EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000152430 (Gene tree)
Gene ID: 66037
Gene Symbol: BOLL
Alias: BOULE
Full Name: boule homolog, RNA binding protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 59,884 bases
Position: chr2:197,726,879-197,786,762
Accession: 14273
RBP type: canonical RBP
Summary: This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000376116	RRM_1	PF00076.22	9.8e-20	1	1
ENSP00000396099	RRM_1	PF00076.22	9.8e-20	1	1
ENSP00000314792	RRM_1	PF00076.22	1.1e-19	1	1
ENSP00000397711	RRM_1	PF00076.22	1.3e-19	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18550751	Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning.	J Neurosci	2008 Jun 11	Hoopfer ED	doi: 10.1523/JNEUROSCI.0677-08.2008.
25605553	Oncogenic Role of BOLL in Colorectal Cancer.	Dig Dis Sci	2015 Jun	Kang KJ	doi: 10.1007/s10620-015-3533-z
10559904	Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule.	Nat Cell Biol	1999 Jul	Maines JZ	-
16425031	Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ.	Dev Genes Evol	2006 Mar	Tung JY	-
15705297	Role of the DAZ genes in male fertility.	Reprod Biomed Online	2005 Jan	Reynolds N	-
14611631	Absence of mDazl produces a final block on germ cell development at meiosis.	Reproduction	2003 Nov	Saunders PT	-
19540345	Structure and RNA binding of the mouse Pumilio-2 Puf domain.	J Struct Biol	2009 Sep	Jenkins HT	doi: 10.1016/j.jsb.2009.06.007
19564913	Boule is present in fish and bisexually expressed in adult and embryonic germ cells of medaka.	PLoS One	2009 Jun 30	Xu H	doi: 10.1371/journal.pone.0006097.
22930651	Expression pattern of Boule in dairy goat testis and its function in promoting the meiosis in male germline stem cells (mGSCs).	J Cell Biochem	2013 Feb	Li M	doi: 10.1002/jcb.24368.
16979959	Cloning and expression of medaka dazl during embryogenesis and gametogenesis.	Gene Expr Patterns	2007 Jan	Xu H	-
20335278	A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule.	Hum Mol Genet	2010 Jun 15	VanGompel MJ	doi: 10.1093/hmg/ddq109
24715697	The roles of DAZL in RNA biology and development.	Wiley Interdiscip Rev RNA	2014 Jul-Aug	Smorag L	doi: 10.1002/wrna.1228
24086306	A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.	PLoS One	2013 Sep 25	He J	doi: 10.1371/journal.pone.0073996
25790371	GDF9 is transiently expressed in oocytes before follicle formation in the human fetal ovary and is regulated by a novel NOBOX transcript.	PLoS One	2015 Mar 19	Bayne RA	doi: 10.1371/journal.pone.0119819
28604658	In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells.	Nat Commun	2017 Jun 12	Jung D	doi: 10.1038/ncomms15680.
26595369	Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.	Reprod Fertil Dev	2017 Apr	Shah SM	doi: 10.1071/RD15159.
19417033	Posttranscriptional regulation of CDC25A by BOLL is a conserved fertility mechanism essential for human spermatogenesis.	J Clin Endocrinol Metab	2009 Jul	Lin YM	doi: 10.1210/jc.2009-0108

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000486206	BOLL-208	574	-	-	- (aa)	-	-
ENST00000392296	BOLL-203	2838	XM_024453054	ENSP00000376116	283 (aa)	XP_024308822	Q8N9W6
ENST00000468827	BOLL-207	476	-	-	- (aa)	-	-
ENST00000430004	BOLL-204	2987	XM_011511694	ENSP00000397711	333 (aa)	XP_011509996	F2Z2G3
ENST00000433157	BOLL-205	1270	-	ENSP00000396099	283 (aa)	-	Q8N9W6
