EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000149658 (Gene tree)
Gene ID: 54915
Gene Symbol: YTHDF1
Alias: FLJ20391|C20orf21
Full Name: YTH N6-methyladenosine RNA binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 20,806 bases
Position: chr20:63,195,429-63,216,234
Accession: 15867
RBP type: canonical RBP
Summary: (YTH N6-Methyladenosine RNA Binding Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include N6-methyladenosine-containing RNA binding. An important paralog of this gene is YTHDF3.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000359364	YTH	PF04146.15	6e-41	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31131257	YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma.	Front Oncol	2019 May 3	Bai Y	doi: 10.3389/fonc.2019.00332
30894375	The Critical Role of RNA m6A Methylation in Cancer.	Cancer Res	2019 Apr 1	Lan Q	doi: 10.1158/0008-5472.CAN-18-2965
26318451	Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.	J Biol Chem	2015 Oct 9	Xu C	doi: 10.1074/jbc.M115.680389

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370334	YTHDF1-201	747	-	ENSP00000359359	52 (aa)	-	Q5JXC6
ENST00000370339	YTHDF1-202	3301	-	ENSP00000359364	559 (aa)	-	Q9BYJ9

Gene Model

Click here to download ENSG00000149658's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000149658	Cytarabine	2E-6	24483146

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149658's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000149658	YTHDF1	99	64.116	ENSG00000198492	YTHDF2	100	65.356
ENSG00000149658	YTHDF1	100	74.074	ENSG00000185728	YTHDF3	100	74.074

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149658	YTHDF1	96	73.345	ENSAPOG00000004358	ythdf1	97	74.028	Acanthochromis_polyacanthus
ENSG00000149658	YTHDF1	100	74.786	ENSAPOG00000010796	YTHDF1	100	75.129	Acanthochromis_polyacanthus
ENSG00000149658	YTHDF1	99	93.297	ENSAMEG00000017323	YTHDF1	98	93.297	Ailuropoda_melanoleuca
ENSG00000149658	YTHDF1	100	74.523	ENSACIG00000020083	YTHDF1	100	73.711	Amphilophus_citrinellus
ENSG00000149658	YTHDF1	96	70.179	ENSACIG00000011264	ythdf1	97	70.403	Amphilophus_citrinellus
ENSG00000149658	YTHDF1	100	74.306	ENSAOCG00000012567	YTHDF1	100	73.958	Amphiprion_ocellaris
ENSG00000149658	YTHDF1	99	71.074	ENSAOCG00000022251	ythdf1	98	73.628	Amphiprion_ocellaris
ENSG00000149658	YTHDF1	100	74.479	ENSAPEG00000008750	YTHDF1	100	74.132	Amphiprion_percula
ENSG00000149658	YTHDF1	96	70.847	ENSAPEG00000021878	ythdf1	95	71.886	Amphiprion_percula
ENSG00000149658	YTHDF1	96	72.613	ENSATEG00000023840	ythdf1	98	72.920	Anabas_testudineus
ENSG00000149658	YTHDF1	100	73.391	ENSATEG00000005996	YTHDF1	100	73.529	Anabas_testudineus
ENSG00000149658	YTHDF1	99	88.151	ENSAPLG00000005985	YTHDF1	99	89.408	Anas_platyrhynchos
ENSG00000149658	YTHDF1	100	85.357	ENSACAG00000005560	YTHDF1	100	86.809	Anolis_carolinensis
ENSG00000149658	YTHDF1	100	82.826	ENSANAG00000021022	-	100	82.826	Aotus_nancymaae
ENSG00000149658	YTHDF1	100	96.959	ENSANAG00000034786	-	100	97.053	Aotus_nancymaae
ENSG00000149658	YTHDF1	100	74.132	ENSACLG00000025518	YTHDF1	100	73.785	Astatotilapia_calliptera
ENSG00000149658	YTHDF1	100	88.730	ENSBTAG00000010383	YTHDF1	100	88.730	Bos_taurus
ENSG00000149658	YTHDF1	100	97.317	ENSCJAG00000010056	YTHDF1	100	97.317	Callithrix_jacchus
ENSG00000149658	YTHDF1	91	92.717	ENSCAFG00000012772	YTHDF1	99	92.717	Canis_familiaris
ENSG00000149658	YTHDF1	91	92.717	ENSCAFG00020001214	YTHDF1	99	92.717	Canis_lupus_dingo
