EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000148337 (Gene tree)
Gene ID: 25792
Gene Symbol: CIZ1
Alias: LSFR1|ZNF356
Full Name: CDKN1A interacting zinc finger protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 38,320 bases
Position: chr9:128,166,064-128,204,383
Accession: 16744
RBP type: canonical RBP
Summary: The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000489129	zf-C2H2_jaz	PF12171.8	2e-07	1	1
ENSP00000362029	zf-C2H2_jaz	PF12171.8	7.2e-07	1	1
ENSP00000489425	zf-C2H2_jaz	PF12171.8	7.2e-07	1	1
ENSP00000439244	zf-C2H2_jaz	PF12171.8	9.2e-07	1	1
ENSP00000486816	zf-C2H2_jaz	PF12171.8	1.8e-06	1	1
ENSP00000362045	zf-C2H2_jaz	PF12171.8	2e-06	1	1
ENSP00000398011	zf-C2H2_jaz	PF12171.8	2e-06	1	1
ENSP00000377232	zf-C2H2_jaz	PF12171.8	2.2e-06	1	1
ENSP00000362039	zf-C2H2_jaz	PF12171.8	2.2e-06	1	1
ENSP00000277465	zf-C2H2_jaz	PF12171.8	2.5e-06	1	1
ENSP00000350169	zf-C2H2_jaz	PF12171.8	2.5e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000467178	CIZ1-211	904	-	-	- (aa)	-	-
ENST00000476727	CIZ1-218	1205	-	-	- (aa)	-	-
ENST00000485001	CIZ1-219	596	-	-	- (aa)	-	-
ENST00000634901	CIZ1-228	3462	-	ENSP00000489425	898 (aa)	-	Q9ULV3
ENST00000324544	CIZ1-202	809	-	ENSP00000321780	252 (aa)	-	F6VD24
ENST00000491487	CIZ1-222	339	-	-	- (aa)	-	-
ENST00000277465	CIZ1-201	2742	-	ENSP00000277465	870 (aa)	-	Q5SYW2
ENST00000471773	CIZ1-212	717	-	-	- (aa)	-	-
ENST00000420484	CIZ1-209	684	-	ENSP00000407265	168 (aa)	-	F6WSM2
ENST00000372948	CIZ1-205	2858	XM_005251891	ENSP00000362039	842 (aa)	XP_005251948	Q9ULV3
ENST00000471839	CIZ1-213	928	-	ENSP00000489129	310 (aa)	-	A0A0U1RQR2
ENST00000485862	CIZ1-220	843	-	-	- (aa)	-	-
ENST00000476541	CIZ1-217	513	-	-	- (aa)	-	-
ENST00000475471	CIZ1-215	836	-	-	- (aa)	-	-
ENST00000629610	CIZ1-226	2855	-	ENSP00000486816	797 (aa)	-	Q9ULV3
ENST00000498156	CIZ1-224	642	-	-	- (aa)	-	-
ENST00000357558	CIZ1-203	2907	-	ENSP00000350169	870 (aa)	-	Q5SYW2
ENST00000393608	CIZ1-207	2645	-	ENSP00000377232	837 (aa)	-	Q9BTG3
ENST00000461765	CIZ1-210	677	-	-	- (aa)	-	-
ENST00000634501	CIZ1-227	1996	-	-	- (aa)	-	-
ENST00000538431	CIZ1-225	2996	XM_017014594	ENSP00000439244	954 (aa)	XP_016870083	F5H2X7
ENST00000476239	CIZ1-216	853	-	-	- (aa)	-	-
ENST00000372938	CIZ1-204	2984	XM_005251888	ENSP00000362029	898 (aa)	XP_005251945	Q9ULV3
ENST00000491954	CIZ1-223	955	-	-	- (aa)	-	-
ENST00000415526	CIZ1-208	2508	-	ENSP00000398011	820 (aa)	-	H0Y5D5
ENST00000372954	CIZ1-206	2731	XM_005251893	ENSP00000362045	818 (aa)	XP_005251950	Q9ULV3
ENST00000488559	CIZ1-221	952	-	-	- (aa)	-	-
ENST00000474442	CIZ1-214	457	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000148337's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000148337's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000148337	CIZ1	99	83.495	ENSAMEG00000015276	CIZ1	98	75.669	Ailuropoda_melanoleuca
