EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000151304 (Gene tree)
Gene ID: 153443
Gene Symbol: SRFBP1
Alias: FLJ25286|p49|STRAP|BUD22|Rlb1
Full Name: serum response factor binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 113,610 bases
Position: chr5:121,961,961-122,075,570
Accession: 26333
RBP type: canonical RBP
Summary: (Serum Response Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with SRFBP1 include Aortic Aneurysm, Familial Thoracic 10.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000341324	BUD22	PF09073.10	2.1e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000504881	SRFBP1-202	567	-	-	- (aa)	-	-
ENST00000339397	SRFBP1-201	2855	XM_017009111	ENSP00000341324	429 (aa)	XP_016864600	Q8NEF9

Gene Model

Click here to download ENSG00000151304's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000151304	Heart Failure	8.8698022E-004	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000151304	rs113075218	5	122026055	A	Coronary artery disease	29212778	[0.029-0.061] unit increase	0.0448	EFO_0000378
ENSG00000151304	rs10059661	5	122074834	C	Lung function (FEV1/FVC)	30804560	[0.025-0.037] unit decrease	0.0308	EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000151304's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000151304	SRFBP1	99	78.638	ENSAMEG00000018050	SRFBP1	99	78.873	Ailuropoda_melanoleuca
ENSG00000151304	SRFBP1	99	39.720	ENSACIG00000019127	-	99	40.826	Amphilophus_citrinellus
ENSG00000151304	SRFBP1	74	69.444	ENSAOCG00000002182	-	64	62.295	Amphiprion_ocellaris
ENSG00000151304	SRFBP1	74	69.444	ENSAPEG00000003041	-	84	35.352	Amphiprion_percula
ENSG00000151304	SRFBP1	99	37.576	ENSATEG00000007289	-	85	37.374	Anabas_testudineus
ENSG00000151304	SRFBP1	100	44.543	ENSACAG00000003779	SRFBP1	100	44.346	Anolis_carolinensis
ENSG00000151304	SRFBP1	100	91.142	ENSANAG00000022485	SRFBP1	100	91.142	Aotus_nancymaae
ENSG00000151304	SRFBP1	99	37.247	ENSACLG00000013909	-	88	37.500	Astatotilapia_calliptera
ENSG00000151304	SRFBP1	78	50.000	ENSAMXG00000040976	srfbp1	92	50.000	Astyanax_mexicanus
ENSG00000151304	SRFBP1	100	76.457	ENSBTAG00000014320	SRFBP1	100	76.690	Bos_taurus
ENSG00000151304	SRFBP1	100	90.210	ENSCJAG00000017177	SRFBP1	100	90.210	Callithrix_jacchus
ENSG00000151304	SRFBP1	100	78.372	ENSCAFG00000000512	SRFBP1	100	78.605	Canis_familiaris
ENSG00000151304	SRFBP1	100	78.372	ENSCAFG00020009389	SRFBP1	100	78.605	Canis_lupus_dingo
ENSG00000151304	SRFBP1	97	59.952	ENSTSYG00000006869	-	99	59.952	Carlito_syrichta
ENSG00000151304	SRFBP1	99	79.812	ENSTSYG00000008630	-	99	79.812	Carlito_syrichta
ENSG00000151304	SRFBP1	100	75.463	ENSCPOG00000004695	SRFBP1	100	75.231	Cavia_porcellus
ENSG00000151304	SRFBP1	100	91.375	ENSCCAG00000032237	-	100	91.375	Cebus_capucinus
ENSG00000151304	SRFBP1	100	96.037	ENSCATG00000040904	SRFBP1	100	96.037	Cercocebus_atys
