EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000151806 (Gene tree)
Gene ID: 60558
Gene Symbol: GUF1
Alias: FLJ13220
Full Name: GUF1 homolog, GTPase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 22,534 bases
Position: chr4:44,678,395-44,700,928
Accession: 25799
RBP type: canonical RBP
Summary: This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000281543	GTP_EFTU	PF00009.27	4.6e-53	1	1
ENSP00000281543	MMR_HSR1	PF01926.23	1.8e-05	1	1
ENSP00000281543	GTP_EFTU_D2	PF03144.25	7.8e-10	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000281543	GUF1-201	4449	XM_024454178	ENSP00000281543	669 (aa)	XP_024309946	Q8N442
ENST00000506793	GUF1-202	3970	-	-	- (aa)	-	-
ENST00000511493	GUF1-203	2278	-	-	- (aa)	-	-
ENST00000513775	GUF1-204	1219	-	ENSP00000422681	98 (aa)	-	D6RBJ0

Gene Model

Click here to download ENSG00000151806's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000151806's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000151806	GUF1	56	33.173	ENSG00000168827	GFM1	80	44.231

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000151806	GUF1	93	79.040	ENSAPOG00000000402	guf1	93	79.040	Acanthochromis_polyacanthus
ENSG00000151806	GUF1	100	91.654	ENSAMEG00000016084	GUF1	100	91.654	Ailuropoda_melanoleuca
ENSG00000151806	GUF1	99	73.763	ENSACIG00000005666	guf1	99	73.763	Amphilophus_citrinellus
ENSG00000151806	GUF1	93	79.516	ENSAOCG00000006219	guf1	92	79.516	Amphiprion_ocellaris
ENSG00000151806	GUF1	93	79.040	ENSAPEG00000008166	guf1	93	79.040	Amphiprion_percula
ENSG00000151806	GUF1	93	79.200	ENSATEG00000018199	guf1	99	75.041	Anabas_testudineus
ENSG00000151806	GUF1	100	76.809	ENSAPLG00000009504	GUF1	99	76.809	Anas_platyrhynchos
ENSG00000151806	GUF1	94	83.016	ENSACAG00000007056	GUF1	95	83.016	Anolis_carolinensis
ENSG00000151806	GUF1	98	96.018	ENSANAG00000010773	GUF1	99	96.018	Aotus_nancymaae
ENSG00000151806	GUF1	94	78.696	ENSACLG00000022239	guf1	99	73.388	Astatotilapia_calliptera
ENSG00000151806	GUF1	80	76.636	ENSAMXG00000005871	guf1	85	76.636	Astyanax_mexicanus
ENSG00000151806	GUF1	100	91.480	ENSBTAG00000000285	GUF1	89	91.480	Bos_taurus
ENSG00000151806	GUF1	92	48.967	WBGene00022862	ZK1236.1	97	48.967	Caenorhabditis_elegans
ENSG00000151806	GUF1	100	96.114	ENSCJAG00000019056	-	100	96.114	Callithrix_jacchus
ENSG00000151806	GUF1	99	53.608	ENSCJAG00000044676	-	95	83.117	Callithrix_jacchus
ENSG00000151806	GUF1	91	94.918	ENSCAFG00000001850	GUF1	100	94.918	Canis_familiaris
ENSG00000151806	GUF1	100	89.836	ENSCAFG00020003101	GUF1	98	94.788	Canis_lupus_dingo
ENSG00000151806	GUF1	100	90.583	ENSCHIG00000010231	GUF1	99	92.500	Capra_hircus
ENSG00000151806	GUF1	99	91.617	ENSTSYG00000010907	GUF1	99	91.617	Carlito_syrichta
ENSG00000151806	GUF1	92	80.519	ENSCAPG00000014980	GUF1	100	79.180	Cavia_aperea
