EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000148296 (Gene tree)
Gene ID: 6838
Gene Symbol: SURF6
Alias: FLJ30322|RRP14
Full Name: surfeit 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,625 bases
Position: chr9:133,328,774-133,336,398
Accession: 11478
RBP type: canonical RBP
Summary: This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000361092	SURF6	PF04935.12	1.3e-40	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16363129	[Properties and functions of a new nucleolar protein, Surf-6, in 3T3 mouse cells].	Bioorg Khim	2005 Nov-Dec	Gurchenkov VV	-
9548374	The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro.	Eur J Cell Biol	1998 Feb	Magoulas C	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000468290	SURF6-202	935	-	-	- (aa)	-	-
ENST00000372022	SURF6-201	4447	-	ENSP00000361092	361 (aa)	-	O75683

Gene Model

Click here to download ENSG00000148296's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000148296	Venous Thromboembolism	6E-11	23509962

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000148296's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000148296	SURF6	99	45.504	ENSAPOG00000021015	surf6	99	40.385	Acanthochromis_polyacanthus
ENSG00000148296	SURF6	99	70.557	ENSAMEG00000011733	SURF6	100	70.557	Ailuropoda_melanoleuca
ENSG00000148296	SURF6	99	44.022	ENSAOCG00000015839	surf6	99	38.710	Amphiprion_ocellaris
ENSG00000148296	SURF6	99	44.022	ENSAPEG00000022442	surf6	99	38.710	Amphiprion_percula
ENSG00000148296	SURF6	99	46.849	ENSATEG00000012640	surf6	99	43.802	Anabas_testudineus
ENSG00000148296	SURF6	88	49.844	ENSAPLG00000005069	SURF6	79	56.929	Anas_platyrhynchos
ENSG00000148296	SURF6	100	88.366	ENSANAG00000021046	SURF6	100	89.474	Aotus_nancymaae
ENSG00000148296	SURF6	99	45.355	ENSACLG00000027819	surf6	99	44.505	Astatotilapia_calliptera
ENSG00000148296	SURF6	99	42.820	ENSAMXG00000012546	surf6	99	41.623	Astyanax_mexicanus
ENSG00000148296	SURF6	99	75.833	ENSBTAG00000011554	SURF6	100	75.346	Bos_taurus
ENSG00000148296	SURF6	66	32.645	WBGene00022765	ZK546.14	52	32.645	Caenorhabditis_elegans
ENSG00000148296	SURF6	99	85.000	ENSCJAG00000017951	SURF6	100	86.150	Callithrix_jacchus
ENSG00000148296	SURF6	100	66.298	ENSCAFG00000005159	-	100	66.298	Canis_familiaris
ENSG00000148296	SURF6	99	71.944	ENSCAFG00000019758	-	100	71.662	Canis_familiaris
ENSG00000148296	SURF6	99	71.944	ENSCAFG00020001156	SURF6	100	71.662	Canis_lupus_dingo
ENSG00000148296	SURF6	100	72.853	ENSCHIG00000025220	SURF6	100	74.238	Capra_hircus
ENSG00000148296	SURF6	99	78.056	ENSTSYG00000008431	SURF6	100	77.839	Carlito_syrichta
ENSG00000148296	SURF6	91	77.064	ENSCAPG00000010696	SURF6	99	77.064	Cavia_aperea
ENSG00000148296	SURF6	99	76.389	ENSCPOG00000030454	SURF6	99	76.389	Cavia_porcellus
ENSG00000148296	SURF6	63	93.450	ENSCCAG00000025688	SURF6	100	93.043	Cebus_capucinus
ENSG00000148296	SURF6	100	95.291	ENSCATG00000042004	SURF6	100	95.291	Cercocebus_atys
ENSG00000148296	SURF6	100	77.008	ENSCLAG00000004429	SURF6	89	77.008	Chinchilla_lanigera
ENSG00000148296	SURF6	100	91.460	ENSCSAG00000015203	-	100	91.460	Chlorocebus_sabaeus
ENSG00000148296	SURF6	100	95.014	ENSCSAG00000018888	-	100	95.014	Chlorocebus_sabaeus
