EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000149218 (Gene tree)
Gene ID: 23052
Gene Symbol: ENDOD1
Alias: KIAA0830
Full Name: endonuclease domain containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 42,842 bases
Position: chr11:95,089,810-95,132,651
Accession: 29129
RBP type: canonical RBP
Summary: ENDOD1 (Endonuclease Domain Containing 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and endonuclease activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000278505	Endonuclease_NS	PF01223.23	2.1e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000278505	ENDOD1-201	4687	-	ENSP00000278505	500 (aa)	-	O94919

Gene Model

Click here to download ENSG00000149218's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000149218	Job Satisfaction	3.1110000E-005	-
ENSG00000149218	Lipoprotein(a)	9.7580000E-005	-
ENSG00000149218	Platelet Function Tests	7.9200000E-010	-
ENSG00000149218	Platelet Function Tests	5.2600000E-006	-
ENSG00000149218	Platelet Function Tests	6.4400000E-006	-
ENSG00000149218	Platelet Function Tests	1.8100000E-006	-
ENSG00000149218	Platelet Function Tests	2.4400000E-007	-
ENSG00000149218	Platelet Function Tests	2.7700000E-011	-
ENSG00000149218	Platelet Function Tests	5.9900000E-011	-
ENSG00000149218	Platelet Function Tests	1.0985900E-005	-
ENSG00000149218	Platelet Function Tests	1.5054100E-005	-
ENSG00000149218	Platelet Function Tests	3.9900000E-006	-
ENSG00000149218	Platelet Function Tests	7.4900000E-007	-
ENSG00000149218	Platelet Function Tests	2.8600000E-011	-
ENSG00000149218	Platelet Function Tests	6.4350132E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000149218	rs10605167	11	95095304	T	Mean platelet volume	27863252	[0.031-0.049] unit decrease	0.03997559	EFO_0004584
ENSG00000149218	rs3740861	11	95129413	G	Heel bone mineral density	30598549	[0.0078-0.0157] unit decrease	0.0117704	EFO_0009270
ENSG00000149218	rs3740861	11	95129413	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149218's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149218	ENDOD1	80	74.314	ENSAMEG00000019907	ENDOD1	100	74.314	Ailuropoda_melanoleuca
ENSG00000149218	ENDOD1	51	30.847	ENSAOCG00000021283	si:dkey-85k7.10	95	30.847	Amphiprion_ocellaris
ENSG00000149218	ENDOD1	51	30.847	ENSAPEG00000018856	si:dkey-85k7.10	95	30.847	Amphiprion_percula
ENSG00000149218	ENDOD1	94	37.866	ENSACAG00000013977	ENDOD1	99	38.153	Anolis_carolinensis
ENSG00000149218	ENDOD1	52	31.034	ENSAMXG00000037726	si:dkey-85k7.10	88	31.970	Astyanax_mexicanus
ENSG00000149218	ENDOD1	100	93.800	ENSCJAG00000039825	ENDOD1	100	93.800	Callithrix_jacchus
ENSG00000149218	ENDOD1	100	92.600	ENSCCAG00000036865	ENDOD1	100	92.600	Cebus_capucinus
ENSG00000149218	ENDOD1	100	96.400	ENSCATG00000044441	ENDOD1	100	96.400	Cercocebus_atys
ENSG00000149218	ENDOD1	100	97.400	ENSCSAG00000003290	ENDOD1	100	97.400	Chlorocebus_sabaeus
ENSG00000149218	ENDOD1	68	83.529	ENSCHOG00000013059	ENDOD1	100	83.529	Choloepus_hoffmanni
ENSG00000149218	ENDOD1	55	31.475	ENSCPBG00000005639	-	54	31.475	Chrysemys_picta_bellii
