EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000148300 (Gene tree)
Gene ID: 57109
Gene Symbol: REXO4
Alias: hPMC2|XPMC2H
Full Name: REX4 homolog, 3'-5' exonuclease
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,115 bases
Position: chr9:133,406,058-133,418,172
Accession: 12820
RBP type: canonical RBP
Summary: (REX4 Homolog, 3'-5' Exonuclease) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ISG20L2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000361010	RNase_T	PF00929.24	2.7e-18	1	1
ENSP00000394229	RNase_T	PF00929.24	2.6e-05	1	1
ENSP00000361003	RNase_T	PF00929.24	3e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494045	REXO4-206	743	-	-	- (aa)	-	-
ENST00000478037	REXO4-205	847	-	-	- (aa)	-	-
ENST00000371935	REXO4-201	1899	-	ENSP00000361003	250 (aa)	-	Q9GZR2
ENST00000454825	REXO4-204	833	-	ENSP00000394229	233 (aa)	-	A0A0C4DG31
ENST00000445916	REXO4-203	860	-	ENSP00000391534	189 (aa)	-	A0A0C4DG22
ENST00000371942	REXO4-202	2360	XM_024447611	ENSP00000361010	422 (aa)	XP_024303379	Q9GZR2

Gene Model

Click here to download ENSG00000148300's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000148300	Stroke	2.4504353E-004	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000148300	rs75685923	9	133410109	T	Squamous cell lung carcinoma	28604730	[1.218378029-1.57363447]	1.3846594	EFO_0000708
ENSG00000148300	rs3118663	9	133416633	A	Blood protein levels	28240269	[0.31-0.48] unit increase	0.3945	EFO_0008011

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000148300's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000148300	REXO4	82	50.142	ENSAPOG00000019264	rexo4	81	50.142	Acanthochromis_polyacanthus
ENSG00000148300	REXO4	97	72.115	ENSAMEG00000011649	REXO4	92	74.740	Ailuropoda_melanoleuca
ENSG00000148300	REXO4	82	51.009	ENSAOCG00000004087	rexo4	81	51.009	Amphiprion_ocellaris
ENSG00000148300	REXO4	82	50.720	ENSAPEG00000009106	rexo4	81	50.720	Amphiprion_percula
ENSG00000148300	REXO4	82	51.685	ENSATEG00000017662	rexo4	81	51.685	Anabas_testudineus
ENSG00000148300	REXO4	80	57.225	ENSAPLG00000005865	REXO4	99	57.225	Anas_platyrhynchos
ENSG00000148300	REXO4	100	89.100	ENSANAG00000028404	REXO4	100	89.100	Aotus_nancymaae
ENSG00000148300	REXO4	97	45.500	ENSACLG00000006007	rexo4	81	53.591	Astatotilapia_calliptera
ENSG00000148300	REXO4	84	49.731	ENSAMXG00000013291	rexo4	82	49.737	Astyanax_mexicanus
ENSG00000148300	REXO4	100	63.318	ENSBTAG00000019721	REXO4	100	64.252	Bos_taurus
ENSG00000148300	REXO4	100	90.047	ENSCJAG00000009774	REXO4	100	90.047	Callithrix_jacchus
ENSG00000148300	REXO4	96	69.492	ENSCAFG00000019767	REXO4	89	72.973	Canis_familiaris
ENSG00000148300	REXO4	99	70.118	ENSCAFG00020000983	-	98	68.310	Canis_lupus_dingo
