EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000149792 (Gene tree)
Gene ID: 740
Gene Symbol: MRPL49
Alias: NOF|NOF1|L49mt|C11orf4
Full Name: mitochondrial ribosomal protein L49
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 5,189 bases
Position: chr11:65,122,183-65,127,371
Accession: 1176
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000434052	Img2	PF05046.14	8e-28	1	1
ENSP00000279242	Img2	PF05046.14	1.8e-27	1	1
ENSP00000437177	Img2	PF05046.14	6.4e-13	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000532671	MRPL49-207	2526	-	-	- (aa)	-	-
ENST00000524482	MRPL49-202	2065	NR_037567	-	- (aa)	-	-
ENST00000533943	MRPL49-208	688	-	ENSP00000434052	127 (aa)	-	H0YDP7
ENST00000279242	MRPL49-201	2019	-	ENSP00000279242	166 (aa)	-	Q13405
ENST00000531705	MRPL49-206	489	-	ENSP00000436740	99 (aa)	-	E9PI78
ENST00000526319	MRPL49-204	1906	-	ENSP00000434190	166 (aa)	-	Q13405
ENST00000526171	MRPL49-203	501	-	ENSP00000437177	140 (aa)	-	E9PNF1
ENST00000528529	MRPL49-205	752	-	-	- (aa)	-	-
ENST00000534078	MRPL49-209	518	-	ENSP00000434222	56 (aa)	-	E9PRD2

Gene Model

Click here to download ENSG00000149792's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149792's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149792	MRPL49	89	57.143	ENSAPOG00000017939	MRPL49	82	57.143	Acanthochromis_polyacanthus
ENSG00000149792	MRPL49	100	92.771	ENSAMEG00000017672	MRPL49	100	92.771	Ailuropoda_melanoleuca
ENSG00000149792	MRPL49	92	58.170	ENSACIG00000006080	MRPL49	92	58.170	Amphilophus_citrinellus
ENSG00000149792	MRPL49	89	57.823	ENSAOCG00000018785	MRPL49	82	57.823	Amphiprion_ocellaris
ENSG00000149792	MRPL49	89	57.823	ENSAPEG00000017747	MRPL49	82	57.823	Amphiprion_percula
ENSG00000149792	MRPL49	100	54.070	ENSATEG00000023045	MRPL49	97	54.070	Anabas_testudineus
ENSG00000149792	MRPL49	81	70.896	ENSACAG00000010808	MRPL49	100	70.896	Anolis_carolinensis
ENSG00000149792	MRPL49	100	92.169	ENSANAG00000034865	MRPL49	100	92.169	Aotus_nancymaae
ENSG00000149792	MRPL49	89	59.184	ENSACLG00000009050	MRPL49	85	59.184	Astatotilapia_calliptera
ENSG00000149792	MRPL49	78	67.692	ENSAMXG00000003487	MRPL49	76	67.692	Astyanax_mexicanus
ENSG00000149792	MRPL49	100	87.952	ENSBTAG00000005075	MRPL49	100	87.952	Bos_taurus
ENSG00000149792	MRPL49	92	31.325	WBGene00011247	mrpl-49	89	31.325	Caenorhabditis_elegans
ENSG00000149792	MRPL49	100	93.976	ENSCJAG00000043917	MRPL49	100	93.976	Callithrix_jacchus
ENSG00000149792	MRPL49	100	91.566	ENSCAFG00000013928	MRPL49	100	91.566	Canis_familiaris
ENSG00000149792	MRPL49	100	90.361	ENSCAFG00020014941	MRPL49	100	90.361	Canis_lupus_dingo
ENSG00000149792	MRPL49	100	90.361	ENSCHIG00000013156	MRPL49	100	90.361	Capra_hircus
ENSG00000149792	MRPL49	100	90.361	ENSTSYG00000014666	MRPL49	100	90.361	Carlito_syrichta
ENSG00000149792	MRPL49	84	87.857	ENSCAPG00000003717	MRPL49	100	87.857	Cavia_aperea