ENSG00000148337	CIZ1	99	90.968	ENSANAG00000037943	CIZ1	98	87.931	Aotus_nancymaae
ENSG00000148337	CIZ1	85	36.364	ENSACLG00000008591	-	69	37.539	Astatotilapia_calliptera
ENSG00000148337	CIZ1	99	83.117	ENSBTAG00000012274	CIZ1	98	77.941	Bos_taurus
ENSG00000148337	CIZ1	99	93.528	ENSCJAG00000019948	CIZ1	100	85.639	Callithrix_jacchus
ENSG00000148337	CIZ1	99	84.416	ENSCAFG00000020086	CIZ1	99	77.918	Canis_familiaris
ENSG00000148337	CIZ1	99	84.416	ENSCAFG00020016118	CIZ1	99	77.198	Canis_lupus_dingo
ENSG00000148337	CIZ1	99	84.740	ENSCHIG00000006845	CIZ1	97	76.289	Capra_hircus
ENSG00000148337	CIZ1	99	87.702	ENSTSYG00000031123	CIZ1	96	81.273	Carlito_syrichta
ENSG00000148337	CIZ1	99	73.482	ENSCAPG00000016903	CIZ1	96	67.268	Cavia_aperea
ENSG00000148337	CIZ1	99	74.121	ENSCPOG00000006863	CIZ1	94	70.305	Cavia_porcellus
ENSG00000148337	CIZ1	99	90.968	ENSCCAG00000026440	CIZ1	95	90.769	Cebus_capucinus
ENSG00000148337	CIZ1	99	98.058	ENSCATG00000034742	CIZ1	99	95.818	Cercocebus_atys
ENSG00000148337	CIZ1	99	69.876	ENSCLAG00000001584	CIZ1	93	71.469	Chinchilla_lanigera
ENSG00000148337	CIZ1	95	95.250	ENSCSAG00000014060	CIZ1	99	95.695	Chlorocebus_sabaeus
ENSG00000148337	CIZ1	99	98.058	ENSCANG00000040660	CIZ1	99	96.556	Colobus_angolensis_palliatus
ENSG00000148337	CIZ1	99	77.273	ENSCGRG00001014777	Ciz1	95	73.159	Cricetulus_griseus_chok1gshd
ENSG00000148337	CIZ1	89	44.043	ENSDARG00000089461	ciz1b	56	43.466	Danio_rerio
ENSG00000148337	CIZ1	99	82.524	ENSDNOG00000036104	CIZ1	97	78.385	Dasypus_novemcinctus
ENSG00000148337	CIZ1	96	74.161	ENSDORG00000012341	Ciz1	98	63.573	Dipodomys_ordii
ENSG00000148337	CIZ1	99	70.968	ENSETEG00000005455	CIZ1	100	67.707	Echinops_telfairi
ENSG00000148337	CIZ1	98	73.300	ENSEASG00005020348	CIZ1	100	73.538	Equus_asinus_asinus
ENSG00000148337	CIZ1	99	83.172	ENSECAG00000007116	CIZ1	95	80.456	Equus_caballus
ENSG00000148337	CIZ1	71	86.667	ENSEEUG00000012590	-	68	78.873	Erinaceus_europaeus
ENSG00000148337	CIZ1	91	41.924	ENSELUG00000023867	-	78	44.898	Esox_lucius
ENSG00000148337	CIZ1	99	83.226	ENSFCAG00000014677	CIZ1	96	79.753	Felis_catus
ENSG00000148337	CIZ1	99	72.500	ENSFDAG00000016651	CIZ1	98	70.246	Fukomys_damarensis
ENSG00000148337	CIZ1	85	36.502	ENSFHEG00000009254	-	63	37.987	Fundulus_heteroclitus
ENSG00000148337	CIZ1	87	37.895	ENSGMOG00000018734	-	99	38.686	Gadus_morhua
ENSG00000148337	CIZ1	56	53.409	ENSGALG00000042325	-	54	57.843	Gallus_gallus
ENSG00000148337	CIZ1	86	36.594	ENSGACG00000016651	-	56	40.239	Gasterosteus_aculeatus
ENSG00000148337	CIZ1	99	99.353	ENSGGOG00000014999	CIZ1	100	97.691	Gorilla_gorilla
ENSG00000148337	CIZ1	85	36.364	ENSHBUG00000021945	-	69	37.855	Haplochromis_burtoni
