EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000147889 (Gene tree)
Gene ID: 1029
Gene Symbol: CDKN2A
Alias: CDK4I|p16|INK4a|MTS1|CMM2|ARF|p19|p14|INK4|p16INK4a|p19Arf|p14ARF|CDKN2|MLM
Full Name: cyclin dependent kinase inhibitor 2A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 27,550 bases
Position: chr9:21,967,752-21,995,301
Accession: 1787
RBP type: non-canonical RBP
Summary: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8224861	The Saccharomyces cerevisiae MTS1 gene encodes a putative RNA-binding protein involved in mitochondrial protein targeting.	Gene	1993 Oct 15	Ellis EM	-
19319956	Increased expression of cellular RNA-binding proteins in HPV-induced neoplasia and cervical cancer.	J Med Virol	2009 May	Fay J	doi: 10.1002/jmv.21406.
25297457	Differential modulation of host genes in the kidney of brown trout Salmo trutta during sporogenesis of Tetracapsuloides bryosalmonae (Myxozoa).	Vet Res	2014 Oct 4	Kumar G	doi: 10.1186/s13567-014-0101-z.
189935	The genome-associated, specific RNA binding proteins of avian and mammalian type C viruses.	Cell	1977 Jan	Sen A	-
23536791	Polypyrimidine tract-binding protein induces p19(Ink4d) expression and inhibits the proliferation of H1299 cells.	PLoS One	2013	Lin S	doi: 10.1371/journal.pone.0058227
12209876	Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence.	J Cell Physiol	2002 Oct	Zhu D	-
15678155	Increased stability of the p16 mRNA with replicative senescence.	EMBO Rep	2005 Feb	Wang W	-
20069554	Hydrogen peroxide induces p16(INK4a) through an AUF1-dependent manner.	J Cell Biochem	2010 Apr 1	Guo GE	doi: 10.1002/jcb.22474.
19052093	Diverse and newly recognized effects associated with short interfering RNA binding site modifications on the Tomato bushy stunt virus p19 silencing suppressor.	J Virol	2009 Mar	Hsieh YC	doi: 10.1128/JVI.02186-08
21402775	Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation.	Mol Cell Biol	2011 May	Nakamura H	doi: 10.1128/MCB.01424-10
20826783	Tgfbeta signaling directly induces Arf promoter remodeling by a mechanism involving Smads 2/3 and p38 MAPK.	J Biol Chem	2010 Nov 12	Zheng Y	doi: 10.1074/jbc.M110.128959
20823831	Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation.	EMBO J	2010 Oct 20	Varallyay E	doi: 10.1038/emboj.2010.215
23508105	HuR maintains a replicative life span by repressing the ARF tumor suppressor.	Mol Cell Biol	2013 May	Kawagishi H	doi: 10.1128/MCB.01277-12
23462617	KSRP silencing favors neural differentiation of P19 teratocarcinoma cells.	Biochim Biophys Acta	2013 May	Giovarelli M	doi: 10.1016/j.bbagrm.2013.02.008
30696738	Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.	MBio	2019 Jan 29	Xu J	doi: 10.1128/mBio.02687-18.
23376479	Studying the RNA silencing pathway with the p19 protein.	FEBS Lett	2013 Apr 17	Danielson DC	doi: 10.1016/j.febslet.2013.01.036
11038348	Sequence-specific DNA binding activity of RNA helicase A to the p16INK4a promoter.	J Biol Chem	2001 Jan 12	Myohanen S	-
21828241	Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression.	Cancer Res	2011 Aug 15	Aguilo F	doi: 10.1158/0008-5472.CAN-10-4379
27919948	Long Noncoding RNA snaR Regulates Proliferation, Migration and Invasion of Triple-negative Breast Cancer Cells.	Anticancer Res	2016 Dec	Lee J	-
27326334	Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7.	ACS Med Chem Lett	2016 Feb 29	Ren C	doi: 10.1021/acsmedchemlett.6b00042
24623306	A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.	Elife	2014 Mar 12	Serra RW	doi: 10.7554/eLife.02313.
27188739	Expression and variability of lipid metabolism genes in intracranial aneurysm.	Cell Mol Biol (Noisy-le-grand)	2016 Apr 30	Synowiec E	-
6323722	It is Rous sarcoma virus protein P12 and not P19 that binds tightly to Rous sarcoma virus RNA.	J Mol Biol	1984 Mar 15	Meric C	-
12955883	Aberrant p16INK4A RNA transcripts expressed in hepatocellular carcinoma cell lines regulate pRb phosphorylation by binding with CDK4, resulting in delayed cell cycle progression.	Liver Int	2003 Jun	Cho JW	-
15890960	Aureusvirus P14 is an efficient RNA silencing suppressor that binds double-stranded RNAs without size specificity.	J Virol	2005 Jun	Merai Z	-
19202064	Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.	Proc Natl Acad Sci U S A	2009 Feb 24	Tzatsos A	doi: 10.1073/pnas.0813139106
20541999	Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.	Mol Cell	2010 Jun 11	Yap KL	doi: 10.1016/j.molcel.2010.03.021.
24798431	Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF.	PLoS One	2014 May 5	Dichamp I	doi: 10.1371/journal.pone.0096136
24062160	Independent parallel functions of p19 plant viral suppressor of RNA silencing required for effective suppressor activity.	Nucleic Acids Res	2014 Jan	Varallyay e	doi: 10.1093/nar/gkt846
23909395	Electronic detection of microRNA at attomolar level with high specificity.	Anal Chem	2013 Sep 3	Ramnani P	doi: 10.1021/ac4018346
23665474	A distant, cis-acting enhancer drives induction of Arf by Tgfβ in the developing eye.	Dev Biol	2013 Aug 1	Zheng Y	doi: 10.1016/j.ydbio.2013.05.003
23475073	Efficient and specific gene knockdown by small interfering RNAs produced in bacteria.	Nat Biotechnol	2013 Apr	Huang L	doi: 10.1038/nbt.2537
28935369	A three-dimensional model of RNase P in the hyperthermophilic archaeon Pyrococcus horikoshii OT3.	Biochem Biophys Res Commun	2017 Nov 18	Gao X	doi: 10.1016/j.bbrc.2017.09.085
31329415	Site-specific crosslinking of a p19 viral suppressor of RNA silencing protein and its RNA targets using an expanded genetic code.	Biochemistry	2019 Jul 22	Ahmed N	doi: 10.1021/acs.biochem.9b00428

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000479692	CDKN2A-205	544	XM_011517676	ENSP00000466887	121 (aa)	XP_011515978	K7ENC6
ENST00000577854	CDKN2A-211	442	-	-	- (aa)	-	-
ENST00000578845	CDKN2A-212	678	XM_005251343	ENSP00000467390	105 (aa)	XP_005251400	P42771
ENST00000380150	CDKN2A-202	493	-	-	- (aa)	-	-
ENST00000498124	CDKN2A-208	880	-	ENSP00000418915	167 (aa)	-	P42771
ENST00000380151	CDKN2A-203	794	-	ENSP00000369496	116 (aa)	-	UPI000036760F
ENST00000530628	CDKN2A-210	748	-	ENSP00000432664	132 (aa)	-	Q8N726
ENST00000498628	CDKN2A-209	926	XM_011517679	ENSP00000467857	105 (aa)	XP_011515981	P42771
ENST00000497750	CDKN2A-207	565	-	ENSP00000468510	104 (aa)	-	K7ES20
ENST00000494262	CDKN2A-206	989	-	ENSP00000464952	105 (aa)	-	P42771
ENST00000579755	CDKN2A-214	1283	-	ENSP00000462950	132 (aa)	-	Q8N726
ENST00000304494	CDKN2A-201	1218	-	ENSP00000307101	156 (aa)	-	P42771
ENST00000470819	CDKN2A-204	856	-	-	- (aa)	-	-
ENST00000579122	CDKN2A-213	666	-	ENSP00000464202	138 (aa)	-	J3QRG6

Gene Model

Click here to download ENSG00000147889's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01522	Endocrine resistance	KEGG
hsa01524	Platinum drug resistance	KEGG
hsa04110	Cell cycle	KEGG
hsa04115	p53 signaling pathway	KEGG
hsa04218	Cellular senescence	KEGG
hsa04934	Cushing syndrome	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05206	MicroRNAs in cancer	KEGG
hsa05212	Pancreatic cancer	KEGG
hsa05214	Glioma	KEGG
hsa05218	Melanoma	KEGG
hsa05219	Bladder cancer	KEGG
hsa05220	Chronic myeloid leukemia	KEGG
hsa05223	Non-small cell lung cancer	KEGG
hsa05225	Hepatocellular carcinoma	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000147889	Basophils	3.1110000E-005	-
ENSG00000147889	Gastrointestinal Neoplasms	7.0100000E-006	23504502
ENSG00000147889	Glioma	1.0590000E-005	-
ENSG00000147889	Platelet Count	6E-14	22139419
ENSG00000147889	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2E-8	23996088

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000147889	rs3731239	9	21974219	?	Nasopharyngeal carcinoma	26545403		1.1904762	EFO_0004252