ENSG00000149658	YTHDF1	100	88.014	ENSCHIG00000026494	YTHDF1	100	88.014	Capra_hircus
ENSG00000149658	YTHDF1	99	93.178	ENSTSYG00000033436	YTHDF1	99	93.178	Carlito_syrichta
ENSG00000149658	YTHDF1	97	91.697	ENSCAPG00000002544	YTHDF1	94	91.360	Cavia_aperea
ENSG00000149658	YTHDF1	100	93.023	ENSCPOG00000010202	YTHDF1	100	93.023	Cavia_porcellus
ENSG00000149658	YTHDF1	100	97.138	ENSCCAG00000024650	YTHDF1	100	97.138	Cebus_capucinus
ENSG00000149658	YTHDF1	100	98.211	ENSCATG00000033272	YTHDF1	100	98.211	Cercocebus_atys
ENSG00000149658	YTHDF1	100	94.286	ENSCLAG00000005989	YTHDF1	100	94.286	Chinchilla_lanigera
ENSG00000149658	YTHDF1	100	98.390	ENSCSAG00000016266	YTHDF1	100	98.390	Chlorocebus_sabaeus
ENSG00000149658	YTHDF1	100	89.643	ENSCPBG00000027183	YTHDF1	100	89.643	Chrysemys_picta_bellii
ENSG00000149658	YTHDF1	99	98.548	ENSCANG00000029082	YTHDF1	98	98.548	Colobus_angolensis_palliatus
ENSG00000149658	YTHDF1	100	93.918	ENSCGRG00001016568	Ythdf1	100	93.918	Cricetulus_griseus_chok1gshd
ENSG00000149658	YTHDF1	98	94.000	ENSCGRG00000009207	Ythdf1	100	94.000	Cricetulus_griseus_crigri
ENSG00000149658	YTHDF1	96	72.445	ENSCSEG00000020623	YTHDF1	98	73.370	Cynoglossus_semilaevis
ENSG00000149658	YTHDF1	99	70.848	ENSCVAG00000017940	ythdf1	97	71.786	Cyprinodon_variegatus
ENSG00000149658	YTHDF1	97	73.036	ENSCVAG00000014378	YTHDF1	99	75.000	Cyprinodon_variegatus
ENSG00000149658	YTHDF1	100	70.195	ENSDARG00000016447	ythdf1	95	73.070	Danio_rerio
ENSG00000149658	YTHDF1	100	89.624	ENSDNOG00000043590	YTHDF1	100	89.624	Dasypus_novemcinctus
ENSG00000149658	YTHDF1	98	87.175	ENSDORG00000002879	Ythdf1	100	87.175	Dipodomys_ordii
ENSG00000149658	YTHDF1	67	85.714	ENSETEG00000017860	-	98	63.462	Echinops_telfairi
ENSG00000149658	YTHDF1	100	93.739	ENSEASG00005023186	YTHDF1	100	93.739	Equus_asinus_asinus
ENSG00000149658	YTHDF1	98	94.000	ENSECAG00000019475	YTHDF1	100	94.106	Equus_caballus
ENSG00000149658	YTHDF1	92	90.485	ENSEEUG00000007461	YTHDF1	100	90.485	Erinaceus_europaeus
ENSG00000149658	YTHDF1	99	71.477	ENSELUG00000022768	ythdf1	99	73.345	Esox_lucius
ENSG00000149658	YTHDF1	94	74.081	ENSELUG00000001906	YTHDF1	99	74.081	Esox_lucius
ENSG00000149658	YTHDF1	100	92.129	ENSFCAG00000008917	YTHDF1	100	92.129	Felis_catus
ENSG00000149658	YTHDF1	100	89.286	ENSFALG00000010463	YTHDF1	100	89.286	Ficedula_albicollis
ENSG00000149658	YTHDF1	100	93.739	ENSFDAG00000019602	YTHDF1	100	93.739	Fukomys_damarensis
ENSG00000149658	YTHDF1	97	75.134	ENSFHEG00000002540	YTHDF1	99	74.336	Fundulus_heteroclitus
ENSG00000149658	YTHDF1	99	71.605	ENSFHEG00000023218	ythdf1	98	71.942	Fundulus_heteroclitus
ENSG00000149658	YTHDF1	86	89.231	ENSGMOG00000019610	ythdf1	95	69.744	Gadus_morhua
ENSG00000149658	YTHDF1	100	88.414	ENSGALG00000005745	YTHDF1	100	89.661	Gallus_gallus
ENSG00000149658	YTHDF1	100	71.711	ENSGAFG00000021100	YTHDF1	99	74.597	Gambusia_affinis
ENSG00000149658	YTHDF1	100	73.649	ENSGACG00000002613	YTHDF1	100	73.142	Gasterosteus_aculeatus
ENSG00000149658	YTHDF1	96	72.456	ENSGACG00000012014	ythdf1	95	72.049	Gasterosteus_aculeatus
ENSG00000149658	YTHDF1	100	89.464	ENSGAGG00000003007	YTHDF1	100	89.464	Gopherus_agassizii
ENSG00000149658	YTHDF1	100	99.642	ENSGGOG00000008340	YTHDF1	100	99.642	Gorilla_gorilla
ENSG00000149658	YTHDF1	96	71.429	ENSHBUG00000011284	ythdf1	98	71.853	Haplochromis_burtoni
ENSG00000149658	YTHDF1	100	73.958	ENSHBUG00000004875	YTHDF1	100	73.611	Haplochromis_burtoni
