EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000147905 (Gene tree)
Gene ID: 84186
Gene Symbol: ZCCHC7
Alias: FLJ22611|AIR1
Full Name: zinc finger CCHC-type containing 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 237,981 bases
Position: chr9:37,120,169-37,358,149
Accession: 26209
RBP type: canonical RBP
Summary: (Zinc Finger CCHC-Type Containing 7) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is CNBP.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000337839	zf-CCHC	PF00098.23	4.6e-06	1	1
ENSP00000443113	zf-CCHC	PF00098.23	4.6e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21878619	Air1 zinc knuckles 4 and 5 and a conserved IWRXY motif are critical for the function and integrity of the Trf4/5-Air1/2-Mtr4 polyadenylation (TRAMP) RNA quality control complex.	J Biol Chem	2011 Oct 28	Fasken MB	doi: 10.1074/jbc.M111.271494

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000322831	ZCCHC7-201	1219	-	ENSP00000316365	205 (aa)	-	X6R4A7
ENST00000497924	ZCCHC7-208	699	-	-	- (aa)	-	-
ENST00000481507	ZCCHC7-205	903	-	-	- (aa)	-	-
ENST00000463625	ZCCHC7-204	732	-	-	- (aa)	-	-
ENST00000461038	ZCCHC7-203	2793	-	-	- (aa)	-	-
ENST00000534928	ZCCHC7-209	2828	XM_005251608	ENSP00000443113	543 (aa)	XP_005251665	Q8N3Z6
ENST00000496099	ZCCHC7-207	721	-	-	- (aa)	-	-
ENST00000336755	ZCCHC7-202	2619	XM_005251612	ENSP00000337839	543 (aa)	XP_005251669	Q8N3Z6
ENST00000488607	ZCCHC7-206	884	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000147905's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000147905	Depressive Disorder, Major	5.001E-5	17728769
ENSG00000147905	Platelet Function Tests	1.1532200E-005	-
ENSG00000147905	Platelet Function Tests	6.0100000E-006	-
ENSG00000147905	Platelet Function Tests	3.1900000E-006	-
ENSG00000147905	Platelet Function Tests	1.1062600E-005	-
ENSG00000147905	Platelet Function Tests	3.0643300E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000147905	rs13293465	9	37127681	?	Body mass index	30595370			EFO_0004340
ENSG00000147905	rs13285624	9	37129499	?	Cardiovascular disease	30595370			EFO_0000319
ENSG00000147905	rs62535711	9	37174832	T	Suicidality	30745170	[0.07-0.14] unit increase	0.105	EFO_0006882
ENSG00000147905	rs12554976	9	37244508	G	Morning person	30696823		1.0287007	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147905's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000147905	ZCCHC7	75	36.580	ENSAPOG00000008351	zcchc7	69	37.204	Acanthochromis_polyacanthus
ENSG00000147905	ZCCHC7	91	33.986	ENSATEG00000020112	zcchc7	99	33.741	Anabas_testudineus
ENSG00000147905	ZCCHC7	99	44.248	ENSACAG00000011894	ZCCHC7	99	43.056	Anolis_carolinensis
ENSG00000147905	ZCCHC7	100	91.707	ENSANAG00000029334	ZCCHC7	100	90.608	Aotus_nancymaae