ENSG00000147889	rs3731211	9	21986848	A	Monocyte count	27863252	[0.021-0.036] unit increase	0.0286498	EFO_0005091
ENSG00000147889	rs3731217	9	21984662	?	Acute lymphoblastic leukemia (B-cell precursor)	23996088			EFO_0000094
ENSG00000147889	rs3731211	9	21986848	A	Platelet count	22139419	[2.42-4.14] 10^9/l increase	3.281	EFO_0004309
ENSG00000147889	rs3731211	9	21986848	A	Lymphocyte counts	27863252	[0.032-0.048] unit increase	0.03979028	EFO_0004587
ENSG00000147889	rs3731211	9	21986848	A	Platelet count	27863252	[0.033-0.049] unit increase	0.04106969	EFO_0004309
ENSG00000147889	rs7036656	9	21990458	T	White blood cell count	27863252	[0.02-0.036] unit increase	0.02800243	EFO_0004308
ENSG00000147889	rs3731211	9	21986848	A	Plateletcrit	27863252	[0.038-0.053] unit increase	0.04550482	EFO_0007985
ENSG00000147889	rs2811710	9	21991924	G	Multiple myeloma	27363682	[NR]	1.15	EFO_0001378
ENSG00000147889	rs3731249	9	21970917	?	Acute lymphoblastic leukemia in childhood (B cell precursor)	29632299	[2.22-3.17]	2.65	EFO_0000094
ENSG00000147889	rs3731217	9	21984662	?	Acute lymphoblastic leukemia in childhood (B cell precursor)	29632299	[0.64-0.77]	1.4285715	EFO_0000094
ENSG00000147889	rs3731211	9	21986848	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000147889	rs7036656	9	21990458	?	White blood cell count	30595370			EFO_0004308
ENSG00000147889	rs3731211	9	21986848	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147889's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	10208428.	IDA	Process
GO:0001953	negative regulation of cell-matrix adhesion	10205165.	IMP	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	21873635.	IBA	Function
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	7739547.8259215.	IDA	Function
GO:0005515	protein binding	9751050.11278317.15232106.17517622.17658461.17909018.17955473.19149898.21988832.23455922.23602568.24855949.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	16243918.	IDA	Component
GO:0005737	cytoplasm	16243918.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007050	cell cycle arrest	15149599.	IDA	Process
GO:0007050	cell cycle arrest	16243918.	IMP	Process
GO:0007265	Ras protein signal transduction	9054499.	IEP	Process
GO:0008285	negative regulation of cell proliferation	15149599.	IDA	Process
GO:0008285	negative regulation of cell proliferation	7603984.16243918.16901784.	IMP	Process
GO:0019901	protein kinase binding	8259215.	IPI	Function
GO:0030308	negative regulation of cell growth	10208428.	IDA	Process
GO:0032088	negative regulation of NF-kappaB transcription factor activity	10353611.	IDA	Process
GO:0034393	positive regulation of smooth muscle cell apoptotic process	20381282.	ISS	Process
GO:0035985	senescence-associated heterochromatin focus	16901784.	IDA	Component
GO:0035986	senescence-associated heterochromatin focus assembly	16901784.	IMP	Process
GO:0042326	negative regulation of phosphorylation	8259215.10208428.	IDA	Process
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	7739547.8259215.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	16901784.	IMP	Process
GO:0051059	NF-kappaB binding	10353611.	IDA	Function
GO:0090398	cellular senescence	16243918.	IMP	Process
GO:0090399	replicative senescence	14720514.	IMP	Process
GO:2000111	positive regulation of macrophage apoptotic process	20381282.	ISS	Process
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	-	TAS	Process
GO:2000774	positive regulation of cellular senescence	16901784.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29665672	Regulatory Network of ARF in Cancer Development.	Mol Cells	2018 May 31	Ko A	doi: 10.14348/molcells.2018.0100
14749371	Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.	Mol Cell Biol	2004 Feb	Scott LA	-
26318587	Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress.	Oncotarget	2015 Sep 29	Dom??nguez D	doi: 10.18632/oncotarget.4958.
22490850	[Expression of multiple tumor suppressor gene p16 and its relationship with prognosis of gastric cancer patients].	Zhonghua Zhong Liu Za Zhi	2012 Jan	Ma JM	-
23804521	Promoter hypermethylation of CDKN2A, MGMT, MLH1, and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients.	Head Neck	2014 Aug	Pierini S	doi: 10.1002/hed.23413
18807517	[Correlation of p16/INK4a gene damages and protein expression in the tumor tissue of sporadic breast cancer].	Arkh Patol	2008 Jul-Aug	Nemtsova MV	-
15450420	Overexpression of p16INK4a correlates with high expression of p73 in breast carcinomas.	Mutat Res	2004 Oct 4	Garcia V	-
26999279	Relationships between p14ARF Gene Methylation and Clinicopathological Features of Colorectal Cancer: A Meta-Analysis.	PLoS One	2016 Mar 21	Zhou Z	doi: 10.1371/journal.pone.0152050
17672936	[Expression and significance of P16INK4A and PTEN in high-risk human papillomavirus-related cervical cancer].	Ai Zheng	2007 May	Zhao XL	-
18245468	TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.	Cancer Res	2008 Feb 1	Yarosh W	doi: 10.1158/0008-5472.CAN-07-5012.
18413741	Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification.	Cancer Res	2008 Apr 15	Majid S	doi: 10.1158/0008-5472.CAN-07-2290.
22960768	Ink4-Arf locus in cancer and aging.	Wiley Interdiscip Rev Dev Biol	2012 Sep-Oct	Sherr CJ	-
22565003	Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer.	J Clin Oncol	2012 Jun 10	Gillison ML	doi: 10.1200/JCO.2011.38.4099
12632492	Studies on microsatellite instability in p16 gene and expression of hMSH2 mRNA in human gastric cancer tissues.	World J Gastroenterol	2003 Mar	Zhang QX	-
25891176	Effects of emodin on the demethylation of tumor-suppressor genes in pancreatic cancer PANC-1 cells.	Oncol Rep	2015 Jun	Zhang H	doi: 10.3892/or.2015.3914
15985168	Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.	BMC Gastroenterol	2005 Jun 28	Attri J	-
15809712	Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues.	Int J Oncol	2005 May	Kim BN	-
22049925	Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.	Cancer Sci	2012 Feb	Rabien A	doi: 10.1111/j.1349-7006.2011.02140.x
23645774	P14ARF is down-regulated during tumour progression and predicts the clinical outcome in human breast cancer.	Anticancer Res	2013 May	Wazir U	-
20682398	Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer.	Cancer Genet Cytogenet	2010 Sep	Pehlivan S	doi: 10.1016/j.cancergencyto.2010.05.019.
27429046	Up-regulation of p16 by miR-877-3p inhibits proliferation of bladder cancer.	Oncotarget	2016 Aug 9	Li S	doi: 10.18632/oncotarget.10575.
28617556	Correlation between methylation of the p16 promoter and cervical cancer incidence.	Eur Rev Med Pharmacol Sci	2017 May	Wang FL	-
29571246	Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression.	Biomed Pharmacother	2018 Feb	Wang F	doi: 10.1016/j.biopha.2018.01.015
30136875	CDKN2A Depletion Causes Aneuploidy and Enhances Cell Proliferation in Non-Immortalized Normal Human Cells.	Cancer Invest	2018	H??lias-Rodzewicz Z	doi: 10.1080/07357907.2018.1491588
23894465	p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells.	PLoS One	2013 Jul 24	Chen YW	doi: 10.1371/journal.pone.0069389
17967182	Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma.	Mol Cancer	2007 Oct 29	Tsou JA	-
15197677	[Investigations to the influence of tumor supressor gene p16 inactivation on the prognosis of head and neck squamous cell carcinoma].	Laryngorhinootologie	2004 Jun	Koscielny S	-
17970082	P16 methylation in serum as a potential marker for the malignancy of colorectal carcinoma.	Anticancer Res	2007 Sep-Oct	Nakayama G	-
12362979	Expression of p16 in sporadic primary uveal melanoma.	Acta Biochim Pol	2002	Lamperska K	-
27323397	GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF.	Oncotarget	2017 Mar 7	Lee S	doi: 10.18632/oncotarget.9957.
