EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000149925 (Gene tree)
Gene ID: 226
Gene Symbol: ALDOA
Alias: N
Full Name: aldolase, fructose-bisphosphate A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 17,368 bases
Position: chr16:30,053,090-30,070,457
Accession: 414
RBP type: non-canonical RBP
Summary: This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000564688	ALDOA-211	613	-	ENSP00000457514	204 (aa)	-	H3BU78
ENST00000563060	ALDOA-206	1550	XM_024450192	ENSP00000455800	364 (aa)	XP_024305960	P04075
ENST00000643777	ALDOA-221	1485	-	ENSP00000494188	364 (aa)	-	P04075
ENST00000564546	ALDOA-209	1579	-	ENSP00000455917	364 (aa)	-	P04075
ENST00000565355	ALDOA-212	538	-	ENSP00000456098	130 (aa)	-	H3BR68
ENST00000569798	ALDOA-219	1499	-	ENSP00000455857	361 (aa)	-	H3BQN4
ENST00000562168	ALDOA-203	666	-	ENSP00000456020	162 (aa)	-	H3BR04
ENST00000567555	ALDOA-217	554	-	-	- (aa)	-	-
ENST00000566012	ALDOA-213	553	-	-	- (aa)	-	-
ENST00000566846	ALDOA-216	512	-	ENSP00000454499	140 (aa)	-	H3BMQ8
ENST00000566146	ALDOA-215	365	-	-	- (aa)	-	-
ENST00000564521	ALDOA-208	2534	-	-	- (aa)	-	-
ENST00000563987	ALDOA-207	586	-	ENSP00000457643	155 (aa)	-	H3BUH7
ENST00000569545	ALDOA-218	1359	-	ENSP00000455700	364 (aa)	-	P04075
ENST00000566130	ALDOA-214	801	-	-	- (aa)	-	-
ENST00000562302	ALDOA-204	502	-	-	- (aa)	-	-
ENST00000395240	ALDOA-201	1447	-	ENSP00000378661	368 (aa)	-	J3KPS3
ENST00000412304	ALDOA-202	1603	-	ENSP00000400452	364 (aa)	-	P04075
ENST00000562679	ALDOA-205	906	-	ENSP00000455455	278 (aa)	-	H3BPS8
ENST00000642816	ALDOA-220	1639	-	ENSP00000496166	418 (aa)	-	P04075
ENST00000564595	ALDOA-210	1672	-	ENSP00000457468	418 (aa)	-	P04075

Gene Model

Click here to download ENSG00000149925's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00030	Pentose phosphate pathway	KEGG
hsa00051	Fructose and mannose metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG
hsa04066	HIF-1 signaling pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000149925	rs2071390	16	30070046	T	Adventurousness	30643258	[0.0095-0.0199] unit decrease	0.014712622	EFO_0008579

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000149925's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000149925	ALDOA	95	70.068	WBGene00011474	aldo-1	98	67.039	Caenorhabditis_elegans
ENSG00000149925	ALDOA	98	65.363	WBGene00017166	aldo-2	97	65.922	Caenorhabditis_elegans
ENSG00000149925	ALDOA	100	85.784	ENSG00000109107	ALDOC	100	83.333	Homo_sapiens
ENSG00000149925	ALDOA	100	98.710	ENSMUSG00000030695	Aldoa	100	98.947	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002576	platelet degranulation	-	TAS	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003779	actin binding	1008835.	TAS	Function
GO:0004332	fructose-bisphosphate aldolase activity	9244396.14766013.	IDA	Function
GO:0005515	protein binding	20849852.23355646.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	23580065.	HDA	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006000	fructose metabolic process	14615364.	IMP	Process
