EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000152670 (Gene tree)
Gene ID: 54514
Gene Symbol: DDX4
Alias: VASA
Full Name: DEAD-box helicase 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 79,163 bases
Position: chr5:55,737,995-55,817,157
Accession: 18700
RBP type: canonical RBP
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000423123	DEAD	PF00270.29	2.3e-49	1	1
ENSP00000427167	DEAD	PF00270.29	3.1e-49	1	1
ENSP00000334167	DEAD	PF00270.29	3.4e-49	1	1
ENSP00000347087	DEAD	PF00270.29	3.4e-49	1	1
ENSP00000425359	DEAD	PF00270.29	3.6e-49	1	1
ENSP00000424838	DEAD	PF00270.29	3.8e-49	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22223882	Regulation of an RNA granule during spermatogenesis: acetylation of MVH in the chromatoid body of germ cells.	J Cell Sci	2011 Dec 15	Nagamori I	doi: 10.1242/jcs.096461
15939379	Exploring embryonic germ line development in the water flea, Daphnia magna, by zinc-finger-containing VASA as a marker.	Gene Expr Patterns	2005 Jun	Sagawa K	-
14747711	Crystallization and preliminary X-ray analysis of the helicase domains of Vasa complexed with RNA and an ATP analogue.	Acta Crystallogr D Biol Crystallogr	2004 Feb	Sengoku T	-
19324033	Ectopic expression of Cvh (Chicken Vasa homologue) mediates the reprogramming of chicken embryonic stem cells to a germ cell fate.	Dev Biol	2009 Jun 1	Lavial F	doi: 10.1016/j.ydbio.2009.03.012
22162380	Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro.	Stem Cells	2012 Mar	Medrano JV	doi: 10.1002/stem.1012.
22133614	Mitf is a transcriptional activator of medaka germ genes in culture.	Biochimie	2012 Mar	Zhao H	doi: 10.1016/j.biochi.2011.11.007
26190108	The Crystal Structure of the Drosophila Germline Inducer Oskar Identifies Two Domains with Distinct Vasa Helicase- and RNA-Binding Activities.	Cell Rep	2015 Jul 28	Jeske M	doi: 10.1016/j.celrep.2015.06.055
26595369	Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.	Reprod Fertil Dev	2017 Apr	Shah SM	doi: 10.1071/RD15159.
22366449	Inhibition of mRNA maturation in trypanosomes causes the formation of novel foci at the nuclear periphery containing cytoplasmic regulators of mRNA fate.	J Cell Sci	2012 Jun 15	Kramer S	doi: 10.1242/jcs.099275
20561531	Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.	J Mol Biol	2010 Aug 20	Filippakopoulos P	doi: 10.1016/j.jmb.2010.06.017
23611023	Pre-stem cell formation by non-platelet RNA-containing particle fusion.	Clin Exp Pharmacol Physiol	2013 Jul	Kong W	doi: 10.1111/1440-1681.12101.
25772273	Vasa, PL10, and Piwi gene expression during caudal regeneration of the polychaete annelid Alitta virens.	Dev Genes Evol	2015 Jun	Kozin VV	doi: 10.1007/s00427-015-0496-1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000514679	DDX4-213	566	-	ENSP00000424112	159 (aa)	-	D6RBL3
ENST00000353507	DDX4-201	2778	-	ENSP00000334167	690 (aa)	-	Q9NQI0
