EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000149115 (Gene tree)
Gene ID: 85456
Gene Symbol: TNKS1BP1
Alias: TAB182|KIAA1741|FLJ45975
Full Name: tankyrase 1 binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 25,324 bases
Position: chr11:57,299,629-57,324,952
Accession: 19081
RBP type: non-canonical RBP
Summary: (Tankyrase 1 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include enzyme binding and ankyrin binding. An important paralog of this gene is KIAA1671.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000528882	TNKS1BP1-204	4336	XM_011545325	ENSP00000431616	243 (aa)	XP_011543627	E9PKK0
ENST00000527207	TNKS1BP1-203	594	-	ENSP00000433576	143 (aa)	-	E9PKE7
ENST00000358252	TNKS1BP1-201	5795	-	ENSP00000350990	1729 (aa)	-	Q9C0C2
ENST00000530920	TNKS1BP1-205	957	-	ENSP00000494351	283 (aa)	-	A0A2R8Y5C4
ENST00000532437	TNKS1BP1-207	5952	XM_006718725	ENSP00000437271	1729 (aa)	XP_006718788	Q9C0C2
ENST00000427750	TNKS1BP1-202	1946	-	-	- (aa)	-	-
ENST00000532273	TNKS1BP1-206	592	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000149115's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149115's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	-	TAS	Process
GO:0005515	protein binding	11854288.25749521.	IPI	Function
GO:0005634	nucleus	11854288.	IDA	Component
GO:0005720	nuclear heterochromatin	11854288.	IDA	Component
GO:0005737	cytoplasm	11854288.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005913	cell-cell adherens junction	11854288.	IDA	Component
GO:0006302	double-strand break repair	25749521.	IMP	Process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	TAS	Process
GO:0007004	telomere maintenance via telomerase	11854288.	NAS	Process
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	25749521.	IMP	Process
GO:0019899	enzyme binding	11854288.	IDA	Function
GO:0030014	CCR4-NOT complex	19558367.	IDA	Component
GO:0031954	positive regulation of protein autophosphorylation	25749521.	IMP	Process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	25749521.	IMP	Process
GO:0044877	protein-containing complex binding	25749521.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0071479	cellular response to ionizing radiation	25749521.	IMP	Process
GO:0071532	ankyrin repeat binding	11854288.	IMP	Function
GO:0071532	ankyrin repeat binding	11854288.	IPI	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17617028	Tankyrase-1 mRNA expression in bladder cancer and paired urine sediment: preliminary experience.	Clin Chem Lab Med	2007	Gelmini S	-
28202517	Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion.	Cancer Res	2017 May 1	Ohishi T	doi: 10.1158/0008-5472.CAN-16-1846
15652747	Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.	Cancer Cell	2005 Jan	Seimiya H	-
28058814	Overexpression of TNKS1BP1 in lung cancers and its involvement in homologous recombination pathway of DNA double-strand breaks.	Cancer Med	2017 Feb	Tan W	doi: 10.1002/cam4.995