ENSG00000149658	YTHDF1	100	94.275	ENSHGLG00000006585	YTHDF1	100	94.275	Heterocephalus_glaber_female
ENSG00000149658	YTHDF1	100	94.275	ENSHGLG00100004683	YTHDF1	100	94.275	Heterocephalus_glaber_male
ENSG00000149658	YTHDF1	99	70.785	ENSHCOG00000008866	ythdf1	98	71.404	Hippocampus_comes
ENSG00000149658	YTHDF1	100	70.323	ENSHCOG00000011303	YTHDF1	100	74.449	Hippocampus_comes
ENSG00000149658	YTHDF1	97	76.000	ENSIPUG00000000425	Ythdf1	98	75.492	Ictalurus_punctatus
ENSG00000149658	YTHDF1	99	94.192	ENSSTOG00000023001	YTHDF1	99	94.192	Ictidomys_tridecemlineatus
ENSG00000149658	YTHDF1	98	94.727	ENSJJAG00000013589	Ythdf1	100	94.727	Jaculus_jaculus
ENSG00000149658	YTHDF1	96	72.072	ENSKMAG00000005595	ythdf1	98	71.504	Kryptolebias_marmoratus
ENSG00000149658	YTHDF1	97	74.061	ENSKMAG00000017472	YTHDF1	99	74.600	Kryptolebias_marmoratus
ENSG00000149658	YTHDF1	100	74.227	ENSLBEG00000012068	YTHDF1	100	72.287	Labrus_bergylta
ENSG00000149658	YTHDF1	96	72.302	ENSLBEG00000014105	ythdf1	94	73.132	Labrus_bergylta
ENSG00000149658	YTHDF1	96	82.537	ENSLACG00000014195	YTHDF1	96	84.831	Latimeria_chalumnae
ENSG00000149658	YTHDF1	100	76.207	ENSLOCG00000005020	ythdf1	95	78.545	Lepisosteus_oculatus
ENSG00000149658	YTHDF1	100	91.771	ENSLAFG00000008884	YTHDF1	100	91.771	Loxodonta_africana
ENSG00000149658	YTHDF1	100	98.390	ENSMFAG00000042868	YTHDF1	100	98.390	Macaca_fascicularis
ENSG00000149658	YTHDF1	100	98.390	ENSMMUG00000009227	YTHDF1	100	98.390	Macaca_mulatta
ENSG00000149658	YTHDF1	100	98.390	ENSMNEG00000030851	YTHDF1	100	98.390	Macaca_nemestrina
ENSG00000149658	YTHDF1	98	98.364	ENSMLEG00000009252	YTHDF1	100	98.364	Mandrillus_leucophaeus
ENSG00000149658	YTHDF1	96	72.222	ENSMAMG00000024255	ythdf1	99	71.924	Mastacembelus_armatus
ENSG00000149658	YTHDF1	100	74.479	ENSMAMG00000011072	YTHDF1	100	73.711	Mastacembelus_armatus
ENSG00000149658	YTHDF1	100	73.958	ENSMZEG00005023596	YTHDF1	100	73.611	Maylandia_zebra
ENSG00000149658	YTHDF1	96	72.581	ENSMZEG00005026397	ythdf1	98	73.002	Maylandia_zebra
ENSG00000149658	YTHDF1	99	87.657	ENSMGAG00000006139	YTHDF1	99	88.909	Meleagris_gallopavo
ENSG00000149658	YTHDF1	100	93.918	ENSMAUG00000017660	Ythdf1	100	93.918	Mesocricetus_auratus
ENSG00000149658	YTHDF1	100	94.812	ENSMICG00000032266	YTHDF1	100	94.812	Microcebus_murinus
ENSG00000149658	YTHDF1	100	93.739	ENSMOCG00000013573	Ythdf1	100	93.739	Microtus_ochrogaster
ENSG00000149658	YTHDF1	96	68.439	ENSMMOG00000017500	ythdf1	96	69.374	Mola_mola
ENSG00000149658	YTHDF1	99	71.549	ENSMMOG00000020467	YTHDF1	94	71.502	Mola_mola
ENSG00000149658	YTHDF1	91	88.258	ENSMODG00000016842	YTHDF1	100	89.432	Monodelphis_domestica
ENSG00000149658	YTHDF1	100	73.494	ENSMALG00000022209	YTHDF1	100	73.424	Monopterus_albus
ENSG00000149658	YTHDF1	96	71.071	ENSMALG00000015672	ythdf1	96	71.631	Monopterus_albus
ENSG00000149658	YTHDF1	100	93.918	MGP_CAROLIEiJ_G0024790	Ythdf1	100	93.918	Mus_caroli
ENSG00000149658	YTHDF1	100	93.918	ENSMUSG00000038848	Ythdf1	100	93.918	Mus_musculus
ENSG00000149658	YTHDF1	100	93.560	MGP_PahariEiJ_G0026237	Ythdf1	100	93.560	Mus_pahari
ENSG00000149658	YTHDF1	100	93.918	MGP_SPRETEiJ_G0025715	Ythdf1	100	93.918	Mus_spretus
ENSG00000149658	YTHDF1	91	87.230	ENSMPUG00000008111	YTHDF1	100	87.623	Mustela_putorius_furo
ENSG00000149658	YTHDF1	97	90.775	ENSMLUG00000002241	YTHDF1	96	90.775	Myotis_lucifugus
ENSG00000149658	YTHDF1	100	94.097	ENSNGAG00000000334	Ythdf1	100	94.097	Nannospalax_galili
ENSG00000149658	YTHDF1	99	69.828	ENSNBRG00000008213	ythdf1	97	70.769	Neolamprologus_brichardi