ENSG00000148300	REXO4	91	64.450	ENSCHIG00000009517	REXO4	100	62.383	Capra_hircus
ENSG00000148300	REXO4	100	79.196	ENSTSYG00000027492	REXO4	100	79.196	Carlito_syrichta
ENSG00000148300	REXO4	100	63.212	ENSCAPG00000014583	REXO4	99	73.066	Cavia_aperea
ENSG00000148300	REXO4	98	66.743	ENSCPOG00000001386	REXO4	97	67.202	Cavia_porcellus
ENSG00000148300	REXO4	100	86.243	ENSCCAG00000027049	REXO4	100	82.938	Cebus_capucinus
ENSG00000148300	REXO4	100	94.709	ENSCATG00000028646	REXO4	100	95.024	Cercocebus_atys
ENSG00000148300	REXO4	100	67.876	ENSCLAG00000006919	REXO4	100	75.676	Chinchilla_lanigera
ENSG00000148300	REXO4	100	93.651	ENSCSAG00000015280	REXO4	99	94.524	Chlorocebus_sabaeus
ENSG00000148300	REXO4	97	55.687	ENSCPBG00000021152	REXO4	100	54.739	Chrysemys_picta_bellii
ENSG00000148300	REXO4	51	57.944	ENSCING00000010751	-	77	57.944	Ciona_intestinalis
ENSG00000148300	REXO4	99	95.724	ENSCANG00000029855	REXO4	100	95.498	Colobus_angolensis_palliatus
ENSG00000148300	REXO4	97	70.602	ENSCGRG00001013126	Rexo4	95	70.602	Cricetulus_griseus_chok1gshd
ENSG00000148300	REXO4	97	70.602	ENSCGRG00000009819	Rexo4	99	70.602	Cricetulus_griseus_crigri
ENSG00000148300	REXO4	87	48.930	ENSCSEG00000019343	rexo4	83	49.589	Cynoglossus_semilaevis
ENSG00000148300	REXO4	50	64.486	ENSCVAG00000014963	rexo4	58	64.186	Cyprinodon_variegatus
ENSG00000148300	REXO4	90	47.938	ENSDARG00000088619	rexo4	79	67.757	Danio_rerio
ENSG00000148300	REXO4	100	63.212	ENSDNOG00000002429	REXO4	94	70.959	Dasypus_novemcinctus
ENSG00000148300	REXO4	98	68.421	ENSDORG00000006190	Rexo4	100	75.362	Dipodomys_ordii
ENSG00000148300	REXO4	100	68.557	ENSEASG00005009915	-	79	73.790	Equus_asinus_asinus
ENSG00000148300	REXO4	100	68.557	ENSECAG00000007896	REXO4	84	76.684	Equus_caballus
ENSG00000148300	REXO4	69	88.372	ENSEEUG00000012135	-	100	61.212	Erinaceus_europaeus
ENSG00000148300	REXO4	84	50.263	ENSELUG00000003539	rexo4	84	50.263	Esox_lucius
ENSG00000148300	REXO4	98	70.335	ENSFCAG00000011652	REXO4	100	68.103	Felis_catus
ENSG00000148300	REXO4	88	58.140	ENSFALG00000001520	REXO4	91	58.140	Ficedula_albicollis
ENSG00000148300	REXO4	92	91.089	ENSFDAG00000016050	REXO4	99	73.050	Fukomys_damarensis
ENSG00000148300	REXO4	89	47.895	ENSFHEG00000002413	rexo4	83	49.858	Fundulus_heteroclitus
ENSG00000148300	REXO4	50	56.808	ENSGMOG00000012876	rexo4	64	56.808	Gadus_morhua
ENSG00000148300	REXO4	52	63.636	ENSGALG00000030609	REXO4	95	74.847	Gallus_gallus
ENSG00000148300	REXO4	50	62.500	ENSGAFG00000015404	-	83	46.595	Gambusia_affinis
ENSG00000148300	REXO4	82	52.422	ENSGACG00000008065	rexo4	79	52.422	Gasterosteus_aculeatus
ENSG00000148300	REXO4	95	55.854	ENSGAGG00000010260	REXO4	98	55.366	Gopherus_agassizii
