EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000151065 (Gene tree)
Gene ID: 196513
Gene Symbol: DCP1B
Alias: FLJ31638
Full Name: decapping mRNA 1B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 58,488 bases
Position: chr12:1,946,048-2,004,535
Accession: 24451
RBP type: canonical RBP
Summary: This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000280665	DCP1	PF06058.13	2.7e-43	1	1
ENSP00000482714	DCP1	PF06058.13	5.6e-34	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16177138	A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.	RNA	2005 Nov	Rehwinkel J	-
18643965	Plant stress granules and mRNA processing bodies are distinct from heat stress granules.	Plant J	2008 Nov	Weber C	doi: 10.1111/j.1365-313X.2008.03623.x
27183195	Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.	Nat Struct Mol Biol	2016 Jun	Valkov E	doi: 10.1038/nsmb.3232
31231973	Pat1 RNA-binding proteins: Multitasking shuttling proteins.	Wiley Interdiscip Rev RNA	2019 Jun 24:e1557	Vindry C	doi: 10.1002/wrna.1557
18280238	mRNA decapping is promoted by an RNA-binding channel in Dcp2.	Mol Cell	2008 Feb 15	Deshmukh MV	doi: 10.1016/j.molcel.2007.11.027.
28089630	The Aspergillus nidulans Pbp1 homolog is required for normal sexual development and secondary metabolism.	Fungal Genet Biol	2017 Mar	Soukup AA	doi: 10.1016/j.fgb.2017.01.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000540622	DCP1B-205	1547	-	ENSP00000444374	390 (aa)	-	F5GZK9
ENST00000537725	DCP1B-204	598	-	-	- (aa)	-	-
ENST00000535873	DCP1B-202	2231	-	ENSP00000482714	153 (aa)	-	B4DVJ6
ENST00000541700	DCP1B-206	948	-	-	- (aa)	-	-
ENST00000536665	DCP1B-203	839	-	-	- (aa)	-	-
ENST00000280665	DCP1B-201	2086	XM_011520927	ENSP00000280665	617 (aa)	XP_011519229	Q8IZD4
ENST00000543381	DCP1B-207	2073	-	ENSP00000445011	119 (aa)	-	F5H4R4

Gene Model

Click here to download ENSG00000151065's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000151065	Hemoglobin A, Glycosylated	2.8130000E-005	19875614
ENSG00000151065	gemcitabine	8E-6	22142827
ENSG00000151065	Pancreatic Carcinoma	8E-6	22142827
ENSG00000151065	Insulin-Like Growth Factor I	8E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000151065	rs10505725	12	1947197	A	Obesity-related traits	23251661	[NR] ng/mL increase	0.03	EFO_0004627
ENSG00000151065	rs11062040	12	1982091	A	Response to gemcitabine in pancreatic cancer	22142827	[1.20-1.70]	1.4	GO_0036272\|EFO_0002618
ENSG00000151065	rs11062040	12	1982091	A	Survival in pancreatic cancer	28470677	[1.2-1.7]	1.4	EFO_0000638\|EFO_0002618

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000151065's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000151065	DCP1B	82	67.347	ENSG00000272886	DCP1A	98	67.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000151065	DCP1B	89	79.817	ENSAPOG00000009617	dcp1b	98	43.323	Acanthochromis_polyacanthus
ENSG00000151065	DCP1B	99	83.251	ENSAMEG00000004141	DCP1B	98	83.087	Ailuropoda_melanoleuca
ENSG00000151065	DCP1B	90	79.439	ENSACIG00000018524	-	100	77.391	Amphilophus_citrinellus