ENSG00000149792	MRPL49	100	84.940	ENSCPOG00000032785	MRPL49	100	84.940	Cavia_porcellus
ENSG00000149792	MRPL49	100	94.578	ENSCCAG00000018444	MRPL49	100	94.578	Cebus_capucinus
ENSG00000149792	MRPL49	100	95.783	ENSCATG00000044183	MRPL49	100	95.783	Cercocebus_atys
ENSG00000149792	MRPL49	100	87.349	ENSCLAG00000016311	MRPL49	100	87.349	Chinchilla_lanigera
ENSG00000149792	MRPL49	100	97.006	ENSCSAG00000007671	-	100	97.006	Chlorocebus_sabaeus
ENSG00000149792	MRPL49	100	92.169	ENSCSAG00000000513	-	100	92.169	Chlorocebus_sabaeus
ENSG00000149792	MRPL49	100	85.542	ENSCHOG00000012855	MRPL49	100	85.542	Choloepus_hoffmanni
ENSG00000149792	MRPL49	100	62.147	ENSCPBG00000023636	-	100	62.147	Chrysemys_picta_bellii
ENSG00000149792	MRPL49	85	51.587	ENSCPBG00000024029	-	96	51.908	Chrysemys_picta_bellii
ENSG00000149792	MRPL49	78	37.692	ENSCING00000000953	-	77	37.692	Ciona_intestinalis
ENSG00000149792	MRPL49	80	44.361	ENSCSAVG00000001577	-	77	44.361	Ciona_savignyi
ENSG00000149792	MRPL49	100	97.590	ENSCANG00000041392	MRPL49	100	97.590	Colobus_angolensis_palliatus
ENSG00000149792	MRPL49	90	85.333	ENSCGRG00001024245	Mrpl49	100	80.120	Cricetulus_griseus_chok1gshd
ENSG00000149792	MRPL49	90	82.667	ENSCGRG00000001386	Mrpl49	100	77.711	Cricetulus_griseus_crigri
ENSG00000149792	MRPL49	100	56.571	ENSCSEG00000003115	MRPL49	97	56.571	Cynoglossus_semilaevis
ENSG00000149792	MRPL49	89	61.224	ENSCVAG00000011562	MRPL49	87	61.224	Cyprinodon_variegatus
ENSG00000149792	MRPL49	78	65.116	ENSDARG00000075422	MRPL49	73	65.116	Danio_rerio
ENSG00000149792	MRPL49	94	85.897	ENSDNOG00000034205	-	100	85.897	Dasypus_novemcinctus
ENSG00000149792	MRPL49	100	84.940	ENSDNOG00000004494	-	100	84.940	Dasypus_novemcinctus
ENSG00000149792	MRPL49	86	82.258	ENSDORG00000003613	Mrpl49	100	82.258	Dipodomys_ordii
ENSG00000149792	MRPL49	74	41.600	FBgn0030433	mRpL49	69	41.600	Drosophila_melanogaster
ENSG00000149792	MRPL49	98	61.350	ENSETEG00000010571	MRPL49	98	60.736	Echinops_telfairi
ENSG00000149792	MRPL49	87	53.472	ENSEBUG00000003645	MRPL49	64	57.364	Eptatretus_burgeri
ENSG00000149792	MRPL49	100	91.566	ENSEASG00005018211	MRPL49	100	91.566	Equus_asinus_asinus
ENSG00000149792	MRPL49	100	92.169	ENSECAG00000022196	MRPL49	100	92.169	Equus_caballus
ENSG00000149792	MRPL49	69	93.182	ENSEEUG00000008212	-	100	59.281	Erinaceus_europaeus
ENSG00000149792	MRPL49	78	63.846	ENSELUG00000016206	mrpl49	73	63.846	Esox_lucius
ENSG00000149792	MRPL49	100	92.771	ENSFCAG00000006256	MRPL49	100	92.771	Felis_catus
ENSG00000149792	MRPL49	100	86.747	ENSFDAG00000011518	MRPL49	100	86.747	Fukomys_damarensis
ENSG00000149792	MRPL49	88	57.534	ENSFHEG00000011616	MRPL49	83	57.534	Fundulus_heteroclitus
ENSG00000149792	MRPL49	88	60.959	ENSGAFG00000015749	MRPL49	84	60.959	Gambusia_affinis
ENSG00000149792	MRPL49	89	57.432	ENSGACG00000013129	-	75	62.205	Gasterosteus_aculeatus
ENSG00000149792	MRPL49	75	62.105	ENSGACG00000013127	MRPL49	66	62.105	Gasterosteus_aculeatus