ENSG00000148337	CIZ1	99	71.246	ENSHGLG00000011900	CIZ1	97	72.738	Heterocephalus_glaber_female
ENSG00000148337	CIZ1	99	71.246	ENSHGLG00100018035	CIZ1	97	72.738	Heterocephalus_glaber_male
ENSG00000148337	CIZ1	85	80.970	ENSSTOG00000033639	-	99	88.353	Ictidomys_tridecemlineatus
ENSG00000148337	CIZ1	81	73.016	ENSJJAG00000015415	-	100	77.165	Jaculus_jaculus
ENSG00000148337	CIZ1	86	35.185	ENSKMAG00000006597	-	68	37.097	Kryptolebias_marmoratus
ENSG00000148337	CIZ1	87	32.990	ENSLBEG00000007927	-	67	37.654	Labrus_bergylta
ENSG00000148337	CIZ1	99	77.922	ENSLAFG00000005106	CIZ1	95	76.208	Loxodonta_africana
ENSG00000148337	CIZ1	99	97.735	ENSMFAG00000034538	CIZ1	99	95.941	Macaca_fascicularis
ENSG00000148337	CIZ1	99	97.411	ENSMMUG00000013712	CIZ1	99	95.699	Macaca_mulatta
ENSG00000148337	CIZ1	99	98.058	ENSMNEG00000041837	CIZ1	99	95.941	Macaca_nemestrina
ENSG00000148337	CIZ1	99	97.735	ENSMLEG00000035347	CIZ1	100	95.111	Mandrillus_leucophaeus
ENSG00000148337	CIZ1	86	36.162	ENSMAMG00000019077	-	72	39.041	Mastacembelus_armatus
ENSG00000148337	CIZ1	85	36.364	ENSMZEG00005000299	-	69	37.539	Maylandia_zebra
ENSG00000148337	CIZ1	56	53.409	ENSMGAG00000004067	-	90	58.416	Meleagris_gallopavo
ENSG00000148337	CIZ1	81	65.354	ENSMAUG00000015443	-	99	72.458	Mesocricetus_auratus
ENSG00000148337	CIZ1	99	87.662	ENSMICG00000003411	CIZ1	86	80.319	Microcebus_murinus
ENSG00000148337	CIZ1	79	76.016	ENSMOCG00000009560	-	99	83.043	Microtus_ochrogaster
ENSG00000148337	CIZ1	98	72.876	MGP_CAROLIEiJ_G0023430	Ciz1	99	77.682	Mus_caroli
ENSG00000148337	CIZ1	98	72.403	ENSMUSG00000039205	Ciz1	99	76.596	Mus_musculus
ENSG00000148337	CIZ1	99	71.795	MGP_PahariEiJ_G0024887	Ciz1	99	77.215	Mus_pahari
ENSG00000148337	CIZ1	98	71.661	MGP_SPRETEiJ_G0024347	Ciz1	99	75.745	Mus_spretus
ENSG00000148337	CIZ1	99	82.848	ENSMPUG00000013449	CIZ1	97	77.047	Mustela_putorius_furo
ENSG00000148337	CIZ1	99	75.325	ENSMLUG00000016220	CIZ1	94	70.433	Myotis_lucifugus
ENSG00000148337	CIZ1	79	73.577	ENSNGAG00000016410	-	99	80.000	Nannospalax_galili
ENSG00000148337	CIZ1	90	78.182	ENSOPRG00000016419	CIZ1	96	62.471	Ochotona_princeps
ENSG00000148337	CIZ1	98	68.440	ENSODEG00000017392	CIZ1	97	69.258	Octodon_degus
ENSG00000148337	CIZ1	99	71.104	ENSOCUG00000015985	CIZ1	98	70.759	Oryctolagus_cuniculus
ENSG00000148337	CIZ1	85	36.604	ENSORLG00000027096	-	68	38.411	Oryzias_latipes
ENSG00000148337	CIZ1	84	33.333	ENSORLG00015000909	-	79	36.755	Oryzias_latipes_hsok
ENSG00000148337	CIZ1	99	78.457	ENSOGAG00000013198	CIZ1	100	75.651	Otolemur_garnettii
ENSG00000148337	CIZ1	99	82.468	ENSOARG00000010311	CIZ1	97	75.032	Ovis_aries
ENSG00000148337	CIZ1	100	99.405	ENSPPAG00000030730	CIZ1	100	99.389	Pan_paniscus
