EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000148187 (Gene tree)
Gene ID: 92399
Gene Symbol: MRRF
Alias: RRF
Full Name: mitochondrial ribosome recycling factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 66,741 bases
Position: chr9:122,264,603-122,331,343
Accession: 7234
RBP type: canonical RBP
Summary: This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362834	RRF	PF01765.19	3.1e-40	1	1
ENSP00000343867	RRF	PF01765.19	5.2e-40	1	1
ENSP00000297908	RRF	PF01765.19	6e-37	1	1
ENSP00000362828	RRF	PF01765.19	2.2e-17	1	1
ENSP00000377850	RRF	PF01765.19	2.2e-17	1	1
ENSP00000395072	RRF	PF01765.19	1.3e-06	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18234219	Structural Insights into ribosome recycling factor interactions with the 70S ribosome.	J Mol Biol	2008 Mar 7	Pai RD	doi: 10.1016/j.jmb.2007.12.048
17660832	Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.	Nat Struct Mol Biol	2007 Aug	Borovinskaya MA	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000373723	MRRF-203	1176	XM_011519185	ENSP00000362828	201 (aa)	XP_011517487	Q96E11
ENST00000373724	MRRF-204	884	-	-	- (aa)	-	-
ENST00000373727	MRRF-205	703	-	-	- (aa)	-	-
ENST00000373729	MRRF-207	870	-	ENSP00000362834	218 (aa)	-	Q96E11
ENST00000373728	MRRF-206	1349	-	-	- (aa)	-	-
ENST00000489572	MRRF-212	1599	-	ENSP00000436360	168 (aa)	-	Q96E11
ENST00000470366	MRRF-211	1186	-	ENSP00000434807	168 (aa)	-	Q96E11
ENST00000467864	MRRF-210	867	-	ENSP00000433288	176 (aa)	-	Q96E11
ENST00000297908	MRRF-201	1841	-	ENSP00000297908	210 (aa)	-	Q96E11
ENST00000394315	MRRF-208	1501	-	ENSP00000377850	201 (aa)	-	Q96E11
ENST00000441707	MRRF-209	858	XM_017015286	ENSP00000395072	153 (aa)	XP_016870775	X6RDS5
ENST00000344641	MRRF-202	9826	XM_011519183	ENSP00000343867	262 (aa)	XP_011517485	Q96E11

Gene Model

Click here to download ENSG00000148187's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000148187	Platelet Function Tests	1.1800000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000148187's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000148187	MRRF	88	69.110	ENSAPOG00000001958	mrrf	84	67.593	Acanthochromis_polyacanthus
ENSG00000148187	MRRF	100	93.119	ENSAMEG00000000756	MRRF	100	88.168	Ailuropoda_melanoleuca
ENSG00000148187	MRRF	88	66.492	ENSACIG00000005017	mrrf	85	65.455	Amphilophus_citrinellus
ENSG00000148187	MRRF	88	68.063	ENSAOCG00000006807	mrrf	83	67.130	Amphiprion_ocellaris
ENSG00000148187	MRRF	88	68.586	ENSAPEG00000007934	mrrf	83	67.593	Amphiprion_percula
ENSG00000148187	MRRF	99	65.899	ENSATEG00000019203	mrrf	84	65.899	Anabas_testudineus
ENSG00000148187	MRRF	96	72.512	ENSAPLG00000014749	MRRF	100	61.217	Anas_platyrhynchos
ENSG00000148187	MRRF	100	96.330	ENSANAG00000027637	-	98	96.172	Aotus_nancymaae
ENSG00000148187	MRRF	100	93.578	ENSANAG00000036027	-	98	92.969	Aotus_nancymaae
ENSG00000148187	MRRF	98	66.355	ENSACLG00000019898	mrrf	83	66.355	Astatotilapia_calliptera