ENSG00000151806	GUF1	97	89.708	ENSCPOG00000014267	GUF1	100	93.284	Cavia_porcellus
ENSG00000151806	GUF1	100	95.217	ENSCCAG00000025409	GUF1	100	95.217	Cebus_capucinus
ENSG00000151806	GUF1	100	97.010	ENSCATG00000040932	GUF1	100	97.010	Cercocebus_atys
ENSG00000151806	GUF1	92	94.137	ENSCLAG00000007505	GUF1	100	94.137	Chinchilla_lanigera
ENSG00000151806	GUF1	100	96.413	ENSCSAG00000017118	GUF1	100	96.413	Chlorocebus_sabaeus
ENSG00000151806	GUF1	99	85.994	ENSCHOG00000001355	GUF1	99	85.994	Choloepus_hoffmanni
ENSG00000151806	GUF1	100	81.791	ENSCPBG00000025668	GUF1	100	81.791	Chrysemys_picta_bellii
ENSG00000151806	GUF1	91	56.390	ENSCING00000003163	-	100	56.390	Ciona_intestinalis
ENSG00000151806	GUF1	91	55.949	ENSCSAVG00000004563	-	95	55.949	Ciona_savignyi
ENSG00000151806	GUF1	100	96.562	ENSCANG00000030205	GUF1	100	96.562	Colobus_angolensis_palliatus
ENSG00000151806	GUF1	100	87.892	ENSCGRG00001015008	Guf1	100	90.299	Cricetulus_griseus_chok1gshd
ENSG00000151806	GUF1	86	86.364	ENSCGRG00000000314	Guf1	99	86.364	Cricetulus_griseus_crigri
ENSG00000151806	GUF1	91	74.426	ENSCSEG00000014139	guf1	92	73.515	Cynoglossus_semilaevis
ENSG00000151806	GUF1	90	72.368	ENSCVAG00000021129	guf1	99	72.533	Cyprinodon_variegatus
ENSG00000151806	GUF1	92	79.092	ENSDARG00000029088	guf1	92	79.092	Danio_rerio
ENSG00000151806	GUF1	99	85.736	ENSDNOG00000007345	GUF1	99	85.736	Dasypus_novemcinctus
ENSG00000151806	GUF1	100	78.176	ENSDORG00000005730	Guf1	96	90.799	Dipodomys_ordii
ENSG00000151806	GUF1	91	55.941	FBgn0024182	waw	87	55.941	Drosophila_melanogaster
ENSG00000151806	GUF1	90	82.041	ENSETEG00000015249	GUF1	90	82.041	Echinops_telfairi
ENSG00000151806	GUF1	100	92.078	ENSEASG00005008712	GUF1	100	92.078	Equus_asinus_asinus
ENSG00000151806	GUF1	100	91.779	ENSECAG00000019296	GUF1	89	91.779	Equus_caballus
ENSG00000151806	GUF1	90	81.180	ENSEEUG00000002894	GUF1	90	81.180	Erinaceus_europaeus
ENSG00000151806	GUF1	93	77.903	ENSELUG00000021933	guf1	99	79.008	Esox_lucius
ENSG00000151806	GUF1	100	92.227	ENSFCAG00000028580	GUF1	100	92.227	Felis_catus
ENSG00000151806	GUF1	77	80.784	ENSFALG00000002932	GUF1	100	80.784	Ficedula_albicollis
ENSG00000151806	GUF1	100	89.717	ENSFDAG00000010613	GUF1	97	93.148	Fukomys_damarensis
ENSG00000151806	GUF1	95	77.129	ENSFHEG00000016859	guf1	99	73.719	Fundulus_heteroclitus
ENSG00000151806	GUF1	92	75.285	ENSGMOG00000005706	guf1	96	75.285	Gadus_morhua
ENSG00000151806	GUF1	95	80.310	ENSGALG00000014217	GUF1	98	80.310	Gallus_gallus
ENSG00000151806	GUF1	93	77.331	ENSGAFG00000016068	guf1	99	73.223	Gambusia_affinis
ENSG00000151806	GUF1	93	77.742	ENSGACG00000018700	guf1	99	77.742	Gasterosteus_aculeatus
ENSG00000151806	GUF1	91	85.246	ENSGAGG00000001879	GUF1	100	85.246	Gopherus_agassizii
ENSG00000151806	GUF1	100	99.552	ENSGGOG00000001699	GUF1	100	99.552	Gorilla_gorilla