ENSG00000148337	CIZ1	99	83.819	ENSPPRG00000012431	CIZ1	98	79.393	Panthera_pardus
ENSG00000148337	CIZ1	99	83.495	ENSPTIG00000009492	CIZ1	97	75.162	Panthera_tigris_altaica
ENSG00000148337	CIZ1	99	100.000	ENSPTRG00000051341	-	100	98.957	Pan_troglodytes
ENSG00000148337	CIZ1	99	100.000	ENSPTRG00000045021	-	100	96.346	Pan_troglodytes
ENSG00000148337	CIZ1	99	97.735	ENSPANG00000024871	CIZ1	100	95.111	Papio_anubis
ENSG00000148337	CIZ1	96	77.441	ENSPEMG00000002769	Ciz1	100	80.932	Peromyscus_maniculatus_bairdii
ENSG00000148337	CIZ1	85	35.484	ENSPREG00000003135	-	65	40.830	Poecilia_reticulata
ENSG00000148337	CIZ1	100	96.887	ENSPPYG00000019645	CIZ1	100	95.868	Pongo_abelii
ENSG00000148337	CIZ1	99	74.351	ENSPCAG00000011814	CIZ1	95	73.430	Procavia_capensis
ENSG00000148337	CIZ1	99	84.691	ENSPCOG00000027303	CIZ1	97	81.594	Propithecus_coquereli
ENSG00000148337	CIZ1	99	80.583	ENSPVAG00000002437	CIZ1	96	75.361	Pteropus_vampyrus
ENSG00000148337	CIZ1	99	73.871	ENSRNOG00000013442	Ciz1	95	68.486	Rattus_norvegicus
ENSG00000148337	CIZ1	99	98.382	ENSRBIG00000034423	CIZ1	99	96.556	Rhinopithecus_bieti
ENSG00000148337	CIZ1	99	98.058	ENSRROG00000037746	CIZ1	99	96.433	Rhinopithecus_roxellana
ENSG00000148337	CIZ1	100	90.241	ENSSBOG00000030332	CIZ1	95	91.656	Saimiri_boliviensis_boliviensis
ENSG00000148337	CIZ1	88	56.786	ENSSHAG00000018645	-	83	59.627	Sarcophilus_harrisii
ENSG00000148337	CIZ1	76	72.464	ENSSARG00000002139	-	78	71.875	Sorex_araneus
ENSG00000148337	CIZ1	98	85.809	ENSSSCG00000005640	CIZ1	97	78.374	Sus_scrofa
ENSG00000148337	CIZ1	89	53.979	ENSTGUG00000003828	-	59	58.491	Taeniopygia_guttata
ENSG00000148337	CIZ1	97	76.000	ENSTBEG00000014306	CIZ1	99	70.078	Tupaia_belangeri
ENSG00000148337	CIZ1	99	85.714	ENSTTRG00000016480	CIZ1	100	80.046	Tursiops_truncatus
ENSG00000148337	CIZ1	99	84.142	ENSUAMG00000009953	CIZ1	100	78.261	Ursus_americanus
ENSG00000148337	CIZ1	95	84.122	ENSUMAG00000022712	-	94	75.622	Ursus_maritimus
ENSG00000148337	CIZ1	55	95.522	ENSVPAG00000009256	-	77	94.444	Vicugna_pacos
ENSG00000148337	CIZ1	99	85.390	ENSVVUG00000013406	CIZ1	91	77.751	Vulpes_vulpes
ENSG00000148337	CIZ1	87	35.688	ENSXMAG00000028127	-	64	39.446	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005515	protein binding	18654987.	IPI	Function
GO:0005634	nucleus	10529385.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0008270	zinc ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23074256	Variant Ciz1 is a circulating biomarker for early-stage lung cancer.	Proc Natl Acad Sci U S A	2012 Nov 6	Higgins G	doi: 10.1073/pnas.1210107109
17108141	Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action.	Cancer Res	2006 Nov 15	den Hollander P	-