ENSG00000149218	ENDOD1	97	45.062	ENSCPBG00000024041	ENDOD1	98	44.856	Chrysemys_picta_bellii
ENSG00000149218	ENDOD1	61	31.818	ENSCPBG00000009952	-	56	31.429	Chrysemys_picta_bellii
ENSG00000149218	ENDOD1	56	32.095	ENSCPBG00000007740	-	65	32.095	Chrysemys_picta_bellii
ENSG00000149218	ENDOD1	100	97.200	ENSCANG00000025695	ENDOD1	100	97.200	Colobus_angolensis_palliatus
ENSG00000149218	ENDOD1	100	84.600	ENSEASG00005011271	ENDOD1	100	84.600	Equus_asinus_asinus
ENSG00000149218	ENDOD1	100	84.800	ENSECAG00000017667	ENDOD1	100	84.800	Equus_caballus
ENSG00000149218	ENDOD1	100	80.400	ENSFCAG00000005079	ENDOD1	100	80.400	Felis_catus
ENSG00000149218	ENDOD1	99	39.960	ENSFALG00000000330	ENDOD1	86	39.960	Ficedula_albicollis
ENSG00000149218	ENDOD1	80	84.040	ENSFDAG00000012281	ENDOD1	94	84.040	Fukomys_damarensis
ENSG00000149218	ENDOD1	93	41.453	ENSGALG00000017205	ENDOD1	93	41.453	Gallus_gallus
ENSG00000149218	ENDOD1	77	41.192	ENSGAGG00000005154	-	99	40.933	Gopherus_agassizii
ENSG00000149218	ENDOD1	51	33.206	ENSGAGG00000016583	-	66	33.206	Gopherus_agassizii
ENSG00000149218	ENDOD1	54	32.646	ENSGAGG00000016563	-	80	33.740	Gopherus_agassizii
ENSG00000149218	ENDOD1	94	99.149	ENSGGOG00000024775	ENDOD1	99	97.468	Gorilla_gorilla
ENSG00000149218	ENDOD1	53	31.250	ENSHBUG00000008382	-	97	31.250	Haplochromis_burtoni
ENSG00000149218	ENDOD1	100	83.600	ENSHGLG00000010395	ENDOD1	100	83.600	Heterocephalus_glaber_female
ENSG00000149218	ENDOD1	100	82.000	ENSHGLG00100000983	ENDOD1	100	82.000	Heterocephalus_glaber_male
ENSG00000149218	ENDOD1	100	84.600	ENSSTOG00000000032	ENDOD1	100	84.600	Ictidomys_tridecemlineatus
ENSG00000149218	ENDOD1	53	31.786	ENSLACG00000005002	-	98	31.786	Latimeria_chalumnae
ENSG00000149218	ENDOD1	100	78.389	ENSLAFG00000010482	ENDOD1	100	78.389	Loxodonta_africana
ENSG00000149218	ENDOD1	100	96.600	ENSMFAG00000037393	ENDOD1	100	96.600	Macaca_fascicularis
ENSG00000149218	ENDOD1	100	97.000	ENSMMUG00000047793	ENDOD1	100	97.000	Macaca_mulatta
ENSG00000149218	ENDOD1	100	97.000	ENSMNEG00000040186	ENDOD1	100	97.000	Macaca_nemestrina
ENSG00000149218	ENDOD1	82	97.800	ENSMLEG00000043710	ENDOD1	100	97.800	Mandrillus_leucophaeus
ENSG00000149218	ENDOD1	100	66.733	ENSMODG00000000165	ENDOD1	100	66.733	Monodelphis_domestica
ENSG00000149218	ENDOD1	80	82.793	ENSMLUG00000014495	ENDOD1	100	82.793	Myotis_lucifugus
ENSG00000149218	ENDOD1	100	96.800	ENSNLEG00000007127	ENDOD1	100	96.800	Nomascus_leucogenys
ENSG00000149218	ENDOD1	100	67.331	ENSMEUG00000008592	ENDOD1	100	67.331	Notamacropus_eugenii
ENSG00000149218	ENDOD1	51	30.496	ENSONIG00000014582	-	98	30.496	Oreochromis_niloticus
ENSG00000149218	ENDOD1	99	58.366	ENSOANG00000010405	-	99	59.252	Ornithorhynchus_anatinus
ENSG00000149218	ENDOD1	99	60.800	ENSOANG00000010505	-	100	60.800	Ornithorhynchus_anatinus
ENSG00000149218	ENDOD1	100	87.600	ENSOCUG00000014040	ENDOD1	100	87.600	Oryctolagus_cuniculus
ENSG00000149218	ENDOD1	53	30.717	ENSOMEG00000007309	-	52	30.717	Oryzias_melastigma
ENSG00000149218	ENDOD1	96	86.694	ENSOGAG00000026634	ENDOD1	100	86.400	Otolemur_garnettii