ENSG00000148300	REXO4	100	98.815	ENSGGOG00000014508	REXO4	100	98.815	Gorilla_gorilla
ENSG00000148300	REXO4	97	45.500	ENSHBUG00000000542	rexo4	81	53.315	Haplochromis_burtoni
ENSG00000148300	REXO4	99	73.522	ENSHGLG00000016901	REXO4	99	73.522	Heterocephalus_glaber_female
ENSG00000148300	REXO4	99	73.522	ENSHGLG00100017444	REXO4	99	73.522	Heterocephalus_glaber_male
ENSG00000148300	REXO4	50	62.559	ENSHCOG00000018196	rexo4	55	62.559	Hippocampus_comes
ENSG00000148300	REXO4	96	41.951	ENSIPUG00000021084	rexo4	81	47.581	Ictalurus_punctatus
ENSG00000148300	REXO4	99	77.412	ENSSTOG00000003754	REXO4	99	76.235	Ictidomys_tridecemlineatus
ENSG00000148300	REXO4	87	86.139	ENSJJAG00000013002	Rexo4	87	73.822	Jaculus_jaculus
ENSG00000148300	REXO4	82	50.000	ENSKMAG00000015039	rexo4	81	50.000	Kryptolebias_marmoratus
ENSG00000148300	REXO4	82	51.233	ENSLBEG00000025570	rexo4	81	51.233	Labrus_bergylta
ENSG00000148300	REXO4	87	52.442	ENSLACG00000012399	REXO4	83	53.388	Latimeria_chalumnae
ENSG00000148300	REXO4	82	55.432	ENSLOCG00000003577	rexo4	81	54.472	Lepisosteus_oculatus
ENSG00000148300	REXO4	95	69.586	ENSLAFG00000011274	REXO4	99	69.586	Loxodonta_africana
ENSG00000148300	REXO4	100	93.562	ENSMFAG00000042425	REXO4	100	94.313	Macaca_fascicularis
ENSG00000148300	REXO4	100	93.600	ENSMMUG00000000935	REXO4	100	94.076	Macaca_mulatta
ENSG00000148300	REXO4	100	94.000	ENSMNEG00000031604	REXO4	100	94.313	Macaca_nemestrina
ENSG00000148300	REXO4	99	95.487	ENSMLEG00000037716	REXO4	100	95.261	Mandrillus_leucophaeus
ENSG00000148300	REXO4	82	51.247	ENSMAMG00000011251	rexo4	82	51.247	Mastacembelus_armatus
ENSG00000148300	REXO4	97	46.000	ENSMZEG00005012336	rexo4	81	53.315	Maylandia_zebra
ENSG00000148300	REXO4	83	59.497	ENSMGAG00000006521	REXO4	99	59.497	Meleagris_gallopavo
ENSG00000148300	REXO4	97	70.120	ENSMAUG00000015137	Rexo4	88	73.421	Mesocricetus_auratus
ENSG00000148300	REXO4	99	76.777	ENSMICG00000008422	REXO4	99	76.777	Microcebus_murinus
ENSG00000148300	REXO4	97	70.048	ENSMOCG00000020607	Rexo4	86	72.823	Microtus_ochrogaster
ENSG00000148300	REXO4	99	53.266	ENSMODG00000012817	REXO4	88	60.836	Monodelphis_domestica
ENSG00000148300	REXO4	89	50.259	ENSMALG00000019705	rexo4	81	52.676	Monopterus_albus
ENSG00000148300	REXO4	94	71.820	MGP_CAROLIEiJ_G0023332	-	98	70.488	Mus_caroli
ENSG00000148300	REXO4	96	70.416	ENSMUSG00000052406	Rexo4	98	70.416	Mus_musculus
ENSG00000148300	REXO4	96	69.660	MGP_PahariEiJ_G0024789	Rexo4	98	69.903	Mus_pahari
ENSG00000148300	REXO4	94	71.322	MGP_SPRETEiJ_G0024249	-	96	71.322	Mus_spretus
ENSG00000148300	REXO4	99	64.948	ENSMPUG00000012315	REXO4	97	71.470	Mustela_putorius_furo
ENSG00000148300	REXO4	96	66.422	ENSNGAG00000010700	Rexo4	89	69.169	Nannospalax_galili
ENSG00000148300	REXO4	97	45.361	ENSNBRG00000011712	rexo4	83	52.210	Neolamprologus_brichardi