ENSG00000148187	MRRF	96	67.143	ENSAMXG00000013693	mrrf	82	67.143	Astyanax_mexicanus
ENSG00000148187	MRRF	100	92.661	ENSBTAG00000018426	MRRF	84	88.550	Bos_taurus
ENSG00000148187	MRRF	53	30.088	WBGene00020625	mrrf-1	51	30.952	Caenorhabditis_elegans
ENSG00000148187	MRRF	100	96.330	ENSCJAG00000020104	MRRF	98	95.785	Callithrix_jacchus
ENSG00000148187	MRRF	100	91.743	ENSCAFG00000032643	MRRF	100	87.786	Canis_familiaris
ENSG00000148187	MRRF	100	91.743	ENSCAFG00020015179	MRRF	100	87.786	Canis_lupus_dingo
ENSG00000148187	MRRF	100	92.202	ENSCHIG00000026312	MRRF	100	87.405	Capra_hircus
ENSG00000148187	MRRF	92	86.567	ENSTSYG00000036200	-	80	86.224	Carlito_syrichta
ENSG00000148187	MRRF	100	93.119	ENSTSYG00000009925	-	100	90.076	Carlito_syrichta
ENSG00000148187	MRRF	100	69.725	ENSCAPG00000008928	MRRF	100	67.939	Cavia_aperea
ENSG00000148187	MRRF	100	91.284	ENSCPOG00000007351	MRRF	100	85.878	Cavia_porcellus
ENSG00000148187	MRRF	99	92.053	ENSCCAG00000021452	-	98	91.154	Cebus_capucinus
ENSG00000148187	MRRF	100	96.789	ENSCCAG00000035511	-	98	96.154	Cebus_capucinus
ENSG00000148187	MRRF	100	96.789	ENSCATG00000044253	MRRF	100	96.190	Cercocebus_atys
ENSG00000148187	MRRF	100	90.367	ENSCLAG00000013089	MRRF	100	85.115	Chinchilla_lanigera
ENSG00000148187	MRRF	100	98.165	ENSCSAG00000013379	MRRF	78	96.947	Chlorocebus_sabaeus
ENSG00000148187	MRRF	100	52.288	ENSCHOG00000012757	MRRF	100	51.145	Choloepus_hoffmanni
ENSG00000148187	MRRF	96	75.714	ENSCPBG00000009881	MRRF	99	66.412	Chrysemys_picta_bellii
ENSG00000148187	MRRF	95	34.450	ENSCING00000018180	-	81	34.426	Ciona_intestinalis
ENSG00000148187	MRRF	100	98.165	ENSCANG00000030811	MRRF	100	96.947	Colobus_angolensis_palliatus
ENSG00000148187	MRRF	100	89.450	ENSCGRG00001014100	Mrrf	100	83.969	Cricetulus_griseus_chok1gshd
ENSG00000148187	MRRF	100	88.991	ENSCGRG00000013789	Mrrf	100	83.588	Cricetulus_griseus_crigri
ENSG00000148187	MRRF	96	63.810	ENSCSEG00000017565	mrrf	81	63.810	Cynoglossus_semilaevis
ENSG00000148187	MRRF	88	69.110	ENSCVAG00000012428	mrrf	81	68.720	Cyprinodon_variegatus
ENSG00000148187	MRRF	96	66.190	ENSDARG00000034174	mrrf	81	66.190	Danio_rerio
ENSG00000148187	MRRF	100	91.743	ENSDNOG00000039795	MRRF	100	88.168	Dasypus_novemcinctus
ENSG00000148187	MRRF	100	92.202	ENSDORG00000015863	Mrrf	100	87.023	Dipodomys_ordii
ENSG00000148187	MRRF	88	38.220	FBgn0035980	mRRF1	75	38.021	Drosophila_melanogaster
ENSG00000148187	MRRF	99	89.352	ENSETEG00000009835	MRRF	100	84.351	Echinops_telfairi
ENSG00000148187	MRRF	96	38.571	ENSEBUG00000003834	mrrf	79	38.021	Eptatretus_burgeri
ENSG00000148187	MRRF	100	91.743	ENSEASG00005021081	MRRF	78	87.405	Equus_asinus_asinus
ENSG00000148187	MRRF	100	92.202	ENSECAG00000025085	MRRF	78	87.786	Equus_caballus
ENSG00000148187	MRRF	98	69.333	ENSEEUG00000011183	MRRF	99	61.390	Erinaceus_europaeus
ENSG00000148187	MRRF	90	63.959	ENSELUG00000005852	mrrf	85	60.090	Esox_lucius
ENSG00000148187	MRRF	100	92.202	ENSFCAG00000038648	MRRF	100	88.571	Felis_catus