ENST00000282278	BOLL-201	2742	-	ENSP00000282278	174 (aa)	-	Q8N9W6
ENST00000321801	BOLL-202	3135	XM_006712715	ENSP00000314792	295 (aa)	XP_006712778	Q8N9W6
ENST00000434976	BOLL-206	1372	-	ENSP00000416911	87 (aa)	-	F8WD91

Gene Model

Click here to download ENSG00000152430's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000152430	Intracranial Aneurysm	4E-8	18997786
ENSG00000152430	Circadian Rhythm	5E-10	26835600

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000152430	rs700641	2	197734509	?	Morning vs. evening chronotype	26835600			EFO_0004354
ENSG00000152430	rs139236944	2	197781302	G	Idiopathic dilated cardiomyopathy	29495422	[1.07-32.64]	1.03	EFO_0009094
ENSG00000152430	rs700651	2	197766990	G	Intracranial aneurysm	18997786	[1.15-1.34]	1.24	EFO_0003870
ENSG00000152430	rs700655	2	197778907	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152430's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000152430	BOLL	51	38.636	ENSG00000234414	RBMY1A1	69	39.286
ENSG00000152430	BOLL	67	38.333	ENSG00000135486	HNRNPA1	61	35.556
ENSG00000152430	BOLL	51	38.636	ENSG00000242389	RBMY1E	69	39.286
ENSG00000152430	BOLL	80	32.857	ENSG00000149187	CELF1	79	39.130
ENSG00000152430	BOLL	51	46.667	ENSG00000099622	CIRBP	84	50.000
ENSG00000152430	BOLL	51	38.636	ENSG00000244395	RBMY1D	69	39.286
ENSG00000152430	BOLL	51	38.636	ENSG00000242875	RBMY1B	69	39.286

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152430	BOLL	84	56.164	ENSAPOG00000007050	-	81	47.788	Acanthochromis_polyacanthus
ENSG00000152430	BOLL	100	94.253	ENSAMEG00000013712	BOLL	100	91.525	Ailuropoda_melanoleuca
ENSG00000152430	BOLL	55	60.417	ENSAMEG00000009059	-	55	41.341	Ailuropoda_melanoleuca
ENSG00000152430	BOLL	55	54.167	ENSACIG00000001931	dazl	63	35.897	Amphilophus_citrinellus
ENSG00000152430	BOLL	89	46.947	ENSAOCG00000023373	-	75	46.947	Amphiprion_ocellaris
ENSG00000152430	BOLL	88	42.520	ENSAPEG00000005335	-	86	51.232	Amphiprion_percula
ENSG00000152430	BOLL	99	78.369	ENSAPLG00000006193	BOLL	99	77.211	Anas_platyrhynchos
ENSG00000152430	BOLL	90	32.184	ENSAPLG00000007738	-	86	32.184	Anas_platyrhynchos
ENSG00000152430	BOLL	55	58.333	ENSACAG00000007822	-	55	38.012	Anolis_carolinensis
ENSG00000152430	BOLL	98	86.691	ENSACAG00000009285	BOLL	89	86.525	Anolis_carolinensis
ENSG00000152430	BOLL	55	60.417	ENSANAG00000034405	DAZL	76	34.634	Aotus_nancymaae
ENSG00000152430	BOLL	100	93.103	ENSANAG00000031449	-	97	93.103	Aotus_nancymaae
ENSG00000152430	BOLL	89	47.368	ENSACLG00000002494	-	76	47.368	Astatotilapia_calliptera
ENSG00000152430	BOLL	72	47.619	ENSACLG00000000529	dazl	87	34.574	Astatotilapia_calliptera
ENSG00000152430	BOLL	100	53.409	ENSAMXG00000005058	-	78	54.040	Astyanax_mexicanus
ENSG00000152430	BOLL	100	95.402	ENSBTAG00000031614	BOLL	100	94.915	Bos_taurus
ENSG00000152430	BOLL	100	96.113	ENSCJAG00000004092	BOLL	99	97.500	Callithrix_jacchus
ENSG00000152430	BOLL	55	60.417	ENSCJAG00000039120	DAZL	78	36.937	Callithrix_jacchus
ENSG00000152430	BOLL	100	94.253	ENSCAFG00000010947	BOLL	100	93.220	Canis_familiaris
ENSG00000152430	BOLL	100	94.253	ENSCAFG00020004659	BOLL	98	94.792	Canis_lupus_dingo
ENSG00000152430	BOLL	54	61.702	ENSCAFG00020027335	-	58	37.430	Canis_lupus_dingo
ENSG00000152430	BOLL	100	95.402	ENSCHIG00000024995	BOLL	100	87.119	Capra_hircus