ENSG00000151806	GUF1	94	78.855	ENSHBUG00000001529	guf1	99	75.372	Haplochromis_burtoni
ENSG00000151806	GUF1	97	91.385	ENSHGLG00000014421	-	99	92.910	Heterocephalus_glaber_female
ENSG00000151806	GUF1	86	81.882	ENSHGLG00000002637	-	94	81.882	Heterocephalus_glaber_female
ENSG00000151806	GUF1	97	91.385	ENSHGLG00100002522	-	99	92.910	Heterocephalus_glaber_male
ENSG00000151806	GUF1	86	79.895	ENSHGLG00100002291	-	94	79.895	Heterocephalus_glaber_male
ENSG00000151806	GUF1	91	78.548	ENSHCOG00000004355	guf1	100	73.071	Hippocampus_comes
ENSG00000151806	GUF1	92	76.861	ENSIPUG00000020387	GUF1	99	72.459	Ictalurus_punctatus
ENSG00000151806	GUF1	98	90.229	ENSSTOG00000003301	GUF1	99	91.418	Ictidomys_tridecemlineatus
ENSG00000151806	GUF1	92	92.997	ENSJJAG00000005872	Guf1	100	92.537	Jaculus_jaculus
ENSG00000151806	GUF1	95	77.673	ENSKMAG00000008683	guf1	91	77.760	Kryptolebias_marmoratus
ENSG00000151806	GUF1	93	75.520	ENSLBEG00000028126	guf1	99	71.901	Labrus_bergylta
ENSG00000151806	GUF1	93	82.258	ENSLACG00000007692	GUF1	94	81.596	Latimeria_chalumnae
ENSG00000151806	GUF1	90	78.536	ENSLOCG00000012397	guf1	90	78.536	Lepisosteus_oculatus
ENSG00000151806	GUF1	100	90.746	ENSLAFG00000011040	GUF1	100	90.746	Loxodonta_africana
ENSG00000151806	GUF1	100	96.861	ENSMFAG00000029386	GUF1	100	96.861	Macaca_fascicularis
ENSG00000151806	GUF1	100	96.861	ENSMMUG00000009270	GUF1	100	96.861	Macaca_mulatta
ENSG00000151806	GUF1	100	97.010	ENSMNEG00000008365	GUF1	100	97.010	Macaca_nemestrina
ENSG00000151806	GUF1	100	97.010	ENSMLEG00000033225	GUF1	100	97.010	Mandrillus_leucophaeus
ENSG00000151806	GUF1	92	78.479	ENSMAMG00000015049	guf1	92	78.479	Mastacembelus_armatus
ENSG00000151806	GUF1	94	78.696	ENSMZEG00005005816	guf1	93	78.696	Maylandia_zebra
ENSG00000151806	GUF1	92	82.143	ENSMGAG00000012118	GUF1	100	82.143	Meleagris_gallopavo
ENSG00000151806	GUF1	100	91.629	ENSMICG00000016714	GUF1	100	91.629	Microcebus_murinus
ENSG00000151806	GUF1	95	83.281	ENSMOCG00000011627	Guf1	99	84.858	Microtus_ochrogaster
ENSG00000151806	GUF1	92	73.333	ENSMMOG00000009682	guf1	92	73.333	Mola_mola
ENSG00000151806	GUF1	100	84.706	ENSMODG00000020592	GUF1	100	84.706	Monodelphis_domestica
ENSG00000151806	GUF1	94	78.130	ENSMALG00000011894	guf1	99	73.625	Monopterus_albus
ENSG00000151806	GUF1	100	87.444	MGP_CAROLIEiJ_G0027274	Guf1	100	89.552	Mus_caroli
ENSG00000151806	GUF1	100	87.444	ENSMUSG00000029208	Guf1	100	89.552	Mus_musculus
ENSG00000151806	GUF1	100	87.593	MGP_PahariEiJ_G0017055	Guf1	100	90.299	Mus_pahari
ENSG00000151806	GUF1	100	87.444	MGP_SPRETEiJ_G0028269	Guf1	100	89.552	Mus_spretus
ENSG00000151806	GUF1	100	91.480	ENSMPUG00000004975	GUF1	100	91.480	Mustela_putorius_furo
ENSG00000151806	GUF1	100	92.708	ENSMLUG00000002116	GUF1	100	92.825	Myotis_lucifugus