ENSG00000148187	MRRF	96	70.476	ENSFALG00000001960	MRRF	100	60.000	Ficedula_albicollis
ENSG00000148187	MRRF	100	90.826	ENSFDAG00000009671	MRRF	100	85.878	Fukomys_damarensis
ENSG00000148187	MRRF	88	68.063	ENSFHEG00000012439	mrrf	80	67.773	Fundulus_heteroclitus
ENSG00000148187	MRRF	88	63.351	ENSGMOG00000016602	mrrf	100	55.094	Gadus_morhua
ENSG00000148187	MRRF	99	69.124	ENSGALG00000001333	MRRF	100	61.069	Gallus_gallus
ENSG00000148187	MRRF	88	68.063	ENSGAFG00000007759	mrrf	81	67.773	Gambusia_affinis
ENSG00000148187	MRRF	99	64.815	ENSGACG00000017355	mrrf	98	58.039	Gasterosteus_aculeatus
ENSG00000148187	MRRF	96	76.667	ENSGAGG00000018315	MRRF	97	66.794	Gopherus_agassizii
ENSG00000148187	MRRF	100	99.541	ENSGGOG00000036258	MRRF	100	98.473	Gorilla_gorilla
ENSG00000148187	MRRF	98	60.748	ENSHBUG00000015190	mrrf	82	60.748	Haplochromis_burtoni
ENSG00000148187	MRRF	100	92.202	ENSHGLG00000010828	MRRF	100	86.260	Heterocephalus_glaber_female
ENSG00000148187	MRRF	100	92.202	ENSHGLG00100005757	MRRF	100	86.260	Heterocephalus_glaber_male
ENSG00000148187	MRRF	88	68.063	ENSHCOG00000003122	mrrf	84	67.290	Hippocampus_comes
ENSG00000148187	MRRF	96	56.190	ENSIPUG00000021524	mrrf	82	57.143	Ictalurus_punctatus
ENSG00000148187	MRRF	100	93.119	ENSSTOG00000012632	MRRF	100	89.313	Ictidomys_tridecemlineatus
ENSG00000148187	MRRF	100	90.367	ENSJJAG00000012872	Mrrf	100	86.260	Jaculus_jaculus
ENSG00000148187	MRRF	99	65.581	ENSKMAG00000010695	mrrf	83	65.581	Kryptolebias_marmoratus
ENSG00000148187	MRRF	96	65.714	ENSLBEG00000023948	mrrf	81	65.714	Labrus_bergylta
ENSG00000148187	MRRF	99	67.742	ENSLACG00000010290	MRRF	87	62.903	Latimeria_chalumnae
ENSG00000148187	MRRF	96	70.952	ENSLOCG00000003021	mrrf	99	59.387	Lepisosteus_oculatus
ENSG00000148187	MRRF	100	89.908	ENSLAFG00000012138	MRRF	100	86.260	Loxodonta_africana
ENSG00000148187	MRRF	100	96.789	ENSMFAG00000044303	MRRF	100	96.517	Macaca_fascicularis
ENSG00000148187	MRRF	100	96.789	ENSMMUG00000012882	MRRF	100	96.517	Macaca_mulatta
ENSG00000148187	MRRF	100	97.248	ENSMNEG00000041393	MRRF	100	97.015	Macaca_nemestrina
ENSG00000148187	MRRF	100	97.706	ENSMLEG00000041718	MRRF	100	97.015	Mandrillus_leucophaeus
ENSG00000148187	MRRF	88	67.016	ENSMAMG00000009215	mrrf	85	64.977	Mastacembelus_armatus
ENSG00000148187	MRRF	98	66.355	ENSMZEG00005017909	mrrf	83	66.355	Maylandia_zebra
ENSG00000148187	MRRF	92	70.647	ENSMGAG00000007925	MRRF	97	69.898	Meleagris_gallopavo
ENSG00000148187	MRRF	100	88.991	ENSMAUG00000003771	Mrrf	100	82.824	Mesocricetus_auratus
ENSG00000148187	MRRF	100	92.381	ENSMICG00000016168	MRRF	100	92.381	Microcebus_murinus
ENSG00000148187	MRRF	100	88.991	ENSMOCG00000018514	Mrrf	100	83.588	Microtus_ochrogaster
ENSG00000148187	MRRF	98	64.486	ENSMMOG00000021317	mrrf	83	62.613	Mola_mola
ENSG00000148187	MRRF	88	67.539	ENSMALG00000017787	mrrf	83	66.822	Monopterus_albus
ENSG00000148187	MRRF	99	88.940	MGP_CAROLIEiJ_G0023489	Mrrf	100	85.115	Mus_caroli