ENSG00000152430	BOLL	100	93.310	ENSTSYG00000014204	BOLL	100	92.905	Carlito_syrichta
ENSG00000152430	BOLL	90	33.708	ENSCAPG00000003209	DAZL	94	33.585	Cavia_aperea
ENSG00000152430	BOLL	80	80.000	ENSCAPG00000001013	BOLL	91	79.221	Cavia_aperea
ENSG00000152430	BOLL	98	89.655	ENSCPOG00000000390	BOLL	97	89.680	Cavia_porcellus
ENSG00000152430	BOLL	100	97.173	ENSCCAG00000026623	BOLL	100	96.949	Cebus_capucinus
ENSG00000152430	BOLL	55	60.417	ENSCCAG00000035747	DAZL	54	40.230	Cebus_capucinus
ENSG00000152430	BOLL	100	97.527	ENSCATG00000004430	BOLL	100	97.288	Cercocebus_atys
ENSG00000152430	BOLL	94	92.481	ENSCLAG00000017375	BOLL	95	92.481	Chinchilla_lanigera
ENSG00000152430	BOLL	100	98.940	ENSCSAG00000011399	BOLL	100	98.644	Chlorocebus_sabaeus
ENSG00000152430	BOLL	87	66.436	ENSCHOG00000012634	BOLL	99	66.436	Choloepus_hoffmanni
ENSG00000152430	BOLL	52	60.000	ENSCPBG00000022547	-	64	40.805	Chrysemys_picta_bellii
ENSG00000152430	BOLL	83	90.278	ENSCPBG00000004725	-	81	89.873	Chrysemys_picta_bellii
ENSG00000152430	BOLL	71	61.972	ENSCSAVG00000004364	-	57	60.784	Ciona_savignyi
ENSG00000152430	BOLL	100	98.587	ENSCANG00000042186	BOLL	100	98.587	Colobus_angolensis_palliatus
ENSG00000152430	BOLL	100	93.103	ENSCGRG00001020168	Boll	98	93.056	Cricetulus_griseus_chok1gshd
ENSG00000152430	BOLL	55	60.417	ENSCGRG00001021961	Dazl	54	40.782	Cricetulus_griseus_chok1gshd
ENSG00000152430	BOLL	92	93.462	ENSCGRG00000004549	Boll	92	93.462	Cricetulus_griseus_crigri
ENSG00000152430	BOLL	72	47.619	ENSCVAG00000008027	-	68	41.593	Cyprinodon_variegatus
ENSG00000152430	BOLL	71	50.000	ENSDARG00000036214	dazl	62	48.958	Danio_rerio
ENSG00000152430	BOLL	97	95.273	ENSDNOG00000017076	BOLL	83	95.018	Dasypus_novemcinctus
ENSG00000152430	BOLL	55	60.417	ENSDNOG00000019085	-	60	40.838	Dasypus_novemcinctus
ENSG00000152430	BOLL	56	37.143	ENSDORG00000011497	Dazl	59	39.752	Dipodomys_ordii
ENSG00000152430	BOLL	97	95.273	ENSDORG00000010791	Boll	99	94.928	Dipodomys_ordii
ENSG00000152430	BOLL	67	63.793	FBgn0011206	bol	76	65.278	Drosophila_melanogaster
ENSG00000152430	BOLL	92	95.000	ENSETEG00000013582	-	54	97.414	Echinops_telfairi
ENSG00000152430	BOLL	99	95.390	ENSEASG00005020122	BOLL	100	93.898	Equus_asinus_asinus
ENSG00000152430	BOLL	92	96.250	ENSECAG00000040654	BOLL	97	90.909	Equus_caballus
ENSG00000152430	BOLL	92	95.000	ENSEEUG00000003441	BOLL	69	94.012	Erinaceus_europaeus
ENSG00000152430	BOLL	83	63.600	ENSELUG00000002317	-	70	63.600	Esox_lucius
ENSG00000152430	BOLL	100	95.402	ENSFCAG00000018564	BOLL	100	94.576	Felis_catus
ENSG00000152430	BOLL	55	40.120	ENSFALG00000008893	-	64	40.120	Ficedula_albicollis
ENSG00000152430	BOLL	94	70.107	ENSFALG00000004255	BOLL	96	69.231	Ficedula_albicollis
ENSG00000152430	BOLL	94	92.857	ENSFDAG00000013036	BOLL	95	92.857	Fukomys_damarensis
ENSG00000152430	BOLL	72	60.317	ENSFHEG00000000765	-	75	44.934	Fundulus_heteroclitus
ENSG00000152430	BOLL	71	45.161	ENSGMOG00000011491	dazl	87	45.977	Gadus_morhua
ENSG00000152430	BOLL	90	33.712	ENSGALG00000011243	DAZL	86	33.712	Gallus_gallus
ENSG00000152430	BOLL	68	60.000	ENSGAFG00000003461	-	65	45.575	Gambusia_affinis
ENSG00000152430	BOLL	77	63.235	ENSGACG00000014439	-	92	43.636	Gasterosteus_aculeatus
ENSG00000152430	BOLL	100	99.293	ENSGGOG00000013594	BOLL	100	99.293	Gorilla_gorilla
ENSG00000152430	BOLL	89	47.368	ENSHBUG00000003183	-	76	47.368	Haplochromis_burtoni
