EuRBPDB

Description

Ensembl ID: ENSG00000150768 (Gene tree)
Gene ID: 1737
Gene Symbol: DLAT
Alias: PDC-E2|E2|DLTA
Full Name: dihydrolipoamide S-acetyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 39,577 bases
Position: chr11:112,024,814-112,064,390
Accession: 2896
RBP type: non-canonical RBP
Summary: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000533297	DLAT-205	2118	-	ENSP00000435374	65 (aa)	-	E9PKC7
ENST00000393051	DLAT-202	3517	-	ENSP00000376771	542 (aa)	-	E9PEJ4
ENST00000280346	DLAT-201	4458	XM_011542647	ENSP00000280346	647 (aa)	XP_011540949	P10515
ENST00000527231	DLAT-203	581	-	-	- (aa)	-	-
ENST00000531306	DLAT-204	1766	-	ENSP00000433432	479 (aa)	-	H0YDD4

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa00620	Pyruvate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000150768	DLAT	91	57.301	WBGene00009082	dlat-1	87	57.883	Caenorhabditis_elegans
ENSG00000150768	DLAT	94	43.524	YNL071W	LAT1	98	46.018	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	9045657.	IDA	Function
GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	3191998.	NAS	Function
GO:0005515	protein binding	15861126.18206651.25525879.	IPI	Function
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005967	mitochondrial pyruvate dehydrogenase complex	3191998.	NAS	Component
GO:0006006	glucose metabolic process	-	IEA	Process
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	-	IEA	Process
GO:0006090	pyruvate metabolic process	-	TAS	Process
GO:0006099	tricarboxylic acid cycle	-	IEA	Process
GO:0030431	sleep	-	IEA	Process
GO:0034604	pyruvate dehydrogenase (NAD+) activity	9045657.	IC	Function
GO:0034604	pyruvate dehydrogenase (NAD+) activity	9242632.	IDA	Function
GO:0042802	identical protein binding	18184587.18184588.	IPI	Function
GO:0045254	pyruvate dehydrogenase complex	9242632.25525879.	IDA	Component