ENSG00000148187	MRRF	99	88.940	ENSMUSG00000026887	Mrrf	100	85.115	Mus_musculus
ENSG00000148187	MRRF	99	90.783	MGP_PahariEiJ_G0024946	Mrrf	100	86.260	Mus_pahari
ENSG00000148187	MRRF	99	90.323	MGP_SPRETEiJ_G0024406	Mrrf	100	85.878	Mus_spretus
ENSG00000148187	MRRF	100	92.661	ENSMPUG00000007190	MRRF	100	87.786	Mustela_putorius_furo
ENSG00000148187	MRRF	100	91.284	ENSMLUG00000004799	MRRF	100	88.168	Myotis_lucifugus
ENSG00000148187	MRRF	99	92.627	ENSNGAG00000020224	Mrrf	100	87.023	Nannospalax_galili
ENSG00000148187	MRRF	98	66.355	ENSNBRG00000021100	mrrf	83	66.355	Neolamprologus_brichardi
ENSG00000148187	MRRF	100	99.541	ENSNLEG00000030419	MRRF	100	98.473	Nomascus_leucogenys
ENSG00000148187	MRRF	99	70.507	ENSMEUG00000015710	MRRF	100	65.649	Notamacropus_eugenii
ENSG00000148187	MRRF	98	87.324	ENSOPRG00000010395	MRRF	100	83.206	Ochotona_princeps
ENSG00000148187	MRRF	100	80.392	ENSODEG00000019840	-	100	83.761	Octodon_degus
ENSG00000148187	MRRF	100	91.284	ENSODEG00000002071	-	100	85.496	Octodon_degus
ENSG00000148187	MRRF	98	66.355	ENSONIG00000003726	mrrf	83	66.355	Oreochromis_niloticus
ENSG00000148187	MRRF	100	80.275	ENSOANG00000008199	MRRF	100	72.519	Ornithorhynchus_anatinus
ENSG00000148187	MRRF	100	91.324	ENSOCUG00000008530	MRRF	100	87.452	Oryctolagus_cuniculus
ENSG00000148187	MRRF	98	62.150	ENSORLG00000009966	mrrf	81	64.583	Oryzias_latipes
ENSG00000148187	MRRF	98	62.150	ENSORLG00020013435	mrrf	76	64.583	Oryzias_latipes_hni
ENSG00000148187	MRRF	98	62.617	ENSORLG00015001687	mrrf	77	64.103	Oryzias_latipes_hsok
ENSG00000148187	MRRF	98	62.617	ENSOMEG00000001486	mrrf	76	64.103	Oryzias_melastigma
ENSG00000148187	MRRF	100	91.743	ENSOGAG00000003046	MRRF	100	89.695	Otolemur_garnettii
ENSG00000148187	MRRF	100	92.661	ENSOARG00000014134	MRRF	100	87.786	Ovis_aries
ENSG00000148187	MRRF	100	99.541	ENSPPAG00000041496	MRRF	100	99.237	Pan_paniscus
ENSG00000148187	MRRF	100	92.202	ENSPPRG00000013309	MRRF	100	88.550	Panthera_pardus
ENSG00000148187	MRRF	100	92.202	ENSPTIG00000007271	MRRF	100	88.550	Panthera_tigris_altaica
ENSG00000148187	MRRF	100	99.541	ENSPTRG00000021324	MRRF	100	99.502	Pan_troglodytes
ENSG00000148187	MRRF	100	97.706	ENSPANG00000025844	MRRF	100	97.015	Papio_anubis
ENSG00000148187	MRRF	98	60.000	ENSPKIG00000005396	mrrf	95	53.937	Paramormyrops_kingsleyae
ENSG00000148187	MRRF	96	75.238	ENSPSIG00000013622	MRRF	99	66.284	Pelodiscus_sinensis
ENSG00000148187	MRRF	96	66.667	ENSPMGG00000023953	mrrf	76	66.667	Periophthalmus_magnuspinnatus
ENSG00000148187	MRRF	100	88.991	ENSPEMG00000012001	Mrrf	100	85.115	Peromyscus_maniculatus_bairdii
ENSG00000148187	MRRF	99	84.793	ENSPCIG00000025530	MRRF	100	78.244	Phascolarctos_cinereus
ENSG00000148187	MRRF	88	68.586	ENSPFOG00000019705	mrrf	81	68.246	Poecilia_formosa
ENSG00000148187	MRRF	88	68.586	ENSPLAG00000005592	mrrf	81	68.246	Poecilia_latipinna
ENSG00000148187	MRRF	88	68.586	ENSPMEG00000014013	mrrf	81	68.246	Poecilia_mexicana
