EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000149480 (Gene tree)
Gene ID: 9219
Gene Symbol: MTA2
Alias: MTA1-L1|MTA1L1
Full Name: metastasis associated 1 family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 8,638 bases
Position: chr11:62,593,203-62,601,840
Accession: 7411
RBP type: non-canonical RBP
Summary: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000524902	MTA2-202	2577	-	ENSP00000431346	495 (aa)	-	O94776
ENST00000527204	MTA2-204	2265	-	ENSP00000431797	495 (aa)	-	O94776
ENST00000526844	MTA2-203	627	-	-	- (aa)	-	-
ENST00000531261	MTA2-206	563	-	-	- (aa)	-	-
ENST00000278823	MTA2-201	3058	-	ENSP00000278823	668 (aa)	-	O94776
ENST00000531179	MTA2-205	625	-	-	- (aa)	-	-
ENST00000532239	MTA2-207	532	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000149480's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149480's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149480	MTA2	100	59.275	ENSMUSG00000021144	Mta1	100	59.610	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000118	histone deacetylase complex	10444591.	TAS	Component
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000790	nuclear chromatin	16217013.	HDA	Component
GO:0000976	transcription regulatory region sequence-specific DNA binding	16217013.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001085	RNA polymerase II transcription factor binding	15920471.	IPI	Function
GO:0001103	RNA polymerase II repressing transcription factor binding	21873635.	IBA	Function
GO:0001103	RNA polymerase II repressing transcription factor binding	22926524.	IPI	Function
GO:0003713	transcription coactivator activity	21873635.	IBA	Function
GO:0003714	transcription corepressor activity	21873635.	IBA	Function
GO:0004407	histone deacetylase activity	-	IEA	Function
GO:0005515	protein binding	17956988.18451879.19703393.20127688.21258344.23752268.25150861.26028330.26496610.27705803.28179136.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	15920471.	IDA	Component
GO:0006306	DNA methylation	-	IEA	Process
GO:0006333	chromatin assembly or disassembly	10444591.	TAS	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0010762	regulation of fibroblast migration	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016575	histone deacetylation	21873635.	IBA	Process
GO:0016581	NuRD complex	21873635.	IBA	Component
GO:0016581	NuRD complex	19644445.22926524.	IDA	Component
GO:0031492	nucleosomal DNA binding	16217013.	HDA	Function
GO:0032991	protein-containing complex	16217013.	HDA	Component
GO:0042826	histone deacetylase binding	21873635.	IBA	Function
GO:0043044	ATP-dependent chromatin remodeling	16217013.	HDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25929737	MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.	BMC Cancer	2015 May 2	Zhou C	doi: 10.1186/s12885-015-1366-y.
23158992	[Expression of metastasis associated 1 family member 2 (MTA2) in gastric cancer and its relationship with transcription factor Sp1].	Zhonghua Zhong Liu Za Zhi	2012 Aug	Zhou CF	doi: 10.3760/cma.j.issn.0253-3766.2012.08.007.
24468085	P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth.	Biochem Biophys Res Commun	2014 Feb 14	Zhou J	doi: 10.1016/j.bbrc.2014.01.062
28061540	Metallothionein 2A an interactive protein linking phosphorylated FADD to NF-??B pathway leads to colorectal cancer formation.	Chin Clin Oncol	2016 Dec	Marikar FM	doi: 10.21037/cco.2016.11.03.
25081667	Short-hairpin RNA-mediated MTA2 silencing inhibits human breast cancer cell line MDA-MB231 proliferation and metastasis.	Asian Pac J Cancer Prev	2014	Lu J	-
24969834	Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression.	Int J Oncol	2014 Sep	Uraki S	doi: 10.3892/ijo.2014.2507
24010737	MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1.	Mol Cancer	2013 Sep 8	Zhou C	doi: 10.1186/1476-4598-12-102.