22751126	p16(INK4A) represses the paracrine tumor-promoting effects of breast stromal fibroblasts.	Oncogene	2013 May 2	Al-Ansari MM	doi: 10.1038/onc.2012.270
21820152	Fluorescence in situ hybridization mapping of esophagectomy specimens from patients with Barrett's esophagus with high-grade dysplasia or adenocarcinoma.	Hum Pathol	2012 Feb	Brankley SM	doi: 10.1016/j.humpath.2011.04.018
19801173	Genome integrity: linking pluripotency and tumorgenicity.	Trends Genet	2009 Oct	Deng W	doi: 10.1016/j.tig.2009.09.004
18676825	COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells.	Cancer Res	2008 Aug 1	Mroz EA	doi: 10.1158/0008-5472.CAN-08-1279.
25611240	The Loss of p16 Expression Worsens the Prognosis of OSCC.	Appl Immunohistochem Mol Morphol	2015 Nov-Dec	P??rez-Say??ns M	doi: 10.1097/PAI.0000000000000133.
24525025	ARF tumor suppression in the nucleolus.	Biochim Biophys Acta	2014 Jun	Maggi LB Jr	doi: 10.1016/j.bbadis.2014.01.016
12149228	ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma.	Blood	2002 Aug 15	Grnbaek K	-
20307196	p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells.	Cancer Invest	2010 Jul	Zhang J	doi: 10.3109/07357900903286941.
12359767	Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.	Cancer Res	2002 Oct 1	Uhrbom L	-
27494112	Expression profiles of MGMT, p16, and APC genes in tumor and matching surgical margin from patients with oral squamous cell carcinoma.	Acta Biochim Pol	2016	Strzelczyk JK	doi: 10.18388/abp.2015_1204
15796965	Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16.	Cancer Genet Cytogenet	2005 Apr 15	Kuroda H	-
17923752	Hypermethylation of p16INK4a in Korean non-small cell lung cancer patients.	J Korean Med Sci	2007 Sep	Hong YS	-
22534780	Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriers.	J Natl Cancer Inst	2012 Jun 20	Mukherjee B	doi: 10.1093/jnci/djs221
21488187	Overexpressions of Cyclin B1, cdc2, p16 and p53 in human breast cancer: the clinicopathologic correlations and prognostic implications.	Yonsei Med J	2011 May	Chae SW	doi: 10.3349/ymj.2011.52.3.445.
17881001	Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.	J Mol Biol	2007 Nov 2	Mahajan A	-
22120712	Abnormal MDMX degradation in tumor cells due to ARF deficiency.	Oncogene	2012 Aug 9	Li X	doi: 10.1038/onc.2011.534
18951899	p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.	Gastroenterology	2009 Jan	Wassermann S	doi: 10.1053/j.gastro.2008.09.019
12532425	Clinical course of bladder neoplasms and single nucleotide polymorphisms in the CDKN2A gene.	Int J Cancer	2003 Mar 10	Sakano S	-
25765380	The Fidelity of p16 Staining as a Surrogate Marker of Human Papillomavirus Status in Fine-Needle Aspirates and Core Biopsies of Neck Node Metastases: Implications for HPV Testing Protocols.	Acta Cytol	2015	Holmes BJ	doi: 10.1159/000375148
26059208	No benefit for regional control and survival by planned neck dissection in primary irradiated oropharyngeal cancer irrespective of p16 expression.	Eur Arch Otorhinolaryngol	2016 Jul	Maquieira R	doi: 10.1007/s00405-015-3675-9
18760195	p16 gene expression in basal cell carcinoma.	Arch Med Res	2008 Oct	Eshkoor SA	doi: 10.1016/j.arcmed.2008.06.003.
27444279	p16 upregulation is linked to poor prognosis in ERG negative prostate cancer.	Tumour Biol	2016 Sep	Burdelski C	-
17658461	Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a.	Biochem Biophys Res Commun	2007 Sep 21	Huang X	-
12152785	Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms.	J Neuropathol Exp Neurol	2002 Aug	Perry A	-
15355988	p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.	J Biol Chem	2004 Nov 26	Woods YL	-
22521293	ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells.	Life Sci	2012 Oct 15	von Brandenstein M	doi: 10.1016/j.lfs.2012.04.014
18817867	Bmi1 promotes prostate tumorigenesis via inhibiting p16(INK4A) and p14(ARF) expression.	Biochim Biophys Acta	2008 Nov	Fan C	doi: 10.1016/j.bbadis.2008.08.009
17201148	Homozygous deletions of the INK4a/ARF locus in renal cell cancer.	Anticancer Res	2006 Nov-Dec	Kasahara T	-
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12824886	Detection of p16 promoter hypermethylation in serum of gastric cancer patients.	Cancer Sci	2003 May	Kanyama Y	-
27573859	MicroRNA-892b influences proliferation, migration and invasion of bladder cancer cells by mediating the p19ARF/cyclin D1/CDK6 and Sp-1/MMP-9 pathways.	Oncol Rep	2016 Oct	Shin SS	doi: 10.3892/or.2016.5052
18243403	Retrospective analysis of the prognostic role of p16 protein inactivation in plasma in patients with locally advanced non-small cell lung cancer.	Lung Cancer	2008 Jul	Sirera R	doi: 10.1016/j.lungcan.2007.12.005
24837742	Methylation of CpG island of p14(ARK), p15(INK4b) and p16(INK4a) genes in coke oven workers.	Hum Exp Toxicol	2015 Feb	Zhang H	doi: 10.1177/0960327114533576
11807902	High prevalence of the G101W germline mutation in the CDKN2A (P16(ink4a)) gene in 62 Italian malignant melanoma families.	Am J Med Genet	2002 Jan 22	Mantelli M	-
20013810	Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer.	Int J Cancer	2010 Aug 15	Mitsunaga S	doi: 10.1002/ijc.25104.
15447998	Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer.	Clin Cancer Res	2004 Sep 15	Wang J	-
12200117	Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin.	Biochem Biophys Res Commun	2002 Aug 30	Deng X	-
15502810	p16INK4A and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasia.	Mod Pathol	2005 May	Wang JL	-
18619950	Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide.	Chem Biol Interact	2008 Aug 11	Shi MD	doi: 10.1016/j.cbi.2008.06.006
18239974	Frequent deletion and methylation in SH3GL2 and CDKN2A loci are associated with early- and late-onset breast carcinoma.	Ann Surg Oncol	2008 Apr	Sinha S	doi: 10.1245/s10434-007-9790-0
22134685	MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases.	Oncol Rep	2012 Apr	Shin KC	doi: 10.3892/or.2011.1566
11733969	Expression of cell-cycle mediators in ovarian cancer cells after transfection with p16(INK4a), p21(WAF1/Cip-1), and p53.	Gynecol Oncol	2001 Dec	Ramirez PT	-
21728901	Methylation status of the gene promoter of cyclin-dependent kinase inhibitor 2A (CDKN2A) in ovarian cancer.	Scand J Clin Lab Invest	2011 Nov	Abou-Zeid AA	doi: 10.3109/00365513.2011.590224
26843058	Increased expression of senescence markers p14(ARF) and p16(INK4a) in breast cancer is associated with an increased risk of disease recurrence and poor survival outcome.	Histopathology	2016 Sep	Pare R	doi: 10.1111/his.12948
27716889	Establishment of two data mining models of lung cancer screening based on three gene promoter methylations combined with telomere damage.	Int J Biol Markers	2017 Mar 2	Wang W	doi: 10.5301/jbm.5000232.