ENSG00000147905	ZCCHC7	99	30.920	ENSACLG00000014533	zcchc7	99	30.655	Astatotilapia_calliptera
ENSG00000147905	ZCCHC7	100	83.902	ENSBTAG00000025859	ZCCHC7	99	73.578	Bos_taurus
ENSG00000147905	ZCCHC7	99	91.626	ENSCJAG00000010465	ZCCHC7	100	90.055	Callithrix_jacchus
ENSG00000147905	ZCCHC7	100	83.902	ENSCAFG00000024624	ZCCHC7	96	78.000	Canis_familiaris
ENSG00000147905	ZCCHC7	100	82.927	ENSCHIG00000009716	ZCCHC7	99	73.578	Capra_hircus
ENSG00000147905	ZCCHC7	100	87.805	ENSTSYG00000004182	ZCCHC7	100	81.400	Carlito_syrichta
ENSG00000147905	ZCCHC7	100	76.585	ENSCPOG00000013472	ZCCHC7	95	69.373	Cavia_porcellus
ENSG00000147905	ZCCHC7	100	91.707	ENSCCAG00000033533	ZCCHC7	100	90.792	Cebus_capucinus
ENSG00000147905	ZCCHC7	100	96.501	ENSCATG00000021090	ZCCHC7	100	96.501	Cercocebus_atys
ENSG00000147905	ZCCHC7	99	81.373	ENSCLAG00000013297	ZCCHC7	99	72.243	Chinchilla_lanigera
ENSG00000147905	ZCCHC7	100	96.317	ENSCSAG00000010760	ZCCHC7	100	96.317	Chlorocebus_sabaeus
ENSG00000147905	ZCCHC7	100	48.485	ENSCPBG00000006836	ZCCHC7	99	46.918	Chrysemys_picta_bellii
ENSG00000147905	ZCCHC7	100	96.133	ENSCANG00000032165	ZCCHC7	100	96.133	Colobus_angolensis_palliatus
ENSG00000147905	ZCCHC7	100	72.195	ENSCGRG00001018503	Zcchc7	99	66.667	Cricetulus_griseus_chok1gshd
ENSG00000147905	ZCCHC7	99	72.772	ENSCGRG00000006136	Zcchc7	99	66.483	Cricetulus_griseus_crigri
ENSG00000147905	ZCCHC7	76	33.753	ENSCSEG00000005022	zcchc7	99	31.376	Cynoglossus_semilaevis
ENSG00000147905	ZCCHC7	68	34.234	ENSCVAG00000019331	zcchc7	99	31.194	Cyprinodon_variegatus
ENSG00000147905	ZCCHC7	99	33.494	ENSDARG00000055443	zcchc7	96	34.300	Danio_rerio
ENSG00000147905	ZCCHC7	100	82.927	ENSDNOG00000004148	ZCCHC7	99	74.678	Dasypus_novemcinctus
ENSG00000147905	ZCCHC7	100	86.829	ENSEASG00005000659	ZCCHC7	99	73.945	Equus_asinus_asinus
ENSG00000147905	ZCCHC7	100	86.829	ENSECAG00000006883	ZCCHC7	99	73.578	Equus_caballus
ENSG00000147905	ZCCHC7	100	85.854	ENSFCAG00000029100	ZCCHC7	99	74.632	Felis_catus
ENSG00000147905	ZCCHC7	99	42.553	ENSFALG00000012975	ZCCHC7	99	42.759	Ficedula_albicollis
ENSG00000147905	ZCCHC7	99	79.902	ENSFDAG00000014200	ZCCHC7	99	72.794	Fukomys_damarensis
ENSG00000147905	ZCCHC7	98	43.386	ENSGALG00000028675	ZCCHC7	99	42.882	Gallus_gallus
ENSG00000147905	ZCCHC7	100	47.009	ENSGAGG00000022960	ZCCHC7	99	46.735	Gopherus_agassizii
ENSG00000147905	ZCCHC7	99	30.468	ENSHBUG00000000064	zcchc7	99	30.506	Haplochromis_burtoni
ENSG00000147905	ZCCHC7	100	80.488	ENSHGLG00000001861	ZCCHC7	99	72.978	Heterocephalus_glaber_female
ENSG00000147905	ZCCHC7	62	66.766	ENSHGLG00100010879	-	98	67.953	Heterocephalus_glaber_male
ENSG00000147905	ZCCHC7	68	36.124	ENSHCOG00000002605	zcchc7	99	31.918	Hippocampus_comes
ENSG00000147905	ZCCHC7	99	31.652	ENSIPUG00000001541	zcchc7	99	32.762	Ictalurus_punctatus