ENST00000506848	DDX4-206	567	-	ENSP00000421960	105 (aa)	-	D6RAF5
ENST00000515709	DDX4-214	470	-	ENSP00000424779	142 (aa)	-	D6RAT7
ENST00000511853	DDX4-211	1984	-	ENSP00000423123	575 (aa)	-	Q9NQI0
ENST00000503129	DDX4-203	1684	-	ENSP00000423102	305 (aa)	-	H0Y960
ENST00000505374	DDX4-204	2884	XM_011543495	ENSP00000424838	724 (aa)	XP_011541797	Q9NQI0
ENST00000511491	DDX4-210	549	-	ENSP00000427522	156 (aa)	-	D6RIB2
ENST00000508580	DDX4-208	600	-	-	- (aa)	-	-
ENST00000506511	DDX4-205	1631	-	ENSP00000427167	518 (aa)	-	D6RCM4
ENST00000514278	DDX4-212	2451	XM_011543497	ENSP00000425359	704 (aa)	XP_011541799	Q9NQI0
ENST00000507645	DDX4-207	554	-	ENSP00000430431	50 (aa)	-	H0YBW0
ENST00000354991	DDX4-202	2324	-	ENSP00000347087	690 (aa)	-	Q9NQI0
ENST00000509312	DDX4-209	486	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000152670's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000152670	Neuroblastoma	3.33e-005	23222812
ENSG00000152670	Neuroblastoma	4.21e-005	23222812
ENSG00000152670	Neuroblastoma	1.76e-005	23222812
ENSG00000152670	Neuroblastoma	9.29e-005	23222812
ENSG00000152670	Neuroblastoma	5.09e-005	23222812
ENSG00000152670	Body Height	9.379e-005	18193045
ENSG00000152670	Body Height	3.808e-005	18193045
ENSG00000152670	Body Height	3.808e-005	18193045

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152670's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000152670	DDX4	64	33.687	ENSG00000105671	DDX49	70	42.697
ENSG00000152670	DDX4	62	35.262	ENSG00000213782	DDX47	77	35.262
ENSG00000152670	DDX4	65	36.508	ENSG00000124228	DDX27	85	32.245
ENSG00000152670	DDX4	68	40.506	ENSG00000080007	DDX43	59	40.506
ENSG00000152670	DDX4	67	32.732	ENSG00000178105	DDX10	54	32.891
ENSG00000152670	DDX4	68	39.698	ENSG00000108654	DDX5	93	46.512
ENSG00000152670	DDX4	72	35.446	ENSG00000118197	DDX59	86	37.500
ENSG00000152670	DDX4	63	31.383	ENSG00000168872	DDX19A	86	31.405
ENSG00000152670	DDX4	63	31.759	ENSG00000109832	DDX25	91	31.667
ENSG00000152670	DDX4	77	52.980	ENSG00000215301	DDX3X	91	51.945
ENSG00000152670	DDX4	78	52.838	ENSG00000067048	DDX3Y	71	51.483
ENSG00000152670	DDX4	69	38.765	ENSG00000183258	DDX41	64	38.765
ENSG00000152670	DDX4	62	30.084	ENSG00000156976	EIF4A2	76	34.783
ENSG00000152670	DDX4	75	30.660	ENSG00000278053	DDX52	66	34.398
ENSG00000152670	DDX4	64	37.366	ENSG00000184735	DDX53	57	37.366
ENSG00000152670	DDX4	67	31.525	ENSG00000141543	EIF4A3	90	31.202
ENSG00000152670	DDX4	76	36.264	ENSG00000198231	DDX42	56	38.424
ENSG00000152670	DDX4	70	30.465	ENSG00000088205	DDX18	89	33.019
ENSG00000152670	DDX4	68	39.798	ENSG00000100201	DDX17	63	60.000
ENSG00000152670	DDX4	59	34.454	ENSG00000111364	DDX55	86	37.647
ENSG00000152670	DDX4	62	33.056	ENSG00000110367	DDX6	71	33.056
ENSG00000152670	DDX4	62	32.133	ENSG00000123064	DDX54	93	34.597
ENSG00000152670	DDX4	63	31.383	ENSG00000157349	DDX19B	90	31.831