27449771	Multiple rare variants in high-risk pancreatic cancer-related genes may increase risk for pancreatic cancer in a subset of patients with and without germline CDKN2A mutations.	Hum Genet	2016 Nov	Yang XR	-
27428416	Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer.	EBioMedicine	2016 Jun	Zhao R	doi: 10.1016/j.ebiom.2016.04.017
27761872	Correlation between indoleamine 2,3 dioxygenase mRNA and CDKN2A/p16 mRNA: a combined strategy to cervical cancer diagnosis.	Med Oncol	2016 Nov	Saffi Junior MC	-
27648827	Association between P16INK4a Promoter Methylation and Ovarian Cancer: A Meta-Analysis of 12 Published Studies.	PLoS One	2016 Sep 20	Xiao X	doi: 10.1371/journal.pone.0163257
28700487	Prognostic role of methylated GSTP1, p16, ESR1 and PITX2 in patients with breast cancer: A systematic meta-analysis under the guideline of PRISMA.	Medicine (Baltimore)	2017 Jul	Sheng X	doi: 10.1097/MD.0000000000007476.
28395715	[Subcellular re-distribution of F-actin in MCF7 cells upon inducible expression of CDKN2A/p16INK4a].	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi	2017 Apr	Liang J	-
28319413	Aberrant promoter hypermethylation of p16, survivin, and retinoblastoma in gastric cancer.	Bratisl Lek Listy	2017	Guo L	doi: 10.4149/BLL_2017_033.
28074012	Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.	Sci Signal	2017 Jan 10	Gamell C	doi: 10.1126/scisignal.aaf8223.
28466822	The effects of CDKN2A rs3731249, rs11515, and rs3088440 polymorphisms on cancer risk.	Cell Mol Biol (Noisy-le-grand)	2017 Mar 31	Dong Y	doi: 10.14715/cmb/2017.63.3.8.
27835607	p16 overexpression and 9p21 deletion are linked to unfavorable tumor phenotype in breast cancer.	Oncotarget	2016 Dec 6	Lebok P	doi: 10.18632/oncotarget.13227.
29254312	p16 gene expression in pancreatic cancer tissue and its importance in diagnosis.	J Biol Regul Homeost Agents	2017 Oct-Dec	Mou H	-
27486979	Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk.	Oncotarget	2016 Aug 30	Campa D	doi: 10.18632/oncotarget.10935.
27588487	p16/Ki-67 co-expression associates high risk human papillomavirus persistence and cervical histopathology: a 3-year cohort study in China.	Oncotarget	2016 Oct 4	Yu LL	doi: 10.18632/oncotarget.11705.
28412731	C-terminal binding protein-2 promotes cell proliferation and migration in breast cancer via suppression of p16INK4A.	Oncotarget	2017 Apr 18	Yang X	doi: 10.18632/oncotarget.15402.
28445153	Increased risk of brain metastases in women with breast cancer and p16 expression in metastatic lymph-nodes.	Oncotarget	2017 Jun 6	Furet E	doi: 10.18632/oncotarget.16953.
28730335	Clinical and prognosis value of the CIMP status combined with MLH1 or p16 INK4a methylation in colorectal cancer.	Med Oncol	2017 Aug	Saadallah-Kallel A	doi: 10.1007/s12032-017-1007-1
28737694	The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer.	Int J Mol Sci	2017 Jul 22	D'Arcangelo D	doi: 10.3390/ijms18071591.
28662664	Dual role for p16 in the metastasis process of HPV positive head and neck cancers.	Mol Cancer	2017 Jun 29	Dok R	doi: 10.1186/s12943-017-0678-8.
29561434	Meta-analysis of CDKN2A methylation to find its role in prostate cancer development and progression, and also to find the effect of CDKN2A expression on disease-free survival (PRISMA).	Medicine (Baltimore)	2018 Mar	Cao Z	doi: 10.1097/MD.0000000000010182.
28592523	Germline CDKN2A/P16INK4A mutations contribute to genetic determinism of sarcoma.	J Med Genet	2017 Sep	Jouenne F	doi: 10.1136/jmedgenet-2016-104402
28939073	Role of CDKN2A/p16 expression in the prognostication of oral squamous cell carcinoma.	Oral Oncol	2017 Oct	Padhi SS	doi: 10.1016/j.oraloncology.2017.07.030
29895125	Clinical efficacy of p16/Ki-67 dual-stained cervical cytology in secondary prevention of cervical cancer.	Pol J Pathol	2018	Celewicz A	doi: 10.5114/pjp.2018.75335.
29758205	Performance of P16/Ki67 dual staining in triaging hr-HPV-positive population during cervical Cancer screening in the younger women.	Clin Chim Acta	2018 Aug	Qian QP	doi: 10.1016/j.cca.2018.05.023
29228217	p19Arf inhibits aggressive progression of H-ras-driven hepatocellular carcinoma.	Carcinogenesis	2018 Mar 8	Kopanja D	doi: 10.1093/carcin/bgx140.
30060056	Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4A, and p57KIP2 transcription.	Acta Biochim Biophys Sin (Shanghai)	2018 Sep 1	Zheng Q	doi: 10.1093/abbs/gmy084.
30059872	In situ expressions of protein 16 (p16CDKN2A) and transforming growth factor beta-1 in patients with cervical intraepithelial neoplasia and cervical cancer.	Eur J Obstet Gynecol Reprod Biol	2018 Sep	Viloria ME	doi: 10.1016/j.ejogrb.2018.07.023
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29283500	Identification of a novel nucleophosmin-interaction motif in the tumor suppressor p14arf.	FEBS J	2018 Mar	Luchinat E	doi: 10.1111/febs.14373
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29927090	P16INK4a gene promoter methylation as a biomarker for the diagnosis of non-small cell lung cancer: An updated meta-analysis.	Thorac Cancer	2018 Aug	Tuo L	doi: 10.1111/1759-7714.12783
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Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr9	21974724	Frame_Shift_Del	novel	*A30Gfs18**	0.58
BLCA	chr9	21974685	Missense_Mutation	NA	P48L	0.47
BLCA	chr9	21971092	Frame_Shift_Ins	novel	*F90Lfs30**	0.68
BLCA	chr9	21971209	Splice_Site	rs730881677	X51_splice	0.73
BLCA	chr9	21974737	Missense_Mutation	novel	L31V	0.41
BLCA	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.45
BLCA	chr9	21971200	Missense_Mutation	novel	M53I	0.35
BLCA	chr9	21974698	Frame_Shift_Del	novel	*N42Rfs75**	0.33
BLCA	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.71
BLCA	chr9	21971004	Missense_Mutation	NA	E119K	0.41
BLCA	chr9	21971037	Missense_Mutation	NA	D108N	0.38
BLCA	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.87
BLCA	chr9	21974793	Nonsense_Mutation	rs141798398	S12*	0.37
BLCA	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.5
BLCA	chr9	21974793	Missense_Mutation	novel	S12L	0.18
BLCA	chr9	21971019	Missense_Mutation	NA	P114T	0.35
BLCA	chr9	21971056	Frame_Shift_Ins	novel	*A102Rfs19**	0.39
BLCA	chr9	21971093	Frame_Shift_Del	novel	*G89Lfs30**	1
BLCA	chr9	21974742	Missense_Mutation	novel	R29P	0.32
BLCA	chr9	21974758	Missense_Mutation	rs761014328	R24G	0.56
BLCA	chr9	21971049	Frame_Shift_Del	novel	*A102Rfs14**	0.5
BLCA	chr9	21971195	Frame_Shift_Del	novel	*M54Tfs91**	0.17
BLCA	chr9	21971037	Missense_Mutation	NA	D108N	0.5
