EuRBPDB

Description

Ensembl ID: ENSG00000149313 (Gene tree)
Gene ID: 60496
Gene Symbol: AASDHPPT
Alias: LYS5|CGI-80|AASD-PPT|ACPS
Full Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 23,210 bases
Position: chr11:106,075,501-106,098,710
Accession: 14235
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000524411	AASDHPPT-202	629	-	ENSP00000435099	190 (aa)	-	E9PLW6
ENST00000525660	AASDHPPT-203	1252	-	ENSP00000437144	138 (aa)	-	Q9NRN7
ENST00000533423	AASDHPPT-204	568	-	ENSP00000437175	160 (aa)	-	E9PNF3
ENST00000534152	AASDHPPT-205	5145	-	-	- (aa)	-	-
ENST00000278618	AASDHPPT-201	2955	-	ENSP00000278618	309 (aa)	-	Q9NRN7

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00770	Pantothenate and CoA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000149313	Echocardiography	9.77593653263457E-6	17903301
ENSG00000149313	Echocardiography	8.76534737674283E-6	17903301
ENSG00000149313	Echocardiography	4.01493500494006E-6	17903301
ENSG00000149313	Echocardiography	6.46688647740653E-6	17903301
ENSG00000149313	Echocardiography	3.86208197500146E-6	17903301
ENSG00000149313	Echocardiography	3.58123560308668E-6	17903301
ENSG00000149313	Echocardiography	1.71437505251101E-6	17903301
ENSG00000149313	Echocardiography	2.23824400564543E-6	17903301
ENSG00000149313	Iron	7.3130000E-004	19880490
ENSG00000149313	Heart Failure	3.2883294E-004	-
ENSG00000149313	Stroke	6.5671064E-004	19369658
ENSG00000149313	Stroke	3.8252212E-004	19369658
ENSG00000149313	Body Mass Index	9.1631454E-005	-
ENSG00000149313	Body Mass Index	8.1632668E-006	-
ENSG00000149313	Body Mass Index	8.2320202E-006	-
ENSG00000149313	Body Mass Index	8.2039824E-006	-
ENSG00000149313	Body Mass Index	5.1283971E-006	-
ENSG00000149313	Body Mass Index	5.4714302E-006	-
ENSG00000149313	Leukoaraiosis	3.2670925E-005	-
ENSG00000149313	Interleukin 1 Receptor Antagonist Protein	6.6230000E-005	-
ENSG00000149313	Colorectal Neoplasms	1E-6	26621817
ENSG00000149313	Endometrial Neoplasms	1E-6	26621817
ENSG00000149313	Anxiety Disorders	7E-6	25390645
ENSG00000149313	Behavior	3E-6	18821565
ENSG00000149313	Hip	6E-6	23251661
ENSG00000149313	Subcutaneous Fat, Abdominal	8E-6	22589738
ENSG00000149313	Schizophrenia	8E-6	26198764

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	18022563.	IDA	Function
GO:0005515	protein binding	16189514.18022563.19615732.25416956.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0008897	holo-[acyl-carrier-protein] synthase activity	21873635.	IBA	Function
GO:0008897	holo-[acyl-carrier-protein] synthase activity	18022563.	IDA	Function
GO:0008897	holo-[acyl-carrier-protein] synthase activity	-	TAS	Function
GO:0015939	pantothenate metabolic process	-	TAS	Process
GO:0019878	lysine biosynthetic process via aminoadipic acid	21873635.	IBA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component