ENSG00000151065	DCP1B	89	79.817	ENSAOCG00000024199	dcp1b	98	41.837	Amphiprion_ocellaris
ENSG00000151065	DCP1B	89	79.817	ENSAPEG00000004530	dcp1b	98	42.507	Amphiprion_percula
ENSG00000151065	DCP1B	89	80.734	ENSATEG00000015045	dcp1b	77	48.541	Anabas_testudineus
ENSG00000151065	DCP1B	88	88.571	ENSAPLG00000004762	DCP1B	99	70.016	Anas_platyrhynchos
ENSG00000151065	DCP1B	82	92.784	ENSACAG00000005541	DCP1B	96	67.829	Anolis_carolinensis
ENSG00000151065	DCP1B	100	95.425	ENSANAG00000025391	DCP1B	100	95.425	Aotus_nancymaae
ENSG00000151065	DCP1B	80	84.211	ENSACLG00000026164	dcp1b	86	54.192	Astatotilapia_calliptera
ENSG00000151065	DCP1B	89	79.817	ENSAMXG00000007683	dcp1b	99	46.190	Astyanax_mexicanus
ENSG00000151065	DCP1B	85	95.050	ENSBTAG00000030285	DCP1B	99	69.044	Bos_taurus
ENSG00000151065	DCP1B	100	91.922	ENSCJAG00000039529	DCP1B	97	91.922	Callithrix_jacchus
ENSG00000151065	DCP1B	89	100.000	ENSCAFG00000015993	DCP1B	100	83.981	Canis_familiaris
ENSG00000151065	DCP1B	89	100.000	ENSCAFG00020012014	DCP1B	100	83.981	Canis_lupus_dingo
ENSG00000151065	DCP1B	81	94.792	ENSCHIG00000014193	DCP1B	99	68.882	Capra_hircus
ENSG00000151065	DCP1B	89	98.113	ENSTSYG00000008455	DCP1B	100	86.386	Carlito_syrichta
ENSG00000151065	DCP1B	92	58.070	ENSCAPG00000012066	DCP1B	100	58.772	Cavia_aperea
ENSG00000151065	DCP1B	89	97.170	ENSCPOG00000005279	DCP1B	99	73.333	Cavia_porcellus
ENSG00000151065	DCP1B	100	94.771	ENSCCAG00000026870	DCP1B	100	94.771	Cebus_capucinus
ENSG00000151065	DCP1B	100	96.732	ENSCATG00000031397	DCP1B	100	96.732	Cercocebus_atys
ENSG00000151065	DCP1B	90	99.065	ENSCLAG00000009657	-	92	99.065	Chinchilla_lanigera
ENSG00000151065	DCP1B	100	94.165	ENSCSAG00000011349	DCP1B	100	94.165	Chlorocebus_sabaeus
ENSG00000151065	DCP1B	98	79.058	ENSCHOG00000003452	DCP1B	100	77.758	Choloepus_hoffmanni
ENSG00000151065	DCP1B	80	95.789	ENSCPBG00000027442	DCP1B	100	70.436	Chrysemys_picta_bellii
ENSG00000151065	DCP1B	87	62.136	ENSCING00000014281	-	81	43.033	Ciona_intestinalis
ENSG00000151065	DCP1B	100	96.078	ENSCANG00000036019	DCP1B	100	96.078	Colobus_angolensis_palliatus
ENSG00000151065	DCP1B	88	92.381	ENSCGRG00001016549	Dcp1b	99	63.269	Cricetulus_griseus_chok1gshd
ENSG00000151065	DCP1B	98	56.848	ENSCGRG00000013122	Dcp1b	99	61.444	Cricetulus_griseus_crigri
ENSG00000151065	DCP1B	88	80.952	ENSCSEG00000009048	dcp1b	58	49.351	Cynoglossus_semilaevis
ENSG00000151065	DCP1B	80	86.316	ENSCVAG00000015026	dcp1b	79	52.199	Cyprinodon_variegatus
ENSG00000151065	DCP1B	89	71.698	ENSDARG00000045484	dcp1b	87	54.545	Danio_rerio
ENSG00000151065	DCP1B	89	100.000	ENSDNOG00000003156	DCP1B	100	81.230	Dasypus_novemcinctus
ENSG00000151065	DCP1B	89	99.057	ENSETEG00000005873	DCP1B	89	99.057	Echinops_telfairi
ENSG00000151065	DCP1B	78	67.742	ENSEBUG00000007205	-	74	67.742	Eptatretus_burgeri
ENSG00000151065	DCP1B	89	100.000	ENSEASG00005008434	DCP1B	89	86.872	Equus_asinus_asinus
ENSG00000151065	DCP1B	89	100.000	ENSECAG00000018293	DCP1B	100	86.548	Equus_caballus
ENSG00000151065	DCP1B	92	60.000	ENSEEUG00000007906	DCP1B	100	59.825	Erinaceus_europaeus
ENSG00000151065	DCP1B	89	83.486	ENSELUG00000011344	dcp1b	95	44.224	Esox_lucius