ENSG00000152430	BOLL	72	47.619	ENSHBUG00000017426	dazl	87	35.106	Haplochromis_burtoni
ENSG00000152430	BOLL	55	64.583	ENSHGLG00000013488	DAZL	61	41.026	Heterocephalus_glaber_female
ENSG00000152430	BOLL	98	84.722	ENSHGLG00000017562	BOLL	99	84.722	Heterocephalus_glaber_female
ENSG00000152430	BOLL	94	86.842	ENSHGLG00100015094	BOLL	95	86.842	Heterocephalus_glaber_male
ENSG00000152430	BOLL	55	64.583	ENSHGLG00100019389	DAZL	61	41.026	Heterocephalus_glaber_male
ENSG00000152430	BOLL	55	85.417	ENSIPUG00000021346	boll	70	53.846	Ictalurus_punctatus
ENSG00000152430	BOLL	100	95.402	ENSSTOG00000003536	BOLL	100	94.237	Ictidomys_tridecemlineatus
ENSG00000152430	BOLL	99	93.262	ENSJJAG00000015508	Boll	100	93.262	Jaculus_jaculus
ENSG00000152430	BOLL	83	61.644	ENSKMAG00000002689	-	69	46.930	Kryptolebias_marmoratus
ENSG00000152430	BOLL	100	84.270	ENSLACG00000015867	BOLL	85	80.205	Latimeria_chalumnae
ENSG00000152430	BOLL	72	51.101	ENSLOCG00000004003	BOLL	78	51.101	Lepisosteus_oculatus
ENSG00000152430	BOLL	55	62.500	ENSLAFG00000009132	-	55	41.341	Loxodonta_africana
ENSG00000152430	BOLL	97	95.273	ENSLAFG00000010956	BOLL	98	95.018	Loxodonta_africana
ENSG00000152430	BOLL	100	98.587	ENSMFAG00000030962	BOLL	100	98.587	Macaca_fascicularis
ENSG00000152430	BOLL	100	98.940	ENSMMUG00000023811	BOLL	100	98.644	Macaca_mulatta
ENSG00000152430	BOLL	100	98.940	ENSMNEG00000033015	BOLL	100	98.644	Macaca_nemestrina
ENSG00000152430	BOLL	100	97.527	ENSMLEG00000023905	BOLL	100	97.527	Mandrillus_leucophaeus
ENSG00000152430	BOLL	89	47.368	ENSMZEG00005008450	-	76	47.368	Maylandia_zebra
ENSG00000152430	BOLL	72	47.619	ENSMZEG00005009515	dazl	87	34.574	Maylandia_zebra
ENSG00000152430	BOLL	55	60.417	ENSMGAG00000010878	-	66	37.949	Meleagris_gallopavo
ENSG00000152430	BOLL	100	93.103	ENSMAUG00000008224	Boll	100	93.972	Mesocricetus_auratus
ENSG00000152430	BOLL	55	60.417	ENSMAUG00000018931	Dazl	53	40.782	Mesocricetus_auratus
ENSG00000152430	BOLL	100	95.402	ENSMICG00000011845	BOLL	100	93.898	Microcebus_murinus
ENSG00000152430	BOLL	55	60.417	ENSMOCG00000016627	Dazl	54	41.011	Microtus_ochrogaster
ENSG00000152430	BOLL	99	92.908	ENSMOCG00000022824	Boll	100	92.908	Microtus_ochrogaster
ENSG00000152430	BOLL	99	93.972	ENSMODG00000012323	BOLL	100	92.881	Monodelphis_domestica
ENSG00000152430	BOLL	81	49.383	ENSMALG00000016791	-	70	49.383	Monopterus_albus
ENSG00000152430	BOLL	55	60.417	MGP_CAROLIEiJ_G0021735	Dazl	61	41.143	Mus_caroli
ENSG00000152430	BOLL	55	60.417	ENSMUSG00000010592	Dazl	61	41.143	Mus_musculus
ENSG00000152430	BOLL	99	93.617	ENSMUSG00000025977	Boll	100	93.617	Mus_musculus
ENSG00000152430	BOLL	100	91.954	MGP_PahariEiJ_G0027387	Boll	100	92.553	Mus_pahari
ENSG00000152430	BOLL	55	60.417	MGP_PahariEiJ_G0020724	Dazl	61	41.860	Mus_pahari
ENSG00000152430	BOLL	55	60.417	MGP_SPRETEiJ_G0022647	Dazl	54	41.011	Mus_spretus
ENSG00000152430	BOLL	100	95.402	ENSMPUG00000007922	BOLL	100	92.905	Mustela_putorius_furo
ENSG00000152430	BOLL	99	91.459	ENSMLUG00000004999	BOLL	99	90.136	Myotis_lucifugus
ENSG00000152430	BOLL	100	93.103	ENSNGAG00000014596	-	98	94.615	Nannospalax_galili
ENSG00000152430	BOLL	56	67.347	ENSNBRG00000019918	-	83	44.037	Neolamprologus_brichardi
ENSG00000152430	BOLL	100	99.647	ENSNLEG00000006885	BOLL	100	99.647	Nomascus_leucogenys
ENSG00000152430	BOLL	92	92.500	ENSMEUG00000011305	BOLL	98	64.350	Notamacropus_eugenii
