EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000152332 (Gene tree)
Gene ID: 127933
Gene Symbol: UHMK1
Alias: KIS|Kist
Full Name: U2AF homology motif kinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 32,456 bases
Position: chr1:162,497,174-162,529,629
Accession: 19683
RBP type: canonical RBP
Summary: The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000441226	RRM_1	PF00076.22	3.1e-06	1	1
ENSP00000420270	RRM_1	PF00076.22	3.5e-06	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16420481	Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65.	FEBS J	2006 Feb	Manceau V	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000538489	UHMK1-203	8446	-	ENSP00000446416	344 (aa)	-	Q8TAS1
ENST00000489294	UHMK1-202	8478	-	ENSP00000420270	419 (aa)	-	Q8TAS1
ENST00000545294	UHMK1-204	8117	-	ENSP00000441226	345 (aa)	-	Q8TAS1
ENST00000282169	UHMK1-201	3345	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000152332's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000152332	Platelet Function Tests	9.0400000E-007	-
ENSG00000152332	Bone Density	4E-7	27424934
ENSG00000152332	Bone Density	3E-6	27424934

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152332's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152332	UHMK1	95	76.696	ENSAPOG00000016327	uhmk1	93	70.118	Acanthochromis_polyacanthus
ENSG00000152332	UHMK1	100	97.136	ENSAMEG00000001572	UHMK1	100	97.136	Ailuropoda_melanoleuca
ENSG00000152332	UHMK1	95	77.946	ENSACIG00000010132	uhmk1	97	77.946	Amphilophus_citrinellus
ENSG00000152332	UHMK1	95	76.401	ENSAOCG00000024473	uhmk1	93	69.882	Amphiprion_ocellaris
ENSG00000152332	UHMK1	95	76.991	ENSAPEG00000023193	uhmk1	93	70.353	Amphiprion_percula
ENSG00000152332	UHMK1	95	77.286	ENSATEG00000008282	uhmk1	94	71.394	Anabas_testudineus
ENSG00000152332	UHMK1	96	88.788	ENSAPLG00000014799	UHMK1	100	88.253	Anas_platyrhynchos
ENSG00000152332	UHMK1	96	42.787	ENSACAG00000022003	-	100	42.298	Anolis_carolinensis
ENSG00000152332	UHMK1	100	100.000	ENSANAG00000022526	UHMK1	100	100.000	Aotus_nancymaae
ENSG00000152332	UHMK1	95	76.106	ENSACLG00000027096	uhmk1	92	70.913	Astatotilapia_calliptera
ENSG00000152332	UHMK1	95	79.635	ENSAMXG00000037781	uhmk1	93	72.861	Astyanax_mexicanus
ENSG00000152332	UHMK1	100	99.761	ENSBTAG00000012694	UHMK1	100	99.761	Bos_taurus
ENSG00000152332	UHMK1	100	99.284	ENSCJAG00000004291	UHMK1	100	99.284	Callithrix_jacchus
ENSG00000152332	UHMK1	100	99.761	ENSCAFG00000013095	UHMK1	100	99.761	Canis_familiaris
ENSG00000152332	UHMK1	96	100.000	ENSCAFG00020001672	UHMK1	100	100.000	Canis_lupus_dingo
ENSG00000152332	UHMK1	100	99.761	ENSCHIG00000019078	UHMK1	100	99.761	Capra_hircus
ENSG00000152332	UHMK1	99	100.000	ENSTSYG00000011273	UHMK1	91	100.000	Carlito_syrichta
ENSG00000152332	UHMK1	96	73.874	ENSCAPG00000009137	UHMK1	100	73.874	Cavia_aperea
ENSG00000152332	UHMK1	100	98.329	ENSCPOG00000004561	UHMK1	100	98.329	Cavia_porcellus