ENSG00000147905	ZCCHC7	100	84.390	ENSSTOG00000030723	ZCCHC7	93	76.654	Ictidomys_tridecemlineatus
ENSG00000147905	ZCCHC7	52	32.441	ENSKMAG00000011357	-	67	31.494	Kryptolebias_marmoratus
ENSG00000147905	ZCCHC7	99	36.607	ENSLOCG00000012834	zcchc7	99	37.478	Lepisosteus_oculatus
ENSG00000147905	ZCCHC7	100	96.317	ENSMFAG00000006899	ZCCHC7	100	96.317	Macaca_fascicularis
ENSG00000147905	ZCCHC7	100	96.317	ENSMNEG00000028022	ZCCHC7	100	96.317	Macaca_nemestrina
ENSG00000147905	ZCCHC7	100	96.317	ENSMLEG00000014436	-	100	96.317	Mandrillus_leucophaeus
ENSG00000147905	ZCCHC7	76	37.004	ENSMAMG00000000481	zcchc7	99	34.264	Mastacembelus_armatus
ENSG00000147905	ZCCHC7	99	31.476	ENSMZEG00005021613	zcchc7	99	30.564	Maylandia_zebra
ENSG00000147905	ZCCHC7	99	74.257	ENSMAUG00000019812	Zcchc7	99	67.159	Mesocricetus_auratus
ENSG00000147905	ZCCHC7	99	72.906	ENSMOCG00000017184	Zcchc7	99	64.037	Microtus_ochrogaster
ENSG00000147905	ZCCHC7	99	68.750	ENSMODG00000002729	ZCCHC7	99	55.376	Monodelphis_domestica
ENSG00000147905	ZCCHC7	99	73.267	MGP_CAROLIEiJ_G0025964	Zcchc7	99	65.314	Mus_caroli
ENSG00000147905	ZCCHC7	99	73.267	ENSMUSG00000035649	Zcchc7	99	64.945	Mus_musculus
ENSG00000147905	ZCCHC7	99	71.429	MGP_PahariEiJ_G0024111	Zcchc7	94	70.031	Mus_pahari
ENSG00000147905	ZCCHC7	99	73.267	MGP_SPRETEiJ_G0026927	Zcchc7	99	64.391	Mus_spretus
ENSG00000147905	ZCCHC7	100	85.366	ENSMPUG00000006023	ZCCHC7	99	68.199	Mustela_putorius_furo
ENSG00000147905	ZCCHC7	68	68.022	ENSMLUG00000012660	-	99	68.293	Myotis_lucifugus
ENSG00000147905	ZCCHC7	99	76.733	ENSNGAG00000001898	Zcchc7	99	70.350	Nannospalax_galili
ENSG00000147905	ZCCHC7	99	30.514	ENSNBRG00000016426	zcchc7	99	30.849	Neolamprologus_brichardi
ENSG00000147905	ZCCHC7	100	97.974	ENSNLEG00000003641	ZCCHC7	100	97.974	Nomascus_leucogenys
ENSG00000147905	ZCCHC7	81	35.256	ENSONIG00000008954	zcchc7	87	36.441	Oreochromis_niloticus
ENSG00000147905	ZCCHC7	99	58.636	ENSOANG00000007577	ZCCHC7	99	54.225	Ornithorhynchus_anatinus
ENSG00000147905	ZCCHC7	99	30.380	ENSORLG00020006628	zcchc7	67	36.444	Oryzias_latipes_hni
ENSG00000147905	ZCCHC7	99	30.380	ENSORLG00015004084	zcchc7	70	33.850	Oryzias_latipes_hsok
ENSG00000147905	ZCCHC7	100	82.927	ENSOARG00000011504	ZCCHC7	99	73.578	Ovis_aries
ENSG00000147905	ZCCHC7	62	99.705	ENSPPAG00000038294	-	100	99.705	Pan_paniscus
ENSG00000147905	ZCCHC7	100	85.366	ENSPTIG00000012509	ZCCHC7	99	74.632	Panthera_tigris_altaica
ENSG00000147905	ZCCHC7	100	99.632	ENSPTRG00000020939	ZCCHC7	100	99.632	Pan_troglodytes
ENSG00000147905	ZCCHC7	100	95.764	ENSPANG00000025472	ZCCHC7	100	95.764	Papio_anubis
ENSG00000147905	ZCCHC7	99	34.590	ENSPKIG00000012787	zcchc7	100	34.590	Paramormyrops_kingsleyae
ENSG00000147905	ZCCHC7	63	46.000	ENSPSIG00000003231	ZCCHC7	99	46.742	Pelodiscus_sinensis
