EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000149016 (Gene tree)
Gene ID: 64852
Gene Symbol: TUT1
Alias: FLJ22347|FLJ22267|FLJ21850|PAPD2|TUTase|TENT1|RBM21
Full Name: terminal uridylyl transferase 1, U6 snRNA-specific
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 17,133 bases
Position: chr11:62,575,045-62,592,177
Accession: 26184
RBP type: canonical RBP
Summary: This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000278279	zf-met	PF12874.7	9.9e-05	1	1
ENSP00000419607	zf-met	PF12874.7	0.0006	1	1
ENSP00000308000	zf-met	PF12874.7	0.00064	1	1
ENSP00000419607	PAP_assoc	PF03828.19	3.7e-05	1	1
ENSP00000308000	PAP_assoc	PF03828.19	3.9e-05	1	1
ENSP00000308000	RRM_1	PF00076.22	0.00016	1	1
ENSP00000419607	RRM_1	PF00076.22	0.00017	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16248944	[Screening and cloning of hepatitis C virus non-structural protein 4A interacting protein gene in hepatocytes].	Zhonghua Gan Zang Bing Za Zhi	2005 Oct	Liu Y	-
12574127	Isolation of a U-insertion/deletion editing complex from Leishmania tarentolae mitochondria.	EMBO J	2003 Feb 17	Aphasizhev R	-
28589955	Crystal structures of U6 snRNA-specific terminal uridylyltransferase.	Nat Commun	2017 Jun 7	Yamashita S	doi: 10.1038/ncomms15788.
16790842	Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase.	RNA	2006 Aug	Trippe R	-
17785418	Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases.	Proc Natl Acad Sci U S A	2007 Sep 11	Stagno J	-
23306079	The novel poly(A) polymerase Star-PAP is a signal-regulated switch at the 3'-end of mRNAs.	Adv Biol Regul	2013 Jan	Li W	doi: 10.1016/j.jbior.2012.10.004
20403364	Structure of the mitochondrial editosome-like complex associated TUTase 1 reveals divergent mechanisms of UTP selection and domain organization.	J Mol Biol	2010 Jun 11	Stagno J	doi: 10.1016/j.jmb.2010.04.021

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000278279	TUT1-201	533	-	ENSP00000278279	165 (aa)	-	J3KN81
ENST00000478537	TUT1-206	643	-	ENSP00000419792	100 (aa)	-	F8WA97
ENST00000476907	TUT1-205	3363	-	ENSP00000419607	874 (aa)	-	Q9H6E5
ENST00000494385	TUT1-207	699	-	ENSP00000420739	143 (aa)	-	C9JBX0
ENST00000308436	TUT1-202	2826	-	ENSP00000308000	912 (aa)	-	F5H0R1
ENST00000469480	TUT1-204	2036	-	-	- (aa)	-	-
ENST00000463241	TUT1-203	752	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000149016's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000149016	Bronchodilator Agents	2E-6	26634245
ENSG00000149016	Forced Expiratory Volume	2E-6	26634245
ENSG00000149016	Bronchodilator Agents	1E-6	26634245
ENSG00000149016	Forced Expiratory Volume	1E-6	26634245
ENSG00000149016	Bronchodilator Agents	5E-6	26634245
ENSG00000149016	Lung Volume Measurements	5E-6	26634245
ENSG00000149016	Bronchodilator Agents	3E-6	26634245
ENSG00000149016	Forced Expiratory Volume	3E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000149016	rs146799327	11	62579559	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.155	GO_0097366\|EFO_0004713
ENSG00000149016	rs111394397	11	62584219	T	Post bronchodilator FEV1	26634245	NR unit increase	0.263	EFO_0004314\|GO_0097366