25969565	Metastasis-associated protein 2 (MTA2) promotes the metastasis of non-small-cell lung cancer through the inhibition of the cell adhesion molecule Ep-CAM and E-cadherin.	Jpn J Clin Oncol	2015 Aug	Zhang B	doi: 10.1093/jjco/hyv062

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	62596729	Missense_Mutation	NA	E264K	0.32
BLCA	chr11	62597390	Missense_Mutation	novel	L207V	0.19
BLCA	chr11	62596799	Missense_Mutation	novel	R240S	0.08
BLCA	chr11	62598076	Missense_Mutation	novel	E146D	0.14
BLCA	chr11	62596313	Missense_Mutation	NA	D328H	0.48
BLCA	chr11	62594601	Missense_Mutation	rs768452845	R536Q	0.3
BLCA	chr11	62595763	Missense_Mutation	novel	R415W	0.13
BLCA	chr11	62593931	Missense_Mutation	novel	L651V	0.98
BLCA	chr11	62595020	Missense_Mutation	novel	L512V	0.05
BRCA	chr11	62598129	Frame_Shift_Del	NA	*Y129Tfs33**	0.46
BRCA	chr11	62600226	Frame_Shift_Del	NA	*C44Sfs9**	0.26
BRCA	chr11	62598592	Missense_Mutation	rs377599047	R80C	0.06
BRCA	chr11	62596056	Missense_Mutation	NA	M356I	0.35
BRCA	chr11	62598076	Silent	NA	E146E	0.11
CESC	chr11	62600675	Missense_Mutation	novel	E15K	0.08
CESC	chr11	62593782	3'UTR	novel		0.3
CESC	chr11	62596058	Missense_Mutation	novel	M356V	0.3
CESC	chr11	62593789	3'UTR	novel		0.67
CESC	chr11	62595809	Missense_Mutation	NA	K399N	0.43
COAD	chr11	62594402	Frame_Shift_Del	NA	*A568Qfs29**	0.23
COAD	chr11	62596316	Missense_Mutation	novel	A327T	0.12
COAD	chr11	62595270	Missense_Mutation	novel	A493T	0.35
COAD	chr11	62594987	Missense_Mutation	novel	D523Y	0.35
COAD	chr11	62600234	Missense_Mutation	novel	K41T	0.31
COAD	chr11	62598129	Frame_Shift_Del	NA	*Y129Tfs33**	0.37
COAD	chr11	62598374	Missense_Mutation	NA	T109A	0.41
COAD	chr11	62598523	Missense_Mutation	NA	R103W	0.29
COAD	chr11	62594406	Missense_Mutation	novel	M565T	0.31
COAD	chr11	62596108	Splice_Site	NA	X339_splice	0.23
COAD	chr11	62594036	Missense_Mutation	novel	L616I	0.36
COAD	chr11	62594631	Missense_Mutation	novel	A526V	0.17
COAD	chr11	62594543	Frame_Shift_Ins	NA	*I556Hfs8**	0.29
COAD	chr11	62600217	Missense_Mutation	NA	R47W	0.24
COAD	chr11	62598035	Missense_Mutation	rs370573471	R160H	0.39
COAD	chr11	62594032	Missense_Mutation	NA	R617Q	0.29
COAD	chr11	62598523	Missense_Mutation	NA	R103W	0.23
DLBC	chr11	62600626	Missense_Mutation	NA	N31S	0.18
ESCA	chr11	62595299	Missense_Mutation	novel	Y483C	0.29
ESCA	chr11	62593440	3'UTR	novel		0.29
ESCA	chr11	62595771	Missense_Mutation	novel	G412E	0.29
GBM	chr11	62595449	Missense_Mutation	novel	S433T	0.23
GBM	chr11	62595425	Missense_Mutation	novel	A441V	0.23
GBM	chr11	62598068	Missense_Mutation	novel	V149G	0.05
GBM	chr11	62596734	Missense_Mutation	NA	R262Q	0.43
GBM	chr11	62594328	Missense_Mutation	novel	A591V	0.3