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	57309323	Missense_Mutation	rs770124427	D1130N	0.25
ACC	chr11	57320335	Missense_Mutation	novel	A158S	0.48
ACC	chr11	57321898	5'UTR	novel		0.15
BLCA	chr11	57308665	Missense_Mutation	rs143761660	A1349V	0.26
BLCA	chr11	57308732	Missense_Mutation	NA	D1327H	0.35
BLCA	chr11	57312789	Silent	NA	L633L	0.3
BLCA	chr11	57310308	Missense_Mutation	novel	M801I	0.09
BLCA	chr11	57308636	Missense_Mutation	NA	P1359S	0.31
BLCA	chr11	57320605	Missense_Mutation	novel	P68S	0.24
BLCA	chr11	57309602	Missense_Mutation	NA	D1037H	0.31
BLCA	chr11	57309025	Missense_Mutation	rs139978039	S1229C	0.09
BLCA	chr11	57310073	Missense_Mutation	novel	D880N	0.39
BLCA	chr11	57312732	Silent	NA	T652T	0.26
BLCA	chr11	57320339	Silent	rs546086969	F156F	0.49
BLCA	chr11	57312698	Missense_Mutation	NA	E664Q	0.32
BLCA	chr11	57309978	Silent	novel	K911K	0.51
BLCA	chr11	57321868	Silent	rs553347344	L6L	0.58
BLCA	chr11	57313417	Missense_Mutation	novel	V424D	0.75
BLCA	chr11	57320518	Frame_Shift_Del	novel	*L97Ffs34**	0.18
BRCA	chr11	57309101	In_Frame_Del	novel	M1203del	0.1
BRCA	chr11	57308402	Missense_Mutation	rs771781037	G1437R	0.34
BRCA	chr11	57320267	Missense_Mutation	novel	D180E	0.1
BRCA	chr11	57308582	Missense_Mutation	rs774760397	G1377S	0.43
BRCA	chr11	57301894	Silent	novel	E1628E	0.32
BRCA	chr11	57312593	Missense_Mutation	NA	A699P	0.26
BRCA	chr11	57313046	Missense_Mutation	NA	P548A	0.23
BRCA	chr11	57320611	Missense_Mutation	rs763983688	R66W	0.38
BRCA	chr11	57309846	Silent	rs763675243	S955S	0.46
BRCA	chr11	57312959	Missense_Mutation	novel	G577C	0.61
BRCA	chr11	57300002	3'UTR	novel		0.41
BRCA	chr11	57300003	3'UTR	novel		0.38
BRCA	chr11	57301944	Splice_Site	novel	X1612_splice	0.05
BRCA	chr11	57302636	Silent	rs775269545	D1502D	0.12
BRCA	chr11	57309332	Frame_Shift_Del	novel	*I1127Lfs6**	0.13
BRCA	chr11	57321798	Missense_Mutation	NA	E30K	0.39
BRCA	chr11	57299805	3'UTR	novel		0.43
BRCA	chr11	57313849	Nonsense_Mutation	NA	S280*	0.5
BRCA	chr11	57321922	5'UTR	novel		0.48
CESC	chr11	57309627	Silent	NA	F1028F	0.22
CESC	chr11	57312789	Silent	NA	L633L	0.14
CESC	chr11	57299999	3'UTR	novel		0.09
CESC	chr11	57301941	Missense_Mutation	novel	P1613S	0.43
CESC	chr11	57302543	Silent	rs138321958	S1533S	0.24
CESC	chr11	57309237	Silent	rs139514655	S1158S	0.5
CESC	chr11	57313654	Missense_Mutation	novel	D345G	0.4
CESC	chr11	57320338	Missense_Mutation	rs151184444	A157T	0.32
CESC	chr11	57302557	Missense_Mutation	NA	A1529S	0.27
CESC	chr11	57308414	Missense_Mutation	NA	A1433S	0.47
CESC	chr11	57302461	Missense_Mutation	NA	E1561K	0.15
CESC	chr11	57308464	Missense_Mutation	rs141792675	S1416L	0.37
CESC	chr11	57313292	Missense_Mutation	NA	A466T	0.47
COAD	chr11	57310153	Missense_Mutation	rs750457239	G853D	0.36
COAD	chr11	57320500	Missense_Mutation	NA	P103S	0.27