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152670	DDX4	69	61.404	ENSAPOG00000021394	ddx4	100	61.404	Acanthochromis_polyacanthus
ENSG00000152670	DDX4	100	92.318	ENSAMEG00000013960	DDX4	100	92.318	Ailuropoda_melanoleuca
ENSG00000152670	DDX4	69	67.920	ENSACIG00000017623	ddx4	100	67.920	Amphilophus_citrinellus
ENSG00000152670	DDX4	69	67.250	ENSAPEG00000008490	ddx4	100	67.250	Amphiprion_percula
ENSG00000152670	DDX4	69	71.212	ENSATEG00000011704	ddx4	100	71.212	Anabas_testudineus
ENSG00000152670	DDX4	76	80.594	ENSAPLG00000011662	DDX4	98	80.594	Anas_platyrhynchos
ENSG00000152670	DDX4	88	77.426	ENSACAG00000014951	DDX4	100	62.517	Anolis_carolinensis
ENSG00000152670	DDX4	100	95.514	ENSANAG00000029060	DDX4	100	95.514	Aotus_nancymaae
ENSG00000152670	DDX4	86	66.197	ENSACLG00000007422	ddx4	93	59.571	Astatotilapia_calliptera
ENSG00000152670	DDX4	86	70.000	ENSAMXG00000010288	ddx4	99	59.762	Astyanax_mexicanus
ENSG00000152670	DDX4	100	91.084	ENSBTAG00000008871	DDX4	100	91.084	Bos_taurus
ENSG00000152670	DDX4	79	43.284	WBGene00001598	glh-1	70	40.296	Caenorhabditis_elegans
ENSG00000152670	DDX4	82	36.728	WBGene00001600	glh-3	81	36.728	Caenorhabditis_elegans
ENSG00000152670	DDX4	99	96.503	ENSCJAG00000001951	DDX4	99	96.503	Callithrix_jacchus
ENSG00000152670	DDX4	100	92.318	ENSCAFG00000006875	DDX4	100	92.318	Canis_familiaris
ENSG00000152670	DDX4	98	89.217	ENSCAFG00020024295	DDX4	100	86.963	Canis_lupus_dingo
ENSG00000152670	DDX4	100	91.358	ENSCHIG00000015567	DDX4	100	91.358	Capra_hircus
ENSG00000152670	DDX4	100	90.783	ENSTSYG00000011848	DDX4	100	90.783	Carlito_syrichta
ENSG00000152670	DDX4	100	68.908	ENSCPOG00000004327	DDX4	100	69.188	Cavia_porcellus
ENSG00000152670	DDX4	100	96.522	ENSCCAG00000028725	DDX4	100	96.522	Cebus_capucinus
ENSG00000152670	DDX4	100	99.132	ENSCATG00000044303	DDX4	100	99.132	Cercocebus_atys
ENSG00000152670	DDX4	100	86.831	ENSCLAG00000005386	DDX4	100	86.831	Chinchilla_lanigera
ENSG00000152670	DDX4	100	97.143	ENSCSAG00000016336	DDX4	100	97.143	Chlorocebus_sabaeus
ENSG00000152670	DDX4	97	85.811	ENSCHOG00000000200	DDX4	100	80.414	Choloepus_hoffmanni
ENSG00000152670	DDX4	93	80.261	ENSCPBG00000026547	DDX4	100	79.964	Chrysemys_picta_bellii
ENSG00000152670	DDX4	92	52.632	ENSCING00000001412	-	93	53.832	Ciona_intestinalis
ENSG00000152670	DDX4	90	54.244	ENSCSAVG00000004304	-	98	49.267	Ciona_savignyi
ENSG00000152670	DDX4	100	93.396	ENSCANG00000003129	DDX4	100	89.645	Colobus_angolensis_palliatus
ENSG00000152670	DDX4	100	89.452	ENSCGRG00001014961	Ddx4	100	89.452	Cricetulus_griseus_chok1gshd
ENSG00000152670	DDX4	100	89.452	ENSCGRG00000001251	Ddx4	100	89.452	Cricetulus_griseus_crigri
ENSG00000152670	DDX4	80	63.696	ENSCSEG00000006039	ddx4	87	53.796	Cynoglossus_semilaevis
ENSG00000152670	DDX4	85	69.860	ENSDARG00000014373	ddx4	99	56.469	Danio_rerio
ENSG00000152670	DDX4	94	88.184	ENSDNOG00000011658	DDX4	100	88.184	Dasypus_novemcinctus
ENSG00000152670	DDX4	100	86.494	ENSDORG00000012201	Ddx4	100	88.098	Dipodomys_ordii