ENSG00000151065	DCP1B	89	100.000	ENSFCAG00000004819	DCP1B	100	86.224	Felis_catus
ENSG00000151065	DCP1B	98	64.491	ENSFALG00000003240	DCP1B	100	68.566	Ficedula_albicollis
ENSG00000151065	DCP1B	89	98.113	ENSFDAG00000018093	DCP1B	100	77.310	Fukomys_damarensis
ENSG00000151065	DCP1B	82	84.694	ENSFHEG00000019846	dcp1b	80	50.000	Fundulus_heteroclitus
ENSG00000151065	DCP1B	80	94.737	ENSGALG00000050288	DCP1B	99	71.961	Gallus_gallus
ENSG00000151065	DCP1B	88	78.095	ENSGAFG00000016200	dcp1b	81	49.030	Gambusia_affinis
ENSG00000151065	DCP1B	90	79.091	ENSGACG00000019692	dcp1b	98	45.312	Gasterosteus_aculeatus
ENSG00000151065	DCP1B	88	91.429	ENSGAGG00000014114	DCP1B	99	70.712	Gopherus_agassizii
ENSG00000151065	DCP1B	100	99.160	ENSGGOG00000010659	DCP1B	100	99.160	Gorilla_gorilla
ENSG00000151065	DCP1B	80	83.158	ENSHBUG00000006101	dcp1b	75	52.695	Haplochromis_burtoni
ENSG00000151065	DCP1B	89	98.113	ENSHGLG00000019233	DCP1B	100	76.661	Heterocephalus_glaber_female
ENSG00000151065	DCP1B	89	97.170	ENSHGLG00100007645	DCP1B	100	76.499	Heterocephalus_glaber_male
ENSG00000151065	DCP1B	77	88.043	ENSHCOG00000014509	dcp1b	98	40.865	Hippocampus_comes
ENSG00000151065	DCP1B	89	100.000	ENSSTOG00000027287	DCP1B	100	82.126	Ictidomys_tridecemlineatus
ENSG00000151065	DCP1B	92	90.909	ENSJJAG00000019553	-	88	93.519	Jaculus_jaculus
ENSG00000151065	DCP1B	86	94.118	ENSJJAG00000020843	-	85	94.118	Jaculus_jaculus
ENSG00000151065	DCP1B	94	78.571	ENSKMAG00000014961	dcp1b	75	80.734	Kryptolebias_marmoratus
ENSG00000151065	DCP1B	98	75.833	ENSLBEG00000015902	-	98	75.833	Labrus_bergylta
ENSG00000151065	DCP1B	80	93.684	ENSLACG00000017357	DCP1B	98	55.825	Latimeria_chalumnae
ENSG00000151065	DCP1B	87	86.408	ENSLOCG00000016629	dcp1b	97	51.189	Lepisosteus_oculatus
ENSG00000151065	DCP1B	100	96.078	ENSMFAG00000028687	DCP1B	100	96.078	Macaca_fascicularis
ENSG00000151065	DCP1B	100	95.462	ENSMMUG00000010992	DCP1B	100	95.462	Macaca_mulatta
ENSG00000151065	DCP1B	100	96.078	ENSMNEG00000045219	DCP1B	100	96.078	Macaca_nemestrina
ENSG00000151065	DCP1B	100	96.732	ENSMLEG00000036414	DCP1B	100	96.732	Mandrillus_leucophaeus
ENSG00000151065	DCP1B	89	79.817	ENSMAMG00000010519	dcp1b	79	45.301	Mastacembelus_armatus
ENSG00000151065	DCP1B	80	84.211	ENSMZEG00005007893	dcp1b	86	54.192	Maylandia_zebra
ENSG00000151065	DCP1B	80	94.737	ENSMGAG00000013437	DCP1B	99	67.794	Meleagris_gallopavo
ENSG00000151065	DCP1B	88	90.476	ENSMAUG00000000763	Dcp1b	99	61.774	Mesocricetus_auratus
ENSG00000151065	DCP1B	89	98.113	ENSMICG00000005702	DCP1B	100	82.334	Microcebus_murinus
ENSG00000151065	DCP1B	88	93.333	ENSMOCG00000016799	Dcp1b	99	64.355	Microtus_ochrogaster
ENSG00000151065	DCP1B	93	79.279	ENSMMOG00000002213	-	99	78.070	Mola_mola
ENSG00000151065	DCP1B	89	100.000	ENSMODG00000018424	DCP1B	99	76.960	Monodelphis_domestica
ENSG00000151065	DCP1B	96	78.632	ENSMALG00000014869	-	94	67.376	Monopterus_albus
ENSG00000151065	DCP1B	88	92.381	MGP_CAROLIEiJ_G0028789	Dcp1b	99	63.636	Mus_caroli
ENSG00000151065	DCP1B	82	92.784	ENSMUSG00000041477	Dcp1b	100	63.533	Mus_musculus