COAD	chr11	57309728	Missense_Mutation	NA	D995N	0.25
COAD	chr11	57301893	Missense_Mutation	novel	P1629S	0.23
COAD	chr11	57320336	Silent	rs370005549	A157A	0.25
COAD	chr11	57310002	Silent	rs769313015	N903N	0.16
COAD	chr11	57302517	Missense_Mutation	rs377332391	R1542Q	0.46
COAD	chr11	57308607	Silent	rs762092652	G1368G	0.31
COAD	chr11	57309644	Frame_Shift_Del	NA	*G1023Ifs8**	0.37
COAD	chr11	57321976	Intron	novel		0.27
COAD	chr11	57309700	Missense_Mutation	NA	S1004T	0.38
COAD	chr11	57313854	Frame_Shift_Del	NA	*S279Pfs56**	0.42
COAD	chr11	57308699	Missense_Mutation	novel	G1338R	0.09
COAD	chr11	57309498	Silent	novel	P1071P	0.13
COAD	chr11	57320556	Missense_Mutation	novel	L84P	0.17
COAD	chr11	57302745	Missense_Mutation	NA	K1466M	0.38
COAD	chr11	57309712	Frame_Shift_Del	NA	*K1000Rfs133**	0.41
COAD	chr11	57309713	Nonsense_Mutation	novel	K1000*	0.41
COAD	chr11	57309231	Silent	NA	D1160D	0.21
COAD	chr11	57313218	Missense_Mutation	rs774783891	W490C	0.3
COAD	chr11	57312597	Silent	rs148587432	G697G	0.28
COAD	chr11	57308602	Missense_Mutation	NA	V1370A	0.07
COAD	chr11	57309966	Silent	novel	H915H	0.17
COAD	chr11	57321967	Intron	novel		0.15
COAD	chr11	57312883	Missense_Mutation	NA	P602H	0.24
COAD	chr11	57310381	Missense_Mutation	rs150510361	K777T	0.29
COAD	chr11	57300953	Missense_Mutation	rs554711702	S1687L	0.31
COAD	chr11	57313832	Missense_Mutation	novel	A286T	0.07
COAD	chr11	57308795	Missense_Mutation	novel	V1306M	0.28
COAD	chr11	57302494	Missense_Mutation	NA	A1550T	0.44
COAD	chr11	57308742	Silent	NA	T1323T	0.32
COAD	chr11	57308402	Missense_Mutation	rs771781037	G1437R	0.45
COAD	chr11	57302158	Missense_Mutation	NA	R1584W	0.17
COAD	chr11	57312877	Missense_Mutation	NA	P604R	0.4
COAD	chr11	57309846	Silent	rs763675243	S955S	0.25
COAD	chr11	57310259	Missense_Mutation	NA	L818I	0.21
COAD	chr11	57301025	Missense_Mutation	rs369411354	R1663Q	0.47
DLBC	chr11	57313530	Silent	novel	T386T	0.25
ESCA	chr11	57320515	Missense_Mutation	novel	P98S	0.61
ESCA	chr11	57299912	3'UTR	novel		0.27
ESCA	chr11	57317875	Silent	rs773632907	S247S	0.61
ESCA	chr11	57300552	Silent	novel	K1726K	0.88
GBM	chr11	57302150	Silent	rs147576300	P1586P	0.33
GBM	chr11	57312918	Silent	rs780973701	Y590Y	0.09
GBM	chr11	57317870	Missense_Mutation	novel	L249P	0.24
GBM	chr11	57301934	Missense_Mutation	novel	A1615G	0.64
GBM	chr11	57308943	Silent	novel	G1256G	0.45
GBM	chr11	57309571	Missense_Mutation	novel	S1047I	0.35
GBM	chr11	57302597	Silent	novel	A1515A	0.22
HNSC	chr11	57317875	Silent	rs773632907	S247S	0.17
HNSC	chr11	57302483	Silent	novel	P1553P	0.19
HNSC	chr11	57308775	Silent	novel	G1312G	0.08
HNSC	chr11	57309559	Missense_Mutation	novel	S1051I	0.28
HNSC	chr11	57320649	Missense_Mutation	novel	L53R	0.16
HNSC	chr11	57320475	Missense_Mutation	novel	G111V	0.2
HNSC	chr11	57320476	Nonsense_Mutation	novel	G111*	0.22
HNSC	chr11	57301938	Missense_Mutation	rs771893296	R1614W	0.14
HNSC	chr11	57300579	Missense_Mutation	novel	N1717K	0.24
