EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000149782 (Gene tree)
Gene ID: 5331
Gene Symbol: PLCB3
Alias: N
Full Name: phospholipase C beta 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 17,930 bases
Position: chr11:64,251,523-64,269,452
Accession: 9056
RBP type: non-canonical RBP
Summary: This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000536243	PLCB3-203	471	-	-	- (aa)	-	-
ENST00000540288	PLCB3-204	4469	XM_011545101	ENSP00000443631	1234 (aa)	XP_011543403	Q01970
ENST00000325234	PLCB3-202	3946	-	ENSP00000324660	1167 (aa)	-	Q01970
ENST00000279230	PLCB3-201	4197	-	ENSP00000279230	1234 (aa)	-	Q01970

Gene Model

Click here to download ENSG00000149782's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04020	Calcium signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04072	Phospholipase D signaling pathway	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04310	Wnt signaling pathway	KEGG
hsa04371	Apelin signaling pathway	KEGG
hsa04540	Gap junction	KEGG
hsa04611	Platelet activation	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa04713	Circadian entrainment	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04723	Retrograde endocannabinoid signaling	KEGG
hsa04724	Glutamatergic synapse	KEGG
hsa04725	Cholinergic synapse	KEGG
hsa04726	Serotonergic synapse	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04730	Long-term depression	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04911	Insulin secretion	KEGG
hsa04912	GnRH signaling pathway	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa04916	Melanogenesis	KEGG
hsa04918	Thyroid hormone synthesis	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04922	Glucagon signaling pathway	KEGG
hsa04924	Renin secretion	KEGG
hsa04925	Aldosterone synthesis and secretion	KEGG
hsa04926	Relaxin signaling pathway	KEGG
hsa04927	Cortisol synthesis and secretion	KEGG
hsa04928	Parathyroid hormone synthesis, secretion and action	KEGG
hsa04933	AGE-RAGE signaling pathway in diabetic complications	KEGG
hsa04934	Cushing syndrome	KEGG
hsa04961	Endocrine and other factor-regulated calcium reabsorption	KEGG
hsa04970	Salivary secretion	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa04972	Pancreatic secretion	KEGG
hsa05010	Alzheimer disease	KEGG
hsa05016	Huntington disease	KEGG
hsa05142	Chagas disease (American trypanosomiasis)	KEGG
hsa05143	African trypanosomiasis	KEGG
hsa05146	Amoebiasis	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05200	Pathways in cancer	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000149782	rs588177	11	64256584	A	High light scatter reticulocyte percentage of red cells	27863252	[0.016-0.031] unit decrease	0.0234532	EFO_0007986
ENSG00000149782	rs12421615	11	64254133	G	Vitiligo	27723757	[1.1-1.2]	1.1498218	EFO_0004208
ENSG00000149782	rs588177	11	64256584	A	High light scatter reticulocyte count	27863252	[0.017-0.032] unit decrease	0.0247408	EFO_0007986
ENSG00000149782	rs588177	11	64256584	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000149782	rs117874826	11	64260194	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000149782	rs589030	11	64264326	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000149782	rs589030	11	64264326	?	Red blood cell count	30595370			EFO_0004305
ENSG00000149782	rs35169799	11	64263769	T	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.025-0.043] unit increase	0.0339	EFO_0007788
ENSG00000149782	rs35169799	11	64263769	T	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.024-0.042] unit increase	0.0327	EFO_0007788
ENSG00000149782	rs35169799	11	64263769	T	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.037-0.061] unit increase	0.0492	EFO_0007788
ENSG00000149782	rs35169799	11	64263769	T	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.037-0.061] unit increase	0.0489	EFO_0007788
ENSG00000149782	rs35169799	11	64263769	T	Type 2 diabetes (adjusted for BMI)	29632382	[1.03-1.08]	1.05	EFO_0001360
ENSG00000149782	rs35169799	11	64263769	T	Type 2 diabetes (adjusted for BMI)	29632382	[1.03-1.09]	1.06	EFO_0001360

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149782's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149782	PLCB3	100	92.227	ENSMUSG00000024960	Plcb3	100	92.227	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003073	regulation of systemic arterial blood pressure	18468998.	IDA	Process
GO:0004435	phosphatidylinositol phospholipase C activity	21873635.	IBA	Function
GO:0004629	phospholipase C activity	-	TAS	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	21822282.23377541.	IPI	Function
GO:0005516	calmodulin binding	21873635.	IBA	Function
GO:0005516	calmodulin binding	12821674.	IDA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007186	G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	TAS	Process
GO:0016020	membrane	-	IEA	Component
GO:0016042	lipid catabolic process	-	IEA	Process
GO:0032959	inositol trisphosphate biosynthetic process	21873635.	IBA	Process
GO:0032991	protein-containing complex	18468998.	IDA	Component
GO:0043647	inositol phosphate metabolic process	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048015	phosphatidylinositol-mediated signaling	21873635.	IBA	Process
GO:0051209	release of sequestered calcium ion into cytosol	21873635.	IBA	Process
GO:0099524	postsynaptic cytosol	-	IEA	Component