ENSG00000148300	REXO4	100	95.745	ENSNLEG00000013130	-	100	95.745	Nomascus_leucogenys
ENSG00000148300	REXO4	100	93.651	ENSNLEG00000007556	-	100	87.204	Nomascus_leucogenys
ENSG00000148300	REXO4	98	55.026	ENSMEUG00000006513	-	89	50.136	Notamacropus_eugenii
ENSG00000148300	REXO4	100	65.803	ENSODEG00000015721	REXO4	99	70.774	Octodon_degus
ENSG00000148300	REXO4	91	51.500	ENSONIG00000020052	rexo4	81	54.648	Oreochromis_niloticus
ENSG00000148300	REXO4	84	61.096	ENSOANG00000002453	REXO4	93	61.096	Ornithorhynchus_anatinus
ENSG00000148300	REXO4	91	51.399	ENSORLG00000006904	rexo4	85	52.877	Oryzias_latipes
ENSG00000148300	REXO4	89	50.127	ENSORLG00020013768	rexo4	85	51.064	Oryzias_latipes_hni
ENSG00000148300	REXO4	91	49.630	ENSORLG00015012070	rexo4	85	51.330	Oryzias_latipes_hsok
ENSG00000148300	REXO4	89	51.813	ENSOMEG00000018327	rexo4	83	52.419	Oryzias_melastigma
ENSG00000148300	REXO4	99	75.895	ENSOGAG00000014040	REXO4	99	74.940	Otolemur_garnettii
ENSG00000148300	REXO4	100	98.578	ENSPPAG00000027911	REXO4	100	98.578	Pan_paniscus
ENSG00000148300	REXO4	97	71.875	ENSPPRG00000002894	REXO4	100	71.154	Panthera_pardus
ENSG00000148300	REXO4	92	62.850	ENSPTIG00000012007	REXO4	89	62.992	Panthera_tigris_altaica
ENSG00000148300	REXO4	100	98.815	ENSPTRG00000023363	REXO4	100	98.815	Pan_troglodytes
ENSG00000148300	REXO4	99	95.724	ENSPANG00000026040	REXO4	100	95.498	Papio_anubis
ENSG00000148300	REXO4	93	46.067	ENSPKIG00000024761	rexo4	81	53.501	Paramormyrops_kingsleyae
ENSG00000148300	REXO4	81	76.768	ENSPSIG00000016908	REXO4	97	55.714	Pelodiscus_sinensis
ENSG00000148300	REXO4	82	48.725	ENSPMGG00000005312	rexo4	81	47.396	Periophthalmus_magnuspinnatus
ENSG00000148300	REXO4	100	68.750	ENSPEMG00000017982	Rexo4	91	75.661	Peromyscus_maniculatus_bairdii
ENSG00000148300	REXO4	74	84.848	ENSPCIG00000017379	REXO4	88	62.334	Phascolarctos_cinereus
ENSG00000148300	REXO4	90	47.044	ENSPFOG00000017751	rexo4	83	47.778	Poecilia_formosa
ENSG00000148300	REXO4	90	48.831	ENSPLAG00000010487	rexo4	83	49.719	Poecilia_latipinna
ENSG00000148300	REXO4	90	47.545	ENSPMEG00000020767	rexo4	83	50.000	Poecilia_mexicana
ENSG00000148300	REXO4	82	50.568	ENSPREG00000021841	rexo4	83	50.000	Poecilia_reticulata
ENSG00000148300	REXO4	100	96.682	ENSPPYG00000019735	REXO4	100	96.682	Pongo_abelii
ENSG00000148300	REXO4	99	68.421	ENSPCAG00000010581	REXO4	99	67.464	Procavia_capensis
ENSG00000148300	REXO4	99	74.882	ENSPCOG00000025466	REXO4	99	74.882	Propithecus_coquereli
ENSG00000148300	REXO4	99	67.708	ENSPVAG00000001429	REXO4	98	67.303	Pteropus_vampyrus
ENSG00000148300	REXO4	97	45.500	ENSPNYG00000013712	rexo4	81	53.315	Pundamilia_nyererei
ENSG00000148300	REXO4	51	68.349	ENSPNAG00000019227	rexo4	79	50.543	Pygocentrus_nattereri