HNSC	chr11	57302772	Missense_Mutation	novel	E1457A	0.5
HNSC	chr11	57302545	Missense_Mutation	novel	S1533G	0.19
HNSC	chr11	57302133	Frame_Shift_Del	novel	*G1592Vfs34**	0.28
HNSC	chr11	57308750	Nonsense_Mutation	novel	E1321*	0.15
HNSC	chr11	57317821	Silent	novel	A265A	0.24
HNSC	chr11	57302840	Intron	novel		0.15
HNSC	chr11	57308419	Missense_Mutation	rs371891458	G1431A	0.23
HNSC	chr11	57312749	Nonsense_Mutation	novel	E647*	0.19
HNSC	chr11	57313289	Missense_Mutation	novel	E467Q	0.35
HNSC	chr11	57312976	Missense_Mutation	rs370520637	P571L	0.21
HNSC	chr11	57320104	Missense_Mutation	novel	E235Q	0.18
HNSC	chr11	57302539	Nonsense_Mutation	novel	Q1535*	0.31
KIRC	chr11	57308710	Missense_Mutation	NA	L1334Q	0.18
KIRC	chr11	57320237	Silent	NA	N190N	0.23
KIRC	chr11	57309862	Frame_Shift_Del	novel	*Q950Rfs9**	0.33
KIRC	chr11	57300569	Missense_Mutation	NA	A1721S	0.26
KIRC	chr11	57309971	Missense_Mutation	rs746946950	H914Y	0.18
KIRC	chr11	57308948	Missense_Mutation	rs749324062	V1255M	0.27
KIRP	chr11	57317825	Missense_Mutation	NA	P264L	0.17
KIRP	chr11	57308917	Missense_Mutation	novel	A1265V	0.18
KIRP	chr11	57308712	Silent	NA	G1333G	0.4
KIRP	chr11	57312758	Missense_Mutation	NA	L644M	0.29
LAML	chr11	57309413	Missense_Mutation	novel	A1100T	0.15
LGG	chr11	57309449	Missense_Mutation	rs201237928	G1088S	0.26
LGG	chr11	57320374	Missense_Mutation	rs777018298	A145T	0.39
LGG	chr11	57310362	Silent	rs748504933	G783G	0.12
LIHC	chr11	57308837	Missense_Mutation	novel	P1292S	0.16
LIHC	chr11	57313188	Silent	novel	I500I	0.18
LIHC	chr11	57309750	Silent	novel	S987S	0.03
LIHC	chr11	57302767	Missense_Mutation	novel	M1459L	0.07
LIHC	chr11	57313013	In_Frame_Del	novel	G558del	0.37
LIHC	chr11	57321968	Intron	novel		0.07
LIHC	chr11	57302587	Missense_Mutation	rs764635374	E1519K	0.32
LUAD	chr11	57302134	Missense_Mutation	novel	G1592C	0.14
LUAD	chr11	57317853	Silent	novel	L255L	0.12
LUAD	chr11	57302543	Silent	rs138321958	S1533S	0.39
LUAD	chr11	57321868	Silent	rs553347344	L6L	0.24
LUAD	chr11	57313017	Silent	NA	D557D	0.26
LUAD	chr11	57308687	Missense_Mutation	novel	M1342L	0.06
LUAD	chr11	57313223	Missense_Mutation	novel	V489L	0.19
LUAD	chr11	57309608	Missense_Mutation	rs768586181	V1035L	0.29
LUAD	chr11	57312867	Silent	novel	T607T	0.37
LUAD	chr11	57310498	Frame_Shift_Del	novel	*P738Hfs87**	0.22
LUAD	chr11	57308927	Missense_Mutation	NA	G1262C	0.24
LUAD	chr11	57320265	Missense_Mutation	NA	R181L	0.2
LUAD	chr11	57309119	Missense_Mutation	novel	L1198M	0.11
LUAD	chr11	57309016	Missense_Mutation	NA	N1232I	0.16
LUAD	chr11	57310039	Missense_Mutation	NA	R891I	0.14
LUAD	chr11	57300538	3'UTR	novel		0.31
LUAD	chr11	57302543	Silent	rs138321958	S1533S	0.25
LUAD	chr11	57320207	Missense_Mutation	NA	R200S	0.16
LUAD	chr11	57308763	Silent	novel	G1316G	0.04
LUAD	chr11	57320582	Missense_Mutation	NA	L75F	0.44
LUAD	chr11	57309418	Missense_Mutation	rs545906142	R1098Q	0.2