ENSG00000152332	UHMK1	100	100.000	ENSCCAG00000033689	UHMK1	100	100.000	Cebus_capucinus
ENSG00000152332	UHMK1	100	99.761	ENSCATG00000037499	UHMK1	100	99.761	Cercocebus_atys
ENSG00000152332	UHMK1	90	86.538	ENSCLAG00000013603	-	99	78.431	Chinchilla_lanigera
ENSG00000152332	UHMK1	100	99.761	ENSCLAG00000004715	-	100	99.761	Chinchilla_lanigera
ENSG00000152332	UHMK1	100	99.761	ENSCSAG00000002742	UHMK1	100	99.761	Chlorocebus_sabaeus
ENSG00000152332	UHMK1	100	95.465	ENSCHOG00000011101	UHMK1	100	95.227	Choloepus_hoffmanni
ENSG00000152332	UHMK1	83	90.278	ENSCPBG00000017971	UHMK1	100	90.278	Chrysemys_picta_bellii
ENSG00000152332	UHMK1	100	99.761	ENSCANG00000032661	UHMK1	100	99.761	Colobus_angolensis_palliatus
ENSG00000152332	UHMK1	100	99.523	ENSCGRG00001013226	Uhmk1	100	99.523	Cricetulus_griseus_chok1gshd
ENSG00000152332	UHMK1	96	99.697	ENSCGRG00000000667	Uhmk1	100	99.394	Cricetulus_griseus_crigri
ENSG00000152332	UHMK1	95	77.946	ENSCSEG00000000806	uhmk1	99	70.913	Cynoglossus_semilaevis
ENSG00000152332	UHMK1	95	76.261	ENSCVAG00000005389	uhmk1	94	70.290	Cyprinodon_variegatus
ENSG00000152332	UHMK1	95	79.635	ENSDARG00000059575	uhmk1	96	71.566	Danio_rerio
ENSG00000152332	UHMK1	100	99.761	ENSDNOG00000009922	UHMK1	100	99.761	Dasypus_novemcinctus
ENSG00000152332	UHMK1	100	99.761	ENSDORG00000011233	Uhmk1	100	99.761	Dipodomys_ordii
ENSG00000152332	UHMK1	95	47.478	ENSEBUG00000001105	uhmk1	95	45.169	Eptatretus_burgeri
ENSG00000152332	UHMK1	100	99.761	ENSECAG00000008744	UHMK1	100	99.761	Equus_caballus
ENSG00000152332	UHMK1	100	82.100	ENSEEUG00000011231	UHMK1	100	82.100	Erinaceus_europaeus
ENSG00000152332	UHMK1	95	79.394	ENSELUG00000003613	uhmk1	99	79.394	Esox_lucius
ENSG00000152332	UHMK1	100	99.523	ENSFCAG00000014123	UHMK1	100	99.523	Felis_catus
ENSG00000152332	UHMK1	96	88.182	ENSFALG00000003546	UHMK1	100	87.258	Ficedula_albicollis
ENSG00000152332	UHMK1	99	97.122	ENSFDAG00000011567	UHMK1	100	99.752	Fukomys_damarensis
ENSG00000152332	UHMK1	90	75.710	ENSFHEG00000012818	uhmk1	92	69.898	Fundulus_heteroclitus
ENSG00000152332	UHMK1	95	74.164	ENSGMOG00000016438	uhmk1	99	68.227	Gadus_morhua
ENSG00000152332	UHMK1	96	88.182	ENSGALG00000002734	UHMK1	99	83.568	Gallus_gallus
ENSG00000152332	UHMK1	95	75.444	ENSGAFG00000016341	uhmk1	93	69.880	Gambusia_affinis
ENSG00000152332	UHMK1	95	75.298	ENSGACG00000003529	uhmk1	99	68.150	Gasterosteus_aculeatus
ENSG00000152332	UHMK1	83	91.319	ENSGAGG00000016257	UHMK1	100	91.319	Gopherus_agassizii
ENSG00000152332	UHMK1	100	100.000	ENSGGOG00000002032	UHMK1	100	100.000	Gorilla_gorilla
ENSG00000152332	UHMK1	95	77.946	ENSHBUG00000010792	uhmk1	99	71.703	Haplochromis_burtoni
ENSG00000152332	UHMK1	100	99.761	ENSHGLG00000004032	UHMK1	100	99.761	Heterocephalus_glaber_female
ENSG00000152332	UHMK1	96	91.818	ENSHGLG00100018664	-	100	92.689	Heterocephalus_glaber_male