ENSG00000151304	SRFBP1	100	73.086	ENSCLAG00000003630	SRFBP1	100	73.086	Chinchilla_lanigera
ENSG00000151304	SRFBP1	100	93.256	ENSCSAG00000014636	SRFBP1	100	94.186	Chlorocebus_sabaeus
ENSG00000151304	SRFBP1	100	94.406	ENSCANG00000041298	SRFBP1	100	94.406	Colobus_angolensis_palliatus
ENSG00000151304	SRFBP1	100	72.158	ENSCGRG00001000718	Srfbp1	98	72.158	Cricetulus_griseus_chok1gshd
ENSG00000151304	SRFBP1	97	71.394	ENSCGRG00000010837	Srfbp1	100	71.394	Cricetulus_griseus_crigri
ENSG00000151304	SRFBP1	100	40.319	ENSCSEG00000011789	-	99	41.163	Cynoglossus_semilaevis
ENSG00000151304	SRFBP1	99	40.189	ENSCVAG00000013010	-	97	39.906	Cyprinodon_variegatus
ENSG00000151304	SRFBP1	79	72.941	ENSDNOG00000017733	SRFBP1	100	72.941	Dasypus_novemcinctus
ENSG00000151304	SRFBP1	79	65.487	ENSETEG00000012408	SRFBP1	100	65.782	Echinops_telfairi
ENSG00000151304	SRFBP1	72	46.923	ENSEBUG00000007806	SRFBP1	58	46.923	Eptatretus_burgeri
ENSG00000151304	SRFBP1	100	81.119	ENSEASG00005012421	SRFBP1	100	81.119	Equus_asinus_asinus
ENSG00000151304	SRFBP1	100	80.653	ENSECAG00000015330	SRFBP1	100	79.720	Equus_caballus
ENSG00000151304	SRFBP1	100	67.209	ENSEEUG00000011514	SRFBP1	100	67.442	Erinaceus_europaeus
ENSG00000151304	SRFBP1	99	38.612	ENSELUG00000018381	-	97	39.140	Esox_lucius
ENSG00000151304	SRFBP1	100	80.653	ENSFCAG00000035118	SRFBP1	100	80.886	Felis_catus
ENSG00000151304	SRFBP1	97	42.986	ENSFALG00000007595	SRFBP1	100	43.891	Ficedula_albicollis
ENSG00000151304	SRFBP1	100	71.824	ENSFDAG00000005102	SRFBP1	100	71.824	Fukomys_damarensis
ENSG00000151304	SRFBP1	68	58.621	ENSGMOG00000012729	-	85	35.682	Gadus_morhua
ENSG00000151304	SRFBP1	99	44.866	ENSGALG00000005316	SRFBP1	99	45.536	Gallus_gallus
ENSG00000151304	SRFBP1	66	42.088	ENSGAFG00000018777	-	87	36.145	Gambusia_affinis
ENSG00000151304	SRFBP1	99	39.863	ENSGACG00000009055	-	83	39.863	Gasterosteus_aculeatus
ENSG00000151304	SRFBP1	97	47.260	ENSGAGG00000024915	SRFBP1	99	47.926	Gopherus_agassizii
ENSG00000151304	SRFBP1	100	97.669	ENSGGOG00000007725	SRFBP1	100	97.669	Gorilla_gorilla
ENSG00000151304	SRFBP1	100	76.334	ENSSTOG00000029184	SRFBP1	98	76.334	Ictidomys_tridecemlineatus
ENSG00000151304	SRFBP1	97	63.221	ENSJJAG00000013229	Srfbp1	100	63.221	Jaculus_jaculus
ENSG00000151304	SRFBP1	99	38.495	ENSLBEG00000013924	-	97	38.495	Labrus_bergylta
ENSG00000151304	SRFBP1	79	39.118	ENSLACG00000004456	SRFBP1	100	39.669	Latimeria_chalumnae
ENSG00000151304	SRFBP1	100	42.457	ENSLOCG00000008772	SRFBP1	100	42.457	Lepisosteus_oculatus
ENSG00000151304	SRFBP1	100	80.046	ENSLAFG00000015303	SRFBP1	98	80.046	Loxodonta_africana
ENSG00000151304	SRFBP1	100	95.804	ENSMFAG00000031263	SRFBP1	100	95.804	Macaca_fascicularis
ENSG00000151304	SRFBP1	100	95.804	ENSMMUG00000021009	SRFBP1	100	95.804	Macaca_mulatta
ENSG00000151304	SRFBP1	100	95.804	ENSMNEG00000040870	SRFBP1	100	95.804	Macaca_nemestrina