LUSC	chr11	57320513	Frame_Shift_Del	novel	*P98Lfs8**	0.21
LUSC	chr11	57302483	Frame_Shift_Del	novel	*S1554Vfs72**	0.25
LUSC	chr11	57310395	Silent	novel	R772R	0.17
LUSC	chr11	57308453	Nonsense_Mutation	novel	E1420*	0.35
LUSC	chr11	57309238	Missense_Mutation	rs150046410	S1158L	0.44
LUSC	chr11	57313392	Silent	novel	V432V	0.3
LUSC	chr11	57313007	Missense_Mutation	NA	Q561E	0.17
LUSC	chr11	57320349	Missense_Mutation	NA	S153L	0.29
LUSC	chr11	57308829	Silent	NA	A1294A	0.12
LUSC	chr11	57302487	Missense_Mutation	NA	S1552F	0.2
LUSC	chr11	57312572	Nonsense_Mutation	novel	E706*	0.28
LUSC	chr11	57309109	Missense_Mutation	novel	R1201T	0.32
LUSC	chr11	57308654	Missense_Mutation	novel	V1353M	0.26
LUSC	chr11	57310273	Missense_Mutation	NA	S813C	0.14
LUSC	chr11	57310020	Silent	novel	Y897Y	0.08
LUSC	chr11	57309725	Missense_Mutation	novel	E996K	0.06
LUSC	chr11	57321962	Intron	novel		0.16
LUSC	chr11	57313172	Missense_Mutation	NA	A506S	0.17
LUSC	chr11	57313174	Missense_Mutation	NA	E505V	0.17
LUSC	chr11	57321873	Translation_Start_Site	novel	MKVS1_?4	0.08
LUSC	chr11	57312621	Silent	NA	L689L	0.55
LUSC	chr11	57313163	Missense_Mutation	novel	A509S	0.32
LUSC	chr11	57302621	Missense_Mutation	novel	W1507C	0.19
LUSC	chr11	57309292	Missense_Mutation	NA	S1140C	0.27
LUSC	chr11	57310451	Missense_Mutation	novel	Q754E	0.27
LUSC	chr11	57312662	Missense_Mutation	novel	P676A	0.32
OV	chr11	57309159	Silent	novel	A1184A	0.08
OV	chr11	57309947	Missense_Mutation	NA	D922Y	0.13
OV	chr11	57300908	Missense_Mutation	NA	P1702L	0.13
OV	chr11	57313522	Missense_Mutation	rs775263373	R389Q	0.3
PAAD	chr11	57309413	Missense_Mutation	novel	A1100T	0.08
PAAD	chr11	57300889	Silent	novel	S1708S	0.19
PAAD	chr11	57309025	Missense_Mutation	novel	S1229F	0.2
PAAD	chr11	57309430	Missense_Mutation	novel	V1094A	0.22
PAAD	chr11	57309858	Silent	novel	E951E	0.18
PRAD	chr11	57300528	Splice_Region	NA		0.21
PRAD	chr11	57308838	Silent	rs755698236	A1291A	0.33
PRAD	chr11	57301833	Missense_Mutation	novel	P1649S	0.3
PRAD	chr11	57309797	Missense_Mutation	rs148640580	A972T	0.19
PRAD	chr11	57320359	Missense_Mutation	novel	R150C	0.34
READ	chr11	57308850	Silent	NA	L1287L	0.48
READ	chr11	57310245	Silent	novel	D822D	0.41
SKCM	chr11	57302787	Missense_Mutation	NA	S1452F	0.83
SKCM	chr11	57309792	Silent	NA	Q973Q	0.83
SKCM	chr11	57300978	Nonsense_Mutation	NA	Q1679*	0.98
SKCM	chr11	57320220	Missense_Mutation	rs141797385	R196Q	0.24
SKCM	chr11	57302514	Missense_Mutation	NA	R1543Q	0.35
SKCM	chr11	57320622	Missense_Mutation	NA	P62L	0.39
SKCM	chr11	57313304	Missense_Mutation	rs555154458	R462C	0.75
SKCM	chr11	57313818	Silent	novel	L290L	0.38
SKCM	chr11	57309866	Missense_Mutation	novel	E949K	0.37
SKCM	chr11	57309378	Silent	novel	R1111R	0.04
SKCM	chr11	57309591	Silent	rs150142077	L1040L	0.34
SKCM	chr11	57302122	Silent	NA	L1596L	0.27
SKCM	chr11	57302617	Missense_Mutation	NA	P1509S	0.13
SKCM	chr11	57312662	Missense_Mutation	NA	P676S	0.27