ENSG00000152332	UHMK1	95	79.635	ENSIPUG00000005095	uhmk1	94	73.399	Ictalurus_punctatus
ENSG00000152332	UHMK1	100	99.523	ENSSTOG00000004265	UHMK1	100	99.523	Ictidomys_tridecemlineatus
ENSG00000152332	UHMK1	100	99.523	ENSJJAG00000015993	Uhmk1	100	99.523	Jaculus_jaculus
ENSG00000152332	UHMK1	95	75.684	ENSKMAG00000016748	uhmk1	93	70.197	Kryptolebias_marmoratus
ENSG00000152332	UHMK1	95	77.946	ENSLBEG00000001341	uhmk1	98	77.946	Labrus_bergylta
ENSG00000152332	UHMK1	96	81.515	ENSLACG00000014100	UHMK1	94	75.476	Latimeria_chalumnae
ENSG00000152332	UHMK1	95	82.067	ENSLOCG00000007180	uhmk1	92	75.616	Lepisosteus_oculatus
ENSG00000152332	UHMK1	100	98.568	ENSLAFG00000007405	UHMK1	100	98.568	Loxodonta_africana
ENSG00000152332	UHMK1	100	99.761	ENSMFAG00000041742	UHMK1	100	99.761	Macaca_fascicularis
ENSG00000152332	UHMK1	100	99.761	ENSMMUG00000019513	UHMK1	100	99.761	Macaca_mulatta
ENSG00000152332	UHMK1	100	99.761	ENSMNEG00000004169	UHMK1	100	99.761	Macaca_nemestrina
ENSG00000152332	UHMK1	100	99.761	ENSMLEG00000038941	UHMK1	100	99.761	Mandrillus_leucophaeus
ENSG00000152332	UHMK1	95	77.515	ENSMAMG00000007396	uhmk1	93	70.309	Mastacembelus_armatus
ENSG00000152332	UHMK1	95	76.106	ENSMZEG00005011160	uhmk1	92	70.913	Maylandia_zebra
ENSG00000152332	UHMK1	96	88.182	ENSMGAG00000005043	UHMK1	100	88.182	Meleagris_gallopavo
ENSG00000152332	UHMK1	100	99.523	ENSMAUG00000001735	Uhmk1	100	99.523	Mesocricetus_auratus
ENSG00000152332	UHMK1	94	97.840	ENSMICG00000046769	-	98	97.840	Microcebus_murinus
ENSG00000152332	UHMK1	100	100.000	ENSMICG00000017256	-	100	100.000	Microcebus_murinus
ENSG00000152332	UHMK1	100	98.100	ENSMOCG00000008369	Uhmk1	100	98.100	Microtus_ochrogaster
ENSG00000152332	UHMK1	95	78.313	ENSMMOG00000006591	uhmk1	99	78.313	Mola_mola
ENSG00000152332	UHMK1	95	76.435	ENSMALG00000013850	uhmk1	99	69.048	Monopterus_albus
ENSG00000152332	UHMK1	100	99.284	MGP_CAROLIEiJ_G0014837	-	100	99.284	Mus_caroli
ENSG00000152332	UHMK1	100	99.284	ENSMUSG00000026667	Uhmk1	100	99.284	Mus_musculus
ENSG00000152332	UHMK1	100	99.523	MGP_PahariEiJ_G0028074	Uhmk1	100	99.523	Mus_pahari
ENSG00000152332	UHMK1	100	99.284	MGP_SPRETEiJ_G0015643	-	100	99.284	Mus_spretus
ENSG00000152332	UHMK1	100	99.761	ENSMPUG00000003619	UHMK1	100	99.761	Mustela_putorius_furo
ENSG00000152332	UHMK1	97	93.694	ENSMLUG00000002872	UHMK1	100	88.915	Myotis_lucifugus
ENSG00000152332	UHMK1	100	99.761	ENSNGAG00000014202	Uhmk1	100	100.000	Nannospalax_galili
ENSG00000152332	UHMK1	95	77.946	ENSNBRG00000016804	uhmk1	99	77.946	Neolamprologus_brichardi
ENSG00000152332	UHMK1	100	100.000	ENSNLEG00000026604	UHMK1	100	100.000	Nomascus_leucogenys
ENSG00000152332	UHMK1	75	98.148	ENSOPRG00000001881	-	77	98.246	Ochotona_princeps
ENSG00000152332	UHMK1	100	99.523	ENSODEG00000006380	UHMK1	100	99.523	Octodon_degus
ENSG00000152332	UHMK1	95	77.879	ENSONIG00000019209	uhmk1	97	72.236	Oreochromis_niloticus