ENSG00000148296	SURF6	99	55.858	ENSCPBG00000021169	SURF6	99	56.319	Chrysemys_picta_bellii
ENSG00000148296	SURF6	53	98.137	ENSCANG00000035022	SURF6	100	98.137	Colobus_angolensis_palliatus
ENSG00000148296	SURF6	99	72.500	ENSCGRG00000017035	Surf6	99	72.500	Cricetulus_griseus_crigri
ENSG00000148296	SURF6	99	43.855	ENSCSEG00000015172	surf6	99	44.847	Cynoglossus_semilaevis
ENSG00000148296	SURF6	70	52.549	ENSCVAG00000015730	surf6	78	47.266	Cyprinodon_variegatus
ENSG00000148296	SURF6	99	40.000	ENSDARG00000035427	surf6	100	40.751	Danio_rerio
ENSG00000148296	SURF6	100	74.792	ENSDNOG00000049519	SURF6	97	74.792	Dasypus_novemcinctus
ENSG00000148296	SURF6	99	75.556	ENSDORG00000010761	Surf6	100	73.961	Dipodomys_ordii
ENSG00000148296	SURF6	91	67.868	ENSETEG00000004239	SURF6	100	70.270	Echinops_telfairi
ENSG00000148296	SURF6	100	77.008	ENSEASG00005009885	SURF6	100	77.562	Equus_asinus_asinus
ENSG00000148296	SURF6	100	78.393	ENSECAG00000021229	SURF6	100	78.393	Equus_caballus
ENSG00000148296	SURF6	51	78.261	ENSEEUG00000001732	-	83	73.370	Erinaceus_europaeus
ENSG00000148296	SURF6	81	73.038	ENSEEUG00000011071	-	99	72.260	Erinaceus_europaeus
ENSG00000148296	SURF6	99	75.000	ENSFCAG00000040914	SURF6	100	74.659	Felis_catus
ENSG00000148296	SURF6	99	49.731	ENSFALG00000001495	SURF6	99	51.351	Ficedula_albicollis
ENSG00000148296	SURF6	91	74.085	ENSFDAG00000007052	SURF6	100	73.476	Fukomys_damarensis
ENSG00000148296	SURF6	99	44.722	ENSFHEG00000002290	surf6	99	44.444	Fundulus_heteroclitus
ENSG00000148296	SURF6	99	47.411	ENSGALG00000038413	SURF6	100	45.308	Gallus_gallus
ENSG00000148296	SURF6	99	43.767	ENSGAFG00000013618	surf6	99	39.722	Gambusia_affinis
ENSG00000148296	SURF6	99	53.684	ENSGAGG00000010286	SURF6	99	53.439	Gopherus_agassizii
ENSG00000148296	SURF6	100	99.723	ENSGGOG00000014426	SURF6	100	99.723	Gorilla_gorilla
ENSG00000148296	SURF6	99	45.355	ENSHBUG00000008764	surf6	99	44.505	Haplochromis_burtoni
ENSG00000148296	SURF6	99	75.833	ENSHGLG00000013027	SURF6	100	75.623	Heterocephalus_glaber_female
ENSG00000148296	SURF6	91	76.596	ENSHGLG00100015654	SURF6	83	76.596	Heterocephalus_glaber_male
ENSG00000148296	SURF6	99	42.936	ENSHCOG00000001639	surf6	99	38.630	Hippocampus_comes
ENSG00000148296	SURF6	99	37.127	ENSIPUG00000008066	surf6	73	43.130	Ictalurus_punctatus
ENSG00000148296	SURF6	99	72.928	ENSSTOG00000020164	SURF6	100	73.003	Ictidomys_tridecemlineatus
ENSG00000148296	SURF6	99	76.667	ENSJJAG00000016287	Surf6	99	76.667	Jaculus_jaculus
ENSG00000148296	SURF6	73	50.376	ENSKMAG00000009936	surf6	100	40.997	Kryptolebias_marmoratus
ENSG00000148296	SURF6	98	40.669	ENSLBEG00000024311	surf6	99	40.669	Labrus_bergylta
ENSG00000148296	SURF6	98	45.915	ENSLACG00000013322	SURF6	99	45.915	Latimeria_chalumnae
ENSG00000148296	SURF6	99	44.986	ENSLOCG00000004072	surf6	99	44.205	Lepisosteus_oculatus
ENSG00000148296	SURF6	99	73.056	ENSLAFG00000026419	SURF6	100	75.623	Loxodonta_africana
ENSG00000148296	SURF6	52	97.917	ENSMFAG00000033030	SURF6	100	97.917	Macaca_fascicularis
ENSG00000148296	SURF6	91	96.353	ENSMMUG00000022339	-	97	96.353	Macaca_mulatta
ENSG00000148296	SURF6	100	96.399	ENSMNEG00000033787	SURF6	100	96.399	Macaca_nemestrina