ENSG00000152670	DDX4	83	51.875	FBgn0283442	vas	71	50.820	Drosophila_melanogaster
ENSG00000152670	DDX4	69	93.994	ENSETEG00000001835	DDX4	71	93.994	Echinops_telfairi
ENSG00000152670	DDX4	73	52.535	ENSEBUG00000003290	-	84	52.765	Eptatretus_burgeri
ENSG00000152670	DDX4	100	90.398	ENSEASG00005012143	DDX4	100	92.222	Equus_asinus_asinus
ENSG00000152670	DDX4	100	89.209	ENSECAG00000023616	DDX4	100	91.419	Equus_caballus
ENSG00000152670	DDX4	82	94.800	ENSEEUG00000012462	DDX4	81	95.491	Erinaceus_europaeus
ENSG00000152670	DDX4	85	70.204	ENSELUG00000017328	ddx4	95	59.969	Esox_lucius
ENSG00000152670	DDX4	100	92.919	ENSFCAG00000012560	DDX4	100	92.919	Felis_catus
ENSG00000152670	DDX4	77	76.854	ENSFALG00000010910	DDX4	95	56.570	Ficedula_albicollis
ENSG00000152670	DDX4	100	87.106	ENSFDAG00000003703	DDX4	100	87.106	Fukomys_damarensis
ENSG00000152670	DDX4	85	67.006	ENSFHEG00000019935	ddx4	95	59.490	Fundulus_heteroclitus
ENSG00000152670	DDX4	90	66.098	ENSGALG00000014713	DDX4	79	66.098	Gallus_gallus
ENSG00000152670	DDX4	85	67.556	ENSGAFG00000016509	ddx4	96	58.216	Gambusia_affinis
ENSG00000152670	DDX4	84	69.278	ENSGACG00000015323	ddx4	100	69.278	Gasterosteus_aculeatus
ENSG00000152670	DDX4	100	99.478	ENSGGOG00000002439	DDX4	100	99.478	Gorilla_gorilla
ENSG00000152670	DDX4	85	65.720	ENSHBUG00000001897	ddx4	93	57.692	Haplochromis_burtoni
ENSG00000152670	DDX4	97	84.068	ENSHGLG00000003594	DDX4	100	79.835	Heterocephalus_glaber_female
ENSG00000152670	DDX4	97	70.608	ENSHGLG00100001008	-	76	84.818	Heterocephalus_glaber_male
ENSG00000152670	DDX4	84	67.146	ENSHCOG00000018337	ddx4	94	61.376	Hippocampus_comes
ENSG00000152670	DDX4	87	68.762	ENSIPUG00000001845	ddx4	88	66.179	Ictalurus_punctatus
ENSG00000152670	DDX4	100	91.781	ENSSTOG00000021044	DDX4	100	91.781	Ictidomys_tridecemlineatus
ENSG00000152670	DDX4	100	88.356	ENSJJAG00000015867	Ddx4	100	88.356	Jaculus_jaculus
ENSG00000152670	DDX4	83	68.802	ENSKMAG00000012439	ddx4	95	59.520	Kryptolebias_marmoratus
ENSG00000152670	DDX4	84	68.033	ENSLBEG00000019504	ddx4	95	59.420	Labrus_bergylta
ENSG00000152670	DDX4	84	73.085	ENSLOCG00000010887	ddx4	100	73.085	Lepisosteus_oculatus
ENSG00000152670	DDX4	100	90.137	ENSLAFG00000005900	DDX4	100	90.137	Loxodonta_africana
ENSG00000152670	DDX4	100	99.304	ENSMFAG00000040186	DDX4	100	99.304	Macaca_fascicularis
ENSG00000152670	DDX4	100	99.304	ENSMMUG00000017386	DDX4	100	99.304	Macaca_mulatta
ENSG00000152670	DDX4	100	99.304	ENSMNEG00000033343	DDX4	100	99.304	Macaca_nemestrina
ENSG00000152670	DDX4	100	96.875	ENSMLEG00000038233	DDX4	100	92.429	Mandrillus_leucophaeus
ENSG00000152670	DDX4	69	66.917	ENSMAMG00000003574	ddx4	100	66.917	Mastacembelus_armatus
ENSG00000152670	DDX4	86	66.197	ENSMZEG00005019116	ddx4	93	58.360	Maylandia_zebra
ENSG00000152670	DDX4	97	84.122	ENSMAUG00000019873	Ddx4	100	76.680	Mesocricetus_auratus