BLCA	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.85
BLCA	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.58
BLCA	chr9	21971210	Splice_Site	NA	X51_splice	0.54
BLCA	chr9	21974696	Nonsense_Mutation	rs730881673	Y44*	0.55
BLCA	chr9	21971200	Missense_Mutation	novel	M53I	0.57
BLCA	chr9	21971178	Missense_Mutation	novel	E61K	0.32
BLCA	chr9	21971155	Frame_Shift_Ins	novel	*E69Tfs80**	0.5
CESC	chr9	21968243	Splice_Site	NA	X153_splice	0.75
CESC	chr9	21974670	Splice_Region	NA		0.39
CESC	chr9	21974736	Missense_Mutation	NA	L31R	0.4
CESC	chr9	21968235	Silent	novel	P155P	0.48
CESC	chr9	21970964	Missense_Mutation	NA	A132V	0.44
CESC	chr9	21974805	Missense_Mutation	novel	S8I	0.61
CESC	chr9	21974806	Missense_Mutation	novel	S8R	0.61
CESC	chr9	21971097	Missense_Mutation	NA	E88K	0.88
CESC	chr9	21967564	3'Flank	novel		0.3
CESC	chr9	21970922	Missense_Mutation	novel	D146G	0.35
CHOL	chr9	21971109	Missense_Mutation	rs11552822	D84Y	0.58
CHOL	chr9	21971004	Missense_Mutation	NA	E119Q	0.41
COAD	chr9	21970976	Missense_Mutation	NA	R128Q	0.33
COAD	chr9	21974678	Splice_Region	NA	Q50Q	0.35
COAD	chr9	21968132	3'UTR	novel		0.26
COAD	chr9	21974609	Intron	NA		0.38
COAD	chr9	21967932	3'UTR	novel		0.21
COAD	chr9	21967532	3'Flank	novel		0.43
COAD	chr9	21967574	3'Flank	novel		0.06
COAD	chr9	21970903	Splice_Region	NA	S152S	0.26
COAD	chr9	21967653	3'Flank	novel		0.13
COAD	chr9	21968126	3'UTR	novel		0.2
COAD	chr9	21968148	3'UTR	novel		0.31
COAD	chr9	21971059	Silent	NA	A100A	0.38
COAD	chr9	21967552	3'Flank	novel		0.38
COAD	chr9	21968105	3'UTR	novel		0.33
COAD	chr9	21967365	3'Flank	novel		0.11
COAD	chr9	21974868	5'UTR	novel		0.38
COAD	chr9	21968025	3'UTR	novel		0.63
COAD	chr9	21967318	3'Flank	rs768959694		0.29
ESCA	chr9	21974677	Splice_Site	novel	X50_splice	0.74
ESCA	chr9	21971024	Missense_Mutation	rs587782797	R112H	0.15
ESCA	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.33
ESCA	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.9
ESCA	chr9	21970895	Splice_Site	novel	X153_splice	0.72
ESCA	chr9	21970900	Splice_Site	NA	X153_splice	0.21
ESCA	chr9	21971026	Frame_Shift_Del	novel	*G111Afs8**	0.52
ESCA	chr9	21974786	Frame_Shift_Del	novel	*P11Lfs29**	0.9
ESCA	chr9	21968243	Splice_Site	NA	X153_splice	0.59
ESCA	chr9	21974718	Frame_Shift_Ins	novel	*L37Rfs7**	0.38
ESCA	chr9	21971176	Frame_Shift_Del	novel	*E61Dfs85**	1
ESCA	chr9	21970902	Missense_Mutation	rs45476696	D153N	0.35
ESCA	chr9	21974725	Missense_Mutation	rs757066045	G35R	0.15
GBM	chr9	21971030	Nonsense_Mutation	NA	W110*	0.52
GBM	chr9	21971027	Missense_Mutation	NA	G111D	0.15
GBM	chr9	21974705	Silent	rs754366579	P41P	0.21
GBM	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.19
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.38
HNSC	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.79
HNSC	chr9	21974764	Frame_Shift_Del	novel	*R22Gfs4**	0.52
HNSC	chr9	21971097	Nonsense_Mutation	rs121913384	E88*	0.58
HNSC	chr9	21971208	Frame_Shift_Del	novel	*V51Sfs2**	0.32
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.3
HNSC	chr9	21968243	Splice_Site	NA	X153_splice	0.15
HNSC	chr9	21971151	In_Frame_Del	novel	L62_E69del	0.33
HNSC	chr9	21971030	Nonsense_Mutation	NA	W110*	0.8
HNSC	chr9	21971007	Missense_Mutation	novel	A118T	0.37
HNSC	chr9	21971009	Frame_Shift_Del	NA	*L117Rfs29**	0.34
HNSC	chr9	21968235	Frame_Shift_Del	novel	*D156Ifs37**	0.59
HNSC	chr9	21971107	Silent	NA	D84D	0.33
HNSC	chr9	21971109	Frame_Shift_Ins	novel	*D84Lfs5**	0.33
HNSC	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.44
HNSC	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.28
HNSC	chr9	21971001	Nonsense_Mutation	NA	E120*	0.31
HNSC	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.46
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.64
HNSC	chr9	21970920	Frame_Shift_Del	novel	*A147Pfs46**	0.76
HNSC	chr9	21968244	Splice_Site	NA	X153_splice	0.57
HNSC	chr9	21971030	Nonsense_Mutation	NA	W110*	0.16
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.75
HNSC	chr9	21970972	Nonsense_Mutation	NA	Y129*	0.64
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.44
HNSC	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.55
HNSC	chr9	21971030	Nonsense_Mutation	NA	W110*	0.69
HNSC	chr9	21971097	Missense_Mutation	NA	E88K	0.67
HNSC	chr9	21974765	In_Frame_Del	novel	T18_A21del	0.28
HNSC	chr9	21971099	Missense_Mutation	novel	R87P	0.78
HNSC	chr9	21971109	Missense_Mutation	NA	D84N	0.67
HNSC	chr9	21974704	Missense_Mutation	NA	N42H	0.58
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.58
HNSC	chr9	21971129	Frame_Shift_Del	novel	*T77Ifs69**	0.35
HNSC	chr9	21971130	Missense_Mutation	novel	T77S	0.36
HNSC	chr9	21974694	Frame_Shift_Del	NA	*G45Vfs8**	0.43
HNSC	chr9	21970901	Splice_Site	NA	X153_splice	0.31
HNSC	chr9	21971209	Splice_Site	NA	X51_splice	0.53
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.72
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.41
HNSC	chr9	21971097	Frame_Shift_Del	NA	*E88Rfs58**	0.63
HNSC	chr9	21971154	Nonsense_Mutation	rs121913383	E69*	0.38
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.18
HNSC	chr9	21971154	Nonsense_Mutation	rs121913383	E69*	0.33
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.43
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.59
HNSC	chr9	21974756	Frame_Shift_Del	novel	R24*	0.71
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.44
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.15
HNSC	chr9	21971209	Splice_Site	NA	X51_splice	0.25
HNSC	chr9	21971210	Splice_Site	NA	X51_splice	0.56
HNSC	chr9	21971181	Frame_Shift_Del	NA	*A60Rfs86**	0.41
HNSC	chr9	21971200	Frame_Shift_Ins	novel	*M53Ifs2**	0.3
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.35
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.44
HNSC	chr9	21971122	Silent	NA	T79T	0.44
HNSC	chr9	21974685	Missense_Mutation	NA	P48L	0.28
HNSC	chr9	21971001	Nonsense_Mutation	NA	E120*	0.42
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.5
HNSC	chr9	21974783	Frame_Shift_Del	novel	*E10Afs28**	0.56
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.32
HNSC	chr9	21974697	Missense_Mutation	novel	Y44C	0.2
HNSC	chr9	21971097	Nonsense_Mutation	rs121913384	E88*	0.33
HNSC	chr9	21968243	Splice_Site	NA	X153_splice	0.42
HNSC	chr9	21971157	Frame_Shift_Del	novel	*A68Rfs78**	0.33
HNSC	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.1
HNSC	chr9	21971030	Nonsense_Mutation	NA	W110*	0.88
HNSC	chr9	21971139	Missense_Mutation	NA	D74N	0.81
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.59
HNSC	chr9	21968243	Splice_Site	NA	X153_splice	0.48