ENSG00000149792	MRPL49	100	62.147	ENSGAGG00000025862	MRPL49	100	62.147	Gopherus_agassizii
ENSG00000149792	MRPL49	100	97.590	ENSGGOG00000024514	MRPL49	100	97.590	Gorilla_gorilla
ENSG00000149792	MRPL49	89	59.184	ENSHBUG00000014033	MRPL49	85	59.184	Haplochromis_burtoni
ENSG00000149792	MRPL49	100	86.747	ENSHGLG00000012648	MRPL49	100	86.747	Heterocephalus_glaber_female
ENSG00000149792	MRPL49	100	86.747	ENSHGLG00100014020	MRPL49	100	86.747	Heterocephalus_glaber_male
ENSG00000149792	MRPL49	99	53.425	ENSHCOG00000014496	-	84	58.678	Hippocampus_comes
ENSG00000149792	MRPL49	99	54.491	ENSIPUG00000017564	MRPL49	89	54.491	Ictalurus_punctatus
ENSG00000149792	MRPL49	100	89.157	ENSSTOG00000003344	MRPL49	100	89.157	Ictidomys_tridecemlineatus
ENSG00000149792	MRPL49	91	78.261	ENSJJAG00000015905	Mrpl49	97	74.603	Jaculus_jaculus
ENSG00000149792	MRPL49	98	57.059	ENSKMAG00000005174	MRPL49	95	57.059	Kryptolebias_marmoratus
ENSG00000149792	MRPL49	89	62.585	ENSLBEG00000011553	MRPL49	82	62.585	Labrus_bergylta
ENSG00000149792	MRPL49	84	62.857	ENSLACG00000007674	MRPL49	85	62.857	Latimeria_chalumnae
ENSG00000149792	MRPL49	100	89.157	ENSLAFG00000001690	MRPL49	100	89.157	Loxodonta_africana
ENSG00000149792	MRPL49	89	91.156	ENSMFAG00000023679	-	100	91.156	Macaca_fascicularis
ENSG00000149792	MRPL49	100	97.590	ENSMFAG00000033395	MRPL49	100	97.590	Macaca_fascicularis
ENSG00000149792	MRPL49	89	91.156	ENSMMUG00000046617	-	100	91.156	Macaca_mulatta
ENSG00000149792	MRPL49	100	96.988	ENSMMUG00000018778	MRPL49	100	96.988	Macaca_mulatta
ENSG00000149792	MRPL49	100	95.783	ENSMNEG00000038966	MRPL49	100	95.783	Macaca_nemestrina
ENSG00000149792	MRPL49	100	96.386	ENSMLEG00000032826	-	100	96.386	Mandrillus_leucophaeus
ENSG00000149792	MRPL49	100	93.976	ENSMLEG00000026765	-	100	93.976	Mandrillus_leucophaeus
ENSG00000149792	MRPL49	100	55.689	ENSMAMG00000015760	MRPL49	97	55.689	Mastacembelus_armatus
ENSG00000149792	MRPL49	89	59.184	ENSMZEG00005012362	MRPL49	85	59.184	Maylandia_zebra
ENSG00000149792	MRPL49	70	93.258	ENSMAUG00000008380	Mrpl49	100	93.258	Mesocricetus_auratus
ENSG00000149792	MRPL49	95	90.506	ENSMICG00000047047	-	96	90.506	Microcebus_murinus
ENSG00000149792	MRPL49	99	77.698	ENSMICG00000016604	-	98	77.698	Microcebus_murinus
ENSG00000149792	MRPL49	100	82.530	ENSMOCG00000015528	Mrpl49	100	82.530	Microtus_ochrogaster
ENSG00000149792	MRPL49	87	57.639	ENSMMOG00000017361	MRPL49	80	57.639	Mola_mola
ENSG00000149792	MRPL49	95	57.233	ENSMALG00000002403	MRPL49	89	57.233	Monopterus_albus
ENSG00000149792	MRPL49	100	83.133	MGP_CAROLIEiJ_G0022584	Mrpl49	100	83.133	Mus_caroli
ENSG00000149792	MRPL49	100	83.133	ENSMUSG00000007338	Mrpl49	100	83.133	Mus_musculus
ENSG00000149792	MRPL49	100	83.133	MGP_PahariEiJ_G0014078	Mrpl49	100	83.133	Mus_pahari
ENSG00000149792	MRPL49	100	83.735	MGP_SPRETEiJ_G0023495	Mrpl49	100	83.735	Mus_spretus