ENSG00000149658	YTHDF1	100	73.958	ENSNBRG00000015321	YTHDF1	100	73.611	Neolamprologus_brichardi
ENSG00000149658	YTHDF1	95	80.226	ENSOPRG00000001758	-	98	79.658	Ochotona_princeps
ENSG00000149658	YTHDF1	100	92.679	ENSODEG00000004380	-	100	92.679	Octodon_degus
ENSG00000149658	YTHDF1	83	90.698	ENSODEG00000000074	-	100	76.773	Octodon_degus
ENSG00000149658	YTHDF1	96	70.069	ENSONIG00000016799	ythdf1	97	71.379	Oreochromis_niloticus
ENSG00000149658	YTHDF1	100	88.414	ENSOANG00000003723	YTHDF1	100	89.305	Ornithorhynchus_anatinus
ENSG00000149658	YTHDF1	100	81.673	ENSOCUG00000012780	YTHDF1	100	80.427	Oryctolagus_cuniculus
ENSG00000149658	YTHDF1	97	73.477	ENSORLG00000009739	YTHDF1	99	73.016	Oryzias_latipes
ENSG00000149658	YTHDF1	96	69.775	ENSORLG00000014665	YTHDF1	95	70.085	Oryzias_latipes
ENSG00000149658	YTHDF1	96	70.242	ENSORLG00020000307	ythdf1	95	70.548	Oryzias_latipes_hni
ENSG00000149658	YTHDF1	97	74.592	ENSORLG00020001332	YTHDF1	99	74.107	Oryzias_latipes_hni
ENSG00000149658	YTHDF1	96	70.069	ENSORLG00015006302	ythdf1	95	70.377	Oryzias_latipes_hsok
ENSG00000149658	YTHDF1	100	70.813	ENSORLG00015018321	YTHDF1	99	72.840	Oryzias_latipes_hsok
ENSG00000149658	YTHDF1	96	72.613	ENSOMEG00000002941	YTHDF1	98	72.906	Oryzias_melastigma
ENSG00000149658	YTHDF1	100	69.440	ENSOMEG00000011843	YTHDF1	95	71.307	Oryzias_melastigma
ENSG00000149658	YTHDF1	100	92.844	ENSOGAG00000000480	YTHDF1	100	92.844	Otolemur_garnettii
ENSG00000149658	YTHDF1	99	83.485	ENSOARG00000011639	YTHDF1	98	84.936	Ovis_aries
ENSG00000149658	YTHDF1	99	99.637	ENSPPAG00000023277	YTHDF1	100	99.637	Pan_paniscus
ENSG00000149658	YTHDF1	100	92.308	ENSPPRG00000020805	YTHDF1	100	92.308	Panthera_pardus
ENSG00000149658	YTHDF1	99	75.360	ENSPTIG00000017355	YTHDF1	100	82.428	Panthera_tigris_altaica
ENSG00000149658	YTHDF1	100	99.642	ENSPTRG00000013730	YTHDF1	100	99.642	Pan_troglodytes
ENSG00000149658	YTHDF1	100	98.390	ENSPANG00000021472	YTHDF1	100	98.390	Papio_anubis
ENSG00000149658	YTHDF1	100	69.123	ENSPKIG00000005427	ythdf1	100	71.154	Paramormyrops_kingsleyae
ENSG00000149658	YTHDF1	99	71.530	ENSPKIG00000005026	YTHDF1	97	71.429	Paramormyrops_kingsleyae
ENSG00000149658	YTHDF1	99	87.184	ENSPSIG00000005529	YTHDF1	97	88.257	Pelodiscus_sinensis
ENSG00000149658	YTHDF1	97	72.867	ENSPMGG00000009101	YTHDF1	99	73.196	Periophthalmus_magnuspinnatus
ENSG00000149658	YTHDF1	93	71.480	ENSPMGG00000015328	ythdf1	96	72.662	Periophthalmus_magnuspinnatus
ENSG00000149658	YTHDF1	98	94.000	ENSPEMG00000020199	Ythdf1	100	94.000	Peromyscus_maniculatus_bairdii
ENSG00000149658	YTHDF1	99	88.448	ENSPCIG00000017170	YTHDF1	100	89.432	Phascolarctos_cinereus
ENSG00000149658	YTHDF1	99	70.320	ENSPFOG00000005405	ythdf1	95	70.984	Poecilia_formosa
ENSG00000149658	YTHDF1	99	72.759	ENSPLAG00000006653	ythdf1	98	72.760	Poecilia_latipinna
ENSG00000149658	YTHDF1	100	70.096	ENSPLAG00000006298	YTHDF1	95	71.235	Poecilia_latipinna
ENSG00000149658	YTHDF1	99	72.281	ENSPMEG00000023753	ythdf1	98	72.242	Poecilia_mexicana
ENSG00000149658	YTHDF1	100	72.000	ENSPMEG00000020969	-	100	72.569	Poecilia_mexicana
ENSG00000149658	YTHDF1	97	70.149	ENSPREG00000017662	YTHDF1	93	71.553	Poecilia_reticulata
ENSG00000149658	YTHDF1	99	71.880	ENSPREG00000002173	ythdf1	98	72.549	Poecilia_reticulata
ENSG00000149658	YTHDF1	86	98.507	ENSPPYG00000011226	YTHDF1	100	98.507	Pongo_abelii
ENSG00000149658	YTHDF1	89	86.263	ENSPCAG00000002452	YTHDF1	98	86.172	Procavia_capensis