ENSG00000148296	SURF6	100	95.291	ENSMLEG00000028750	SURF6	100	95.291	Mandrillus_leucophaeus
ENSG00000148296	SURF6	99	43.716	ENSMAMG00000018269	surf6	99	40.000	Mastacembelus_armatus
ENSG00000148296	SURF6	99	45.355	ENSMZEG00005003188	surf6	99	44.505	Maylandia_zebra
ENSG00000148296	SURF6	99	48.238	ENSMGAG00000006371	SURF6	100	44.935	Meleagris_gallopavo
ENSG00000148296	SURF6	99	74.444	ENSMAUG00000020676	Surf6	99	74.444	Mesocricetus_auratus
ENSG00000148296	SURF6	99	83.333	ENSMICG00000046077	SURF6	100	83.102	Microcebus_murinus
ENSG00000148296	SURF6	99	73.889	ENSMOCG00000011956	Surf6	99	73.333	Microtus_ochrogaster
ENSG00000148296	SURF6	99	62.983	ENSMODG00000012744	SURF6	99	62.810	Monodelphis_domestica
ENSG00000148296	SURF6	99	40.921	ENSMALG00000012310	surf6	99	39.840	Monopterus_albus
ENSG00000148296	SURF6	99	72.778	MGP_CAROLIEiJ_G0023325	Surf6	99	72.778	Mus_caroli
ENSG00000148296	SURF6	99	72.778	ENSMUSG00000036160	Surf6	99	72.778	Mus_musculus
ENSG00000148296	SURF6	99	73.056	MGP_PahariEiJ_G0024782	Surf6	99	73.056	Mus_pahari
ENSG00000148296	SURF6	99	73.056	MGP_SPRETEiJ_G0024242	Surf6	99	73.056	Mus_spretus
ENSG00000148296	SURF6	99	68.464	ENSMPUG00000012416	SURF6	94	68.280	Mustela_putorius_furo
ENSG00000148296	SURF6	99	73.333	ENSNGAG00000015358	Surf6	99	75.833	Nannospalax_galili
ENSG00000148296	SURF6	99	44.809	ENSNBRG00000007805	surf6	99	40.278	Neolamprologus_brichardi
ENSG00000148296	SURF6	100	94.183	ENSNLEG00000013079	SURF6	100	94.183	Nomascus_leucogenys
ENSG00000148296	SURF6	71	56.250	ENSMEUG00000006545	-	70	55.078	Notamacropus_eugenii
ENSG00000148296	SURF6	99	73.961	ENSODEG00000015789	SURF6	99	73.961	Octodon_degus
ENSG00000148296	SURF6	98	44.565	ENSONIG00000011294	surf6	98	40.385	Oreochromis_niloticus
ENSG00000148296	SURF6	99	45.856	ENSOANG00000011709	-	99	45.304	Ornithorhynchus_anatinus
ENSG00000148296	SURF6	99	42.936	ENSORLG00000003980	surf6	86	38.504	Oryzias_latipes
ENSG00000148296	SURF6	99	42.936	ENSORLG00020009339	surf6	86	38.504	Oryzias_latipes_hni
ENSG00000148296	SURF6	99	42.936	ENSORLG00015016272	surf6	86	38.333	Oryzias_latipes_hsok
ENSG00000148296	SURF6	98	42.340	ENSOMEG00000011772	surf6	86	37.500	Oryzias_melastigma
ENSG00000148296	SURF6	99	80.278	ENSOGAG00000027199	SURF6	100	80.609	Otolemur_garnettii
ENSG00000148296	SURF6	91	60.000	ENSOARG00000003711	SURF6	99	59.697	Ovis_aries
ENSG00000148296	SURF6	100	99.446	ENSPPAG00000032305	SURF6	100	99.446	Pan_paniscus
ENSG00000148296	SURF6	100	74.515	ENSPPRG00000003090	SURF6	100	74.515	Panthera_pardus
ENSG00000148296	SURF6	100	99.446	ENSPTRG00000021514	SURF6	100	99.446	Pan_troglodytes
ENSG00000148296	SURF6	100	94.460	ENSPANG00000026036	SURF6	100	94.460	Papio_anubis
ENSG00000148296	SURF6	99	45.924	ENSPKIG00000025080	surf6	90	42.623	Paramormyrops_kingsleyae
ENSG00000148296	SURF6	99	55.616	ENSPSIG00000011771	SURF6	99	55.616	Pelodiscus_sinensis
ENSG00000148296	SURF6	70	49.416	ENSPMGG00000004798	surf6	86	44.141	Periophthalmus_magnuspinnatus
ENSG00000148296	SURF6	99	72.222	ENSPEMG00000012589	Surf6	99	73.056	Peromyscus_maniculatus_bairdii
ENSG00000148296	SURF6	99	62.534	ENSPCIG00000017358	SURF6	99	63.636	Phascolarctos_cinereus
ENSG00000148296	SURF6	99	43.526	ENSPLAG00000021874	surf6	99	40.710	Poecilia_latipinna