ENSG00000149016	rs116766958	11	62579038	T	Post bronchodilator FEV1	26634245	NR unit increase	0.266	EFO_0004314\|GO_0097366
ENSG00000149016	rs146799327	11	62579559	T	Post bronchodilator FEV1	26634245	NR unit increase	0.822	EFO_0004314\|GO_0097366
ENSG00000149016	rs79021925	11	62581062	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149016's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000149016	TUT1	55	41.026	ENSG00000107951	MTPAP	77	33.333

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149016	TUT1	89	53.933	ENSAPOG00000016423	tut1	93	45.581	Acanthochromis_polyacanthus
ENSG00000149016	TUT1	99	87.743	ENSAMEG00000006723	-	99	87.743	Ailuropoda_melanoleuca
ENSG00000149016	TUT1	96	49.640	ENSACIG00000000948	tut1	61	50.730	Amphilophus_citrinellus
ENSG00000149016	TUT1	97	46.099	ENSAOCG00000021912	tut1	93	46.479	Amphiprion_ocellaris
ENSG00000149016	TUT1	97	46.099	ENSAPEG00000005144	tut1	93	46.479	Amphiprion_percula
ENSG00000149016	TUT1	97	46.853	ENSATEG00000014590	tut1	61	48.540	Anabas_testudineus
ENSG00000149016	TUT1	100	97.902	ENSANAG00000029063	-	100	93.478	Aotus_nancymaae
ENSG00000149016	TUT1	96	47.482	ENSACLG00000013406	tut1	92	45.540	Astatotilapia_calliptera
ENSG00000149016	TUT1	96	48.921	ENSAMXG00000042139	tut1	93	47.393	Astyanax_mexicanus
ENSG00000149016	TUT1	100	94.667	ENSBTAG00000011846	TUT1	99	87.743	Bos_taurus
ENSG00000149016	TUT1	100	98.601	ENSCJAG00000033294	-	100	93.364	Callithrix_jacchus
ENSG00000149016	TUT1	93	93.548	ENSCAFG00000015822	TUT1	99	86.857	Canis_familiaris
ENSG00000149016	TUT1	93	93.548	ENSCAFG00020013039	-	99	86.857	Canis_lupus_dingo
ENSG00000149016	TUT1	100	94.667	ENSCHIG00000006765	-	99	87.858	Capra_hircus
ENSG00000149016	TUT1	100	86.022	ENSTSYG00000000147	-	99	82.967	Carlito_syrichta
ENSG00000149016	TUT1	100	81.944	ENSCAPG00000013001	-	99	80.925	Cavia_aperea
ENSG00000149016	TUT1	93	92.473	ENSCPOG00000014281	-	99	76.142	Cavia_porcellus
ENSG00000149016	TUT1	100	97.902	ENSCCAG00000018819	-	100	93.640	Cebus_capucinus
ENSG00000149016	TUT1	100	97.902	ENSCATG00000036770	-	100	95.614	Cercocebus_atys
ENSG00000149016	TUT1	93	92.473	ENSCLAG00000000215	-	99	74.857	Chinchilla_lanigera
ENSG00000149016	TUT1	100	98.601	ENSCSAG00000006566	-	100	95.812	Chlorocebus_sabaeus
ENSG00000149016	TUT1	97	95.652	ENSCHOG00000007746	-	72	82.082	Choloepus_hoffmanni
ENSG00000149016	TUT1	90	67.778	ENSCPBG00000017909	-	61	61.961	Chrysemys_picta_bellii
ENSG00000149016	TUT1	100	97.849	ENSCANG00000043244	-	100	95.633	Colobus_angolensis_palliatus
ENSG00000149016	TUT1	90	86.047	ENSCGRG00001017583	Tut1	99	76.826	Cricetulus_griseus_chok1gshd
ENSG00000149016	TUT1	90	86.047	ENSCGRG00000015008	Tut1	99	76.826	Cricetulus_griseus_crigri
ENSG00000149016	TUT1	97	46.154	ENSCSEG00000012807	tut1	61	49.635	Cynoglossus_semilaevis
ENSG00000149016	TUT1	99	45.833	ENSCVAG00000005396	tut1	93	45.205	Cyprinodon_variegatus
ENSG00000149016	TUT1	97	48.227	ENSDARG00000057321	tut1	61	50.000	Danio_rerio
ENSG00000149016	TUT1	100	94.667	ENSDNOG00000038908	-	99	88.330	Dasypus_novemcinctus
ENSG00000149016	TUT1	100	92.473	ENSDORG00000004018	Tut1	98	84.000	Dipodomys_ordii
