G	0.36
UCEC	chr8	116726038	Missense_Mutation	NA	E89D	0.22
UCEC	chr8	116644902	3'UTR	novel		0.21
UCEC	chr8	116644960	3'UTR	rs750379790		0.23
UCEC	chr8	116655872	Missense_Mutation	NA	L231I	0.26
UCEC	chr8	116648820	Nonsense_Mutation	novel	Q272*	0.17
UCEC	chr8	116755791	Missense_Mutation	novel	S3P	0.3
UCEC	chr8	116726142	Nonsense_Mutation	novel	E55*	0.65
UCEC	chr8	116756020	5'Flank	novel		0.56
UCEC	chr8	116658882	Missense_Mutation	novel	T130A	0.48
UCEC	chr8	116755721	Missense_Mutation	novel	K26R	0.33
UCEC	chr8	116755680	Nonsense_Mutation	novel	Q40*	0.1
UCEC	chr8	116644886	3'UTR	novel		0.45
UCEC	chr8	116658817	Missense_Mutation	NA	I151M	0.27
UCEC	chr8	116644887	3'UTR	novel		0.29
UCEC	chr8	116658805	Splice_Region	novel		0.69
UCEC	chr8	116726030	Missense_Mutation	novel	A92D	0.54
UCEC	chr8	116646502	Silent	rs201413928	P310P	0.34
UCEC	chr8	116644902	3'UTR	novel		0.24
UCEC	chr8	116658886	Missense_Mutation	novel	F128L	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.2083	0.018626
KIRC	AMP	0.1136	0.15559
LGG	AMP	0.1657	6.7949e-16
LIHC	AMP	0.6108	1.1795e-21
SARC	AMP	0.2724	0.18425
SKCM	AMP	0.4414	2.8957e-05
TGCT	AMP	0.5867	0.13696
THCA	DEL	0.01	0.038162
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
THYM	0.00057	Kaplan-Meier Survival Analysis
KIRC	0.017	Kaplan-Meier Survival Analysis
SARC	0.014	Kaplan-Meier Survival Analysis
ACC	0.017	Kaplan-Meier Survival Analysis
HNSC	0.018	Kaplan-Meier Survival Analysis
SKCM	0.0014	Kaplan-Meier Survival Analysis
BRCA	0.017	Kaplan-Meier Survival Analysis
ESCA	0.032	Kaplan-Meier Survival Analysis
KIRP	0.0008	Kaplan-Meier Survival Analysis
PAAD	0.0023	Kaplan-Meier Survival Analysis
CESC	0.0027	Kaplan-Meier Survival Analysis
LAML	0.028	Kaplan-Meier Survival Analysis
LIHC	0.00036	Kaplan-Meier Survival Analysis
LUAD	0.0058	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742