ENSG00000148296	SURF6	99	44.751	ENSPMEG00000009276	surf6	99	41.504	Poecilia_mexicana
ENSG00000148296	SURF6	71	52.308	ENSPMEG00000009994	surf6	76	47.104	Poecilia_mexicana
ENSG00000148296	SURF6	73	50.379	ENSPREG00000021969	surf6	86	46.792	Poecilia_reticulata
ENSG00000148296	SURF6	100	98.338	ENSPPYG00000019728	SURF6	100	98.338	Pongo_abelii
ENSG00000148296	SURF6	86	65.385	ENSPCAG00000002906	SURF6	93	66.667	Procavia_capensis
ENSG00000148296	SURF6	99	79.722	ENSPCOG00000015707	SURF6	100	79.501	Propithecus_coquereli
ENSG00000148296	SURF6	100	71.816	ENSPVAG00000017042	SURF6	100	73.130	Pteropus_vampyrus
ENSG00000148296	SURF6	99	45.355	ENSPNYG00000003445	surf6	99	44.505	Pundamilia_nyererei
ENSG00000148296	SURF6	69	53.333	ENSPNAG00000006939	surf6	69	47.843	Pygocentrus_nattereri
ENSG00000148296	SURF6	99	73.056	ENSRNOG00000005031	Surf6	99	73.056	Rattus_norvegicus
ENSG00000148296	SURF6	100	96.676	ENSRBIG00000028268	SURF6	100	96.676	Rhinopithecus_bieti
ENSG00000148296	SURF6	100	96.676	ENSRROG00000012667	SURF6	100	96.676	Rhinopithecus_roxellana
ENSG00000148296	SURF6	100	81.163	ENSSBOG00000024264	-	100	79.778	Saimiri_boliviensis_boliviensis
ENSG00000148296	SURF6	99	62.534	ENSSHAG00000003742	SURF6	99	62.912	Sarcophilus_harrisii
ENSG00000148296	SURF6	99	46.361	ENSSFOG00015016640	surf6	97	43.127	Scleropages_formosus
ENSG00000148296	SURF6	99	46.667	ENSSMAG00000009846	surf6	99	42.936	Scophthalmus_maximus
ENSG00000148296	SURF6	99	46.537	ENSSDUG00000007947	surf6	99	40.701	Seriola_dumerili
ENSG00000148296	SURF6	99	46.281	ENSSLDG00000015027	surf6	99	40.214	Seriola_lalandi_dorsalis
ENSG00000148296	SURF6	99	52.685	ENSSPUG00000015954	SURF6	99	55.026	Sphenodon_punctatus
ENSG00000148296	SURF6	99	44.828	ENSSPAG00000005916	surf6	99	42.818	Stegastes_partitus
ENSG00000148296	SURF6	99	71.389	ENSSSCG00000032106	SURF6	100	70.994	Sus_scrofa
ENSG00000148296	SURF6	70	59.761	ENSTGUG00000005445	-	99	60.956	Taeniopygia_guttata
ENSG00000148296	SURF6	99	48.276	ENSTGUG00000005438	-	100	49.322	Taeniopygia_guttata
ENSG00000148296	SURF6	99	44.904	ENSTRUG00000023872	surf6	99	44.628	Takifugu_rubripes
ENSG00000148296	SURF6	99	41.463	ENSTNIG00000007503	surf6	75	51.341	Tetraodon_nigroviridis
ENSG00000148296	SURF6	99	70.350	ENSUAMG00000014627	SURF6	100	69.841	Ursus_americanus
ENSG00000148296	SURF6	99	72.778	ENSVVUG00000027289	SURF6	100	72.480	Vulpes_vulpes
ENSG00000148296	SURF6	99	44.865	ENSXETG00000005018	surf6	99	44.809	Xenopus_tropicalis
ENSG00000148296	SURF6	99	43.175	ENSXCOG00000001322	surf6	99	38.843	Xiphophorus_couchianus
ENSG00000148296	SURF6	99	43.213	ENSXMAG00000024608	surf6	99	39.011	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001652	granular component	-	ISS	Component
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003677	DNA binding	-	ISS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	-	ISS	Function
GO:0005515	protein binding	22113938.27705803.	IPI	Function
GO:0005654	nucleoplasm	-	IEA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0022625	cytosolic large ribosomal subunit	21873635.	IBA	Component
GO:0042273	ribosomal large subunit biogenesis	21873635.	IBA	Process
GO:0042274	ribosomal small subunit biogenesis	21873635.	IBA	Process