ENSG00000149016	TUT1	90	50.769	ENSEBUG00000014170	tut1	63	44.257	Eptatretus_burgeri
ENSG00000149016	TUT1	100	97.902	ENSEASG00005007531	-	99	90.722	Equus_asinus_asinus
ENSG00000149016	TUT1	100	97.902	ENSECAG00000009471	-	98	90.951	Equus_caballus
ENSG00000149016	TUT1	100	89.333	ENSEEUG00000001238	-	100	82.494	Erinaceus_europaeus
ENSG00000149016	TUT1	96	50.360	ENSELUG00000011532	tut1	93	48.387	Esox_lucius
ENSG00000149016	TUT1	93	96.774	ENSFCAG00000008859	-	99	87.816	Felis_catus
ENSG00000149016	TUT1	93	94.624	ENSFDAG00000021131	-	99	77.029	Fukomys_damarensis
ENSG00000149016	TUT1	98	50.505	ENSFHEG00000006279	tut1	93	45.413	Fundulus_heteroclitus
ENSG00000149016	TUT1	90	51.111	ENSGMOG00000013378	tut1	70	47.289	Gadus_morhua
ENSG00000149016	TUT1	97	45.775	ENSGAFG00000008587	tut1	82	56.164	Gambusia_affinis
ENSG00000149016	TUT1	89	51.685	ENSGACG00000009956	tut1	98	35.471	Gasterosteus_aculeatus
ENSG00000149016	TUT1	90	65.556	ENSGAGG00000007912	-	77	49.457	Gopherus_agassizii
ENSG00000149016	TUT1	99	100.000	ENSGGOG00000013564	-	100	98.794	Gorilla_gorilla
ENSG00000149016	TUT1	96	47.482	ENSHBUG00000022855	tut1	92	45.070	Haplochromis_burtoni
ENSG00000149016	TUT1	93	95.699	ENSHGLG00000002742	-	99	75.657	Heterocephalus_glaber_female
ENSG00000149016	TUT1	93	95.699	ENSHGLG00100017588	-	99	76.082	Heterocephalus_glaber_male
ENSG00000149016	TUT1	96	45.324	ENSHCOG00000016358	tut1	61	50.741	Hippocampus_comes
ENSG00000149016	TUT1	90	54.444	ENSIPUG00000017671	tut1	62	52.000	Ictalurus_punctatus
ENSG00000149016	TUT1	100	95.804	ENSSTOG00000002859	-	99	88.215	Ictidomys_tridecemlineatus
ENSG00000149016	TUT1	100	93.548	ENSJJAG00000022329	Tut1	99	85.796	Jaculus_jaculus
ENSG00000149016	TUT1	97	46.809	ENSKMAG00000010023	tut1	61	49.635	Kryptolebias_marmoratus
ENSG00000149016	TUT1	97	46.043	ENSLBEG00000014969	tut1	93	43.925	Labrus_bergylta
ENSG00000149016	TUT1	96	53.571	ENSLACG00000011278	tut1	93	49.296	Latimeria_chalumnae
ENSG00000149016	TUT1	96	53.901	ENSLOCG00000013105	tut1	93	50.000	Lepisosteus_oculatus
ENSG00000149016	TUT1	100	90.667	ENSLAFG00000003340	-	99	88.774	Loxodonta_africana
ENSG00000149016	TUT1	100	97.849	ENSMFAG00000000912	-	100	95.175	Macaca_fascicularis
ENSG00000149016	TUT1	100	98.788	ENSMMUG00000006595	-	100	98.788	Macaca_mulatta
ENSG00000149016	TUT1	100	97.849	ENSMNEG00000029841	-	100	95.066	Macaca_nemestrina
ENSG00000149016	TUT1	100	97.902	ENSMLEG00000040498	-	100	95.504	Mandrillus_leucophaeus
ENSG00000149016	TUT1	96	46.099	ENSMAMG00000008173	tut1	93	45.116	Mastacembelus_armatus
ENSG00000149016	TUT1	96	47.482	ENSMZEG00005009777	tut1	92	45.540	Maylandia_zebra
ENSG00000149016	TUT1	90	83.544	ENSMAUG00000012453	Tut1	99	83.544	Mesocricetus_auratus
ENSG00000149016	TUT1	99	96.479	ENSMICG00000009841	-	99	88.145	Microcebus_murinus
ENSG00000149016	TUT1	93	86.022	ENSMOCG00000015834	Tut1	99	76.941	Microtus_ochrogaster
ENSG00000149016	TUT1	97	46.853	ENSMMOG00000002589	tut1	72	46.047	Mola_mola
ENSG00000149016	TUT1	100	81.944	ENSMODG00000007710	-	99	69.021	Monodelphis_domestica
ENSG00000149016	TUT1	97	48.252	ENSMALG00000003624	tut1	61	49.091	Monopterus_albus