ENSG00000152430	BOLL	92	96.250	ENSOPRG00000013693	BOLL	98	77.410	Ochotona_princeps
ENSG00000152430	BOLL	55	52.083	ENSOPRG00000001387	-	51	39.106	Ochotona_princeps
ENSG00000152430	BOLL	94	84.962	ENSODEG00000008471	BOLL	95	84.962	Octodon_degus
ENSG00000152430	BOLL	89	50.192	ENSONIG00000015267	-	98	50.192	Oreochromis_niloticus
ENSG00000152430	BOLL	90	80.769	ENSOANG00000019928	-	88	93.007	Ornithorhynchus_anatinus
ENSG00000152430	BOLL	99	92.580	ENSOCUG00000013979	BOLL	99	92.388	Oryctolagus_cuniculus
ENSG00000152430	BOLL	88	39.300	ENSORLG00000025401	boll	54	39.300	Oryzias_latipes
ENSG00000152430	BOLL	100	94.253	ENSOGAG00000007207	BOLL	100	92.203	Otolemur_garnettii
ENSG00000152430	BOLL	100	95.402	ENSOARG00000015644	BOLL	100	94.576	Ovis_aries
ENSG00000152430	BOLL	100	99.647	ENSPPAG00000033757	BOLL	100	99.647	Pan_paniscus
ENSG00000152430	BOLL	100	95.402	ENSPPRG00000007352	BOLL	100	94.915	Panthera_pardus
ENSG00000152430	BOLL	100	95.402	ENSPTIG00000011925	BOLL	100	94.915	Panthera_tigris_altaica
ENSG00000152430	BOLL	100	99.647	ENSPTRG00000012777	BOLL	100	99.647	Pan_troglodytes
ENSG00000152430	BOLL	100	98.940	ENSPANG00000009570	BOLL	100	98.644	Papio_anubis
ENSG00000152430	BOLL	54	53.191	ENSPKIG00000009153	-	58	53.191	Paramormyrops_kingsleyae
ENSG00000152430	BOLL	100	71.264	ENSPKIG00000000551	BOLL	72	71.338	Paramormyrops_kingsleyae
ENSG00000152430	BOLL	90	34.082	ENSPSIG00000009803	-	72	35.656	Pelodiscus_sinensis
ENSG00000152430	BOLL	97	86.182	ENSPSIG00000018004	BOLL	86	84.375	Pelodiscus_sinensis
ENSG00000152430	BOLL	61	52.830	ENSPMGG00000017006	-	78	45.000	Periophthalmus_magnuspinnatus
ENSG00000152430	BOLL	53	39.752	ENSPEMG00000019679	Dazl	81	39.752	Peromyscus_maniculatus_bairdii
ENSG00000152430	BOLL	100	93.103	ENSPEMG00000018168	Boll	100	93.286	Peromyscus_maniculatus_bairdii
ENSG00000152430	BOLL	85	59.350	ENSPMAG00000009126	BOLL	91	50.685	Petromyzon_marinus
ENSG00000152430	BOLL	98	91.103	ENSPCIG00000010605	-	93	91.103	Phascolarctos_cinereus
ENSG00000152430	BOLL	97	75.273	ENSPCIG00000029134	-	89	74.517	Phascolarctos_cinereus
ENSG00000152430	BOLL	68	60.000	ENSPFOG00000005602	-	64	42.478	Poecilia_formosa
ENSG00000152430	BOLL	55	66.667	ENSPLAG00000006076	-	65	45.575	Poecilia_latipinna
ENSG00000152430	BOLL	75	56.923	ENSPMEG00000022615	-	78	45.045	Poecilia_mexicana
ENSG00000152430	BOLL	55	66.667	ENSPREG00000012098	-	65	45.575	Poecilia_reticulata
ENSG00000152430	BOLL	100	99.293	ENSPPYG00000013050	BOLL	100	99.306	Pongo_abelii
ENSG00000152430	BOLL	100	95.402	ENSPCOG00000002476	BOLL	97	95.402	Propithecus_coquereli
ENSG00000152430	BOLL	87	81.724	ENSPVAG00000015269	BOLL	99	81.724	Pteropus_vampyrus
ENSG00000152430	BOLL	72	47.619	ENSPNYG00000020484	dazl	87	34.574	Pundamilia_nyererei
ENSG00000152430	BOLL	97	49.834	ENSPNAG00000023174	-	83	50.831	Pygocentrus_nattereri
ENSG00000152430	BOLL	100	91.954	ENSRNOG00000015798	Boll	98	92.014	Rattus_norvegicus
ENSG00000152430	BOLL	55	60.417	ENSRNOG00000023474	Dazl	57	42.105	Rattus_norvegicus
ENSG00000152430	BOLL	100	91.954	ENSRNOG00000054379	LOC108348134	98	92.014	Rattus_norvegicus
ENSG00000152430	BOLL	100	98.940	ENSRBIG00000042131	BOLL	100	98.940	Rhinopithecus_bieti
ENSG00000152430	BOLL	100	98.940	ENSRROG00000016942	BOLL	100	98.305	Rhinopithecus_roxellana