GBM	chr11	62598108	Missense_Mutation	rs202171761	V136M	0.46
GBM	chr11	62594583	Missense_Mutation	novel	I542S	0.26
GBM	chr11	62600639	Missense_Mutation	novel	I27V	0.12
HNSC	chr11	62598128	Frame_Shift_Ins	novel	*Y129Lfs6**	0.14
HNSC	chr11	62598054	Missense_Mutation	novel	Q154E	0.35
HNSC	chr11	62594382	Missense_Mutation	novel	S573C	0.21
HNSC	chr11	62594565	Missense_Mutation	novel	S548F	0.19
HNSC	chr11	62596284	Frame_Shift_Del	novel	*T338Pfs19**	0.42
HNSC	chr11	62596729	Nonsense_Mutation	novel	E264*	0.33
HNSC	chr11	62595398	Missense_Mutation	novel	N450S	0.49
HNSC	chr11	62596083	Silent	NA	I347I	0.27
KIRC	chr11	62595439	Silent	novel	P436P	0.16
KIRC	chr11	62598608	Silent	NA	G74G	0.26
LAML	chr11	62593756	3'UTR	novel		0.1
LAML	chr11	62598534	Missense_Mutation	novel	A99G	0.05
LAML	chr11	62597714	Splice_Site	novel	X164_splice	0.09
LAML	chr11	62593756	3'UTR	novel		0.29
LAML	chr11	62596671	Missense_Mutation	rs760158792	Y283C	0.44
LAML	chr11	62593756	3'UTR	novel		0.25
LGG	chr11	62595441	Frame_Shift_Del	novel	*S435Lfs26**	0.2
LGG	chr11	62594008	Missense_Mutation	NA	M625R	0.07
LGG	chr11	62594289	Missense_Mutation	novel	P604H	0.3
LGG	chr11	62598039	Missense_Mutation	novel	D159Y	0.04
LGG	chr11	62596526	Missense_Mutation	NA	W297R	0.26
LIHC	chr11	62600213	Missense_Mutation	novel	R48H	0.37
LIHC	chr11	62597366	Nonsense_Mutation	novel	Q215*	0.13
LIHC	chr11	62597367	Silent	novel	R214R	0.14
LIHC	chr11	62593739	3'UTR	novel		0.28
LUAD	chr11	62600636	Missense_Mutation	NA	E28Q	0.08
LUAD	chr11	62595848	Missense_Mutation	novel	M386I	0.13
LUAD	chr11	62594632	Missense_Mutation	novel	A526S	0.17
LUAD	chr11	62596644	Missense_Mutation	novel	Q292L	0.31
LUAD	chr11	62596815	Frame_Shift_Ins	novel	*M235Tfs48**	0.13
LUAD	chr11	62595365	Missense_Mutation	NA	L461P	0.1
LUSC	chr11	62595753	Missense_Mutation	novel	T418M	0.29
LUSC	chr11	62594354	Silent	NA	G582G	0.1
OV	chr11	62598360	Missense_Mutation	NA	E113D	0.39
OV	chr11	62598360	Missense_Mutation	novel	E113D	0.22
OV	chr11	62595839	Silent	novel	R389R	0.15
OV	chr11	62596826	Splice_Site	NA	X232_splice	0.24
OV	chr11	62593939	Missense_Mutation	novel	P648L	0.06
OV	chr11	62593756	3'UTR	novel		0.1
OV	chr11	62595855	Missense_Mutation	NA	P384R	0.23
PRAD	chr11	62593993	Missense_Mutation	NA	R630P	0.4
READ	chr11	62595479	Missense_Mutation	novel	R423K	0.15
READ	chr11	62594273	Silent	novel	A609A	0.26
READ	chr11	62595431	Missense_Mutation	novel	T439S	0.17
SKCM	chr11	62593976	Silent	rs748199521	L636L	0.05
SKCM	chr11	62595066	Silent	NA	S496S	0.22
SKCM	chr11	62600223	Missense_Mutation	rs762827302	L45F	0.43
SKCM	chr11	62594605	Missense_Mutation	NA	P535S	0.49
SKCM	chr11	62598057	Missense_Mutation	NA	Y153H	0.17
SKCM	chr11	62594525	Silent	NA	A561A	0.53
SKCM	chr11	62596083	Silent	NA	I347I	0.38