ENSG00000147905	ZCCHC7	73	33.251	ENSPMGG00000024157	zcchc7	99	31.295	Periophthalmus_magnuspinnatus
ENSG00000147905	ZCCHC7	62	62.315	ENSPEMG00000017839	Zcchc7	91	62.315	Peromyscus_maniculatus_bairdii
ENSG00000147905	ZCCHC7	99	67.805	ENSPCIG00000014809	ZCCHC7	99	56.159	Phascolarctos_cinereus
ENSG00000147905	ZCCHC7	74	37.647	ENSPFOG00000011650	zcchc7	100	33.871	Poecilia_formosa
ENSG00000147905	ZCCHC7	76	35.158	ENSPLAG00000000650	zcchc7	99	32.671	Poecilia_latipinna
ENSG00000147905	ZCCHC7	99	31.515	ENSPREG00000006666	zcchc7	99	31.770	Poecilia_reticulata
ENSG00000147905	ZCCHC7	62	64.140	ENSPVAG00000005870	-	100	64.140	Pteropus_vampyrus
ENSG00000147905	ZCCHC7	99	30.618	ENSPNYG00000023260	zcchc7	99	30.655	Pundamilia_nyererei
ENSG00000147905	ZCCHC7	99	31.227	ENSPNAG00000018219	zcchc7	99	32.092	Pygocentrus_nattereri
ENSG00000147905	ZCCHC7	99	68.137	ENSRNOG00000013078	Zcchc7	99	64.207	Rattus_norvegicus
ENSG00000147905	ZCCHC7	100	96.317	ENSRBIG00000034561	ZCCHC7	100	96.317	Rhinopithecus_bieti
ENSG00000147905	ZCCHC7	100	95.948	ENSRROG00000045031	ZCCHC7	100	95.948	Rhinopithecus_roxellana
ENSG00000147905	ZCCHC7	100	90.732	ENSSBOG00000025850	ZCCHC7	100	89.871	Saimiri_boliviensis_boliviensis
ENSG00000147905	ZCCHC7	99	69.268	ENSSHAG00000014544	ZCCHC7	99	56.058	Sarcophilus_harrisii
ENSG00000147905	ZCCHC7	99	35.154	ENSSFOG00015008796	zcchc7	99	36.301	Scleropages_formosus
ENSG00000147905	ZCCHC7	60	47.222	ENSSMAG00000011216	zcchc7	72	35.611	Scophthalmus_maximus
ENSG00000147905	ZCCHC7	87	32.534	ENSSDUG00000022377	zcchc7	74	31.931	Seriola_dumerili
ENSG00000147905	ZCCHC7	87	33.448	ENSSLDG00000001166	zcchc7	66	35.874	Seriola_lalandi_dorsalis
ENSG00000147905	ZCCHC7	99	76.699	ENSSARG00000002111	ZCCHC7	99	68.921	Sorex_araneus
ENSG00000147905	ZCCHC7	100	81.951	ENSSSCG00000005346	ZCCHC7	99	73.211	Sus_scrofa
ENSG00000147905	ZCCHC7	58	38.329	ENSTRUG00000021124	zcchc7	99	31.661	Takifugu_rubripes
ENSG00000147905	ZCCHC7	56	37.975	ENSTNIG00000004441	-	98	37.658	Tetraodon_nigroviridis
ENSG00000147905	ZCCHC7	100	73.659	ENSTBEG00000008439	ZCCHC7	100	70.902	Tupaia_belangeri
ENSG00000147905	ZCCHC7	100	83.902	ENSTTRG00000006054	ZCCHC7	100	71.691	Tursiops_truncatus
ENSG00000147905	ZCCHC7	100	85.366	ENSUMAG00000011473	ZCCHC7	99	74.632	Ursus_maritimus
ENSG00000147905	ZCCHC7	100	83.902	ENSVPAG00000001007	ZCCHC7	100	76.750	Vicugna_pacos
ENSG00000147905	ZCCHC7	100	82.927	ENSVVUG00000019974	ZCCHC7	99	74.342	Vulpes_vulpes
ENSG00000147905	ZCCHC7	97	37.768	ENSXETG00000006542	zcchc7	99	39.757	Xenopus_tropicalis
ENSG00000147905	ZCCHC7	99	33.455	ENSXMAG00000012691	zcchc7	99	33.635	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	25416956.25556234.	IPI	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0008270	zinc ion binding	-	IEA	Function