ENSG00000152430	BOLL	55	60.417	ENSSBOG00000033845	DAZL	69	37.391	Saimiri_boliviensis_boliviensis
ENSG00000152430	BOLL	100	96.820	ENSSBOG00000027161	BOLL	100	96.875	Saimiri_boliviensis_boliviensis
ENSG00000152430	BOLL	100	90.805	ENSSHAG00000018057	BOLL	92	92.430	Sarcophilus_harrisii
ENSG00000152430	BOLL	88	52.672	ENSSFOG00015023350	boll	74	52.672	Scleropages_formosus
ENSG00000152430	BOLL	90	51.866	ENSSDUG00000004624	-	74	51.866	Seriola_dumerili
ENSG00000152430	BOLL	92	44.785	ENSSLDG00000003410	-	89	47.737	Seriola_lalandi_dorsalis
ENSG00000152430	BOLL	55	60.417	ENSSARG00000008473	-	55	40.223	Sorex_araneus
ENSG00000152430	BOLL	97	83.333	ENSSPUG00000000618	-	94	84.337	Sphenodon_punctatus
ENSG00000152430	BOLL	55	62.500	ENSSSCG00000030671	-	55	41.341	Sus_scrofa
ENSG00000152430	BOLL	98	93.478	ENSSSCG00000016082	BOLL	99	93.478	Sus_scrofa
ENSG00000152430	BOLL	77	38.095	ENSTGUG00000003145	-	70	38.095	Taeniopygia_guttata
ENSG00000152430	BOLL	95	68.519	ENSTGUG00000010496	BOLL	100	68.364	Taeniopygia_guttata
ENSG00000152430	BOLL	53	60.870	ENSTRUG00000021705	-	79	40.611	Takifugu_rubripes
ENSG00000152430	BOLL	92	95.000	ENSTBEG00000017343	BOLL	98	69.789	Tupaia_belangeri
ENSG00000152430	BOLL	55	60.417	ENSTBEG00000012225	-	51	42.135	Tupaia_belangeri
ENSG00000152430	BOLL	100	95.402	ENSUAMG00000016037	BOLL	98	90.625	Ursus_americanus
ENSG00000152430	BOLL	100	95.402	ENSUMAG00000020969	BOLL	98	90.625	Ursus_maritimus
ENSG00000152430	BOLL	100	94.253	ENSVVUG00000025901	BOLL	98	94.792	Vulpes_vulpes
ENSG00000152430	BOLL	55	54.167	ENSXETG00000025199	dazl	61	38.172	Xenopus_tropicalis
ENSG00000152430	BOLL	85	54.667	ENSXCOG00000020319	-	85	61.039	Xiphophorus_couchianus
ENSG00000152430	BOLL	55	66.667	ENSXMAG00000021766	-	65	45.575	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005515	protein binding	16001084.25416956.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	11390979.	IDA	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007281	germ cell development	-	IEA	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008494	translation activator activity	21873635.	IBA	Function
GO:0008494	translation activator activity	16001084.	IDA	Function
GO:0045948	positive regulation of translational initiation	21873635.	IBA	Process
GO:0045948	positive regulation of translational initiation	16001084.	IDA	Process
GO:0051321	meiotic cell cycle	12499397.	IDA	Process
GO:0070935	3'-UTR-mediated mRNA stabilization	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25605553	Oncogenic Role of BOLL in Colorectal Cancer.	Dig Dis Sci	2015 Jun	Kang KJ	doi: 10.1007/s10620-015-3533-z

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	197756486	Missense_Mutation	novel	A224V	0.59
BLCA	chr2	197756505	Missense_Mutation	NA	Y218N	0.2
BLCA	chr2	197777058	Splice_Site	novel	X92_splice	0.37
BRCA	chr2	197779036	Frame_Shift_Del	NA	*S54Pfs6**	0.11	RRM_1
BRCA	chr2	197777103	Missense_Mutation	rs577424738	V78I	0.27	RRM_1
BRCA	chr2	197781833	Missense_Mutation	NA	L6F	0.26
BRCA	chr2	197777069	Frame_Shift_Ins	NA	*I89Nfs6**	0.32	RRM_1
CESC	chr2	197756514	Missense_Mutation	novel	E215K	0.21
CESC	chr2	197766567	Missense_Mutation	novel	Q173E	0.36
CESC	chr2	197786007	5'Flank	novel		0.22
CESC	chr2	197785257	5'UTR	novel		0.48
CESC	chr2	197784671	Intron	novel		0.5
CESC	chr2	197785057	Splice_Region	rs555126144		0.17
CHOL	chr2	197728434	3'UTR	novel		0.07