SKCM	chr11	62594382	Missense_Mutation	NA	S573F	0.47
SKCM	chr11	62600625	Silent	NA	N31N	0.52
SKCM	chr11	62595023	Missense_Mutation	NA	P511S	0.36
STAD	chr11	62597633	Silent	rs141754862	I190I	0.08
STAD	chr11	62593877	Nonstop_Mutation	NA	669Rext85	0.17
STAD	chr11	62594994	Silent	NA	I520I	0.29
STAD	chr11	62595427	Silent	rs780111889	S440S	0.37
STAD	chr11	62596754	Missense_Mutation	NA	Q255H	0.11
STAD	chr11	62594399	Silent	NA	G567G	0.15
STAD	chr11	62598129	Frame_Shift_Del	NA	*Y129Tfs33**	0.28
TGCT	chr11	62600241	Missense_Mutation	novel	E39Q	0.29
THYM	chr11	62596648	Missense_Mutation	novel	R291S	0.08
UCEC	chr11	62596505	Missense_Mutation	NA	V304F	0.26
UCEC	chr11	62593990	Missense_Mutation	rs777136719	R631Q	0.59
UCEC	chr11	62594544	Frame_Shift_Del	NA	*G555Afs4**	0.45
UCEC	chr11	62593888	Missense_Mutation	NA	V665D	0.31
UCEC	chr11	62595426	Missense_Mutation	rs769924403	A441T	0.47
UCEC	chr11	62595843	Missense_Mutation	novel	C388Y	0.28
UCEC	chr11	62598129	Frame_Shift_Del	NA	*Y129Tfs33**	0.41
UCEC	chr11	62594318	Silent	NA	Q594Q	0.39
UCEC	chr11	62593563	3'UTR	rs368340681		0.39
UCEC	chr11	62596029	Silent	novel	L365L	0.3
UCEC	chr11	62595753	Missense_Mutation	novel	T418M	0.31
UCEC	chr11	62596715	Nonsense_Mutation	novel	W268*	0.51
UCEC	chr11	62598574	Silent	NA	R86R	0.37
UCEC	chr11	62593606	3'UTR	novel		0.21
UCEC	chr11	62595062	Nonsense_Mutation	novel	R498*	0.15
UCEC	chr11	62597706	Missense_Mutation	novel	S166Y	0.5
UCEC	chr11	62595752	Splice_Region	rs150945923	T418T	0.39
UCEC	chr11	62593570	3'UTR	novel		0.37
UCEC	chr11	62596490	Missense_Mutation	novel	M309L	0.3
UCEC	chr11	62597357	Missense_Mutation	novel	L218M	0.22
UCEC	chr11	62595062	Nonsense_Mutation	novel	R498*	0.12
UCEC	chr11	62595309	Nonsense_Mutation	NA	R480*	0.23
UCEC	chr11	62593829	3'UTR	novel		0.39
UCEC	chr11	62595305	Missense_Mutation	rs746902489	R481Q	0.24
UCEC	chr11	62595284	Missense_Mutation	NA	A488V	0.24
UCEC	chr11	62593589	3'UTR	novel		0.45
UCS	chr11	62596648	Missense_Mutation	rs759893426	R291C	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1685	0.018342
TGCT	DEL	0.7067	0.21504

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0069	Kaplan-Meier Survival Analysis
STAD	0.0037	Kaplan-Meier Survival Analysis
SARC	0.016	Kaplan-Meier Survival Analysis
MESO	0.0082	Kaplan-Meier Survival Analysis
ACC	0.00053	Kaplan-Meier Survival Analysis
BRCA	0.006	Kaplan-Meier Survival Analysis
ESCA	0.027	Kaplan-Meier Survival Analysis
KIRP	0.039	Kaplan-Meier Survival Analysis
PCPG	0.04	Kaplan-Meier Survival Analysis
CESC	0.016	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
LIHC	0.00071	Kaplan-Meier Survival Analysis
OV	0.012	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742