ENSG00000149792	MRPL49	100	92.771	ENSMPUG00000012227	MRPL49	100	92.771	Mustela_putorius_furo
ENSG00000149792	MRPL49	100	88.554	ENSMLUG00000015373	MRPL49	100	88.554	Myotis_lucifugus
ENSG00000149792	MRPL49	93	88.312	ENSNGAG00000008255	Mrpl49	100	86.145	Nannospalax_galili
ENSG00000149792	MRPL49	100	97.590	ENSNLEG00000005505	MRPL49	100	97.590	Nomascus_leucogenys
ENSG00000149792	MRPL49	84	79.286	ENSMEUG00000009437	MRPL49	100	79.286	Notamacropus_eugenii
ENSG00000149792	MRPL49	93	79.221	ENSOPRG00000009881	MRPL49	99	77.576	Ochotona_princeps
ENSG00000149792	MRPL49	100	86.145	ENSODEG00000017907	-	100	86.145	Octodon_degus
ENSG00000149792	MRPL49	100	78.571	ENSODEG00000000580	-	100	78.571	Octodon_degus
ENSG00000149792	MRPL49	100	82.530	ENSODEG00000018605	-	100	82.530	Octodon_degus
ENSG00000149792	MRPL49	89	59.184	ENSONIG00000021419	MRPL49	83	59.184	Oreochromis_niloticus
ENSG00000149792	MRPL49	100	82.530	ENSOCUG00000014882	MRPL49	100	82.530	Oryctolagus_cuniculus
ENSG00000149792	MRPL49	79	69.466	ENSORLG00000001995	MRPL49	75	69.466	Oryzias_latipes
ENSG00000149792	MRPL49	89	63.265	ENSORLG00020021002	MRPL49	96	59.756	Oryzias_latipes_hni
ENSG00000149792	MRPL49	98	59.509	ENSORLG00015015420	MRPL49	98	59.509	Oryzias_latipes_hsok
ENSG00000149792	MRPL49	100	60.000	ENSOMEG00000011162	MRPL49	100	60.000	Oryzias_melastigma
ENSG00000149792	MRPL49	100	87.952	ENSOGAG00000015018	MRPL49	100	87.952	Otolemur_garnettii
ENSG00000149792	MRPL49	100	89.286	ENSOARG00000012774	MRPL49	100	89.286	Ovis_aries
ENSG00000149792	MRPL49	100	99.398	ENSPPAG00000037118	MRPL49	100	99.398	Pan_paniscus
ENSG00000149792	MRPL49	100	93.373	ENSPPRG00000024886	MRPL49	100	93.373	Panthera_pardus
ENSG00000149792	MRPL49	100	93.373	ENSPTIG00000021250	MRPL49	100	93.373	Panthera_tigris_altaica
ENSG00000149792	MRPL49	100	99.398	ENSPTRG00000003867	MRPL49	100	99.398	Pan_troglodytes
ENSG00000149792	MRPL49	100	96.988	ENSPANG00000004414	-	100	96.988	Papio_anubis
ENSG00000149792	MRPL49	100	82.530	ENSPANG00000033737	-	100	78.916	Papio_anubis
ENSG00000149792	MRPL49	78	64.341	ENSPKIG00000023054	MRPL49	78	64.844	Paramormyrops_kingsleyae
ENSG00000149792	MRPL49	89	56.463	ENSPMGG00000013887	MRPL49	82	56.463	Periophthalmus_magnuspinnatus
ENSG00000149792	MRPL49	93	64.286	ENSPEMG00000022676	-	97	64.286	Peromyscus_maniculatus_bairdii
ENSG00000149792	MRPL49	83	60.145	ENSPMAG00000000130	MRPL49	91	64.286	Petromyzon_marinus
ENSG00000149792	MRPL49	94	65.649	ENSPCIG00000007713	-	85	65.854	Phascolarctos_cinereus
ENSG00000149792	MRPL49	78	66.667	ENSPFOG00000020078	MRPL49	74	66.667	Poecilia_formosa
ENSG00000149792	MRPL49	78	65.891	ENSPFOG00000020458	-	74	65.891	Poecilia_formosa
ENSG00000149792	MRPL49	78	66.667	ENSPLAG00000006894	MRPL49	73	66.667	Poecilia_latipinna
ENSG00000149792	MRPL49	78	66.667	ENSPLAG00000017623	-	73	66.667	Poecilia_latipinna
ENSG00000149792	MRPL49	87	61.379	ENSPMEG00000023131	MRPL49	73	66.667	Poecilia_mexicana