ENSG00000148300	REXO4	94	83.168	ENSRNOG00000027867	Rexo4	99	68.599	Rattus_norvegicus
ENSG00000148300	REXO4	100	95.238	ENSRBIG00000037515	REXO4	100	95.261	Rhinopithecus_bieti
ENSG00000148300	REXO4	100	94.709	ENSRROG00000028864	REXO4	100	95.024	Rhinopithecus_roxellana
ENSG00000148300	REXO4	100	86.243	ENSSBOG00000032587	REXO4	100	77.962	Saimiri_boliviensis_boliviensis
ENSG00000148300	REXO4	83	63.764	ENSSHAG00000005827	REXO4	91	63.536	Sarcophilus_harrisii
ENSG00000148300	REXO4	50	71.963	ENSSFOG00015017394	rexo4	59	71.963	Scleropages_formosus
ENSG00000148300	REXO4	87	51.467	ENSSMAG00000015441	rexo4	82	51.781	Scophthalmus_maximus
ENSG00000148300	REXO4	87	50.521	ENSSDUG00000023346	rexo4	79	51.923	Seriola_dumerili
ENSG00000148300	REXO4	87	50.532	ENSSLDG00000011085	rexo4	83	51.226	Seriola_lalandi_dorsalis
ENSG00000148300	REXO4	97	56.667	ENSSPUG00000015868	REXO4	84	59.557	Sphenodon_punctatus
ENSG00000148300	REXO4	82	52.247	ENSSPAG00000007221	rexo4	81	52.247	Stegastes_partitus
ENSG00000148300	REXO4	88	84.158	ENSSSCG00000023173	REXO4	99	66.901	Sus_scrofa
ENSG00000148300	REXO4	83	60.274	ENSTGUG00000005537	REXO4	91	58.981	Taeniopygia_guttata
ENSG00000148300	REXO4	82	52.691	ENSTRUG00000013225	rexo4	84	52.691	Takifugu_rubripes
ENSG00000148300	REXO4	86	50.820	ENSTNIG00000005873	rexo4	100	50.820	Tetraodon_nigroviridis
ENSG00000148300	REXO4	68	89.744	ENSTTRG00000007681	-	97	59.882	Tursiops_truncatus
ENSG00000148300	REXO4	99	72.471	ENSUAMG00000018676	REXO4	98	72.471	Ursus_americanus
ENSG00000148300	REXO4	99	58.854	ENSUMAG00000023164	REXO4	98	68.767	Ursus_maritimus
ENSG00000148300	REXO4	98	70.853	ENSVVUG00000027337	REXO4	97	70.142	Vulpes_vulpes
ENSG00000148300	REXO4	76	49.245	ENSXETG00000023096	rexo4	83	53.443	Xenopus_tropicalis
ENSG00000148300	REXO4	91	44.853	ENSXMAG00000013686	rexo4	86	48.442	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000726	non-recombinational repair	21602889.	IDA	Process
GO:0000737	DNA catabolic process, endonucleolytic	21602889.	IDA	Process
GO:0000738	DNA catabolic process, exonucleolytic	21602889.	IDA	Process
GO:0003697	single-stranded DNA binding	21602889.	IDA	Function
GO:0003713	transcription coactivator activity	21602889.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004519	endonuclease activity	21602889.	IDA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005634	nucleus	10908561.	NAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	10908561.	NAS	Process
GO:0006364	rRNA processing	-	IEA	Process
GO:0008408	3'-5' exonuclease activity	21602889.	IDA	Function
GO:0016607	nuclear speck	-	IDA	Component
GO:0045944	positive regulation of transcription by RNA polymerase II	21602889.	IDA	Process