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0006096	glycolytic process	14615364.	IMP	Process
GO:0006754	ATP biosynthetic process	14615364.	IMP	Process
GO:0006941	striated muscle contraction	14615364.	IMP	Process
GO:0007015	actin filament organization	1008835.	TAS	Process
GO:0007339	binding of sperm to zona pellucida	23355646.	IMP	Process
GO:0008092	cytoskeletal protein binding	9244396.	IDA	Function
GO:0008360	regulation of cell shape	9244396.	IDA	Process
GO:0015629	actin cytoskeleton	9244396.	IDA	Component
GO:0015631	tubulin binding	17329259.	TAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0030388	fructose 1,6-bisphosphate metabolic process	9244396.14766013.	IDA	Process
GO:0031093	platelet alpha granule lumen	-	TAS	Component
GO:0031430	M band	-	IEA	Component
GO:0031674	I band	1008835.	TAS	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0042802	identical protein binding	14766013.	TAS	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046716	muscle cell cellular homeostasis	14615364.	IMP	Process
GO:0051289	protein homotetramerization	-	ISS	Process
GO:0061621	canonical glycolysis	-	TAS	Process
GO:0061827	sperm head	23355646.	IDA	Component
GO:0070061	fructose binding	10048322.14766013.	IDA	Function
GO:0070062	extracellular exosome	12519789.19056867.19199708.20458337.23533145.	HDA	Component
GO:0070062	extracellular exosome	17641064.	IDA	Component
GO:1904724	tertiary granule lumen	-	TAS	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29453983	Aldolase A overexpression is associated with poor prognosis and promotes tumor progression by the epithelial-mesenchymal transition in colon cancer.	Biochem Biophys Res Commun	2018 Mar 4	Ye F	doi: 10.1016/j.bbrc.2018.02.123
29693182	High expression of fructose-bisphosphate aldolaseA induces progression of renal cell carcinoma.	Oncol Rep	2018 Jun	Huang Z	doi: 10.3892/or.2018.6378
27468721	Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue.	Tumour Biol	2016 Oct	Yamamoto T	-
26854714	ALDOA functions as an oncogene in the highly metastatic pancreatic cancer.	Cancer Lett	2016 Apr 28	Ji S	doi: 10.1016/j.canlet.2016.01.054
28000858	Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis.	Int J Oncol	2017 Feb	Kawai K	doi: 10.3892/ijo.2016.3814
28610954	Feedback regulation of ALDOA activates the HIF-1α/MMP9 axis to promote lung cancer progression.	Cancer Lett	2017 Sep 10	Chang YC	doi: 10.1016/j.canlet.2017.06.001
29084207	Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.	Oncogene	2018 Feb 22	Ma D	doi: 10.1038/onc.2017.398

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	30070284	3'UTR	novel		0.46
BLCA	chr16	30068649	Missense_Mutation	novel	D110N	0.18
BLCA	chr16	30068858	Silent	rs746865548	K140K	0.16
BLCA	chr16	30069855	Silent	novel	Q275Q	0.11
BLCA	chr16	30067494	Missense_Mutation	NA	E53K	0.17
BLCA	chr16	30067662	Splice_Site	novel	X108_splice	0.31
BLCA	chr16	30069345	Missense_Mutation	NA	D194N	0.12
BLCA	chr16	30068884	Missense_Mutation	rs762685202	R149H	0.24
BRCA	chr16	30065810	Intron	NA		0.18
BRCA	chr16	30069641	Missense_Mutation	rs201658390	A256V	0.39