24126760	CIZ1 regulates the proliferation, cycle distribution and colony formation of RKO human colorectal cancer cells.	Mol Med Rep	2013 Dec	Yin J	doi: 10.3892/mmr.2013.1716
20831784	Differential detection of alternatively spliced variants of Ciz1 in normal and cancer cells using a custom exon-junction microarray.	BMC Cancer	2010 Sep 10	Rahman FA	doi: 10.1186/1471-2407-10-482.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr9	128178403	Missense_Mutation	NA	G529A	0.09
BLCA	chr9	128179106	Missense_Mutation	novel	Q367H	0.61
BLCA	chr9	128185618	Frame_Shift_Del	novel	*G166Vfs43**	0.17
BLCA	chr9	128169090	Missense_Mutation	novel	E753K	0.18
BLCA	chr9	128180470	Missense_Mutation	rs201442924	A246P	0.08
BLCA	chr9	128169072	Missense_Mutation	NA	E759K	0.31
BLCA	chr9	128178398	Frame_Shift_Del	novel	E530*	0.22
BLCA	chr9	128180757	Missense_Mutation	novel	E216Q	0.17
BRCA	chr9	128180480	Frame_Shift_Del	novel	*K242Nfs21**	0.41
BRCA	chr9	128179035	Missense_Mutation	novel	V391E	0.15
BRCA	chr9	128179264	Missense_Mutation	novel	V315F	0.09
BRCA	chr9	128169117	Missense_Mutation	novel	E744K	0.21
BRCA	chr9	128185767	Missense_Mutation	rs770956884	R123Q	0.12
BRCA	chr9	128166394	Missense_Mutation	NA	A834S	0.14
BRCA	chr9	128169501	Nonsense_Mutation	NA	R684*	0.12
CESC	chr9	128177751	Missense_Mutation	rs751261139	G545R	0.36
CESC	chr9	128185605	Missense_Mutation	NA	S177L	0.27
CESC	chr9	128177576	Missense_Mutation	novel	S603C	0.33
CESC	chr9	128176475	Missense_Mutation	novel	E607K	0.36
CESC	chr9	128170106	Missense_Mutation	NA	E649K	0.23
CESC	chr9	128166156	3'UTR	NA		0.36
CESC	chr9	128166135	3'UTR	NA		0.19
CESC	chr9	128180737	Silent	novel	R222R	0.13
COAD	chr9	128179280	Silent	novel	P309P	0.19
COAD	chr9	128166142	3'UTR	novel		0.3
COAD	chr9	128178901	Missense_Mutation	novel	H436Y	0.27
COAD	chr9	128178832	Missense_Mutation	novel	E459K	0.28
COAD	chr9	128169501	Nonsense_Mutation	NA	R684*	0.28
COAD	chr9	128166268	Frame_Shift_Del	NA	*T876Hfs5**	0.4
COAD	chr9	128177672	Missense_Mutation	rs370598569	R571H	0.22
COAD	chr9	128178960	Missense_Mutation	novel	P416L	0.3
COAD	chr9	128169477	Missense_Mutation	rs767617433	R692C	0.16
COAD	chr9	128185579	Missense_Mutation	rs141376660	R186W	0.12
COAD	chr9	128166179	3'UTR	novel		0.47
COAD	chr9	128178710	Splice_Region	NA	G499G	0.26
COAD	chr9	128166394	Missense_Mutation	novel	A834T	0.08
COAD	chr9	128185600	Missense_Mutation	rs150582882	R179W	0.24
COAD	chr9	128178473	Missense_Mutation	NA	P506S	0.29
COAD	chr9	128185638	Missense_Mutation	novel	G166V	0.22
COAD	chr9	128166103	3'UTR	novel		0.29
COAD	chr9	128179074	Missense_Mutation	NA	Q378R	0.39
COAD	chr9	128178749	Silent	rs201067611	C486C	0.1
COAD	chr9	128166350	Silent	NA	C848C	0.26
COAD	chr9	128169486	Missense_Mutation	rs139103399	V689I	0.47
COAD	chr9	128166078	3'UTR	novel		0.42
