EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000150991 (Gene tree)
Gene ID: 7316
Gene Symbol: UBC
Alias: N
Full Name: ubiquitin C
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 5,765 bases
Position: chr12:124,911,604-124,917,368
Accession: 12468
RBP type: non-canonical RBP
Summary: This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000546120	UBC-213	718	-	ENSP00000438394	229 (aa)	-	Q5PY61
ENST00000541645	UBC-210	548	-	ENSP00000445337	155 (aa)	-	F5H388
ENST00000535131	UBC-202	563	-	ENSP00000439492	149 (aa)	-	F5H265
ENST00000535859	UBC-203	582	-	ENSP00000437452	122 (aa)	-	F5H6Q2
ENST00000540700	UBC-208	627	-	ENSP00000441238	134 (aa)	-	F5GYU3
ENST00000538617	UBC-206	1303	-	ENSP00000443053	305 (aa)	-	Q96C32
ENST00000541272	UBC-209	582	-	ENSP00000440205	169 (aa)	-	F5GXK7
ENST00000339647	UBC-201	2688	-	ENSP00000344818	685 (aa)	-	P0CG48
ENST00000540351	UBC-207	622	-	ENSP00000442800	160 (aa)	-	F5H747
ENST00000536661	UBC-204	624	-	-	- (aa)	-	-
ENST00000544481	UBC-212	477	-	-	- (aa)	-	-
ENST00000546271	UBC-214	559	-	ENSP00000438289	136 (aa)	-	F5H2Z3
ENST00000536769	UBC-205	3745	-	ENSP00000441543	685 (aa)	-	P0CG48
ENST00000542416	UBC-211	517	-	ENSP00000441556	61 (aa)	-	F5GZ39

Gene Model

Click here to download ENSG00000150991's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03320	PPAR signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000150991's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000150991	UBC	100	98.817	WBGene00006727	ubq-1	99	98.817	Caenorhabditis_elegans
ENSG00000150991	UBC	100	100.000	ENSMUSG00000008348	Ubc	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0000187	activation of MAPK activity	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	Process
GO:0000717	nucleotide-excision repair, DNA duplex unwinding	-	TAS	Process
GO:0002020	protease binding	21185309.	IPI	Function
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	-	TAS	Process
GO:0002756	MyD88-independent toll-like receptor signaling pathway	-	TAS	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	8702753.16256071.16424905.16482222.16763556.16810318.16845370.16874300.16874301.16936636.16996503.17006543.17028573.17067581.17070805.17110928.17139261.17159902.17170702.17183367.17255943.17268548.17290220.17304240.17318174.17318178.17320083.17363902.17363905.17568776.17703191.17948050.18239685.18309296.18388957.18539148.18539162.18566587.18566590.18680311.19026640.19098711.19111546.19111555.19131971.19153604.19166840.19233177.19262565.19285159.19322197.19322201.19373254.19376117.19407811.19427866.19536131.19619542.19680224.19763089.19779455.19796170.19798103.19820695.19909340.20006610.20059542.20150893.20395957.20491914.20495530.20601937.20936779.21150319.21900206.22795130.24879152.	IPI	Function
GO:0005615	extracellular space	16502470.	HDA	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005741	mitochondrial outer membrane	-	TAS	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	Process
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	Process
GO:0006625	protein targeting to peroxisome	-	TAS	Process
GO:0007179	transforming growth factor beta receptor signaling pathway	-	TAS	Process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	Process
GO:0007254	JNK cascade	-	TAS	Process
GO:0010008	endosome membrane	-	TAS	Component
GO:0016055	Wnt signaling pathway	-	TAS	Process
GO:0016197	endosomal transport	-	TAS	Process
GO:0016567	protein ubiquitination	21873635.	IBA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0019058	viral life cycle	-	TAS	Process
GO:0019068	virion assembly	-	TAS	Process
GO:0019221	cytokine-mediated signaling pathway	-	TAS	Process
GO:0019941	modification-dependent protein catabolic process	21873635.	IBA	Process
GO:0019985	translesion synthesis	-	TAS	Process
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	TAS	Process
GO:0030666	endocytic vesicle membrane	-	TAS	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031386	protein tag	21873635.	IBA	Function
GO:0031625	ubiquitin protein ligase binding	21873635.	IBA	Function
GO:0031982	vesicle	19190083.	HDA	Component
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	Process
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	-	TAS	Process
GO:0036297	interstrand cross-link repair	-	TAS	Process
GO:0042276	error-prone translesion synthesis	-	TAS	Process
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	Process
GO:0043065	positive regulation of apoptotic process	-	TAS	Process
GO:0043066	negative regulation of apoptotic process	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043657	host cell	-	IEA	Component
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	Process
GO:0051403	stress-activated MAPK cascade	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0070911	global genome nucleotide-excision repair	-	TAS	Process
GO:0070987	error-free translesion synthesis	-	TAS	Process
GO:0075733	intracellular transport of virus	-	TAS	Process