ENSG00000149792	MRPL49	87	60.690	ENSPREG00000005735	MRPL49	84	60.690	Poecilia_reticulata
ENSG00000149792	MRPL49	100	98.795	ENSPPYG00000003076	MRPL49	100	98.795	Pongo_abelii
ENSG00000149792	MRPL49	100	60.843	ENSPCAG00000015282	MRPL49	98	60.123	Procavia_capensis
ENSG00000149792	MRPL49	100	90.964	ENSPCOG00000025188	MRPL49	100	90.964	Propithecus_coquereli
ENSG00000149792	MRPL49	100	87.349	ENSPVAG00000007916	MRPL49	100	87.349	Pteropus_vampyrus
ENSG00000149792	MRPL49	89	59.184	ENSPNYG00000005274	MRPL49	88	59.184	Pundamilia_nyererei
ENSG00000149792	MRPL49	77	66.142	ENSPNAG00000004978	MRPL49	72	66.142	Pygocentrus_nattereri
ENSG00000149792	MRPL49	100	83.735	ENSRNOG00000020975	Mrpl49	100	83.735	Rattus_norvegicus
ENSG00000149792	MRPL49	100	97.590	ENSRBIG00000033618	MRPL49	100	97.590	Rhinopithecus_bieti
ENSG00000149792	MRPL49	100	97.590	ENSRROG00000044624	MRPL49	100	97.590	Rhinopithecus_roxellana
ENSG00000149792	MRPL49	100	93.373	ENSSBOG00000028984	MRPL49	100	93.373	Saimiri_boliviensis_boliviensis
ENSG00000149792	MRPL49	84	80.714	ENSSHAG00000000390	MRPL49	100	80.714	Sarcophilus_harrisii
ENSG00000149792	MRPL49	87	57.241	ENSSFOG00015019687	MRPL49	95	57.931	Scleropages_formosus
ENSG00000149792	MRPL49	89	59.864	ENSSMAG00000001559	MRPL49	97	53.757	Scophthalmus_maximus
ENSG00000149792	MRPL49	88	59.589	ENSSDUG00000013816	MRPL49	98	55.747	Seriola_dumerili
ENSG00000149792	MRPL49	99	55.367	ENSSLDG00000001537	MRPL49	95	55.367	Seriola_lalandi_dorsalis
ENSG00000149792	MRPL49	66	87.156	ENSSARG00000011597	MRPL49	100	87.156	Sorex_araneus
ENSG00000149792	MRPL49	87	57.931	ENSSPAG00000000302	MRPL49	81	57.534	Stegastes_partitus
ENSG00000149792	MRPL49	100	86.747	ENSSSCG00000013001	MRPL49	100	86.747	Sus_scrofa
ENSG00000149792	MRPL49	90	55.346	ENSTRUG00000002203	MRPL49	87	55.346	Takifugu_rubripes
ENSG00000149792	MRPL49	98	54.491	ENSTNIG00000003284	MRPL49	98	54.491	Tetraodon_nigroviridis
ENSG00000149792	MRPL49	100	85.542	ENSTBEG00000007929	MRPL49	100	85.542	Tupaia_belangeri
ENSG00000149792	MRPL49	100	91.566	ENSTTRG00000017247	MRPL49	100	91.566	Tursiops_truncatus
ENSG00000149792	MRPL49	100	93.373	ENSUAMG00000012283	MRPL49	100	93.373	Ursus_americanus
ENSG00000149792	MRPL49	100	93.373	ENSUMAG00000008222	MRPL49	100	93.373	Ursus_maritimus
ENSG00000149792	MRPL49	98	68.000	ENSVPAG00000005206	MRPL49	100	85.714	Vicugna_pacos
ENSG00000149792	MRPL49	100	91.566	ENSVVUG00000027381	MRPL49	100	91.566	Vulpes_vulpes
ENSG00000149792	MRPL49	80	69.925	ENSXETG00000031584	MRPL49	96	69.925	Xenopus_tropicalis
ENSG00000149792	MRPL49	87	62.069	ENSXCOG00000002126	MRPL49	84	62.069	Xiphophorus_couchianus
ENSG00000149792	MRPL49	87	62.069	ENSXMAG00000024309	MRPL49	81	62.069	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0005515	protein binding	20601428.	IPI	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	20601428.	IDA	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process