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.66
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.13
HNSC	chr9	21968243	Splice_Site	NA	X153_splice	0.49
HNSC	chr9	21971036	Missense_Mutation	novel	D108V	0.85
HNSC	chr9	21974696	Nonsense_Mutation	novel	Y44*	0.6
HNSC	chr9	21974721	Frame_Shift_Ins	rs398123152	*A36Gfs8**	0.4
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.26
HNSC	chr9	21971111	Missense_Mutation	NA	H83R	0.35
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.53
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.43
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.29
HNSC	chr9	21968243	Splice_Site	NA	X153_splice	0.25
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.57
HNSC	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.4
HNSC	chr9	21974679	Missense_Mutation	NA	Q50R	0.54
HNSC	chr9	21971046	In_Frame_Del	novel	A100_L104del	0.5
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.35
HNSC	chr9	21971064	Frame_Shift_Del	novel	*R99Gfs47**	0.53
HNSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.86
HNSC	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.36
HNSC	chr9	21974800	Nonsense_Mutation	novel	E10*	0.72
HNSC	chr9	21971108	Missense_Mutation	NA	D84G	0.24
HNSC	chr9	21971001	Nonsense_Mutation	NA	E120*	0.44
HNSC	chr9	21968234	Frame_Shift_Del	novel	*D156Ifs37**	0.79
HNSC	chr9	21968235	Silent	novel	P155P	0.8
HNSC	chr9	21970901	Splice_Site	NA	X153_splice	0.75
HNSC	chr9	21971097	Nonsense_Mutation	rs121913384	E88*	0.44
HNSC	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.15
HNSC	chr9	21971089	Missense_Mutation	novel	F90L	0.47
HNSC	chr9	21970901	Splice_Site	NA	X153_splice	0.17
HNSC	chr9	21970902	Missense_Mutation	rs45476696	D153N	0.17
HNSC	chr9	21974766	Frame_Shift_Del	novel	*W15Pfs22**	0.69
HNSC	chr9	21971024	Missense_Mutation	rs587782797	R112H	0.32
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.43
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.19
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.64
HNSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.4
KIRP	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.81
LGG	chr9	21971039	Missense_Mutation	rs370823171	R107H	0.42
LGG	chr9	21974685	Missense_Mutation	rs763804037	P48R	0.21
LGG	chr9	21971030	Nonsense_Mutation	NA	W110*	0.1
LIHC	chr9	21971191	Missense_Mutation	rs771138120	S56R	0.47
LIHC	chr9	21974752	Frame_Shift_Del	novel	*G23Rfs27**	0.41
LIHC	chr9	21971102	Missense_Mutation	novel	A86D	0.31
LIHC	chr9	21974777	Frame_Shift_Ins	novel	*T18Gfs27**	0.6
LIHC	chr9	21971036	Missense_Mutation	NA	D108G	0.34
LIHC	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.4
LIHC	chr9	21968151	3'UTR	novel		0.44
LIHC	chr9	21971112	Missense_Mutation	NA	H83D	0.59
LIHC	chr9	21971210	Splice_Site	NA	X51_splice	0.35
LIHC	chr9	21971109	Missense_Mutation	rs11552822	D84Y	0.39
LIHC	chr9	21974714	Frame_Shift_Del	novel	*N39Tfs14**	0.21
LUAD	chr9	21971004	In_Frame_Del	novel	V115_A118del	0.12
LUAD	chr9	21971210	Splice_Site	NA	X51_splice	0.53
LUAD	chr9	21971037	Frame_Shift_Del	novel	*L104Cfs11**	0.2
LUAD	chr9	21971040	Frame_Shift_Del	novel	*G101Rfs12**	0.23
LUAD	chr9	21971146	Missense_Mutation	NA	N71K	0.4
LUAD	chr9	21971108	Missense_Mutation	NA	D84V	0.33
LUAD	chr9	21971200	Missense_Mutation	rs104894095	M53I	0.11
LUAD	chr9	21974624	Intron	novel		0.04
LUAD	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.44
LUAD	chr9	21971057	Missense_Mutation	NA	G101V	0.35
LUAD	chr9	21974524	Intron	novel		0.31
LUAD	chr9	21971048	Missense_Mutation	NA	L104Q	0.16
LUAD	chr9	21971078	Missense_Mutation	NA	L94P	0.27
LUAD	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.35
LUAD	chr9	21974488	Intron	novel		0.24
LUAD	chr9	21974561	Intron	novel		0.19
LUAD	chr9	21971004	Nonsense_Mutation	NA	E119*	0.18
LUAD	chr9	21971025	Frame_Shift_Del	novel	*R112Vfs34**	0.31
LUAD	chr9	21970915	Silent	rs768280139	A148A	0.15
LUAD	chr9	21971058	Missense_Mutation	rs104894094	G101W	0.73
LUAD	chr9	21971109	Missense_Mutation	NA	D84N	0.22
LUAD	chr9	21971204	Missense_Mutation	NA	M52R	0.5
LUAD	chr9	21974781	Missense_Mutation	novel	L16Q	0.36
LUAD	chr9	21971058	Frame_Shift_Ins	novel	*G101Wfs19**	0.48
LUAD	chr9	21971060	Missense_Mutation	novel	A100G	0.47
LUAD	chr9	21971109	Missense_Mutation	NA	D84N	0.23
LUAD	chr9	21971026	Silent	NA	G111G	0.44
LUAD	chr9	21971141	Missense_Mutation	novel	A73D	0.3
LUAD	chr9	21971057	Missense_Mutation	NA	G101V	0.62
LUAD	chr9	21974783	Frame_Shift_Ins	novel	*W15Cfs12**	0.33
LUAD	chr9	21971109	Missense_Mutation	NA	D84N	0.17
LUSC	chr9	21971193	Frame_Shift_Del	novel	*S56Afs90**	0.63
LUSC	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.64
LUSC	chr9	21974793	Frame_Shift_Ins	novel	*S12Cfs3**	0.74
LUSC	chr9	21974731	Nonsense_Mutation	NA	E33*	0.84
LUSC	chr9	21974731	Nonsense_Mutation	NA	E33*	0.4
LUSC	chr9	21974732	Silent	novel	L32L	0.37
LUSC	chr9	21971117	Missense_Mutation	rs11552823	P81L	0.4
LUSC	chr9	21974763	Missense_Mutation	NA	R22P	0.26
LUSC	chr9	21971106	Missense_Mutation	NA	A85P	0.73
LUSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.73
LUSC	chr9	21971001	Nonsense_Mutation	NA	E120*	0.78
LUSC	chr9	21971097	Nonsense_Mutation	rs121913384	E88*	0.56
LUSC	chr9	21974810	Frame_Shift_Del	novel	*S7Afs19**	0.19
LUSC	chr9	21974678	Missense_Mutation	NA	Q50H	0.46
LUSC	chr9	21968189	3'UTR	novel		0.64
LUSC	chr9	21971109	Missense_Mutation	NA	D84N	0.35
LUSC	chr9	21971154	Nonsense_Mutation	rs121913383	E69*	0.93
LUSC	chr9	21971007	Missense_Mutation	NA	A118P	0.71
LUSC	chr9	21974696	Nonsense_Mutation	NA	Y44*	0.81
LUSC	chr9	21971210	Splice_Site	NA	X51_splice	0.82
LUSC	chr9	21971027	Frame_Shift_Del	novel	*G111Afs35**	0.76
LUSC	chr9	21974694	Frame_Shift_Del	NA	*G45Vfs8**	0.73
LUSC	chr9	21970979	Frame_Shift_Del	novel	*R124Hfs19**	0.13
LUSC	chr9	21968187	3'UTR	novel		0.39
LUSC	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.48
LUSC	chr9	21971209	Splice_Site	NA	X51_splice	0.35
LUSC	chr9	21974731	Nonsense_Mutation	NA	E33*	0.48
LUSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.83
LUSC	chr9	21971176	Frame_Shift_Del	NA	*V59Afs58**	0.67
LUSC	chr9	21971030	Nonsense_Mutation	NA	W110*	0.39
LUSC	chr9	21971108	Missense_Mutation	NA	D84G	0.6
LUSC	chr9	21974705	In_Frame_Del	novel	L32_P41del	0.43
LUSC	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.5
LUSC	chr9	21970902	Missense_Mutation	rs45476696	D153N	0.18
LUSC	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.5
LUSC	chr9	21971030	Nonsense_Mutation	NA	W110*	0.37