COAD	chr2	197774149	Intron	novel		0.22
COAD	chr2	197728555	Nonstop_Mutation	novel	284Yext11	0.18
COAD	chr2	197774114	Intron	novel		0.08
COAD	chr2	197779060	Missense_Mutation	rs778462794	E46K	0.51	RRM_1
COAD	chr2	197781831	Missense_Mutation	NA	S7F	0.5
COAD	chr2	197728534	3'UTR	novel		0.17
COAD	chr2	197786027	5'Flank	novel		0.26
COAD	chr2	197728382	3'UTR	novel		0.22
COAD	chr2	197777103	Missense_Mutation	rs577424738	V78I	0.35	RRM_1
COAD	chr2	197777103	Missense_Mutation	rs577424738	V78I	0.42	RRM_1
COAD	chr2	197771874	Missense_Mutation	rs750315080	S154L	0.12
COAD	chr2	197771933	In_Frame_Ins	novel	T134_G135insLIVID	0.04
COAD	chr2	197774073	Intron	novel		0.05
COAD	chr2	197774075	Intron	novel		0.02
ESCA	chr2	197771913	Missense_Mutation	novel	H141R	0.5
ESCA	chr2	197771914	Missense_Mutation	novel	H141N	0.51
ESCA	chr2	197785258	5'UTR	novel		0.25
ESCA	chr2	197786166	5'Flank	novel		0.24
ESCA	chr2	197786095	5'Flank	novel		0.19
GBM	chr2	197779035	Missense_Mutation	NA	S54F	0.4	RRM_1
GBM	chr2	197728499	3'UTR	rs747368316		0.19
HNSC	chr2	197781751	Missense_Mutation	rs377264153	R34C	0.23
HNSC	chr2	197781797	Silent	novel	L18L	0.22
HNSC	chr2	197756429	Missense_Mutation	novel	E243A	0.3
HNSC	chr2	197771984	Splice_Site	novel	X118_splice	0.15
HNSC	chr2	197728418	3'UTR	novel		0.19
KIRP	chr2	197779031	Silent	NA	Q55Q	0.41
LIHC	chr2	197786035	5'Flank	novel		0.06
LIHC	chr2	197777103	Missense_Mutation	rs577424738	V78I	0.23	RRM_1
LUAD	chr2	197781816	Missense_Mutation	novel	P12H	0.13
LUAD	chr2	197781817	Missense_Mutation	rs761048419	P12T	0.13
LUAD	chr2	197757378	Missense_Mutation	novel	G192A	0.19
LUAD	chr2	197771951	Missense_Mutation	novel	M128I	0.11
LUAD	chr2	197766587	Missense_Mutation	NA	S166I	0.19
LUAD	chr2	197766587	Missense_Mutation	NA	S166I	0.18
LUAD	chr2	197777112	Missense_Mutation	NA	Y75D	0.25	RRM_1
LUAD	chr2	197778979	Missense_Mutation	NA	K73E	0.18	RRM_1
LUSC	chr2	197786100	5'Flank	novel		0.32
LUSC	chr2	197771869	Missense_Mutation	novel	P156A	0.37
LUSC	chr2	197785995	5'Flank	novel		0.21
LUSC	chr2	197786084	5'Flank	novel		0.53
LUSC	chr2	197771866	Missense_Mutation	novel	P157A	0.2
LUSC	chr2	197766600	Missense_Mutation	rs753383912	R162S	0.11
LUSC	chr2	197775672	Silent	NA	G115G	0.15
LUSC	chr2	197771874	Nonsense_Mutation	novel	S154*	0.48
LUSC	chr2	197728493	3'UTR	novel		0.3
LUSC	chr2	197757351	Splice_Site	novel	X200_splice	0.22
LUSC	chr2	197781738	Missense_Mutation	rs777269851	G38A	0.12	RRM_1
OV	chr2	197766585	Missense_Mutation	NA	S167A	0.28
OV	chr2	197775676	Missense_Mutation	novel	V114E	0.27
OV	chr2	197781798	Missense_Mutation	NA	L18S	0.46
PRAD	chr2	197775672	Silent	NA	G115G	0.24
READ	chr2	197728545	3'UTR	novel		0.31
SARC	chr2	197756445	Missense_Mutation	novel	E238K	0.47
SARC	chr2	197785235	5'UTR	novel		0.09
SARC	chr2	197743113	Missense_Mutation	novel	A259V	0.62
SARC	chr2	197785056	Splice_Region	novel		0.33
SKCM	chr2	197756438	Missense_Mutation	novel	S240L	0.33
SKCM	chr2	197775673	Missense_Mutation	NA	G115E	0.21
SKCM	chr2	197775673	Missense_Mutation	NA	G115E	0.09
SKCM	chr2	197777104	Silent	NA	F77F	0.14
SKCM	chr2	197775723	Silent	NA	Y98Y	0.43
SKCM	chr2	197728508	3'UTR	NA		0.28
SKCM	chr2	197779035	Missense_Mutation	NA	S54F	0.29	RRM_1
SKCM	chr2	197781738	Missense_Mutation	NA	G38E	0.21	RRM_1
SKCM	chr2	197781751	Missense_Mutation	rs377264153	R34C	0.54