ENSG00000149016	TUT1	93	86.022	MGP_CAROLIEiJ_G0022670	Tut1	99	77.143	Mus_caroli
ENSG00000149016	TUT1	99	87.324	ENSMUSG00000071645	Tut1	99	77.790	Mus_musculus
ENSG00000149016	TUT1	93	86.022	MGP_PahariEiJ_G0014164	Tut1	99	78.653	Mus_pahari
ENSG00000149016	TUT1	99	87.324	MGP_SPRETEiJ_G0023583	Tut1	99	77.677	Mus_spretus
ENSG00000149016	TUT1	93	94.624	ENSMPUG00000013938	-	99	87.858	Mustela_putorius_furo
ENSG00000149016	TUT1	100	94.667	ENSMLUG00000000349	-	99	74.456	Myotis_lucifugus
ENSG00000149016	TUT1	100	92.473	ENSNGAG00000002988	Tut1	99	83.352	Nannospalax_galili
ENSG00000149016	TUT1	96	47.482	ENSNBRG00000022055	tut1	61	48.905	Neolamprologus_brichardi
ENSG00000149016	TUT1	100	99.301	ENSNLEG00000003780	-	100	98.026	Nomascus_leucogenys
ENSG00000149016	TUT1	100	80.556	ENSMEUG00000012756	-	91	78.960	Notamacropus_eugenii
ENSG00000149016	TUT1	97	92.754	ENSOPRG00000011835	-	74	89.946	Ochotona_princeps
ENSG00000149016	TUT1	93	91.398	ENSODEG00000002204	-	100	72.509	Octodon_degus
ENSG00000149016	TUT1	96	48.201	ENSONIG00000019913	tut1	60	53.077	Oreochromis_niloticus
ENSG00000149016	TUT1	96	73.118	ENSOANG00000012458	-	99	72.854	Ornithorhynchus_anatinus
ENSG00000149016	TUT1	100	95.804	ENSOCUG00000017215	-	100	85.793	Oryctolagus_cuniculus
ENSG00000149016	TUT1	97	43.972	ENSORLG00000004342	tut1	73	43.192	Oryzias_latipes
ENSG00000149016	TUT1	97	43.972	ENSORLG00015018834	tut1	73	43.192	Oryzias_latipes_hsok
ENSG00000149016	TUT1	96	44.604	ENSOMEG00000005129	tut1	72	44.507	Oryzias_melastigma
ENSG00000149016	TUT1	100	96.774	ENSOGAG00000000828	-	99	87.400	Otolemur_garnettii
ENSG00000149016	TUT1	100	93.333	ENSOARG00000015269	-	99	83.805	Ovis_aries
ENSG00000149016	TUT1	100	99.542	ENSPPAG00000037200	-	100	99.342	Pan_paniscus
ENSG00000149016	TUT1	93	96.774	ENSPPRG00000000257	-	99	88.787	Panthera_pardus
ENSG00000149016	TUT1	93	96.774	ENSPTIG00000017573	-	99	87.816	Panthera_tigris_altaica
ENSG00000149016	TUT1	100	100.000	ENSPTRG00000003770	TUT1	100	99.452	Pan_troglodytes
ENSG00000149016	TUT1	100	97.849	ENSPANG00000010908	-	96	92.005	Papio_anubis
ENSG00000149016	TUT1	96	53.957	ENSPKIG00000022062	tut1	60	49.638	Paramormyrops_kingsleyae
ENSG00000149016	TUT1	93	64.516	ENSPSIG00000004972	-	67	54.104	Pelodiscus_sinensis
ENSG00000149016	TUT1	96	45.324	ENSPMGG00000004299	tut1	62	48.529	Periophthalmus_magnuspinnatus
ENSG00000149016	TUT1	100	87.413	ENSPEMG00000018332	Tut1	99	77.055	Peromyscus_maniculatus_bairdii
ENSG00000149016	TUT1	92	48.148	ENSPMAG00000005825	tut1	54	51.711	Petromyzon_marinus
ENSG00000149016	TUT1	95	82.796	ENSPCIG00000017805	-	99	66.667	Phascolarctos_cinereus
ENSG00000149016	TUT1	96	47.482	ENSPFOG00000016195	tut1	62	49.442	Poecilia_formosa
ENSG00000149016	TUT1	96	47.482	ENSPLAG00000022064	tut1	62	49.442	Poecilia_latipinna
ENSG00000149016	TUT1	96	47.482	ENSPMEG00000019175	tut1	62	49.814	Poecilia_mexicana
ENSG00000149016	TUT1	99	46.154	ENSPREG00000020464	tut1	62	49.442	Poecilia_reticulata
ENSG00000149016	TUT1	100	98.601	ENSPPYG00000003162	-	100	97.826	Pongo_abelii
ENSG00000149016	TUT1	97	84.634	ENSPCAG00000002956	-	99	84.634	Procavia_capensis