SKCM	chr11	57300953	Missense_Mutation	rs554711702	S1687L	0.38
SKCM	chr11	57317887	Splice_Region	rs759548669	R243R	0.1
SKCM	chr11	57309259	Missense_Mutation	novel	P1151L	0.35
SKCM	chr11	57309260	Missense_Mutation	novel	P1151S	0.35
SKCM	chr11	57310499	Missense_Mutation	NA	P738S	0.15
SKCM	chr11	57309753	Silent	NA	F986F	0.73
SKCM	chr11	57320594	Silent	rs150087591	P71P	0.41
SKCM	chr11	57313699	Missense_Mutation	NA	P330L	0.39
SKCM	chr11	57308907	Silent	rs760524520	F1268F	0.31
SKCM	chr11	57313100	Missense_Mutation	novel	G530R	0.39
SKCM	chr11	57309222	Silent	NA	D1163D	0.4
SKCM	chr11	57309895	Missense_Mutation	NA	T939I	0.14
SKCM	chr11	57309192	Silent	NA	S1173S	0.46
SKCM	chr11	57309716	Nonsense_Mutation	NA	E999*	0.19
SKCM	chr11	57309835	Missense_Mutation	NA	R959K	0.47
SKCM	chr11	57312867	Silent	NA	T607T	0.26
SKCM	chr11	57302693	Missense_Mutation	NA	E1483D	0.35
SKCM	chr11	57302469	Missense_Mutation	NA	S1558F	0.44
SKCM	chr11	57320185	Missense_Mutation	NA	P208S	0.06
SKCM	chr11	57301923	Missense_Mutation	NA	P1619S	0.26
SKCM	chr11	57320605	Missense_Mutation	novel	P68S	0.33
SKCM	chr11	57309285	Silent	NA	K1142K	0.32
SKCM	chr11	57312736	Missense_Mutation	NA	V651G	0.39
SKCM	chr11	57308768	Silent	rs780561452	L1315L	0.26
SKCM	chr11	57308938	Missense_Mutation	novel	T1258I	0.59
SKCM	chr11	57308435	Missense_Mutation	rs148443497	P1426S	0.22
SKCM	chr11	57302570	Silent	novel	T1524T	0.61
SKCM	chr11	57302571	Missense_Mutation	novel	T1524I	0.64
SKCM	chr11	57320365	Missense_Mutation	NA	P148S	0.31
SKCM	chr11	57308444	Missense_Mutation	novel	P1423S	0.48
SKCM	chr11	57301012	Silent	NA	A1667A	0.46
SKCM	chr11	57312599	Missense_Mutation	NA	G697R	0.33
STAD	chr11	57302744	Frame_Shift_Ins	novel	*A1467Gfs46**	0.5
STAD	chr11	57309638	Missense_Mutation	rs765769784	G1025R	0.4
STAD	chr11	57309884	Missense_Mutation	rs778792813	R943W	0.41
STAD	chr11	57310459	Missense_Mutation	novel	G751A	0.18
STAD	chr11	57308896	Missense_Mutation	novel	R1272M	0.06
STAD	chr11	57308897	Missense_Mutation	novel	R1272G	0.06
STAD	chr11	57309835	Missense_Mutation	NA	R959K	0.24
STAD	chr11	57302744	Frame_Shift_Ins	novel	*A1467Gfs46**	0.32
STAD	chr11	57320653	Missense_Mutation	novel	A52S	0.22
STAD	chr11	57300914	Missense_Mutation	rs756294920	T1700M	0.06
STAD	chr11	57309177	Silent	NA	S1178S	0.1
STAD	chr11	57313404	Silent	rs768441436	F428F	0.18
STAD	chr11	57309178	Missense_Mutation	novel	S1178C	0.06
STAD	chr11	57320607	Missense_Mutation	NA	P67H	0.25
STAD	chr11	57309092	Missense_Mutation	NA	G1207S	0.23
STAD	chr11	57312724	Missense_Mutation	rs766751523	R655Q	0.15
STAD	chr11	57301881	Missense_Mutation	NA	R1633W	0.16
STAD	chr11	57320421	Frame_Shift_Del	novel	*P129Lfs2**	0.23
STAD	chr11	57310432	Frame_Shift_Del	novel	*G760Vfs65**	0.35
STAD	chr11	57302138	Silent	NA	P1590P	0.3
STAD	chr11	57313052	Frame_Shift_Del	NA	*D546Mfs106**	0.08
STAD	chr11	57300917	Missense_Mutation	NA	L1699P	0.15