ENSG00000149658	YTHDF1	100	95.170	ENSPCOG00000025969	YTHDF1	100	95.170	Propithecus_coquereli
ENSG00000149658	YTHDF1	98	83.273	ENSPVAG00000017568	YTHDF1	98	84.104	Pteropus_vampyrus
ENSG00000149658	YTHDF1	100	73.958	ENSPNYG00000002266	YTHDF1	100	73.611	Pundamilia_nyererei
ENSG00000149658	YTHDF1	96	72.581	ENSPNYG00000014007	ythdf1	98	73.002	Pundamilia_nyererei
ENSG00000149658	YTHDF1	100	70.425	ENSPNAG00000012447	ythdf1	100	73.298	Pygocentrus_nattereri
ENSG00000149658	YTHDF1	100	93.739	ENSRNOG00000027015	Ythdf1	100	93.739	Rattus_norvegicus
ENSG00000149658	YTHDF1	100	96.959	ENSRBIG00000044959	YTHDF1	100	96.959	Rhinopithecus_bieti
ENSG00000149658	YTHDF1	100	96.780	ENSRROG00000033014	YTHDF1	100	96.780	Rhinopithecus_roxellana
ENSG00000149658	YTHDF1	97	95.387	ENSSBOG00000027278	YTHDF1	100	95.285	Saimiri_boliviensis_boliviensis
ENSG00000149658	YTHDF1	99	87.814	ENSSHAG00000010430	YTHDF1	89	89.068	Sarcophilus_harrisii
ENSG00000149658	YTHDF1	99	74.603	ENSSFOG00015000284	ythdf1	100	73.942	Scleropages_formosus
ENSG00000149658	YTHDF1	94	80.567	ENSSMAG00000007635	YTHDF1	94	74.120	Scophthalmus_maximus
ENSG00000149658	YTHDF1	73	82.781	ENSSMAG00000013715	ythdf1	94	64.300	Scophthalmus_maximus
ENSG00000149658	YTHDF1	96	73.214	ENSSDUG00000000435	ythdf1	96	73.451	Seriola_dumerili
ENSG00000149658	YTHDF1	99	75.088	ENSSDUG00000015823	YTHDF1	99	75.352	Seriola_dumerili
ENSG00000149658	YTHDF1	100	71.201	ENSSLDG00000001054	YTHDF1	100	71.908	Seriola_lalandi_dorsalis
ENSG00000149658	YTHDF1	96	69.966	ENSSLDG00000024948	ythdf1	96	71.477	Seriola_lalandi_dorsalis
ENSG00000149658	YTHDF1	91	86.275	ENSSPUG00000015143	YTHDF1	100	88.063	Sphenodon_punctatus
ENSG00000149658	YTHDF1	96	68.866	ENSSPAG00000014989	ythdf1	96	70.234	Stegastes_partitus
ENSG00000149658	YTHDF1	100	73.322	ENSSPAG00000003666	YTHDF1	100	72.978	Stegastes_partitus
ENSG00000149658	YTHDF1	100	88.929	ENSSSCG00000040086	YTHDF1	100	88.929	Sus_scrofa
ENSG00000149658	YTHDF1	99	88.065	ENSTGUG00000007565	YTHDF1	100	89.512	Taeniopygia_guttata
ENSG00000149658	YTHDF1	96	70.051	ENSTRUG00000005049	YTHDF1	98	70.924	Takifugu_rubripes
ENSG00000149658	YTHDF1	99	71.380	ENSTRUG00000004288	ythdf1	98	71.453	Takifugu_rubripes
ENSG00000149658	YTHDF1	100	72.203	ENSTNIG00000003975	YTHDF1	100	72.949	Tetraodon_nigroviridis
ENSG00000149658	YTHDF1	99	71.781	ENSTNIG00000012490	ythdf1	99	72.680	Tetraodon_nigroviridis
ENSG00000149658	YTHDF1	99	87.500	ENSTTRG00000001804	YTHDF1	98	87.477	Tursiops_truncatus
ENSG00000149658	YTHDF1	97	93.173	ENSUAMG00000011021	YTHDF1	100	92.927	Ursus_americanus
ENSG00000149658	YTHDF1	91	92.731	ENSUMAG00000022290	YTHDF1	100	92.731	Ursus_maritimus
ENSG00000149658	YTHDF1	91	92.323	ENSVVUG00000015275	YTHDF1	99	92.323	Vulpes_vulpes
ENSG00000149658	YTHDF1	96	82.288	ENSXETG00000027086	ythdf1	94	83.146	Xenopus_tropicalis
ENSG00000149658	YTHDF1	96	72.563	ENSXCOG00000002490	ythdf1	93	73.626	Xiphophorus_couchianus
ENSG00000149658	YTHDF1	97	70.413	ENSXCOG00000008115	YTHDF1	94	71.728	Xiphophorus_couchianus
ENSG00000149658	YTHDF1	96	72.727	ENSXMAG00000008525	ythdf1	94	73.481	Xiphophorus_maculatus
ENSG00000149658	YTHDF1	97	74.061	ENSXMAG00000015644	YTHDF1	99	74.911	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	28106072.	IPI	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0043022	ribosome binding	26046440.	IDA	Function
GO:0045727	positive regulation of translation	28106072.28106076.	IMP	Process
GO:0045948	positive regulation of translational initiation	26046440.	IDA	Process