ENSG00000149016	TUT1	100	95.804	ENSPCOG00000017464	-	100	86.630	Propithecus_coquereli
ENSG00000149016	TUT1	97	93.478	ENSPVAG00000003444	-	85	87.169	Pteropus_vampyrus
ENSG00000149016	TUT1	96	47.482	ENSPNYG00000018764	tut1	92	44.601	Pundamilia_nyererei
ENSG00000149016	TUT1	96	48.921	ENSPNAG00000011889	tut1	62	49.289	Pygocentrus_nattereri
ENSG00000149016	TUT1	100	89.510	ENSRNOG00000020047	Tut1	99	77.968	Rattus_norvegicus
ENSG00000149016	TUT1	100	97.902	ENSRBIG00000021240	-	100	95.415	Rhinopithecus_bieti
ENSG00000149016	TUT1	100	97.902	ENSRROG00000043315	-	100	95.672	Rhinopithecus_roxellana
ENSG00000149016	TUT1	100	97.902	ENSSBOG00000003827	-	100	93.593	Saimiri_boliviensis_boliviensis
ENSG00000149016	TUT1	90	82.171	ENSSHAG00000003368	-	99	68.192	Sarcophilus_harrisii
ENSG00000149016	TUT1	97	55.714	ENSSFOG00015005639	tut1	93	52.113	Scleropages_formosus
ENSG00000149016	TUT1	97	44.681	ENSSMAG00000011449	tut1	61	49.635	Scophthalmus_maximus
ENSG00000149016	TUT1	89	51.685	ENSSDUG00000003613	tut1	61	48.540	Seriola_dumerili
ENSG00000149016	TUT1	89	51.685	ENSSLDG00000022487	tut1	61	48.905	Seriola_lalandi_dorsalis
ENSG00000149016	TUT1	87	58.779	ENSSPUG00000008143	-	90	55.189	Sphenodon_punctatus
ENSG00000149016	TUT1	95	54.167	ENSSPAG00000023390	tut1	61	50.365	Stegastes_partitus
ENSG00000149016	TUT1	90	89.023	ENSSSCG00000013063	-	99	88.889	Sus_scrofa
ENSG00000149016	TUT1	96	45.652	ENSTRUG00000016451	tut1	71	44.134	Takifugu_rubripes
ENSG00000149016	TUT1	100	45.890	ENSTNIG00000012852	tut1	99	43.349	Tetraodon_nigroviridis
ENSG00000149016	TUT1	98	90.141	ENSTTRG00000002460	-	99	84.536	Tursiops_truncatus
ENSG00000149016	TUT1	99	87.629	ENSUAMG00000027237	-	99	87.514	Ursus_americanus
ENSG00000149016	TUT1	99	87.629	ENSUMAG00000012710	-	99	87.514	Ursus_maritimus
ENSG00000149016	TUT1	100	95.699	ENSVPAG00000005413	-	100	89.153	Vicugna_pacos
ENSG00000149016	TUT1	93	94.624	ENSVVUG00000029882	-	99	86.629	Vulpes_vulpes
ENSG00000149016	TUT1	93	50.538	ENSXETG00000005640	tut1	89	50.476	Xenopus_tropicalis
ENSG00000149016	TUT1	97	47.552	ENSXCOG00000017824	tut1	79	58.678	Xiphophorus_couchianus
ENSG00000149016	TUT1	96	47.482	ENSXMAG00000027272	tut1	62	50.370	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	18288197.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	21102410.	IDA	Function
GO:0004652	polynucleotide adenylyltransferase activity	18288197.	IDA	Function
GO:0005515	protein binding	18288197.21102410.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	16790842.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	18305108.21102410.	IDA	Component
GO:0006378	mRNA polyadenylation	21102410.	IDA	Process
GO:0006378	mRNA polyadenylation	18288197.	IMP	Process
GO:0016180	snRNA processing	16790842.	IMP	Process
GO:0016607	nuclear speck	18288197.18305108.	IDA	Component
GO:0019899	enzyme binding	18305108.	IPI	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0050265	RNA uridylyltransferase activity	16790842.18288197.	IDA	Function
GO:0071044	histone mRNA catabolic process	18172165.	IMP	Process
GO:0098789	pre-mRNA cleavage required for polyadenylation	21102410.	IDA	Process