ENSG00000148187	MRRF	88	68.063	ENSPREG00000009134	mrrf	81	67.773	Poecilia_reticulata
ENSG00000148187	MRRF	100	94.954	ENSPPYG00000020693	-	100	94.275	Pongo_abelii
ENSG00000148187	MRRF	100	99.541	ENSPPYG00000019570	MRRF	100	99.237	Pongo_abelii
ENSG00000148187	MRRF	100	78.431	ENSPCAG00000005641	MRRF	100	82.278	Procavia_capensis
ENSG00000148187	MRRF	100	91.743	ENSPCOG00000026480	-	100	90.476	Propithecus_coquereli
ENSG00000148187	MRRF	99	86.111	ENSPCOG00000012906	-	100	82.443	Propithecus_coquereli
ENSG00000148187	MRRF	100	91.284	ENSPVAG00000000864	MRRF	100	87.023	Pteropus_vampyrus
ENSG00000148187	MRRF	98	65.421	ENSPNYG00000012453	mrrf	83	65.421	Pundamilia_nyererei
ENSG00000148187	MRRF	88	67.016	ENSPNAG00000017686	mrrf	83	66.825	Pygocentrus_nattereri
ENSG00000148187	MRRF	99	90.323	ENSRNOG00000025997	Mrrf	100	85.115	Rattus_norvegicus
ENSG00000148187	MRRF	100	98.624	ENSRBIG00000035112	MRRF	100	97.328	Rhinopithecus_bieti
ENSG00000148187	MRRF	100	98.624	ENSRROG00000028983	MRRF	100	97.328	Rhinopithecus_roxellana
ENSG00000148187	MRRF	100	95.872	ENSSBOG00000022727	MRRF	98	95.000	Saimiri_boliviensis_boliviensis
ENSG00000148187	MRRF	99	84.793	ENSSHAG00000012469	MRRF	100	77.481	Sarcophilus_harrisii
ENSG00000148187	MRRF	89	61.856	ENSSFOG00015001131	mrrf	87	59.130	Scleropages_formosus
ENSG00000148187	MRRF	88	65.445	ENSSMAG00000020126	mrrf	83	64.953	Scophthalmus_maximus
ENSG00000148187	MRRF	88	68.063	ENSSDUG00000016181	mrrf	84	66.820	Seriola_dumerili
ENSG00000148187	MRRF	88	68.063	ENSSLDG00000016309	mrrf	84	66.820	Seriola_lalandi_dorsalis
ENSG00000148187	MRRF	99	61.574	ENSSPUG00000001582	MRRF	99	54.231	Sphenodon_punctatus
ENSG00000148187	MRRF	99	64.352	ENSSPAG00000005380	mrrf	85	64.352	Stegastes_partitus
ENSG00000148187	MRRF	100	91.284	ENSSSCG00000005532	MRRF	100	87.405	Sus_scrofa
ENSG00000148187	MRRF	96	70.000	ENSTGUG00000006813	MRRF	100	59.924	Taeniopygia_guttata
ENSG00000148187	MRRF	88	41.885	ENSTRUG00000005792	mrrf	85	43.925	Takifugu_rubripes
ENSG00000148187	MRRF	97	50.000	ENSTNIG00000004946	mrrf	82	50.000	Tetraodon_nigroviridis
ENSG00000148187	MRRF	100	92.661	ENSTBEG00000016569	MRRF	100	87.405	Tupaia_belangeri
ENSG00000148187	MRRF	92	92.500	ENSTTRG00000007123	MRRF	98	92.347	Tursiops_truncatus
ENSG00000148187	MRRF	100	92.661	ENSUMAG00000003435	MRRF	97	87.786	Ursus_maritimus
ENSG00000148187	MRRF	100	79.739	ENSVPAG00000008622	MRRF	100	74.046	Vicugna_pacos
ENSG00000148187	MRRF	100	91.284	ENSVVUG00000009449	MRRF	77	86.641	Vulpes_vulpes
ENSG00000148187	MRRF	96	67.619	ENSXETG00000016327	mrrf	100	57.854	Xenopus_tropicalis
ENSG00000148187	MRRF	88	67.539	ENSXCOG00000005067	mrrf	81	67.299	Xiphophorus_couchianus
ENSG00000148187	MRRF	88	67.539	ENSXMAG00000023463	mrrf	81	67.299	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0032790	ribosome disassembly	19716793.	IDA	Process
GO:0043023	ribosomal large subunit binding	21873635.	IBA	Function
GO:0070126	mitochondrial translational termination	-	TAS	Process