BRCA	chr16	30069855	Missense_Mutation	NA	Q275H	0.28
BRCA	chr16	30070083	Intron	novel		0.64
BRCA	chr16	30070275	3'UTR	novel		0.1
BRCA	chr16	30065810	Intron	NA		0.06
BRCA	chr16	30068838	Missense_Mutation	novel	R134G	0.09
BRCA	chr16	30068649	Missense_Mutation	NA	D110H	0.14
BRCA	chr16	30065810	Intron	NA		0.33
BRCA	chr16	30069529	Missense_Mutation	NA	D219N	0.3
BRCA	chr16	30068917	Missense_Mutation	NA	S160L	0.19
BRCA	chr16	30065810	Intron	NA		0.32
BRCA	chr16	30067284	Silent	rs760287676	P10P	0.17
CESC	chr16	30065870	Intron	novel		0.18
CESC	chr16	30068863	Missense_Mutation	rs11553108	G142V	0.51
CESC	chr16	30065785	Intron	novel		0.31
CESC	chr16	30069987	Silent	NA	E319E	0.29
CESC	chr16	30053399	Intron	novel		0.42
CESC	chr16	30070204	Missense_Mutation	rs756789043	A363T	0.53
CESC	chr16	30065810	Intron	rs574106376		0.32
CESC	chr16	30065810	Intron	NA		0.39
CESC	chr16	30055309	5'UTR	novel		0.23
CESC	chr16	30065810	Intron	rs574106376		0.45
COAD	chr16	30068883	Missense_Mutation	rs772548302	R149C	0.33
COAD	chr16	30069383	Silent	NA	T206T	0.28
COAD	chr16	30070263	3'UTR	novel		0.29
COAD	chr16	30068902	Frame_Shift_Ins	novel	*E156Rfs45**	0.04
COAD	chr16	30067563	Missense_Mutation	NA	G76C	0.52
COAD	chr16	30068985	Splice_Region	novel		0.08
COAD	chr16	30068936	Silent	novel	E166E	0.12
COAD	chr16	30069349	Missense_Mutation	NA	G195E	0.47
ESCA	chr16	30066970	Intron	rs768781534		0.31
GBM	chr16	30067516	Missense_Mutation	rs760143922	R60L	0.04
GBM	chr16	30069663	Silent	rs747443135	P263P	0.34
GBM	chr16	30068862	Missense_Mutation	novel	G142R	0.39
GBM	chr16	30068932	Missense_Mutation	novel	M165K	0.11
GBM	chr16	30070174	Frame_Shift_Del	novel	*A353Pfs32**	0.14
GBM	chr16	30069366	Missense_Mutation	rs372394541	R201C	0.08
HNSC	chr16	30069909	Silent	rs756568844	L293L	0.26
HNSC	chr16	30068930	Silent	rs11553120	I164I	0.12
HNSC	chr16	30070095	Intron	novel		0.23
HNSC	chr16	30070288	3'UTR	novel		0.24
KIRC	chr16	30067643	Frame_Shift_Del	novel	*G103Vfs7**	0.18
KIRC	chr16	30070332	3'UTR	novel		0.75
LGG	chr16	30069930	In_Frame_Del	rs760550827	S301del	0.12
LIHC	chr16	30069311	Silent	NA	G182G	0.32
LUAD	chr16	30070109	Splice_Region	novel		0.3
LUAD	chr16	30070232	3'UTR	novel		0.33
LUAD	chr16	30067612	Missense_Mutation	rs747482925	R92H	0.32
LUAD	chr16	30069320	Silent	novel	P185P	0.17
LUAD	chr16	30068662	Frame_Shift_Ins	novel	*L116Pfs38**	0.13
LUAD	chr16	30068823	Missense_Mutation	NA	D129H	0.13
LUAD	chr16	30069525	Silent	rs772297021	L217L	0.19
LUAD	chr16	30070166	Missense_Mutation	novel	G350V	0.14
LUSC	chr16	30069629	Missense_Mutation	NA	A252V	0.19
LUSC	chr16	30067511	Silent	novel	F58F	0.23
LUSC	chr16	30069827	Splice_Region	novel		0.09
LUSC	chr16	30070178	Missense_Mutation	rs766537404	S354T	0.41
LUSC	chr16	30069841	Silent	rs111252736	L271L	0.22
LUSC	chr16	30068855	Silent	NA	K139K	0.16
LUSC	chr16	30069529	Missense_Mutation	novel	D219H	0.14
OV	chr16	30070139	Missense_Mutation	NA	G341E	0.21
OV	chr16	30070213	3'UTR	novel		0.11
OV	chr16	30068930	Missense_Mutation	novel	I164M	0.07
OV	chr16	30069887	Missense_Mutation	novel	A286D	0.43