GO:1990247	N6-methyladenosine-containing RNA binding	24284625.26046440.26318451.28106072.28106076.	IDA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr20	63202940	Missense_Mutation	NA	R334G	0.28
BLCA	chr20	63202371	Missense_Mutation	novel	I523M	0.15	YTH
BLCA	chr20	63203606	Missense_Mutation	novel	G112R	0.33
BLCA	chr20	63203080	Frame_Shift_Ins	novel	*Q287Pfs62**	0.61
BLCA	chr20	63203747	Missense_Mutation	rs773451524	G65R	0.36
BRCA	chr20	63203555	Missense_Mutation	NA	F129L	0.35
BRCA	chr20	63203791	Nonsense_Mutation	NA	S50*	0.11
BRCA	chr20	63203509	Missense_Mutation	NA	S144N	0.2
BRCA	chr20	63202434	Silent	novel	V502V	0.35
BRCA	chr20	63202878	Silent	novel	V354V	0.27
BRCA	chr20	63203637	Silent	NA	H101H	0.2
BRCA	chr20	63203673	Silent	rs752258620	Y89Y	0.48
BRCA	chr20	63202638	Silent	novel	V434V	0.45
BRCA	chr20	63213921	Missense_Mutation	novel	Q25H	0.13
BRCA	chr20	63203694	Silent	rs777452530	P82P	0.07
BRCA	chr20	63202589	Missense_Mutation	NA	E451K	0.29	YTH
BRCA	chr20	63203203	Missense_Mutation	NA	P246H	0.2
CESC	chr20	63195574	3'UTR	novel		0.39
CESC	chr20	63195662	3'UTR	novel		0.38
CESC	chr20	63202729	Missense_Mutation	novel	R404H	0.52	YTH
CESC	chr20	63195520	3'UTR	novel		0.24
CESC	chr20	63203528	Missense_Mutation	NA	Q138E	0.2
COAD	chr20	63202935	Silent	rs753193369	N335N	0.36
COAD	chr20	63196721	Missense_Mutation	rs377660170	R556Q	0.15
COAD	chr20	63202729	Missense_Mutation	NA	R404L	0.1	YTH
COAD	chr20	63203476	Frame_Shift_Del	NA	*P155Rfs26**	0.27
COAD	chr20	63203373	Silent	NA	G189G	0.37
COAD	chr20	63202575	Silent	NA	P455P	0.19
COAD	chr20	63196490	3'UTR	novel		0.36
COAD	chr20	63213911	Missense_Mutation	NA	V29F	0.22
COAD	chr20	63202932	Silent	rs34046235	A336A	0.2
COAD	chr20	63203719	Missense_Mutation	rs373868224	P74L	0.22
COAD	chr20	63202636	Missense_Mutation	novel	Y435S	0.13	YTH
ESCA	chr20	63202990	Missense_Mutation	novel	Y317F	0.19
GBM	chr20	63202317	Missense_Mutation	novel	K541N	0.2
GBM	chr20	63203328	Silent	novel	G204G	0.1
GBM	chr20	63203088	Silent	novel	P284P	0.19
GBM	chr20	63203667	Missense_Mutation	novel	Q91H	0.13
GBM	chr20	63203322	Silent	novel	V206V	0.31
GBM	chr20	63203049	Missense_Mutation	novel	Q297H	0.56
GBM	chr20	63203502	Silent	rs563225888	A146A	0.46
GBM	chr20	63203350	Missense_Mutation	NA	S197F	0.24
GBM	chr20	63203351	Missense_Mutation	novel	S197P	0.24
GBM	chr20	63202660	Missense_Mutation	novel	C427S	0.36	YTH
GBM	chr20	63202659	Missense_Mutation	novel	C427W	0.55	YTH
HNSC	chr20	63196722	Missense_Mutation	novel	R556G	0.16
HNSC	chr20	63203553	Missense_Mutation	rs779558343	F129L	0.3
HNSC	chr20	63215602	Splice_Site	novel	X10_splice	0.41
HNSC	chr20	63203504	Missense_Mutation	novel	A146P	0.17
HNSC	chr20	63202614	Silent	novel	G442G	0.68
KIRC	chr20	63213933	Silent	NA	G21G	0.28
KIRP	chr20	63202440	Silent	novel	K500K	0.13
KIRP	chr20	63202291	Missense_Mutation	novel	R550H	0.05
LGG	chr20	63202490	Missense_Mutation	NA	V484I	0.15	YTH
LGG	chr20	63196731	Missense_Mutation	rs534172624	R553W	0.48
LIHC	chr20	63202738	Missense_Mutation	novel	D401G	0.36	YTH
LIHC	chr20	63213926	Missense_Mutation	novel	H24N	0.04
LIHC	chr20	63213927	Nonsense_Mutation	novel	*L23Ffs5**	0.04
LIHC	chr20	63196532	3'UTR	novel		0.28
LIHC	chr20	63203747	Missense_Mutation	novel	G65R	0.31
LUAD	chr20	63202302	Missense_Mutation	NA	E546D	0.4
LUAD	chr20	63202771	Missense_Mutation	NA	R390P	0.32	YTH
LUAD	chr20	63196658	3'UTR	novel		0.15
LUAD	chr20	63202681	Missense_Mutation	NA	R420L	0.47	YTH