STAD	chr11	57312596	Missense_Mutation	rs200365694	G698S	0.18
STAD	chr11	57308651	Nonsense_Mutation	NA	E1354*	0.31
THCA	chr11	57301910	In_Frame_Ins	novel	D1622_E1623insG	0.04
THCA	chr11	57308469	Silent	NA	Y1414Y	0.31
UCEC	chr11	57310075	Missense_Mutation	rs374813552	R879Q	0.37
UCEC	chr11	57320250	Missense_Mutation	rs371562715	R186H	0.34
UCEC	chr11	57309095	Missense_Mutation	novel	T1206A	0.38
UCEC	chr11	57312597	Silent	rs148587432	G697G	0.28
UCEC	chr11	57313149	Silent	novel	G513G	0.31
UCEC	chr11	57313372	Missense_Mutation	rs756603766	D439G	0.33
UCEC	chr11	57317835	Missense_Mutation	novel	S261P	0.38
UCEC	chr11	57312918	Silent	rs780973701	Y590Y	0.43
UCEC	chr11	57300952	Silent	rs141896209	S1687S	0.44
UCEC	chr11	57309393	Missense_Mutation	novel	Q1106H	0.67
UCEC	chr11	57320442	Missense_Mutation	novel	A122V	0.21
UCEC	chr11	57321949	Splice_Region	novel		0.39
UCEC	chr11	57300953	Missense_Mutation	rs554711702	S1687L	0.32
UCEC	chr11	57320380	Missense_Mutation	NA	R143W	0.36
UCEC	chr11	57309178	Missense_Mutation	novel	S1178Y	0.51
UCEC	chr11	57313020	Silent	rs374237093	G556G	0.45
UCEC	chr11	57313806	Silent	novel	A294A	0.32
UCEC	chr11	57309629	Missense_Mutation	novel	F1028L	0.36
UCEC	chr11	57320097	Missense_Mutation	novel	S237I	0.36
UCEC	chr11	57300967	Silent	rs76459169	S1682S	0.3
UCEC	chr11	57301867	Silent	rs149022895	S1637S	0.42
UCEC	chr11	57300589	Missense_Mutation	rs757935996	S1714L	0.45
UCEC	chr11	57309814	Missense_Mutation	novel	S966I	0.44
UCEC	chr11	57302543	Silent	rs138321958	S1533S	0.17
UCEC	chr11	57309797	Missense_Mutation	rs148640580	A972T	0.19
UCEC	chr11	57313691	Missense_Mutation	rs199806060	A333T	0.12
UCEC	chr11	57309226	Missense_Mutation	NA	T1162N	0.05
UCEC	chr11	57310207	Missense_Mutation	rs376099913	R835Q	0.15
UCEC	chr11	57300600	Splice_Region	rs756675913	G1710G	0.16
UCEC	chr11	57308664	Silent	rs148991284	A1349A	0.2
UCEC	chr11	57301878	Missense_Mutation	novel	T1634A	0.33
UCEC	chr11	57300973	Silent	novel	K1680K	0.25
UCEC	chr11	57309043	Missense_Mutation	novel	G1223E	0.33
UCEC	chr11	57320265	Missense_Mutation	rs142187077	R181H	0.37
UCEC	chr11	57308945	Missense_Mutation	rs777911492	G1256R	0.48
UCEC	chr11	57309846	Silent	rs763675243	S955S	0.26
UCEC	chr11	57310010	Missense_Mutation	novel	D901Y	0.38
UCEC	chr11	57320250	Missense_Mutation	rs371562715	R186H	0.36
UCEC	chr11	57299759	3'UTR	novel		0.37
UCEC	chr11	57310033	Missense_Mutation	rs764546037	S893Y	0.53
UCEC	chr11	57320204	Silent	novel	T201T	0.29
UCEC	chr11	57299922	3'UTR	rs762257367		0.63
UCEC	chr11	57309986	Missense_Mutation	novel	L909V	0.52
UCEC	chr11	57301904	Missense_Mutation	NA	V1625A	0.39
UCEC	chr11	57320529	Missense_Mutation	novel	S93N	0.4
UCEC	chr11	57308509	Missense_Mutation	novel	V1401D	0.51
UCEC	chr11	57320648	Silent	NA	L53L	0.59
UCEC	chr11	57300589	Missense_Mutation	rs757935996	S1714L	0.36
UCEC	chr11	57321874	Silent	novel	S4S	0.25