ESCA	chr9	128166398	Missense_Mutation	novel	K832N	0.16
ESCA	chr9	128166349	Missense_Mutation	novel	A849T	0.19
ESCA	chr9	128169126	Missense_Mutation	rs767189940	E741K	0.29
ESCA	chr9	128179049	Silent	novel	Q386Q	0.16
ESCA	chr9	128166323	Silent	novel	T857T	0.38
GBM	chr9	128179274	Missense_Mutation	novel	F311L	0.66
GBM	chr9	128178995	Missense_Mutation	novel	Q404H	0.18
HNSC	chr9	128179159	Missense_Mutation	novel	S350T	0.39
HNSC	chr9	128179091	Silent	novel	Q372Q	0.51
HNSC	chr9	128179358	Silent	rs370276550	P283P	0.21
KIRC	chr9	128176378	Missense_Mutation	NA	P639L	0.27
KIRP	chr9	128170075	Missense_Mutation	novel	C659F	0.1	zf-C2H2_jaz
KIRP	chr9	128177668	Silent	novel	P572P	0.46
KIRP	chr9	128185586	Frame_Shift_Del	novel	*K183Nfs80**	0.31
LGG	chr9	128169067	Silent	novel	E760E	0.39
LGG	chr9	128179316	Missense_Mutation	novel	D297E	0.44
LIHC	chr9	128180787	Nonsense_Mutation	novel	E206*	0.38
LIHC	chr9	128167145	Missense_Mutation	novel	S772Y	0.49
LIHC	chr9	128179036	Missense_Mutation	rs780756425	V391M	0.47
LUAD	chr9	128170033	Missense_Mutation	novel	T673I	0.23	zf-C2H2_jaz
LUAD	chr9	128179274	Silent	novel	F311F	0.1
LUAD	chr9	128180757	Missense_Mutation	novel	E216K	0.25
LUAD	chr9	128179129	Nonsense_Mutation	NA	Q360*	0.26
LUAD	chr9	128179266	Missense_Mutation	NA	R314P	0.28
LUSC	chr9	128169501	Nonsense_Mutation	NA	R684*	0.64
LUSC	chr9	128190326	Splice_Region	novel		0.95
LUSC	chr9	128169069	Missense_Mutation	novel	E760K	0.14
LUSC	chr9	128180775	Missense_Mutation	novel	D210N	0.53
LUSC	chr9	128185717	Missense_Mutation	novel	P140T	0.21
OV	chr9	128166864	Silent	novel	V794V	0.25
OV	chr9	128176473	Splice_Region	novel	E607E	0.22
PAAD	chr9	128180492	Silent	rs371780195	I238I	0.16
PAAD	chr9	128185680	Missense_Mutation	novel	P152H	0.16
READ	chr9	128169501	Nonsense_Mutation	NA	R684*	0.35
SKCM	chr9	128190382	Missense_Mutation	NA	S78F	0.26
SKCM	chr9	128190438	Silent	novel	L59L	0.25
SKCM	chr9	128180768	Missense_Mutation	NA	P212L	0.28
SKCM	chr9	128179352	Silent	NA	A285A	0.38
SKCM	chr9	128169420	Missense_Mutation	rs752622423	D711N	0.49
SKCM	chr9	128185680	Missense_Mutation	NA	P152L	0.33
SKCM	chr9	128178993	Missense_Mutation	novel	P405L	0.26
SKCM	chr9	128185662	Missense_Mutation	NA	S158F	0.08
STAD	chr9	128169067	Silent	novel	E760E	0.31
STAD	chr9	128178869	Missense_Mutation	NA	Q446H	0.27
STAD	chr9	128166787	Missense_Mutation	novel	K820R	0.12
STAD	chr9	128179129	Nonsense_Mutation	NA	Q360*	0.36
STAD	chr9	128180767	Frame_Shift_Ins	novel	*E213Rfs4**	0.17
STAD	chr9	128179305	Missense_Mutation	novel	E301G	0.3
STAD	chr9	128177755	Silent	rs551659002	G543G	0.43
STAD	chr9	128178384	Silent	rs550697095	A535A	0.09
STAD	chr9	128179348	Missense_Mutation	NA	M287L	0.25
STAD	chr9	128170090	Missense_Mutation	rs754102259	R654H	0.29