ENSG00000152670	DDX4	97	79.730	ENSMICG00000028132	-	96	76.341	Microcebus_murinus
ENSG00000152670	DDX4	100	92.786	ENSMICG00000008994	-	100	92.786	Microcebus_murinus
ENSG00000152670	DDX4	100	88.767	ENSMOCG00000013250	Ddx4	100	88.767	Microtus_ochrogaster
ENSG00000152670	DDX4	84	66.803	ENSMMOG00000004689	ddx4	86	66.803	Mola_mola
ENSG00000152670	DDX4	100	82.240	ENSMODG00000019511	DDX4	100	82.650	Monodelphis_domestica
ENSG00000152670	DDX4	100	88.098	MGP_CAROLIEiJ_G0018893	Ddx4	100	88.098	Mus_caroli
ENSG00000152670	DDX4	100	88.372	ENSMUSG00000021758	Ddx4	100	88.372	Mus_musculus
ENSG00000152670	DDX4	100	88.356	MGP_PahariEiJ_G0015964	Ddx4	100	88.356	Mus_pahari
ENSG00000152670	DDX4	100	88.782	MGP_SPRETEiJ_G0019772	Ddx4	100	88.782	Mus_spretus
ENSG00000152670	DDX4	100	92.603	ENSMPUG00000007596	DDX4	100	92.603	Mustela_putorius_furo
ENSG00000152670	DDX4	100	82.401	ENSMLUG00000001189	DDX4	100	82.810	Myotis_lucifugus
ENSG00000152670	DDX4	100	86.986	ENSNGAG00000013259	Ddx4	100	86.986	Nannospalax_galili
ENSG00000152670	DDX4	85	64.431	ENSNBRG00000014442	ddx4	100	59.352	Neolamprologus_brichardi
ENSG00000152670	DDX4	100	97.574	ENSNLEG00000001662	DDX4	100	97.574	Nomascus_leucogenys
ENSG00000152670	DDX4	85	77.692	ENSMEUG00000007757	DDX4	71	80.858	Notamacropus_eugenii
ENSG00000152670	DDX4	80	88.115	ENSOPRG00000008071	DDX4	100	68.670	Ochotona_princeps
ENSG00000152670	DDX4	100	85.734	ENSODEG00000016951	-	100	85.734	Octodon_degus
ENSG00000152670	DDX4	98	82.638	ENSODEG00000003839	-	100	78.738	Octodon_degus
ENSG00000152670	DDX4	82	67.579	ENSONIG00000012063	ddx4	98	67.516	Oreochromis_niloticus
ENSG00000152670	DDX4	65	86.253	ENSOANG00000004888	-	94	86.253	Ornithorhynchus_anatinus
ENSG00000152670	DDX4	100	89.026	ENSOCUG00000008597	DDX4	100	89.026	Oryctolagus_cuniculus
ENSG00000152670	DDX4	82	70.825	ENSORLG00000020672	ddx4	90	62.827	Oryzias_latipes
ENSG00000152670	DDX4	82	70.825	ENSORLG00020014206	ddx4	90	63.393	Oryzias_latipes_hni
ENSG00000152670	DDX4	82	70.440	ENSORLG00015016600	ddx4	90	62.912	Oryzias_latipes_hsok
ENSG00000152670	DDX4	82	69.280	ENSOMEG00000010651	ddx4	97	58.567	Oryzias_melastigma
ENSG00000152670	DDX4	100	92.170	ENSOGAG00000007588	DDX4	100	92.170	Otolemur_garnettii
ENSG00000152670	DDX4	100	91.257	ENSOARG00000007644	DDX4	100	91.257	Ovis_aries
ENSG00000152670	DDX4	100	100.000	ENSPPAG00000033915	DDX4	100	100.000	Pan_paniscus
ENSG00000152670	DDX4	100	92.775	ENSPPRG00000011417	DDX4	100	92.775	Panthera_pardus
ENSG00000152670	DDX4	100	92.052	ENSPTIG00000007748	DDX4	100	92.052	Panthera_tigris_altaica
ENSG00000152670	DDX4	100	100.000	ENSPTRG00000016884	DDX4	100	100.000	Pan_troglodytes
ENSG00000152670	DDX4	100	98.957	ENSPANG00000010945	DDX4	100	98.957	Papio_anubis
ENSG00000152670	DDX4	88	80.115	ENSPSIG00000017179	DDX4	99	75.801	Pelodiscus_sinensis
ENSG00000152670	DDX4	65	63.369	ENSPMGG00000015642	ddx4	94	63.369	Periophthalmus_magnuspinnatus