UCEC	chr11	57299658	3'UTR	novel		0.17
UCEC	chr11	57313815	Frame_Shift_Del	novel	*A292Qfs43**	0.11
UCEC	chr11	57299677	3'UTR	novel		0.37
UCEC	chr11	57312738	Silent	rs567644664	A650A	0.34
UCEC	chr11	57313104	Silent	novel	G528G	0.27
UCEC	chr11	57310440	Silent	rs201680603	G757G	0.37
UCEC	chr11	57299962	3'UTR	novel		0.41
UCEC	chr11	57309704	Missense_Mutation	novel	P1003S	0.54
UCEC	chr11	57313203	Silent	rs569807284	P495P	0.39
UCEC	chr11	57312669	Frame_Shift_Del	novel	*E674Sfs34**	0.42
UCEC	chr11	57320211	Missense_Mutation	novel	P199H	0.33
UCEC	chr11	57309735	Missense_Mutation	novel	Q992H	0.2
UCEC	chr11	57310460	Missense_Mutation	novel	G751C	0.14
UCEC	chr11	57302716	Missense_Mutation	novel	S1476P	0.28
UCEC	chr11	57313565	Silent	novel	L375L	0.48
UCEC	chr11	57320266	Missense_Mutation	rs768422961	R181C	0.08
UCEC	chr11	57309259	Missense_Mutation	NA	P1151H	0.4
UCEC	chr11	57317885	Missense_Mutation	novel	S244I	0.53
UCEC	chr11	57309332	Frame_Shift_Del	novel	*I1127Lfs6**	0.12
UCEC	chr11	57320196	Missense_Mutation	rs368145617	T204M	0.29
UCEC	chr11	57313845	Missense_Mutation	rs766464702	E281D	0.39
UCEC	chr11	57302218	Missense_Mutation	rs201181917	E1564K	0.25
UCEC	chr11	57302744	Missense_Mutation	novel	K1466N	0.29
UCEC	chr11	57308704	Missense_Mutation	novel	G1336V	0.43
UCEC	chr11	57308949	Silent	rs374665676	G1254G	0.49
UCEC	chr11	57309370	Missense_Mutation	novel	C1114Y	0.22
UCEC	chr11	57310248	Missense_Mutation	novel	Q821H	0.13
UCEC	chr11	57312857	Missense_Mutation	novel	A611T	0.18
UCEC	chr11	57301843	Silent	novel	V1645V	0.5
UCEC	chr11	57309492	Silent	novel	S1073S	0.27
UCEC	chr11	57320229	Missense_Mutation	novel	G193D	0.26
UCEC	chr11	57300982	Silent	NA	S1677S	0.36
UCEC	chr11	57308495	Missense_Mutation	novel	G1406W	0.05
UCEC	chr11	57321892	5'UTR	rs367695396		0.2
UCEC	chr11	57299664	3'UTR	novel		0.49
UCEC	chr11	57309157	Missense_Mutation	novel	R1185K	0.11
UCEC	chr11	57309366	Silent	rs113027859	I1115I	0.41
UCEC	chr11	57309845	Missense_Mutation	rs556509857	A956T	0.4
UCEC	chr11	57313233	Silent	rs764059160	S485S	0.35
UCEC	chr11	57302543	Silent	rs138321958	S1533S	0.28
UCEC	chr11	57309249	Silent	novel	T1154T	0.35
UCEC	chr11	57320486	Silent	novel	A107A	0.24
UCS	chr11	57308742	Silent	novel	T1323T	0.44
UCS	chr11	57309581	Missense_Mutation	rs780942582	D1044Y	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1576	0.018342
TGCT	DEL	0.6467	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.007	Kaplan-Meier Survival Analysis
KIRC	0.0029	Kaplan-Meier Survival Analysis
SARC	0.0043	Kaplan-Meier Survival Analysis
MESO	0.00073	Kaplan-Meier Survival Analysis
SKCM	0.00096	Kaplan-Meier Survival Analysis
ESCA	0.0056	Kaplan-Meier Survival Analysis
KIRP	0.029	Kaplan-Meier Survival Analysis
PAAD	0.00061	Kaplan-Meier Survival Analysis
GBM	0.041	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.00085	Kaplan-Meier Survival Analysis
OV	0.045	Kaplan-Meier Survival Analysis