LUAD	chr20	63202614	Silent	novel	G442G	0.08
LUAD	chr20	63203021	Missense_Mutation	rs745461335	A307S	0.28
LUAD	chr20	63203532	Frame_Shift_Del	novel	*S137Lfs44**	0.22
LUAD	chr20	63202774	Missense_Mutation	NA	G389V	0.15
LUSC	chr20	63203656	Missense_Mutation	novel	G95V	0.34
LUSC	chr20	63202942	Missense_Mutation	novel	N333I	0.3
LUSC	chr20	63202575	Silent	NA	P455P	0.11
LUSC	chr20	63202774	Missense_Mutation	NA	G389V	0.17
LUSC	chr20	63202969	Missense_Mutation	novel	P324L	0.53
LUSC	chr20	63202929	Silent	novel	A337A	0.46
LUSC	chr20	63202543	Missense_Mutation	novel	S466C	0.15	YTH
OV	chr20	63203290	Missense_Mutation	novel	S217F	0.22
OV	chr20	63202385	Missense_Mutation	novel	V519L	0.12	YTH
OV	chr20	63202451	Frame_Shift_Ins	novel	N497*	0.08	YTH
OV	chr20	63202652	Missense_Mutation	novel	S430C	0.19	YTH
OV	chr20	63202677	Silent	novel	L421L	0.19
OV	chr20	63196650	3'UTR	rs373457427		0.23
OV	chr20	63203342	Missense_Mutation	rs374927858	V200I	0.21
OV	chr20	63196624	3'UTR	novel		0.48
OV	chr20	63202658	Missense_Mutation	novel	M428L	0.16	YTH
OV	chr20	63202879	Missense_Mutation	novel	V354A	0.47
OV	chr20	63202709	Missense_Mutation	novel	W411G	0.05	YTH
OV	chr20	63196630	3'UTR	novel		0.09
OV	chr20	63202986	Silent	novel	Q318Q	0.13
PAAD	chr20	63203637	Silent	NA	H101H	0.18
PAAD	chr20	63202730	Missense_Mutation	novel	R404C	0.06	YTH
PRAD	chr20	63203125	Missense_Mutation	NA	G272D	0.36
PRAD	chr20	63203502	Silent	rs563225888	A146A	0.09
READ	chr20	63196703	3'UTR	rs373068552		0.25
READ	chr20	63196674	3'UTR	novel		0.07
READ	chr20	63203713	Missense_Mutation	NA	S76Y	0.25
READ	chr20	63203427	Silent	rs147844381	S171S	0.36
READ	chr20	63203556	Silent	rs746455610	A128A	0.35
SKCM	chr20	63196538	3'UTR	novel		0.38
SKCM	chr20	63202348	Missense_Mutation	NA	S531F	0.15
SKCM	chr20	63203570	Missense_Mutation	NA	P124S	0.48
SKCM	chr20	63203091	Silent	NA	A283A	0.26
SKCM	chr20	63203580	Silent	NA	F120F	0.26
SKCM	chr20	63202784	Silent	NA	L386L	0.19
SKCM	chr20	63203690	Missense_Mutation	NA	P84S	0.11
SKCM	chr20	63203741	Missense_Mutation	NA	P67S	0.19
SKCM	chr20	63203350	Missense_Mutation	NA	S197F	0.24
SKCM	chr20	63203406	Silent	rs148684762	P178P	0.44
SKCM	chr20	63203407	Missense_Mutation	novel	P178L	0.44
SKCM	chr20	63203740	Missense_Mutation	NA	P67L	0.26
SKCM	chr20	63202425	Silent	NA	S505S	0.22
SKCM	chr20	63202527	Silent	rs745319206	K471K	0.36
SKCM	chr20	63213931	Missense_Mutation	NA	S22L	0.09
SKCM	chr20	63203553	Silent	NA	F129F	0.3
SKCM	chr20	63203689	Missense_Mutation	NA	P84L	0.28
SKCM	chr20	63203083	Missense_Mutation	NA	P286L	0.47
SKCM	chr20	63203614	Missense_Mutation	NA	G109E	0.18
SKCM	chr20	63203285	Missense_Mutation	NA	N219Y	0.11
SKCM	chr20	63203072	Missense_Mutation	NA	P290S	0.51
SKCM	chr20	63196649	3'UTR	novel		0.47
STAD	chr20	63202491	Silent	rs763697350	D483D	0.41
STAD	chr20	63203800	Missense_Mutation	rs779046558	S47N	0.29
STAD	chr20	63202935	Silent	rs753193369	N335N	0.38
STAD	chr20	63203572	Frame_Shift_Del	novel	*F123Sfs58**	0.43
STAD	chr20	63202294	Missense_Mutation	NA	V549A	0.16
STAD	chr20	63202729	Missense_Mutation	novel	R404H	0.04	YTH
STAD	chr20	63202881	Silent	rs765559966	N353N	0.36
STAD	chr20	63203183	Missense_Mutation	rs543127893	G253R	0.3
STAD	chr20	63202300	Missense_Mutation	rs749778238	E547V	0.29
STAD	chr20	63213909	Silent	NA	V29V	0.28
STAD	chr20	63196490	3'UTR	novel		0.35
STAD	chr20	63203558	Missense_Mutation	NA	A128T	0.16
STAD	chr20	63202697	Nonsense_Mutation	NA	E415*	0.14	YTH