ENSG00000151065	DCP1B	82	92.784	MGP_PahariEiJ_G0022544	Dcp1b	99	63.446	Mus_pahari
ENSG00000151065	DCP1B	88	92.381	MGP_SPRETEiJ_G0029821	Dcp1b	99	63.754	Mus_spretus
ENSG00000151065	DCP1B	89	99.057	ENSMPUG00000018069	DCP1B	100	83.144	Mustela_putorius_furo
ENSG00000151065	DCP1B	98	78.010	ENSMLUG00000002252	DCP1B	100	81.305	Myotis_lucifugus
ENSG00000151065	DCP1B	89	95.283	ENSNGAG00000022519	Dcp1b	99	67.532	Nannospalax_galili
ENSG00000151065	DCP1B	80	84.211	ENSNBRG00000004185	dcp1b	93	81.633	Neolamprologus_brichardi
ENSG00000151065	DCP1B	100	98.693	ENSNLEG00000002698	DCP1B	100	98.693	Nomascus_leucogenys
ENSG00000151065	DCP1B	89	100.000	ENSMEUG00000003431	DCP1B	86	92.000	Notamacropus_eugenii
ENSG00000151065	DCP1B	89	97.170	ENSOPRG00000003721	DCP1B	99	62.742	Ochotona_princeps
ENSG00000151065	DCP1B	100	86.555	ENSODEG00000001245	-	96	77.037	Octodon_degus
ENSG00000151065	DCP1B	100	92.437	ENSODEG00000013181	-	96	82.963	Octodon_degus
ENSG00000151065	DCP1B	91	88.889	ENSOANG00000012232	-	95	83.088	Ornithorhynchus_anatinus
ENSG00000151065	DCP1B	89	100.000	ENSOCUG00000011593	DCP1B	100	73.948	Oryctolagus_cuniculus
ENSG00000151065	DCP1B	86	81.373	ENSORLG00000014000	dcp1b	79	49.185	Oryzias_latipes
ENSG00000151065	DCP1B	86	81.373	ENSORLG00020016483	dcp1b	79	50.138	Oryzias_latipes_hni
ENSG00000151065	DCP1B	87	81.553	ENSORLG00015015461	dcp1b	79	81.553	Oryzias_latipes_hsok
ENSG00000151065	DCP1B	86	81.373	ENSOMEG00000009287	dcp1b	99	41.642	Oryzias_melastigma
ENSG00000151065	DCP1B	89	98.113	ENSOGAG00000031515	DCP1B	100	82.848	Otolemur_garnettii
ENSG00000151065	DCP1B	78	96.774	ENSOARG00000012960	DCP1B	99	67.532	Ovis_aries
ENSG00000151065	DCP1B	100	99.160	ENSPPAG00000031510	DCP1B	100	99.160	Pan_paniscus
ENSG00000151065	DCP1B	89	100.000	ENSPPRG00000023318	DCP1B	100	86.710	Panthera_pardus
ENSG00000151065	DCP1B	89	100.000	ENSPTIG00000021851	DCP1B	100	86.710	Panthera_tigris_altaica
ENSG00000151065	DCP1B	100	99.160	ENSPTRG00000004525	DCP1B	100	99.160	Pan_troglodytes
ENSG00000151065	DCP1B	100	96.732	ENSPANG00000008311	DCP1B	100	96.732	Papio_anubis
ENSG00000151065	DCP1B	92	78.761	ENSPKIG00000000520	dcp1b	100	47.582	Paramormyrops_kingsleyae
ENSG00000151065	DCP1B	80	93.750	ENSPSIG00000009160	DCP1B	99	69.032	Pelodiscus_sinensis
ENSG00000151065	DCP1B	87	82.524	ENSPMGG00000004607	-	93	80.000	Periophthalmus_magnuspinnatus
ENSG00000151065	DCP1B	88	91.429	ENSPEMG00000019470	Dcp1b	99	64.620	Peromyscus_maniculatus_bairdii
ENSG00000151065	DCP1B	77	76.087	ENSPMAG00000005651	-	83	72.269	Petromyzon_marinus
ENSG00000151065	DCP1B	89	100.000	ENSPCIG00000019743	DCP1B	99	77.760	Phascolarctos_cinereus
ENSG00000151065	DCP1B	88	80.000	ENSPFOG00000005090	dcp1b	81	52.695	Poecilia_formosa
ENSG00000151065	DCP1B	82	84.694	ENSPLAG00000005883	dcp1b	95	41.840	Poecilia_latipinna
ENSG00000151065	DCP1B	89	79.439	ENSPMEG00000001391	dcp1b	81	50.000	Poecilia_mexicana
ENSG00000151065	DCP1B	88	80.000	ENSPREG00000004280	dcp1b	81	50.139	Poecilia_reticulata
ENSG00000151065	DCP1B	98	96.335	ENSPPYG00000004145	DCP1B	100	97.053	Pongo_abelii
ENSG00000151065	DCP1B	95	100.000	ENSPCOG00000026128	DCP1B	100	100.000	Propithecus_coquereli