ENSG00000151806	GUF1	94	91.746	ENSNGAG00000012997	Guf1	100	92.537	Nannospalax_galili
ENSG00000151806	GUF1	90	74.876	ENSNBRG00000021743	guf1	99	75.041	Neolamprologus_brichardi
ENSG00000151806	GUF1	99	98.496	ENSNLEG00000017299	GUF1	99	98.496	Nomascus_leucogenys
ENSG00000151806	GUF1	75	71.200	ENSMEUG00000013023	-	100	71.200	Notamacropus_eugenii
ENSG00000151806	GUF1	68	77.582	ENSOPRG00000005400	-	73	77.582	Ochotona_princeps
ENSG00000151806	GUF1	91	94.059	ENSODEG00000000238	GUF1	99	94.059	Octodon_degus
ENSG00000151806	GUF1	94	79.332	ENSONIG00000015782	guf1	99	79.332	Oreochromis_niloticus
ENSG00000151806	GUF1	91	85.082	ENSOANG00000007142	GUF1	100	85.082	Ornithorhynchus_anatinus
ENSG00000151806	GUF1	100	89.851	ENSOCUG00000017915	GUF1	100	89.851	Oryctolagus_cuniculus
ENSG00000151806	GUF1	92	78.479	ENSORLG00000009541	guf1	98	78.479	Oryzias_latipes
ENSG00000151806	GUF1	71	79.651	ENSORLG00020019714	guf1	97	79.651	Oryzias_latipes_hni
ENSG00000151806	GUF1	92	78.317	ENSORLG00015014707	guf1	92	78.317	Oryzias_latipes_hsok
ENSG00000151806	GUF1	93	78.710	ENSOMEG00000016542	guf1	92	78.710	Oryzias_melastigma
ENSG00000151806	GUF1	94	88.013	ENSOGAG00000014573	GUF1	100	88.013	Otolemur_garnettii
ENSG00000151806	GUF1	100	90.732	ENSOARG00000015231	GUF1	100	90.732	Ovis_aries
ENSG00000151806	GUF1	100	95.815	ENSPPAG00000031418	GUF1	100	95.815	Pan_paniscus
ENSG00000151806	GUF1	100	92.227	ENSPPRG00000007366	GUF1	100	92.227	Panthera_pardus
ENSG00000151806	GUF1	100	92.227	ENSPTIG00000009828	GUF1	100	92.227	Panthera_tigris_altaica
ENSG00000151806	GUF1	100	99.701	ENSPTRG00000016022	GUF1	100	99.701	Pan_troglodytes
ENSG00000151806	GUF1	100	97.160	ENSPANG00000020532	GUF1	100	95.665	Papio_anubis
ENSG00000151806	GUF1	95	78.233	ENSPKIG00000000883	guf1	93	78.233	Paramormyrops_kingsleyae
ENSG00000151806	GUF1	59	86.835	ENSPSIG00000005099	GUF1	96	86.835	Pelodiscus_sinensis
ENSG00000151806	GUF1	90	73.102	ENSPMGG00000021369	guf1	99	73.102	Periophthalmus_magnuspinnatus
ENSG00000151806	GUF1	95	82.306	ENSPEMG00000021702	Guf1	99	83.886	Peromyscus_maniculatus_bairdii
ENSG00000151806	GUF1	65	62.642	ENSPMAG00000007928	guf1	100	62.870	Petromyzon_marinus
ENSG00000151806	GUF1	99	84.925	ENSPCIG00000028571	GUF1	100	90.492	Phascolarctos_cinereus
ENSG00000151806	GUF1	95	76.656	ENSPFOG00000006450	guf1	93	76.656	Poecilia_formosa
ENSG00000151806	GUF1	95	73.344	ENSPLAG00000023710	guf1	92	74.359	Poecilia_latipinna
ENSG00000151806	GUF1	95	76.341	ENSPMEG00000023603	guf1	93	76.341	Poecilia_mexicana
ENSG00000151806	GUF1	95	72.642	ENSPMEG00000014175	guf1	92	74.519	Poecilia_mexicana
ENSG00000151806	GUF1	93	76.923	ENSPREG00000003893	guf1	93	76.923	Poecilia_reticulata
ENSG00000151806	GUF1	100	98.514	ENSPPYG00000014702	GUF1	100	98.514	Pongo_abelii