ENSG00000152670	DDX4	100	88.767	ENSPEMG00000010086	Ddx4	100	88.767	Peromyscus_maniculatus_bairdii
ENSG00000152670	DDX4	98	79.867	ENSPCIG00000024758	DDX4	100	82.692	Phascolarctos_cinereus
ENSG00000152670	DDX4	82	69.002	ENSPFOG00000018842	ddx4	96	58.685	Poecilia_formosa
ENSG00000152670	DDX4	82	69.214	ENSPLAG00000020726	ddx4	96	58.842	Poecilia_latipinna
ENSG00000152670	DDX4	82	69.002	ENSPMEG00000002976	ddx4	96	58.685	Poecilia_mexicana
ENSG00000152670	DDX4	82	69.214	ENSPREG00000017840	ddx4	96	58.842	Poecilia_reticulata
ENSG00000152670	DDX4	100	98.897	ENSPPYG00000015472	DDX4	100	98.897	Pongo_abelii
ENSG00000152670	DDX4	100	77.793	ENSPCAG00000002675	DDX4	100	77.793	Procavia_capensis
ENSG00000152670	DDX4	97	92.023	ENSPVAG00000002448	DDX4	100	92.023	Pteropus_vampyrus
ENSG00000152670	DDX4	85	66.667	ENSPNYG00000022212	ddx4	84	66.667	Pundamilia_nyererei
ENSG00000152670	DDX4	75	73.782	ENSPNAG00000003686	ddx4	84	63.669	Pygocentrus_nattereri
ENSG00000152670	DDX4	97	89.459	ENSRNOG00000026686	Ddx4	99	89.459	Rattus_norvegicus
ENSG00000152670	DDX4	100	98.957	ENSRBIG00000028795	DDX4	100	98.957	Rhinopithecus_bieti
ENSG00000152670	DDX4	100	98.783	ENSRROG00000045392	DDX4	100	98.783	Rhinopithecus_roxellana
ENSG00000152670	DDX4	84	46.371	YPL119C	DBP1	68	50.119	Saccharomyces_cerevisiae
ENSG00000152670	DDX4	100	95.658	ENSSBOG00000035231	DDX4	100	95.658	Saimiri_boliviensis_boliviensis
ENSG00000152670	DDX4	100	81.335	ENSSHAG00000009132	DDX4	100	81.744	Sarcophilus_harrisii
ENSG00000152670	DDX4	83	73.125	ENSSFOG00015006531	ddx4	76	71.774	Scleropages_formosus
ENSG00000152670	DDX4	83	67.220	ENSSMAG00000009800	ddx4	97	58.044	Scophthalmus_maximus
ENSG00000152670	DDX4	88	66.864	ENSSDUG00000022015	ddx4	96	60.420	Seriola_dumerili
ENSG00000152670	DDX4	69	69.424	ENSSLDG00000015312	ddx4	100	69.424	Seriola_lalandi_dorsalis
ENSG00000152670	DDX4	100	78.897	ENSSARG00000004206	DDX4	100	79.724	Sorex_araneus
ENSG00000152670	DDX4	81	85.193	ENSSPUG00000007260	DDX4	80	85.193	Sphenodon_punctatus
ENSG00000152670	DDX4	69	66.000	ENSSPAG00000014307	ddx4	100	66.000	Stegastes_partitus
ENSG00000152670	DDX4	100	91.495	ENSSSCG00000016913	DDX4	100	91.495	Sus_scrofa
ENSG00000152670	DDX4	76	76.027	ENSTGUG00000002548	DDX4	100	76.027	Taeniopygia_guttata
ENSG00000152670	DDX4	85	59.754	ENSTNIG00000014474	ddx4	94	57.944	Tetraodon_nigroviridis
ENSG00000152670	DDX4	81	93.204	ENSTBEG00000003569	DDX4	87	74.744	Tupaia_belangeri
ENSG00000152670	DDX4	100	85.950	ENSTTRG00000009316	DDX4	100	85.124	Tursiops_truncatus
ENSG00000152670	DDX4	98	88.870	ENSUAMG00000023028	DDX4	100	87.124	Ursus_americanus
ENSG00000152670	DDX4	98	88.870	ENSUMAG00000009291	DDX4	100	87.268	Ursus_maritimus
ENSG00000152670	DDX4	99	89.106	ENSVPAG00000009491	DDX4	99	90.223	Vicugna_pacos
ENSG00000152670	DDX4	100	92.518	ENSVVUG00000021369	DDX4	100	92.518	Vulpes_vulpes
ENSG00000152670	DDX4	99	55.587	ENSXETG00000030832	DDX4	99	56.294	Xenopus_tropicalis