ENSG00000152332	UHMK1	100	99.523	ENSOCUG00000012411	UHMK1	100	99.523	Oryctolagus_cuniculus
ENSG00000152332	UHMK1	95	77.812	ENSORLG00000014340	uhmk1	99	70.702	Oryzias_latipes
ENSG00000152332	UHMK1	95	77.204	ENSORLG00020001220	uhmk1	99	69.952	Oryzias_latipes_hni
ENSG00000152332	UHMK1	95	75.964	ENSORLG00015019846	uhmk1	99	68.227	Oryzias_latipes_hsok
ENSG00000152332	UHMK1	95	76.418	ENSOMEG00000001693	uhmk1	92	70.309	Oryzias_melastigma
ENSG00000152332	UHMK1	100	100.000	ENSOGAG00000016110	UHMK1	100	100.000	Otolemur_garnettii
ENSG00000152332	UHMK1	100	96.181	ENSOARG00000010744	UHMK1	100	96.181	Ovis_aries
ENSG00000152332	UHMK1	100	100.000	ENSPPAG00000041163	UHMK1	100	100.000	Pan_paniscus
ENSG00000152332	UHMK1	100	99.523	ENSPPRG00000002673	UHMK1	100	99.523	Panthera_pardus
ENSG00000152332	UHMK1	95	99.696	ENSPTIG00000010715	UHMK1	100	99.696	Panthera_tigris_altaica
ENSG00000152332	UHMK1	100	100.000	ENSPTRG00000001601	UHMK1	100	100.000	Pan_troglodytes
ENSG00000152332	UHMK1	100	99.761	ENSPANG00000001321	UHMK1	100	99.761	Papio_anubis
ENSG00000152332	UHMK1	95	81.763	ENSPKIG00000015328	uhmk1	96	73.913	Paramormyrops_kingsleyae
ENSG00000152332	UHMK1	95	85.106	ENSPSIG00000014622	UHMK1	100	85.106	Pelodiscus_sinensis
ENSG00000152332	UHMK1	95	70.821	ENSPMGG00000023620	uhmk1	97	64.748	Periophthalmus_magnuspinnatus
ENSG00000152332	UHMK1	100	99.523	ENSPEMG00000001487	Uhmk1	100	99.523	Peromyscus_maniculatus_bairdii
ENSG00000152332	UHMK1	100	97.613	ENSPCIG00000021507	UHMK1	100	97.613	Phascolarctos_cinereus
ENSG00000152332	UHMK1	95	74.852	ENSPFOG00000015923	uhmk1	93	69.157	Poecilia_formosa
ENSG00000152332	UHMK1	95	74.852	ENSPLAG00000014766	uhmk1	93	69.398	Poecilia_latipinna
ENSG00000152332	UHMK1	95	74.852	ENSPMEG00000023850	uhmk1	93	69.157	Poecilia_mexicana
ENSG00000152332	UHMK1	95	74.852	ENSPREG00000013295	uhmk1	93	69.398	Poecilia_reticulata
ENSG00000152332	UHMK1	97	94.659	ENSPPYG00000000582	UHMK1	100	91.294	Pongo_abelii
ENSG00000152332	UHMK1	100	83.771	ENSPCAG00000000531	UHMK1	100	83.771	Procavia_capensis
ENSG00000152332	UHMK1	100	100.000	ENSPCOG00000025540	UHMK1	100	100.000	Propithecus_coquereli
ENSG00000152332	UHMK1	100	98.091	ENSPVAG00000002624	UHMK1	100	98.091	Pteropus_vampyrus
ENSG00000152332	UHMK1	95	77.946	ENSPNYG00000021906	uhmk1	99	71.703	Pundamilia_nyererei
ENSG00000152332	UHMK1	95	79.331	ENSPNAG00000011288	uhmk1	94	72.616	Pygocentrus_nattereri
ENSG00000152332	UHMK1	100	99.045	ENSRNOG00000002941	Uhmk1	100	99.045	Rattus_norvegicus
ENSG00000152332	UHMK1	100	99.045	ENSRNOG00000056731	AABR07027799.1	100	99.045	Rattus_norvegicus
ENSG00000152332	UHMK1	100	100.000	ENSRBIG00000044498	UHMK1	100	100.000	Rhinopithecus_bieti
ENSG00000152332	UHMK1	100	100.000	ENSRROG00000031530	UHMK1	100	100.000	Rhinopithecus_roxellana
ENSG00000152332	UHMK1	100	100.000	ENSSBOG00000028187	UHMK1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000152332	UHMK1	100	95.012	ENSSHAG00000012358	UHMK1	100	95.012	Sarcophilus_harrisii