ENSG00000151806	GUF1	92	78.862	ENSPCAG00000016375	GUF1	100	78.862	Procavia_capensis
ENSG00000151806	GUF1	96	84.783	ENSPVAG00000010262	GUF1	100	84.783	Pteropus_vampyrus
ENSG00000151806	GUF1	94	78.855	ENSPNYG00000000062	guf1	99	75.372	Pundamilia_nyererei
ENSG00000151806	GUF1	92	79.450	ENSPNAG00000025157	guf1	99	74.711	Pygocentrus_nattereri
ENSG00000151806	GUF1	100	86.697	ENSRNOG00000002207	Guf1	100	87.444	Rattus_norvegicus
ENSG00000151806	GUF1	100	89.630	ENSRBIG00000042292	GUF1	100	89.630	Rhinopithecus_bieti
ENSG00000151806	GUF1	100	96.712	ENSRROG00000038444	GUF1	100	96.712	Rhinopithecus_roxellana
ENSG00000151806	GUF1	90	49.513	YLR289W	-	94	49.513	Saccharomyces_cerevisiae
ENSG00000151806	GUF1	100	95.366	ENSSBOG00000030808	GUF1	100	95.366	Saimiri_boliviensis_boliviensis
ENSG00000151806	GUF1	96	88.006	ENSSHAG00000003081	GUF1	99	85.973	Sarcophilus_harrisii
ENSG00000151806	GUF1	92	79.126	ENSSFOG00015004296	guf1	99	74.050	Scleropages_formosus
ENSG00000151806	GUF1	95	77.165	ENSSMAG00000013101	guf1	99	73.719	Scophthalmus_maximus
ENSG00000151806	GUF1	91	80.066	ENSSDUG00000013385	guf1	99	74.545	Seriola_dumerili
ENSG00000151806	GUF1	91	79.901	ENSSLDG00000022775	guf1	97	79.542	Seriola_lalandi_dorsalis
ENSG00000151806	GUF1	93	82.183	ENSSPUG00000002681	GUF1	94	82.183	Sphenodon_punctatus
ENSG00000151806	GUF1	92	79.288	ENSSPAG00000010713	guf1	99	74.711	Stegastes_partitus
ENSG00000151806	GUF1	100	90.732	ENSSSCG00000008807	GUF1	100	90.732	Sus_scrofa
ENSG00000151806	GUF1	92	82.143	ENSTGUG00000008453	GUF1	100	82.143	Taeniopygia_guttata
ENSG00000151806	GUF1	93	79.677	ENSTRUG00000007961	guf1	96	79.677	Takifugu_rubripes
ENSG00000151806	GUF1	92	79.058	ENSTNIG00000004218	guf1	100	79.058	Tetraodon_nigroviridis
ENSG00000151806	GUF1	60	87.356	ENSTBEG00000016947	-	81	87.356	Tupaia_belangeri
ENSG00000151806	GUF1	100	87.294	ENSTTRG00000016020	GUF1	100	87.294	Tursiops_truncatus
ENSG00000151806	GUF1	100	92.101	ENSUAMG00000026589	GUF1	100	92.101	Ursus_americanus
ENSG00000151806	GUF1	99	92.216	ENSUMAG00000001595	GUF1	98	92.216	Ursus_maritimus
ENSG00000151806	GUF1	100	91.181	ENSVPAG00000011078	GUF1	100	91.181	Vicugna_pacos
ENSG00000151806	GUF1	91	94.918	ENSVVUG00000023099	GUF1	100	94.918	Vulpes_vulpes
ENSG00000151806	GUF1	92	81.656	ENSXETG00000008432	guf1	100	81.656	Xenopus_tropicalis
ENSG00000151806	GUF1	90	73.102	ENSXCOG00000008816	guf1	99	73.267	Xiphophorus_couchianus
ENSG00000151806	GUF1	93	77.097	ENSXMAG00000004189	guf1	99	72.893	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	-	IEA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	-	IEA	Component
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0006412	translation	-	IEA	Process
GO:0043022	ribosome binding	-	IEA	Function
GO:0045727	positive regulation of translation	-	IEA	Process