SKCM	chr2	197728505	3'UTR	NA		0.41
SKCM	chr2	197786075	5'Flank	novel		0.33
SKCM	chr2	197786036	5'Flank	novel		0.18
SKCM	chr2	197771882	Silent	NA	E151E	0.29
SKCM	chr2	197728477	3'UTR	rs151126588		0.15
SKCM	chr2	197756446	Missense_Mutation	novel	M237I	0.78
STAD	chr2	197728477	3'UTR	rs151126588		0.24
STAD	chr2	197777071	Missense_Mutation	NA	K88N	0.2	RRM_1
STAD	chr2	197756501	Missense_Mutation	NA	Q219R	0.31
STAD	chr2	197757394	Missense_Mutation	NA	T187A	0.27
STAD	chr2	197777104	Silent	NA	F77F	0.1
THCA	chr2	197775737	Missense_Mutation	NA	E94Q	0.21	RRM_1
UCEC	chr2	197766596	Missense_Mutation	NA	S163F	0.33
UCEC	chr2	197771968	Missense_Mutation	NA	P123S	0.34
UCEC	chr2	197786164	5'Flank	novel		0.5
UCEC	chr2	197756516	Missense_Mutation	novel	S214Y	0.34
UCEC	chr2	197779036	Frame_Shift_Del	NA	*S54Pfs6**	0.23	RRM_1
UCEC	chr2	197728329	3'UTR	novel		0.3
UCEC	chr2	197728275	3'UTR	novel		0.2
UCEC	chr2	197781816	Missense_Mutation	novel	P12L	0.14
UCEC	chr2	197727001	3'UTR	novel		0.4
UCEC	chr2	197777069	Missense_Mutation	novel	I89S	0.41	RRM_1
UCEC	chr2	197781750	Missense_Mutation	novel	R34H	0.03
UCEC	chr2	197786027	5'Flank	novel		0.2
UCEC	chr2	197728439	3'UTR	novel		0.28
UCEC	chr2	197777069	Missense_Mutation	novel	I89S	0.11	RRM_1
UCEC	chr2	197771867	Silent	novel	P156P	0.45
UCEC	chr2	197775674	Missense_Mutation	novel	G115W	0.28
UCEC	chr2	197728123	3'UTR	novel		0.35
UCEC	chr2	197785004	Intron	novel		0.5
UCEC	chr2	197785235	5'UTR	novel		0.22
UCEC	chr2	197786042	5'Flank	rs759920185		0.35
UCEC	chr2	197728176	3'UTR	novel		0.34
UCEC	chr2	197774166	Intron	novel		0.18
UCEC	chr2	197771979	Missense_Mutation	novel	S119Y	0.23
UCEC	chr2	197775731	Frame_Shift_Ins	novel	*L96Tfs2**	0.19	RRM_1
UCEC	chr2	197781817	Missense_Mutation	rs761048419	P12S	0.36
UCEC	chr2	197727004	3'UTR	novel		0.18
UCEC	chr2	197728276	3'UTR	novel		0.36
UCEC	chr2	197779037	Missense_Mutation	novel	F53L	0.29	RRM_1
UCEC	chr2	197743126	Missense_Mutation	NA	H255N	0.32
UCEC	chr2	197757377	Silent	novel	G192G	0.19
UCEC	chr2	197786109	5'Flank	novel		0.33
UCEC	chr2	197786157	5'Flank	novel		0.09
UCEC	chr2	197743113	Missense_Mutation	novel	A259D	0.33
UCEC	chr2	197781838	Missense_Mutation	novel	S5A	0.35
UCEC	chr2	197775664	Splice_Site	NA	X118_splice	0.03
UCEC	chr2	197785292	5'UTR	novel		0.63
UCEC	chr2	197774021	Intron	novel		0.09
UCEC	chr2	197786164	5'Flank	novel		0.55
UCEC	chr2	197726937	3'UTR	novel		0.29
UCEC	chr2	197756526	Missense_Mutation	novel	L211M	0.21
UCEC	chr2	197728446	3'UTR	novel		0.24
UCEC	chr2	197781832	Missense_Mutation	NA	S7A	0.24
UCEC	chr2	197786026	5'Flank	novel		0.45
UCEC	chr2	197728381	3'UTR	novel		0.21
UCEC	chr2	197771916	Missense_Mutation	novel	Y140C	0.18
UCEC	chr2	197779061	Silent	rs573658606	N45N	0.31
UCEC	chr2	197786210	5'Flank	novel		0.3
UCEC	chr2	197757397	Missense_Mutation	novel	T186A	0.54
UCEC	chr2	197785988	5'Flank	NA		0.44
UCEC	chr2	197726921	3'UTR	novel		0.41
UCEC	chr2	197757399	Missense_Mutation	novel	A185V	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.139	0.012962
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.0272	0.2014

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.011	Kaplan-Meier Survival Analysis
ESCA	0.0014	Kaplan-Meier Survival Analysis
BLCA	0.014	Kaplan-Meier Survival Analysis
DLBC	0.019	Kaplan-Meier Survival Analysis
LGG	0.014	Kaplan-Meier Survival Analysis