ENSG00000149218	ENDOD1	100	99.200	ENSPPAG00000036031	ENDOD1	100	99.200	Pan_paniscus
ENSG00000149218	ENDOD1	100	80.800	ENSPPRG00000004151	-	100	80.800	Panthera_pardus
ENSG00000149218	ENDOD1	84	76.850	ENSPTIG00000021253	ENDOD1	99	76.850	Panthera_tigris_altaica
ENSG00000149218	ENDOD1	100	99.400	ENSPTRG00000045007	ENDOD1	100	99.400	Pan_troglodytes
ENSG00000149218	ENDOD1	100	96.800	ENSPANG00000009553	ENDOD1	100	96.800	Papio_anubis
ENSG00000149218	ENDOD1	58	32.399	ENSPKIG00000003602	-	54	32.288	Paramormyrops_kingsleyae
ENSG00000149218	ENDOD1	63	31.624	ENSPKIG00000007324	-	50	32.770	Paramormyrops_kingsleyae
ENSG00000149218	ENDOD1	58	34.268	ENSPKIG00000019032	-	54	34.169	Paramormyrops_kingsleyae
ENSG00000149218	ENDOD1	51	34.586	ENSPSIG00000010161	-	91	34.733	Pelodiscus_sinensis
ENSG00000149218	ENDOD1	57	33.108	ENSPSIG00000009892	-	99	33.108	Pelodiscus_sinensis
ENSG00000149218	ENDOD1	96	41.788	ENSPSIG00000011246	ENDOD1	100	41.788	Pelodiscus_sinensis
ENSG00000149218	ENDOD1	52	30.877	ENSPMGG00000009447	si:dkey-243k1.3	99	30.877	Periophthalmus_magnuspinnatus
ENSG00000149218	ENDOD1	100	68.924	ENSPCIG00000001331	ENDOD1	100	68.924	Phascolarctos_cinereus
ENSG00000149218	ENDOD1	53	31.673	ENSPFOG00000007195	-	99	31.673	Poecilia_formosa
ENSG00000149218	ENDOD1	54	31.561	ENSPREG00000018344	-	99	31.561	Poecilia_reticulata
ENSG00000149218	ENDOD1	100	83.800	ENSPCAG00000000704	ENDOD1	100	83.800	Procavia_capensis
ENSG00000149218	ENDOD1	100	87.200	ENSPCOG00000008619	ENDOD1	100	87.200	Propithecus_coquereli
ENSG00000149218	ENDOD1	56	30.721	ENSPNYG00000003385	si:ch211-165i18.2	86	32.411	Pundamilia_nyererei
ENSG00000149218	ENDOD1	53	30.137	ENSPNAG00000025759	-	94	30.137	Pygocentrus_nattereri
ENSG00000149218	ENDOD1	53	31.186	ENSPNAG00000004857	si:dkey-85k7.10	95	31.186	Pygocentrus_nattereri
ENSG00000149218	ENDOD1	50	30.970	ENSPNAG00000025288	-	94	30.970	Pygocentrus_nattereri
ENSG00000149218	ENDOD1	51	30.605	ENSPNAG00000025281	-	93	30.605	Pygocentrus_nattereri
ENSG00000149218	ENDOD1	100	96.800	ENSRBIG00000025792	ENDOD1	100	96.800	Rhinopithecus_bieti
ENSG00000149218	ENDOD1	100	96.800	ENSRROG00000025221	ENDOD1	100	96.800	Rhinopithecus_roxellana
ENSG00000149218	ENDOD1	100	66.335	ENSSHAG00000016362	ENDOD1	100	66.335	Sarcophilus_harrisii
ENSG00000149218	ENDOD1	95	41.875	ENSSPUG00000004451	ENDOD1	97	42.062	Sphenodon_punctatus
ENSG00000149218	ENDOD1	52	30.208	ENSTNIG00000004190	si:dkey-85k7.10	97	30.208	Tetraodon_nigroviridis
ENSG00000149218	ENDOD1	90	87.054	ENSTBEG00000014696	ENDOD1	99	87.054	Tupaia_belangeri
ENSG00000149218	ENDOD1	69	73.121	ENSUAMG00000007826	-	100	73.121	Ursus_americanus
ENSG00000149218	ENDOD1	69	73.121	ENSUMAG00000007178	ENDOD1	100	73.121	Ursus_maritimus
ENSG00000149218	ENDOD1	53	30.584	ENSXETG00000030024	-	93	30.584	Xenopus_tropicalis
ENSG00000149218	ENDOD1	53	30.719	ENSXMAG00000009699	-	94	31.293	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002576	platelet degranulation	-	TAS	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004519	endonuclease activity	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr11	95128806	Missense_Mutation	NA	D244N	0.45