SARC	chr16	30068666	Silent	novel	P115P	0.32
SKCM	chr16	30069884	Missense_Mutation	rs543994647	N285S	0.17
SKCM	chr16	30070186	Missense_Mutation	NA	L357F	0.2
SKCM	chr16	30069339	Missense_Mutation	NA	L192F	0.04
SKCM	chr16	30068930	Silent	rs11553120	I164I	0.23
SKCM	chr16	30069496	Splice_Region	novel		0.11
STAD	chr16	30068865	Frame_Shift_Del	novel	*A143Gfs35**	0.05
STAD	chr16	30070077	Intron	rs371593891		0.22
STAD	chr16	30067618	Frame_Shift_Ins	novel	*Q96Pfs38**	0.26
STAD	chr16	30068873	Silent	rs769378422	F145F	0.29
TGCT	chr16	30069645	Silent	novel	L257L	0.42
UCEC	chr16	30070397	3'UTR	novel		0.29
UCEC	chr16	30069606	Missense_Mutation	NA	F244L	0.47
UCEC	chr16	30067464	Missense_Mutation	rs757047929	R43W	0.55
UCEC	chr16	30068861	Silent	rs150741747	D141D	0.51
UCEC	chr16	30063866	5'UTR	novel		0.41
UCEC	chr16	30063746	5'UTR	novel		0.37
UCEC	chr16	30065756	Intron	novel		0.3
UCEC	chr16	30069366	Missense_Mutation	rs372394541	R201C	0.37
UCEC	chr16	30070281	3'UTR	rs780327435		0.52
UCEC	chr16	30055229	5'UTR	novel		0.48
UCEC	chr16	30070375	3'UTR	novel		0.32
UCEC	chr16	30070192	Missense_Mutation	rs373670009	V359I	0.46
UCEC	chr16	30067324	Missense_Mutation	novel	V24M	0.17
UCEC	chr16	30069835	Missense_Mutation	NA	T269A	0.16
UCEC	chr16	30053382	Intron	novel		0.37
UCEC	chr16	30063903	5'UTR	novel		0.29
UCEC	chr16	30066958	Intron	rs549434187		0.42
UCEC	chr16	30069331	Missense_Mutation	novel	P189H	0.3
UCEC	chr16	30054853	5'UTR	novel		0.51
UCEC	chr16	30054802	5'UTR	novel		0.32
UCEC	chr16	30054868	5'UTR	novel		0.34
UCEC	chr16	30069650	Missense_Mutation	rs750880048	R259H	0.33
UCEC	chr16	30063742	5'UTR	novel		0.34
UCEC	chr16	30069376	Missense_Mutation	novel	Y204C	0.3
UCEC	chr16	30067323	Silent	novel	I23I	0.48
UCEC	chr16	30069664	Missense_Mutation	NA	A264T	0.38
UCEC	chr16	30068861	Silent	rs150741747	D141D	0.36
UCEC	chr16	30067660	Missense_Mutation	novel	K108R	0.24
UCEC	chr16	30068874	Missense_Mutation	NA	A146T	0.3
UCEC	chr16	30070252	3'UTR	novel		0.3
UCEC	chr16	30069985	Nonsense_Mutation	NA	E319*	0.45
UCEC	chr16	30069366	Missense_Mutation	rs372394541	R201C	0.17
UCEC	chr16	30069383	Silent	novel	T206T	0.36
UCEC	chr16	30054813	5'UTR	novel		0.42
UCEC	chr16	30067480	Missense_Mutation	novel	G48D	0.4
UCEC	chr16	30069310	Missense_Mutation	novel	G182D	0.14
UCEC	chr16	30069936	Silent	rs200761497	Y302Y	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.0556	0.23475
LUAD	AMP	0.2461	0.20955

Survival Analysis

Cancer	P-value	Q-value
THYM	0.035	Kaplan-Meier Survival Analysis
MESO	0.027	Kaplan-Meier Survival Analysis
HNSC	0.0093	Kaplan-Meier Survival Analysis
SKCM	0.0059	Kaplan-Meier Survival Analysis
BRCA	0.028	Kaplan-Meier Survival Analysis
COAD	0.044	Kaplan-Meier Survival Analysis
BLCA	0.032	Kaplan-Meier Survival Analysis
LAML	0.0022	Kaplan-Meier Survival Analysis
GBM	0.018	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.044	Kaplan-Meier Survival Analysis
CHOL	0.034	Kaplan-Meier Survival Analysis
THCA	0.0018	Kaplan-Meier Survival Analysis
LUAD	0.00019	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742