ENSG00000152332	UHMK1	95	82.675	ENSSFOG00015002013	uhmk1	93	76.108	Scleropages_formosus
ENSG00000152332	UHMK1	95	77.581	ENSSMAG00000003891	uhmk1	92	71.635	Scophthalmus_maximus
ENSG00000152332	UHMK1	95	78.171	ENSSDUG00000000226	uhmk1	95	70.561	Seriola_dumerili
ENSG00000152332	UHMK1	95	78.171	ENSSLDG00000000833	uhmk1	95	70.561	Seriola_lalandi_dorsalis
ENSG00000152332	UHMK1	96	87.879	ENSSPUG00000005763	UHMK1	99	82.979	Sphenodon_punctatus
ENSG00000152332	UHMK1	95	77.581	ENSSPAG00000001165	uhmk1	99	66.033	Stegastes_partitus
ENSG00000152332	UHMK1	100	99.761	ENSSSCG00000006342	UHMK1	100	99.761	Sus_scrofa
ENSG00000152332	UHMK1	96	88.182	ENSTGUG00000017148	UHMK1	100	88.218	Taeniopygia_guttata
ENSG00000152332	UHMK1	95	75.074	ENSTRUG00000022479	uhmk1	92	69.565	Takifugu_rubripes
ENSG00000152332	UHMK1	95	76.292	ENSTNIG00000010802	uhmk1	99	70.690	Tetraodon_nigroviridis
ENSG00000152332	UHMK1	100	99.523	ENSTBEG00000017334	UHMK1	100	99.523	Tupaia_belangeri
ENSG00000152332	UHMK1	100	99.761	ENSUAMG00000027426	UHMK1	100	99.761	Ursus_americanus
ENSG00000152332	UHMK1	96	96.364	ENSUMAG00000022774	UHMK1	94	88.489	Ursus_maritimus
ENSG00000152332	UHMK1	100	99.284	ENSVPAG00000010726	UHMK1	100	99.284	Vicugna_pacos
ENSG00000152332	UHMK1	99	99.707	ENSVVUG00000009990	UHMK1	100	99.757	Vulpes_vulpes
ENSG00000152332	UHMK1	95	76.900	ENSXCOG00000005880	uhmk1	97	76.900	Xiphophorus_couchianus
ENSG00000152332	UHMK1	95	74.852	ENSXMAG00000016056	uhmk1	93	69.398	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	12093740.	IDA	Function
GO:0005515	protein binding	12093740.26420826.	IPI	Function
GO:0005524	ATP binding	12093740.	IC	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	12093740.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0007050	cell cycle arrest	21873635.	IBA	Process
GO:0007050	cell cycle arrest	12093740.	IMP	Process
GO:0016740	transferase activity	12093740.	IC	Function
GO:0018105	peptidyl-serine phosphorylation	21873635.	IBA	Process
GO:0018105	peptidyl-serine phosphorylation	12093740.	IDA	Process
GO:0018105	peptidyl-serine phosphorylation	-	ISS	Process
GO:0030424	axon	-	ISS	Component
GO:0031175	neuron projection development	-	ISS	Process
GO:0032839	dendrite cytoplasm	-	ISS	Component
GO:0043021	ribonucleoprotein complex binding	21873635.	IBA	Function
GO:0043021	ribonucleoprotein complex binding	-	ISS	Function
GO:0045948	positive regulation of translational initiation	21873635.	IBA	Process
GO:0045948	positive regulation of translational initiation	-	ISS	Process
GO:0046777	protein autophosphorylation	12093740.	IDA	Process
GO:0046825	regulation of protein export from nucleus	21873635.	IBA	Process
GO:0046825	regulation of protein export from nucleus	12093740.	IDA	Process
GO:0071598	neuronal ribonucleoprotein granule	21873635.	IBA	Component
GO:0071598	neuronal ribonucleoprotein granule	-	ISS	Component