ENSG00000151065	DCP1B	89	98.113	ENSPVAG00000001978	DCP1B	100	84.603	Pteropus_vampyrus
ENSG00000151065	DCP1B	80	84.211	ENSPNYG00000020418	dcp1b	77	50.139	Pundamilia_nyererei
ENSG00000151065	DCP1B	50	47.619	ENSPNAG00000003792	dcp1b	74	45.667	Pygocentrus_nattereri
ENSG00000151065	DCP1B	88	94.286	ENSRNOG00000007340	Dcp1b	99	63.857	Rattus_norvegicus
ENSG00000151065	DCP1B	100	96.078	ENSRBIG00000032794	DCP1B	100	96.078	Rhinopithecus_bieti
ENSG00000151065	DCP1B	100	96.078	ENSRROG00000041000	DCP1B	100	96.078	Rhinopithecus_roxellana
ENSG00000151065	DCP1B	100	94.118	ENSSBOG00000033086	DCP1B	100	94.118	Saimiri_boliviensis_boliviensis
ENSG00000151065	DCP1B	98	69.634	ENSSHAG00000012569	DCP1B	99	73.750	Sarcophilus_harrisii
ENSG00000151065	DCP1B	89	80.734	ENSSFOG00015023556	dcp1b	100	47.442	Scleropages_formosus
ENSG00000151065	DCP1B	89	81.651	ENSSMAG00000000547	dcp1b	80	45.679	Scophthalmus_maximus
ENSG00000151065	DCP1B	89	81.651	ENSSDUG00000004916	dcp1b	87	54.762	Seriola_dumerili
ENSG00000151065	DCP1B	99	77.236	ENSSLDG00000008782	dcp1b	99	77.236	Seriola_lalandi_dorsalis
ENSG00000151065	DCP1B	87	91.262	ENSSARG00000005668	-	50	91.667	Sorex_araneus
ENSG00000151065	DCP1B	87	89.423	ENSSPUG00000009607	-	86	90.654	Sphenodon_punctatus
ENSG00000151065	DCP1B	97	77.966	ENSSPAG00000008731	-	100	77.966	Stegastes_partitus
ENSG00000151065	DCP1B	78	95.699	ENSSSCG00000023976	-	91	92.453	Sus_scrofa
ENSG00000151065	DCP1B	76	53.333	ENSSSCG00000038481	-	95	53.125	Sus_scrofa
ENSG00000151065	DCP1B	82	89.691	ENSTGUG00000012575	DCP1B	100	70.492	Taeniopygia_guttata
ENSG00000151065	DCP1B	83	82.828	ENSTRUG00000016408	dcp1b	85	60.851	Takifugu_rubripes
ENSG00000151065	DCP1B	81	84.375	ENSTNIG00000007579	dcp1b	99	41.562	Tetraodon_nigroviridis
ENSG00000151065	DCP1B	87	93.269	ENSTTRG00000003017	-	53	86.175	Tursiops_truncatus
ENSG00000151065	DCP1B	98	82.906	ENSUAMG00000017535	-	86	87.963	Ursus_americanus
ENSG00000151065	DCP1B	98	81.414	ENSUMAG00000011668	DCP1B	100	82.873	Ursus_maritimus
ENSG00000151065	DCP1B	96	84.211	ENSVVUG00000019477	-	93	84.211	Vulpes_vulpes
ENSG00000151065	DCP1B	89	98.113	ENSVVUG00000020529	DCP1B	100	83.010	Vulpes_vulpes
ENSG00000151065	DCP1B	90	84.112	ENSXETG00000000899	dcp1b	98	55.574	Xenopus_tropicalis
ENSG00000151065	DCP1B	97	75.862	ENSXCOG00000013593	-	94	77.570	Xiphophorus_couchianus
ENSG00000151065	DCP1B	88	80.000	ENSXMAG00000011153	dcp1b	81	49.307	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	IEA	Process
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	21873635.	IBA	Process
GO:0000932	P-body	21873635.	IBA	Component
GO:0005515	protein binding	15231747.16364915.19966221.21516116.25036637.25416956.26133670.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008047	enzyme activator activity	-	IEA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016787	hydrolase activity	-	IEA	Function
GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA	21873635.	IBA	Process
GO:0043085	positive regulation of catalytic activity	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	-	TAS	Process