STAD	chr20	63203317	Missense_Mutation	novel	S208N	0.32
STAD	chr20	63203578	Missense_Mutation	novel	N121I	0.1
STAD	chr20	63196651	3'UTR	novel		0.2
STAD	chr20	63203673	Silent	rs752258620	Y89Y	0.29
STAD	chr20	63203735	Missense_Mutation	NA	S69P	0.08
STAD	chr20	63196726	Missense_Mutation	novel	Q554H	0.19
STAD	chr20	63203616	Silent	NA	P108P	0.19
STAD	chr20	63202315	Missense_Mutation	rs759033271	R542H	0.14
STAD	chr20	63202640	Missense_Mutation	rs149076716	V434I	0.41	YTH
UCEC	chr20	63203125	Missense_Mutation	NA	G272D	0.23
UCEC	chr20	63215590	Silent	novel	G13G	0.06
UCEC	chr20	63215592	Nonsense_Mutation	novel	G13*	0.34
UCEC	chr20	63196705	3'UTR	rs752500107		0.34
UCEC	chr20	63213905	Missense_Mutation	NA	D31Y	0.25
UCEC	chr20	63202670	Missense_Mutation	novel	A424T	0.51	YTH
UCEC	chr20	63202929	Silent	rs763110293	A337A	0.38
UCEC	chr20	63196721	Missense_Mutation	rs377660170	R556Q	0.37
UCEC	chr20	63202371	Silent	NA	I523I	0.29
UCEC	chr20	63202767	Silent	NA	V391V	0.24
UCEC	chr20	63202682	Missense_Mutation	NA	R420C	0.46	YTH
UCEC	chr20	63203556	Silent	rs746455610	A128A	0.29
UCEC	chr20	63196547	3'UTR	novel		0.31
UCEC	chr20	63203625	Frame_Shift_Del	novel	*F105Lfs76**	0.07
UCEC	chr20	63203321	Missense_Mutation	rs187686193	V207I	0.38
UCEC	chr20	63203790	Silent	novel	S50S	0.43
UCEC	chr20	63202564	Missense_Mutation	rs757695071	G459D	0.29	YTH
UCEC	chr20	63196651	3'UTR	novel		0.36
UCEC	chr20	63202424	Missense_Mutation	novel	R506W	0.33	YTH
UCEC	chr20	63202772	Missense_Mutation	NA	R390C	0.36	YTH
UCEC	chr20	63196490	3'UTR	novel		0.29
UCEC	chr20	63203571	Frame_Shift_Ins	novel	E125*	0.44
UCEC	chr20	63196650	3'UTR	rs373457427		0.35
UCEC	chr20	63196616	3'UTR	rs183864484		0.36
UCEC	chr20	63215582	Missense_Mutation	NA	N16T	0.32
UCEC	chr20	63202803	Silent	rs762159571	P379P	0.33
UCEC	chr20	63196490	3'UTR	novel		0.31
UCEC	chr20	63203645	Missense_Mutation	novel	F99I	0.36
UCEC	chr20	63196490	3'UTR	novel		0.39
UCEC	chr20	63202929	Silent	rs763110293	A337A	0.39
UCEC	chr20	63203322	Silent	rs143100976	V206V	0.56
UCEC	chr20	63202435	Missense_Mutation	NA	V502A	0.18	YTH
UCEC	chr20	63196471	3'UTR	novel		0.41
UCEC	chr20	63202664	Missense_Mutation	novel	R426S	0.05	YTH
UCEC	chr20	63203757	Silent	novel	P61P	0.33
UCEC	chr20	63203628	Silent	NA	V104V	0.25
UCEC	chr20	63196703	3'UTR	rs373068552		0.39
UCEC	chr20	63202484	Missense_Mutation	novel	N486D	0.19	YTH
UCEC	chr20	63202729	Missense_Mutation	novel	R404H	0.13	YTH
UCEC	chr20	63203556	Silent	rs746455610	A128A	0.17
UCEC	chr20	63213873	Missense_Mutation	novel	Q41H	0.23
UCEC	chr20	63202853	Missense_Mutation	novel	E363K	0.44
UCEC	chr20	63203405	Missense_Mutation	NA	G179R	0.27
UCEC	chr20	63203672	Missense_Mutation	rs780946682	G90R	0.29
UCEC	chr20	63195533	3'UTR	rs546446386		0.35
UCEC	chr20	63196649	3'UTR	novel		0.32
UCS	chr20	63203723	Frame_Shift_Del	novel	*A73Lfs108**	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	AMP	0.2892	0.013414
PRAD	AMP	0.0589	0.07085
READ	AMP	0.8606	0.033971
SARC	AMP	0.3035	0.033553
SKCM	AMP	0.455	0.058021

Survival Analysis

Cancer	P-value	Q-value
THYM	0.018	Kaplan-Meier Survival Analysis
MESO	0.0082	Kaplan-Meier Survival Analysis
BRCA	0.0077	Kaplan-Meier Survival Analysis
PAAD	0.035	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LGG	0.0015	Kaplan-Meier Survival Analysis
THCA	0.011	Kaplan-Meier Survival Analysis
LUAD	0.026	Kaplan-Meier Survival Analysis
UVM	0.0044	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742