BLCA	chr11	95129288	Silent	rs766060664	V404V	0.06
BLCA	chr11	95129114	Missense_Mutation	novel	I346M	0.54
BLCA	chr11	95129678	3'UTR	novel		0.24
BRCA	chr11	95128997	Silent	novel	S307S	0.06
BRCA	chr11	95090111	Missense_Mutation	novel	A62T	0.14
CESC	chr11	95129131	Missense_Mutation	novel	A352V	0.45
CESC	chr11	95129228	Missense_Mutation	NA	I384M	0.36
CESC	chr11	95090122	Silent	novel	F65F	0.35
CESC	chr11	95132336	3'UTR	novel		0.36
COAD	chr11	95128917	Missense_Mutation	novel	K281Q	0.28
COAD	chr11	95129705	3'UTR	novel		0.41
COAD	chr11	95128399	Missense_Mutation	novel	L108P	0.26	Endonuclease_NS
COAD	chr11	95129461	Missense_Mutation	novel	T462I	0.07
COAD	chr11	95129518	Frame_Shift_Del	NA	*F482Lfs71**	0.3
COAD	chr11	95128957	Missense_Mutation	rs200901212	R294L	0.3
COAD	chr11	95129579	Nonstop_Mutation	NA	501Yext11	0.34
DLBC	chr11	95089857	5'UTR	novel		0.17
ESCA	chr11	95132325	3'UTR	novel		0.33
GBM	chr11	95128533	Missense_Mutation	novel	V153I	0.15	Endonuclease_NS
GBM	chr11	95128913	Frame_Shift_Ins	novel	*I282Nfs6**	0.44
GBM	chr11	95128916	Missense_Mutation	novel	K280N	0.33
GBM	chr11	95128936	Missense_Mutation	novel	N287T	0.08
GBM	chr11	95128997	Silent	novel	S307S	0.07
HNSC	chr11	95128379	Splice_Region	novel	I101I	0.18
HNSC	chr11	95128872	Missense_Mutation	novel	Q266E	0.47
HNSC	chr11	95129537	Silent	novel	R487R	0.17
KIRP	chr11	95128993	Missense_Mutation	NA	S306C	0.41
KIRP	chr11	95129596	3'UTR	novel		0.57
KIRP	chr11	95090112	Missense_Mutation	NA	A62V	0.47
LIHC	chr11	95090192	Missense_Mutation	novel	G89C	0.38	Endonuclease_NS
LIHC	chr11	95128513	Missense_Mutation	NA	P146R	0.33	Endonuclease_NS
LIHC	chr11	95090113	Silent	NA	A62A	0.28
LUAD	chr11	95129578	Silent	novel	*501*	0.26
LUAD	chr11	95129292	Missense_Mutation	novel	A406S	0.37
LUAD	chr11	95129310	Missense_Mutation	NA	L412F	0.13
LUAD	chr11	95128712	Missense_Mutation	novel	K212N	0.39	Endonuclease_NS
LUAD	chr11	95129465	Silent	novel	V463V	0.31
LUAD	chr11	95129442	Missense_Mutation	NA	A456P	0.1
LUAD	chr11	95129190	Missense_Mutation	NA	I372V	0.26
LUAD	chr11	95129291	Silent	novel	V405V	0.28
LUSC	chr11	95128758	Missense_Mutation	NA	P228S	0.22	Endonuclease_NS
LUSC	chr11	95128623	Missense_Mutation	rs771483722	D183N	0.31	Endonuclease_NS
LUSC	chr11	95128910	Silent	NA	K278K	0.28
LUSC	chr11	95128461	Missense_Mutation	novel	A129P	0.14	Endonuclease_NS
LUSC	chr11	95129496	Missense_Mutation	NA	L474V	0.14
OV	chr11	95128563	Missense_Mutation	novel	S163T	0.08	Endonuclease_NS
OV	chr11	95129055	Missense_Mutation	novel	F327V	0.07
OV	chr11	95128918	Missense_Mutation	novel	K281R	0.21
PAAD	chr11	95129042	Silent	novel	E322E	0.08
PRAD	chr11	95129549	Missense_Mutation	novel	K491N	0.18
READ	chr11	95128487	Silent	NA	S137S	0.33
READ	chr11	95129163	Missense_Mutation	NA	C363R	0.38
READ	chr11	95129747	3'UTR	novel		0.5
READ	chr11	95129753	3'UTR	novel		0.67
SARC	chr11	95131946	3'UTR	novel		0.58
SKCM	chr11	95129322	Missense_Mutation	novel	L416F	0.33
SKCM	chr11	95129312	Silent	rs752589406	L412L	0.56