ENSG00000151304	SRFBP1	89	80.000	ENSMAMG00000004632	-	87	38.677	Mastacembelus_armatus
ENSG00000151304	SRFBP1	99	38.351	ENSMZEG00005000432	-	88	38.604	Maylandia_zebra
ENSG00000151304	SRFBP1	97	71.053	ENSMAUG00000009431	Srfbp1	95	71.053	Mesocricetus_auratus
ENSG00000151304	SRFBP1	100	80.186	ENSMICG00000042923	SRFBP1	100	80.186	Microcebus_murinus
ENSG00000151304	SRFBP1	99	68.998	ENSMOCG00000006206	Srfbp1	97	68.998	Microtus_ochrogaster
ENSG00000151304	SRFBP1	99	35.957	ENSMMOG00000021202	-	97	38.116	Mola_mola
ENSG00000151304	SRFBP1	100	59.817	ENSMODG00000013487	-	99	59.817	Monodelphis_domestica
ENSG00000151304	SRFBP1	89	75.000	ENSMALG00000001812	-	73	76.667	Monopterus_albus
ENSG00000151304	SRFBP1	100	68.837	MGP_CAROLIEiJ_G0022271	Srfbp1	98	69.070	Mus_caroli
ENSG00000151304	SRFBP1	100	66.821	ENSMUSG00000024528	Srfbp1	98	66.821	Mus_musculus
ENSG00000151304	SRFBP1	100	67.130	MGP_PahariEiJ_G0019004	Srfbp1	98	67.051	Mus_pahari
ENSG00000151304	SRFBP1	100	67.130	MGP_SPRETEiJ_G0023184	Srfbp1	98	67.130	Mus_spretus
ENSG00000151304	SRFBP1	97	78.744	ENSMPUG00000013031	SRFBP1	100	78.744	Mustela_putorius_furo
ENSG00000151304	SRFBP1	99	77.049	ENSMLUG00000009984	SRFBP1	100	77.283	Myotis_lucifugus
ENSG00000151304	SRFBP1	99	69.789	ENSNGAG00000013229	Srfbp1	99	69.789	Nannospalax_galili
ENSG00000151304	SRFBP1	99	39.462	ENSNBRG00000001146	-	98	39.909	Neolamprologus_brichardi
ENSG00000151304	SRFBP1	100	95.571	ENSNLEG00000011949	SRFBP1	100	95.571	Nomascus_leucogenys
ENSG00000151304	SRFBP1	66	71.818	ENSOPRG00000003881	-	83	71.818	Ochotona_princeps
ENSG00000151304	SRFBP1	97	73.077	ENSODEG00000007258	SRFBP1	100	73.077	Octodon_degus
ENSG00000151304	SRFBP1	86	48.205	ENSOANG00000010042	-	99	48.205	Ornithorhynchus_anatinus
ENSG00000151304	SRFBP1	100	77.156	ENSOCUG00000009556	SRFBP1	100	75.291	Oryctolagus_cuniculus
ENSG00000151304	SRFBP1	99	36.714	ENSORLG00000014234	-	88	37.323	Oryzias_latipes
ENSG00000151304	SRFBP1	99	35.701	ENSORLG00020020129	-	88	35.946	Oryzias_latipes_hni
ENSG00000151304	SRFBP1	99	39.683	ENSORLG00015000238	-	99	39.955	Oryzias_latipes_hsok
ENSG00000151304	SRFBP1	99	76.457	ENSOGAG00000032423	SRFBP1	100	76.457	Otolemur_garnettii
ENSG00000151304	SRFBP1	100	97.902	ENSPPAG00000035848	SRFBP1	100	97.902	Pan_paniscus
ENSG00000151304	SRFBP1	100	81.119	ENSPPRG00000001695	SRFBP1	100	81.352	Panthera_pardus
ENSG00000151304	SRFBP1	100	80.886	ENSPTIG00000012305	SRFBP1	100	81.119	Panthera_tigris_altaica
ENSG00000151304	SRFBP1	100	97.669	ENSPTRG00000017172	SRFBP1	100	97.669	Pan_troglodytes
ENSG00000151304	SRFBP1	100	93.706	ENSPANG00000003799	SRFBP1	100	95.105	Papio_anubis
ENSG00000151304	SRFBP1	99	35.446	ENSPKIG00000024291	-	99	35.050	Paramormyrops_kingsleyae
ENSG00000151304	SRFBP1	100	47.357	ENSPSIG00000010650	SRFBP1	99	47.357	Pelodiscus_sinensis