LUSC	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.54
LUSC	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.76
LUSC	chr9	21974773	In_Frame_Del	novel	W15_A19delinsS	0.18
LUSC	chr9	21974722	Frame_Shift_Del	NA	*A36Rfs17**	0.26
LUSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.42
LUSC	chr9	21971109	Missense_Mutation	rs11552822	D84Y	0.35
LUSC	chr9	21971030	Nonsense_Mutation	NA	W110*	0.35
LUSC	chr9	21968244	Splice_Site	NA	X153_splice	0.61
LUSC	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.56
LUSC	chr9	21971030	Nonsense_Mutation	NA	W110*	0.27
LUSC	chr9	21970892	Splice_Site	novel	X149_splice	0.12
LUSC	chr9	21971097	Nonsense_Mutation	rs121913384	E88*	0.57
LUSC	chr9	21971001	Nonsense_Mutation	NA	E120*	0.46
LUSC	chr9	21971195	Frame_Shift_Del	NA	*G55Afs91**	0.41
LUSC	chr9	21971209	Splice_Site	NA	X51_splice	0.5
LUSC	chr9	21971048	Frame_Shift_Del	novel	*L94Rfs42**	0.5
LUSC	chr9	21968180	3'UTR	rs200667152		0.83
LUSC	chr9	21974589	Intron	novel		0.1
LUSC	chr9	21971016	In_Frame_Del	novel	A109_P114del	0.44
LUSC	chr9	21971111	Missense_Mutation	NA	H83L	0.68
LUSC	chr9	21974696	Nonsense_Mutation	rs730881673	Y44*	0.51
LUSC	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.72
LUSC	chr9	21971066	Missense_Mutation	NA	H98P	0.18
LUSC	chr9	21971061	Missense_Mutation	rs200863613	A100S	0.47
LUSC	chr9	21974685	Missense_Mutation	novel	P48Q	0.55
LUSC	chr9	21971115	Frame_Shift_Del	novel	*V82Cfs64**	0.48
LUSC	chr9	21971116	Silent	novel	P81P	0.48
LUSC	chr9	21971037	Missense_Mutation	NA	D108N	0.34
LUSC	chr9	21971109	Missense_Mutation	NA	D84N	0.2
LUSC	chr9	21971109	Missense_Mutation	rs11552822	D84Y	0.41
LUSC	chr9	21971108	Missense_Mutation	NA	D84G	0.23
LUSC	chr9	21971150	In_Frame_Del	novel	L63_P70del	0.27
LUSC	chr9	21971018	Frame_Shift_Del	novel	*W110Rfs5**	0.58
LUSC	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.92
LUSC	chr9	21970900	Splice_Site	NA	X153_splice	0.39
LUSC	chr9	21971093	Missense_Mutation	NA	G89V	0.34
LUSC	chr9	21971129	Frame_Shift_Del	novel	*A76Vfs69**	0.31
LUSC	chr9	21968235	Frame_Shift_Del	novel	*D156Ifs37**	0.29
LUSC	chr9	21971055	Frame_Shift_Del	rs774904310	*A102Rfs44**	0.17
LUSC	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.42
LUSC	chr9	21971109	Missense_Mutation	NA	D84N	0.84
LUSC	chr9	21971197	Frame_Shift_Ins	novel	*M54Ifs66**	0.31
LUSC	chr9	21971183	Frame_Shift_Del	novel	*V59Gfs87**	0.85
LUSC	chr9	21971185	Frame_Shift_Del	novel	*A57Gfs61**	0.85
LUSC	chr9	21971019	Missense_Mutation	NA	P114T	0.37
LUSC	chr9	21971036	Missense_Mutation	NA	D108G	0.83
LUSC	chr9	21974696	Nonsense_Mutation	NA	Y44*	0.23
LUSC	chr9	21974769	Missense_Mutation	NA	A20E	0.52
OV	chr9	21974605	Intron	novel		0.07
OV	chr9	21971037	Missense_Mutation	rs121913381	D108Y	0.35
PAAD	chr9	21974770	In_Frame_Ins	NA	T18_A19dup	0.31
PAAD	chr9	21971097	Frame_Shift_Del	NA	*E88Rfs58**	0.26
PAAD	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.24
PAAD	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.34
PAAD	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.41
PAAD	chr9	21971001	Nonsense_Mutation	NA	E120*	0.4
PAAD	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.22
PAAD	chr9	21971097	Nonsense_Mutation	rs121913384	E88*	0.32
PAAD	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.14
PAAD	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.23
PAAD	chr9	21971112	Missense_Mutation	NA	H83D	0.13
PAAD	chr9	21974761	Missense_Mutation	novel	G23C	0.09
PAAD	chr9	21974696	Frame_Shift_Del	NA	Y44*	0.31
PAAD	chr9	21974680	Nonsense_Mutation	NA	Q50*	0.26
PAAD	chr9	21971144	Frame_Shift_Del	novel	*E69Afs74**	0.33
PAAD	chr9	21971011	Frame_Shift_Del	novel	*G111Afs3**	0.1
PAAD	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.45
PAAD	chr9	21971144	Frame_Shift_Ins	novel	*C72Lfs48**	0.23
PAAD	chr9	21971096	Frame_Shift_Ins	novel	*E88Gfs59**	0.25
PAAD	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.08
PAAD	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.13
PAAD	chr9	21971004	Missense_Mutation	NA	E119K	0.1
PAAD	chr9	21971064	In_Frame_Del	novel	L97_H98del	0.44
PAAD	chr9	21971004	Frame_Shift_Ins	novel	E119*	0.17
PAAD	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.35
PAAD	chr9	21974769	Frame_Shift_Del	novel	*T18Gfs23**	0.5
PAAD	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.13
PAAD	chr9	21974728	In_Frame_Del	NA	V28_E33del	0.28
PAAD	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.23
PCPG	chr9	21970989	Missense_Mutation	rs34170727	R124C	0.46
PRAD	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.43
READ	chr9	21968184	3'UTR	novel		0.24
READ	chr9	21974594	Intron	novel		0.12
SARC	chr9	21974783	Nonsense_Mutation	rs138677674	W15*	0.54
SARC	chr9	21968232	Splice_Site	novel	X153_splice	0.91
SKCM	chr9	21971030	Nonsense_Mutation	NA	W110*	0.9
SKCM	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.32
SKCM	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.62
SKCM	chr9	21971188	Silent	NA	A57A	0.65
SKCM	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.67
SKCM	chr9	21971209	Splice_Site	NA	X51_splice	0.63
SKCM	chr9	21974685	Missense_Mutation	NA	P48L	0.27
SKCM	chr9	21974686	Missense_Mutation	novel	P48S	0.27
SKCM	chr9	21971110	Missense_Mutation	NA	H83Q	0.3
SKCM	chr9	21971154	Nonsense_Mutation	rs121913383	E69*	0.21
SKCM	chr9	21971054	Frame_Shift_Ins	novel	*A102Gfs18**	0.28
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.42
SKCM	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.38
SKCM	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.71
SKCM	chr9	21971188	Silent	NA	A57A	0.71
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.35
SKCM	chr9	21971193	Frame_Shift_Ins	novel	*S56Qfs64**	0.67
SKCM	chr9	21974700	Frame_Shift_Del	novel	*S43Lfs76**	0.57
SKCM	chr9	21971030	Nonsense_Mutation	NA	W110*	0.76
SKCM	chr9	21971163	Frame_Shift_Del	novel	*H66Tfs80**	0.86
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.12
SKCM	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.83
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.31
SKCM	chr9	21974680	Nonsense_Mutation	NA	Q50*	0.53
SKCM	chr9	21974681	Silent	NA	I49I	0.52
SKCM	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.64
SKCM	chr9	21971122	Silent	NA	T79T	0.65
SKCM	chr9	21971187	Nonsense_Mutation	rs121913387	R58*	0.25
SKCM	chr9	21971188	Silent	NA	A57A	0.18
SKCM	chr9	21971210	Splice_Site	NA	X51_splice	0.55
SKCM	chr9	21971054	Missense_Mutation	NA	A102V	0.9
SKCM	chr9	21971097	Missense_Mutation	NA	E88K	0.58
SKCM	chr9	21974680	Nonsense_Mutation	NA	Q50*	0.6
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.82