TGCT	chr9	128179223	Silent	rs145714867	P328P	0.12
UCEC	chr9	128167125	Missense_Mutation	novel	S779P	0.18
UCEC	chr9	128178917	Missense_Mutation	novel	Q430H	0.14
UCEC	chr9	128185640	Silent	novel	V165V	0.32
UCEC	chr9	128169444	Missense_Mutation	NA	H703Y	0.12
UCEC	chr9	128169667	Intron	novel		0.24
UCEC	chr9	128185734	Missense_Mutation	NA	A134V	0.1
UCEC	chr9	128167123	Silent	rs756753256	S779S	0.12
UCEC	chr9	128178984	Missense_Mutation	NA	Q408R	0.43
UCEC	chr9	128177605	Missense_Mutation	novel	F593L	0.11
UCEC	chr9	128166305	Silent	rs760629916	S863S	0.43
UCEC	chr9	128169442	Silent	rs747018616	H703H	0.39
UCEC	chr9	128180738	Missense_Mutation	rs756660946	R222Q	0.35
UCEC	chr9	128185749	Missense_Mutation	novel	S129F	0.48
UCEC	chr9	128180718	Splice_Region	rs199649739		0.18
UCEC	chr9	128185551	Missense_Mutation	novel	R195Q	0.27
UCEC	chr9	128178758	Silent	novel	V483V	0.13
UCEC	chr9	128179071	Missense_Mutation	novel	V379A	0.48
UCEC	chr9	128179179	Missense_Mutation	NA	K343R	0.45
UCEC	chr9	128176459	Missense_Mutation	novel	M612T	0.45
UCEC	chr9	128169640	Intron	rs539223689		0.4
UCEC	chr9	128180800	Missense_Mutation	novel	Q201H	0.18
UCEC	chr9	128180510	Silent	rs45579839	P232P	0.23
UCEC	chr9	128179414	Missense_Mutation	rs151058866	S265P	0.45
UCEC	chr9	128185738	Missense_Mutation	novel	A133T	0.33
UCEC	chr9	128166205	Missense_Mutation	novel	K897E	0.33
UCEC	chr9	128179209	Missense_Mutation	novel	T333I	0.36
UCEC	chr9	128166376	Missense_Mutation	novel	T840A	0.34
UCEC	chr9	128180764	Missense_Mutation	NA	E213D	0.41
UCEC	chr9	128179111	Nonsense_Mutation	novel	Q366*	0.41
UCEC	chr9	128180480	Silent	novel	K242K	0.42
UCEC	chr9	128180491	Missense_Mutation	rs114082772	A239T	0.36
UCEC	chr9	128166301	Missense_Mutation	rs373808543	R865C	0.4
UCEC	chr9	128185552	Nonsense_Mutation	novel	R195*	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4167	0.067545
LAML	DEL	0.0052	0.24147
LGG	AMP	0.0585	0.21332
LIHC	DEL	0.2514	0.12467
PRAD	AMP	0.0813	0.059049
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCS	DEL	0.5357	0.089783

Survival Analysis

Cancer	P-value	Q-value
SARC	0.042	Kaplan-Meier Survival Analysis
MESO	0.00079	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.029	Kaplan-Meier Survival Analysis
SKCM	0.0033	Kaplan-Meier Survival Analysis
PRAD	0.016	Kaplan-Meier Survival Analysis
KIRP	0.035	Kaplan-Meier Survival Analysis
COAD	0.022	Kaplan-Meier Survival Analysis
PAAD	0.0013	Kaplan-Meier Survival Analysis
PCPG	0.029	Kaplan-Meier Survival Analysis
BLCA	0.021	Kaplan-Meier Survival Analysis
LIHC	0.0028	Kaplan-Meier Survival Analysis
LGG	0.0032	Kaplan-Meier Survival Analysis
UVM	0.0001	Kaplan-Meier Survival Analysis
OV	0.014	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742