SKCM	chr11	95129178	Missense_Mutation	NA	V368M	0.13
SKCM	chr11	95128758	Missense_Mutation	NA	P228S	0.29	Endonuclease_NS
SKCM	chr11	95128512	Missense_Mutation	novel	P146S	0.05	Endonuclease_NS
SKCM	chr11	95128852	Missense_Mutation	novel	P259L	0.41
SKCM	chr11	95128582	Missense_Mutation	NA	S169F	0.15	Endonuclease_NS
SKCM	chr11	95128989	Missense_Mutation	NA	L305F	0.42
SKCM	chr11	95129438	Silent	NA	D454D	0.5
STAD	chr11	95129705	3'UTR	novel		0.24
STAD	chr11	95128385	Silent	NA	D103D	0.22
STAD	chr11	95129200	Missense_Mutation	NA	C375Y	0.22
STAD	chr11	95128914	Frame_Shift_Del	NA	*I282Sfs64**	0.11
STAD	chr11	95129092	Missense_Mutation	NA	F339S	0.14
STAD	chr11	95128641	Nonsense_Mutation	novel	Q189*	0.46	Endonuclease_NS
STAD	chr11	95129414	Silent	rs371181575	G446G	0.18
UCEC	chr11	95128635	Missense_Mutation	novel	T187A	0.39	Endonuclease_NS
UCEC	chr11	95129380	Missense_Mutation	novel	V435A	0.06
UCEC	chr11	95132313	3'UTR	novel		0.34
UCEC	chr11	95128422	Missense_Mutation	NA	E116K	0.15	Endonuclease_NS
UCEC	chr11	95129414	Silent	rs371181575	G446G	0.21
UCEC	chr11	95128589	Missense_Mutation	novel	Q171H	0.09	Endonuclease_NS
UCEC	chr11	95128757	Silent	NA	V227V	0.11
UCEC	chr11	95129193	Nonsense_Mutation	novel	E373*	0.37
UCEC	chr11	95129352	Missense_Mutation	novel	V426F	0.32
UCEC	chr11	95129636	3'UTR	novel		0.38
UCEC	chr11	95132270	3'UTR	rs531681345		0.12
UCEC	chr11	95129269	Missense_Mutation	novel	P398H	0.28
UCEC	chr11	95128408	Missense_Mutation	rs764362909	A111V	0.32	Endonuclease_NS
UCEC	chr11	95129716	3'UTR	novel		0.25
UCEC	chr11	95128831	In_Frame_Ins	novel	K252_D253insLSSLV	0.15
UCEC	chr11	95132030	3'UTR	novel		0.26
UCEC	chr11	95128408	Missense_Mutation	rs764362909	A111V	0.35	Endonuclease_NS
UCEC	chr11	95128380	Missense_Mutation	rs746016010	D102N	0.31	Endonuclease_NS
UCEC	chr11	95128379	Splice_Region	novel	I101I	0.42
UCEC	chr11	95129136	Missense_Mutation	novel	L354M	0.33
UCEC	chr11	95128907	Missense_Mutation	NA	E277D	0.26
UCEC	chr11	95128675	Missense_Mutation	novel	T200I	0.06	Endonuclease_NS
UCEC	chr11	95129631	3'UTR	novel		0.08
UCEC	chr11	95129370	Missense_Mutation	novel	R432S	0.31
UCEC	chr11	95128400	Silent	NA	L108L	0.17
UCEC	chr11	95128849	In_Frame_Ins	novel	L258_P259insREN	0.07
UCEC	chr11	95129257	Missense_Mutation	novel	L394S	0.06
UCEC	chr11	95129576	Silent	novel	L500L	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1413	0.018342
LUSC	DEL	0.2236	0.00011543
TGCT	DEL	0.7333	0.21504
UCS	DEL	0.375	0.061343

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.015	Kaplan-Meier Survival Analysis
HNSC	0.038	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
ESCA	0.0069	Kaplan-Meier Survival Analysis
PAAD	0.00095	Kaplan-Meier Survival Analysis
BLCA	0.00011	Kaplan-Meier Survival Analysis
CESC	0.023	Kaplan-Meier Survival Analysis
GBM	0.04	Kaplan-Meier Survival Analysis
LIHC	0.032	Kaplan-Meier Survival Analysis
LGG	0.00024	Kaplan-Meier Survival Analysis
CHOL	0.01	Kaplan-Meier Survival Analysis
THCA	0.0049	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742