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.48
SKCM	chr9	21971174	Frame_Shift_Del	novel	*R58Afs57**	0.41
SKCM	chr9	21971209	Splice_Site	NA	X51_splice	0.53
SKCM	chr9	21971093	Frame_Shift_Del	novel	*E88Lfs30**	0.5
SKCM	chr9	21974760	Missense_Mutation	NA	G23D	0.21
SKCM	chr9	21971209	Splice_Site	NA	X51_splice	0.51
SKCM	chr9	21968243	Splice_Site	NA	X153_splice	0.12
SKCM	chr9	21974680	Nonsense_Mutation	NA	Q50*	0.34
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.82
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.63
SKCM	chr9	21971195	Splice_Site	novel	X51_splice	0.23
SKCM	chr9	21974716	In_Frame_Del	NA	L32_L37del	0.97
SKCM	chr9	21974680	Nonsense_Mutation	NA	Q50*	0.47
SKCM	chr9	21974685	Missense_Mutation	NA	P48L	0.8
SKCM	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.51
SKCM	chr9	21971097	Missense_Mutation	NA	E88K	0.09
SKCM	chr9	21971098	Silent	rs546300971	R87R	0.09
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.79
SKCM	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.85
SKCM	chr9	21971117	Missense_Mutation	rs11552823	P81L	0.38
SKCM	chr9	21971117	Missense_Mutation	rs11552823	P81L	0.62
SKCM	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.69
SKCM	chr9	21971103	Frame_Shift_Ins	novel	A86*	0.26
SKCM	chr9	21971105	In_Frame_Ins	novel	A85delinsDLLS	0.21
SKCM	chr9	21971111	Missense_Mutation	NA	H83R	0.92
SKCM	chr9	21971029	Nonsense_Mutation	rs121913389	W110*	0.58
SKCM	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.34
SKCM	chr9	21971123	Frame_Shift_Ins	novel	*T79Nfs41**	0.68
SKCM	chr9	21971018	Missense_Mutation	rs121913386	P114L	0.24
STAD	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.67
STAD	chr9	21970968	Missense_Mutation	rs755927351	R131C	0.13
STAD	chr9	21971001	Nonsense_Mutation	NA	E120*	0.41
STAD	chr9	21974696	Nonsense_Mutation	NA	Y44*	0.51
STAD	chr9	21974680	Nonsense_Mutation	NA	Q50*	0.37
STAD	chr9	21971134	Silent	NA	P75P	0.31
STAD	chr9	21971107	Silent	NA	D84D	0.29
STAD	chr9	21971191	Silent	NA	S56S	0.33
STAD	chr9	21974516	Intron	novel		0.38
STAD	chr9	21974698	Frame_Shift_Del	novel	*Y44Tfs9**	0.41
STAD	chr9	21971133	Missense_Mutation	rs774633329	A76T	0.44
STAD	chr9	21971194	Silent	novel	G55G	0.42
STAD	chr9	21974717	Silent	novel	L37L	0.42
STAD	chr9	21971115	Missense_Mutation	NA	V82M	0.22
STAD	chr9	21974761	Missense_Mutation	novel	G23R	0.46
STAD	chr9	21971140	Silent	rs730881679	A73A	0.25
STAD	chr9	21974574	Intron	novel		0.25
STAD	chr9	21974781	Missense_Mutation	novel	L16R	0.38
STAD	chr9	21974568	Intron	novel		0.2
STAD	chr9	21970982	Missense_Mutation	rs104894098	V126D	0.41
STAD	chr9	21971089	Frame_Shift_Ins	novel	*L91Pfs29**	0.23
STAD	chr9	21974680	Nonsense_Mutation	NA	Q50*	0.26
STAD	chr9	21970957	Silent	novel	A134A	0.36
STAD	chr9	21971139	Missense_Mutation	rs760640852	D74Y	0.39
STAD	chr9	21971114	Missense_Mutation	NA	V82E	0.33
STAD	chr9	21971025	Frame_Shift_Del	novel	*R112Vfs34**	0.4
STAD	chr9	21974716	In_Frame_Del	NA	L32_L37del	0.53
STAD	chr9	21971112	Missense_Mutation	rs121913385	H83Y	0.73
STAD	chr9	21971120	Missense_Mutation	NA	R80Q	0.54
STAD	chr9	21974721	Frame_Shift_Ins	rs398123152	*A36Gfs8**	0.65
THCA	chr9	21971121	Nonsense_Mutation	rs121913388	R80*	0.37
THYM	chr9	21974778	Frame_Shift_Del	rs587782206	*L16Pfs9**	0.74
UCEC	chr9	21967653	3'Flank	novel		0.34
UCEC	chr9	21974419	Intron	novel		0.28
UCEC	chr9	21974697	Frame_Shift_Ins	NA	*Y44Lfs76**	0.91
UCEC	chr9	21971002	Missense_Mutation	novel	E119D	0.61
UCEC	chr9	21968691	Intron	novel		0.47
UCEC	chr9	21974580	Intron	novel		0.44
UCEC	chr9	21970968	Missense_Mutation	rs755927351	R131C	0.21
UCEC	chr9	21967753	3'UTR	novel		0.47
UCEC	chr9	21968177	3'UTR	novel		0.48
UCEC	chr9	21974655	Intron	novel		0.19
UCEC	chr9	21967291	3'Flank	novel		0.17
UCEC	chr9	21967658	3'Flank	novel		0.43
UCEC	chr9	21974580	Intron	novel		0.39
UCEC	chr9	21967533	3'Flank	novel		0.31
UCEC	chr9	21967620	3'Flank	novel		0.33
UCEC	chr9	21974540	Intron	novel		0.33
UCEC	chr9	21971172	Silent	novel	L63L	0.5
UCEC	chr9	21967988	3'UTR	novel		0.5
UCEC	chr9	21968729	Intron	NA		0.33
UCEC	chr9	21974540	Intron	novel		0.47
UCEC	chr9	21967425	3'Flank	novel		0.35
UCEC	chr9	21967595	3'Flank	novel		0.36
UCEC	chr9	21968132	3'UTR	novel		0.54
UCEC	chr9	21970916	Missense_Mutation	NA	A148V	0.64
UCEC	chr9	21970915	Silent	rs768280139	A148A	0.28
UCEC	chr9	21967217	3'Flank	novel		0.37
UCEC	chr9	21967584	3'Flank	novel		0.33
UCEC	chr9	21974406	Intron	novel		0.53
UCEC	chr9	21967552	3'Flank	novel		0.22
UCEC	chr9	21968706	Intron	novel		0.14
UCEC	chr9	21968126	3'UTR	novel		0.3
UCEC	chr9	21967712	3'Flank	novel		0.22
UCEC	chr9	21967318	3'Flank	rs768959694		0.5
UCEC	chr9	21975036	5'UTR	novel		0.26
UCEC	chr9	21974589	Intron	NA		0.25
UCEC	chr9	21967481	3'Flank	novel		0.4
UCEC	chr9	21968203	3'UTR	novel		0.27
UCEC	chr9	21968218	3'UTR	novel		0.36
UCEC	chr9	21968112	3'UTR	novel		0.43
UCEC	chr9	21970981	Silent	NA	V126V	0.34
UCEC	chr9	21974570	Intron	novel		0.06
UCEC	chr9	21967155	3'Flank	novel		0.43
UCEC	chr9	21968772	Intron	novel		0.44
UCS	chr9	21974700	Missense_Mutation	NA	S43I	0.09

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2889	4.0214e-06
BLCA	DEL	0.5539	6.9584e-213
BRCA	DEL	0.2917	5.2601e-27
CHOL	DEL	0.6111	2.3685e-05
COAD	DEL	0.1153	0.037327
DLBC	DEL	0.375	3.3713e-22
ESCA	DEL	0.6902	3.8792e-136
GBM	DEL	0.7383	0
HNSC	DEL	0.567	4.3284e-264
KIRC	DEL	0.2462	1.7881e-20
KIRP	DEL	0.1319	2.2596e-17
LAML	DEL	0.0157	0.24147
LGG	DEL	0.3197	2.2203e-106
LIHC	DEL	0.3649	3.0821e-22
LUAD	DEL	0.4826	3.2185e-144
LUSC	DEL	0.6886	1.0672e-198
MESO	DEL	0.5862	1.0694e-72
SARC	DEL	0.4008	4.1463e-30
SKCM	DEL	0.7166	8.2901e-218
STAD	DEL	0.3764	4.5257e-56
TGCT	DEL	0.3467	7.3329e-05
THCA	DEL	0.0301	0.24038
THYM	DEL	0.0813	0.022012

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00057	Kaplan-Meier Survival Analysis
SARC	0.047	Kaplan-Meier Survival Analysis
MESO	0.00033	Kaplan-Meier Survival Analysis
ACC	0.00028	Kaplan-Meier Survival Analysis
HNSC	0.00022	Kaplan-Meier Survival Analysis
PRAD	0.017	Kaplan-Meier Survival Analysis
KIRP	0.022	Kaplan-Meier Survival Analysis
COAD	0.00065	Kaplan-Meier Survival Analysis
PCPG	0.014	Kaplan-Meier Survival Analysis
KICH	0.035	Kaplan-Meier Survival Analysis
UCEC	0.00015	Kaplan-Meier Survival Analysis
LIHC	0.0011	Kaplan-Meier Survival Analysis
LGG	0.0037	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
UVM	0.032	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

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Cell lines and drugs in GSE70138 or GSE92742