ENSG00000151304	SRFBP1	99	40.323	ENSPMGG00000001675	-	99	40.183	Periophthalmus_magnuspinnatus
ENSG00000151304	SRFBP1	100	61.239	ENSPCIG00000028532	SRFBP1	94	61.239	Phascolarctos_cinereus
ENSG00000151304	SRFBP1	99	39.696	ENSPFOG00000005272	-	87	39.785	Poecilia_formosa
ENSG00000151304	SRFBP1	98	35.800	ENSPLAG00000018282	-	87	37.673	Poecilia_latipinna
ENSG00000151304	SRFBP1	98	36.382	ENSPMEG00000020184	-	88	37.624	Poecilia_mexicana
ENSG00000151304	SRFBP1	98	40.783	ENSPREG00000017248	-	98	41.514	Poecilia_reticulata
ENSG00000151304	SRFBP1	100	96.503	ENSPPYG00000015714	SRFBP1	100	96.503	Pongo_abelii
ENSG00000151304	SRFBP1	100	80.886	ENSPCOG00000027331	SRFBP1	100	80.886	Propithecus_coquereli
ENSG00000151304	SRFBP1	58	87.013	ENSPVAG00000017512	-	58	87.013	Pteropus_vampyrus
ENSG00000151304	SRFBP1	99	40.183	ENSPNYG00000010355	-	99	39.773	Pundamilia_nyererei
ENSG00000151304	SRFBP1	71	52.985	ENSPNAG00000029666	srfbp1	91	52.985	Pygocentrus_nattereri
ENSG00000151304	SRFBP1	100	67.361	ENSRNOG00000014808	Srfbp1	98	67.361	Rattus_norvegicus
ENSG00000151304	SRFBP1	97	90.670	ENSRBIG00000031064	SRFBP1	99	90.670	Rhinopithecus_bieti
ENSG00000151304	SRFBP1	100	94.872	ENSRROG00000026932	SRFBP1	100	94.872	Rhinopithecus_roxellana
ENSG00000151304	SRFBP1	100	91.375	ENSSBOG00000015464	-	99	91.375	Saimiri_boliviensis_boliviensis
ENSG00000151304	SRFBP1	100	61.060	ENSSHAG00000016003	SRFBP1	99	61.060	Sarcophilus_harrisii
ENSG00000151304	SRFBP1	99	39.535	ENSSFOG00015001274	srfbp1	99	39.746	Scleropages_formosus
ENSG00000151304	SRFBP1	99	37.282	ENSSDUG00000001828	-	86	37.087	Seriola_dumerili
ENSG00000151304	SRFBP1	100	72.158	ENSSARG00000010669	SRFBP1	100	74.246	Sorex_araneus
ENSG00000151304	SRFBP1	97	46.154	ENSSPUG00000009204	SRFBP1	99	46.313	Sphenodon_punctatus
ENSG00000151304	SRFBP1	74	69.444	ENSSPAG00000010728	-	68	69.444	Stegastes_partitus
ENSG00000151304	SRFBP1	100	79.487	ENSSSCG00000022656	SRFBP1	100	79.720	Sus_scrofa
ENSG00000151304	SRFBP1	81	85.000	ENSTTRG00000007726	SRFBP1	83	85.000	Tursiops_truncatus
ENSG00000151304	SRFBP1	97	81.884	ENSUAMG00000016707	SRFBP1	100	82.126	Ursus_americanus
ENSG00000151304	SRFBP1	97	77.458	ENSUMAG00000018340	SRFBP1	100	73.872	Ursus_maritimus
ENSG00000151304	SRFBP1	100	78.788	ENSVPAG00000005714	SRFBP1	100	80.420	Vicugna_pacos
ENSG00000151304	SRFBP1	100	78.372	ENSVVUG00000019178	SRFBP1	100	78.372	Vulpes_vulpes
ENSG00000151304	SRFBP1	97	43.868	ENSXETG00000004681	srfbp1	97	43.868	Xenopus_tropicalis
ENSG00000151304	SRFBP1	67	42.071	ENSXCOG00000003410	-	99	37.378	Xiphophorus_couchianus
ENSG00000151304	SRFBP1	98	37.628	ENSXMAG00000026251	-	86	38.493	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0030490	maturation of SSU-rRNA	21873635.	IBA	Process
GO:0030686	90S preribosome	21873635.	IBA	Component
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component