ENSG00000152670	DDX4	85	68.172	ENSXMAG00000009677	ddx4	94	61.969	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21421998.	IDA	Component
GO:0007140	male meiotic nuclear division	-	ISS	Process
GO:0007141	male meiosis I	-	ISS	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0010529	negative regulation of transposition	-	ISS	Process
GO:0016887	ATPase activity	-	ISS	Function
GO:0030154	cell differentiation	-	IEA	Process
GO:0030317	flagellated sperm motility	21034600.	IMP	Process
GO:0031047	gene silencing by RNA	-	IEA	Process
GO:0034587	piRNA metabolic process	-	ISS	Process
GO:0043046	DNA methylation involved in gamete generation	-	ISS	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0071546	pi-body	-	ISS	Component
GO:0071547	piP-body	-	ISS	Component
GO:1990511	piRNA biosynthetic process	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24727449	DDX4 (DEAD box polypeptide 4) colocalizes with cancer stem cell marker CD133 in ovarian cancers.	Biochem Biophys Res Commun	2014 May 2	Kim KH	doi: 10.1016/j.bbrc.2014.03.144
28612512	Germline factor DDX4 functions in blood-derived cancer cell phenotypes.	Cancer Sci	2017 Aug	Schudrowitz N	doi: 10.1111/cas.13299
18805576	Germ cell specific protein VASA is over-expressed in epithelial ovarian cancer and disrupts DNA damage-induced G2 checkpoint.	Gynecol Oncol	2008 Nov	Hashimoto H	doi: 10.1016/j.ygyno.2008.08.014

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr5	55760221	Missense_Mutation	rs770286750	R50Q	0.46
ACC	chr5	55767914	Missense_Mutation	novel	R123L	0.49
BLCA	chr5	55798449	Nonsense_Mutation	novel	S498*	0.12
BLCA	chr5	55792713	Missense_Mutation	NA	E459K	0.43	DEAD
BLCA	chr5	55798562	Missense_Mutation	NA	R536G	0.36
BLCA	chr5	55781951	Nonsense_Mutation	novel	Q199*	0.47
BLCA	chr5	55814909	Missense_Mutation	novel	E575A	0.15
BLCA	chr5	55781079	Missense_Mutation	novel	D170E	0.15
BLCA	chr5	55767913	Missense_Mutation	rs374972771	R123W	0.31
BLCA	chr5	55787909	Missense_Mutation	novel	K361E	0.12	DEAD
BLCA	chr5	55798549	Silent	NA	L531L	0.36
BLCA	chr5	55779994	Nonsense_Mutation	novel	S142*	0.42
BLCA	chr5	55767913	Missense_Mutation	rs374972771	R123W	0.11
BLCA	chr5	55813754	Missense_Mutation	NA	S566L	0.39
BLCA	chr5	55739000	Missense_Mutation	novel	H13Y	0.17
BRCA	chr5	55785755	Missense_Mutation	NA	P250S	0.11
BRCA	chr5	55785811	Silent	rs754067892	F268F	0.14
BRCA	chr5	55786662	Missense_Mutation	NA	G337W	0.37	DEAD
BRCA	chr5	55798449	Missense_Mutation	NA	S498L	0.27
BRCA	chr5	55760254	Missense_Mutation	NA	S61F	0.41
BRCA	chr5	55746186	Missense_Mutation	NA	G31A	0.29
BRCA	chr5	55816687	3'UTR	novel		0.14
BRCA	chr5	55746219	Nonsense_Mutation	novel	S42*	0.09
CESC	chr5	55815363	Silent	rs773439110	Y679Y	0.42
COAD	chr5	55738958	5'UTR	novel		0.29
COAD	chr5	55781086	Missense_Mutation	rs534079199	E173K	0.44
COAD	chr5	55815343	Missense_Mutation	novel	E673K	0.29
COAD	chr5	55786632	Missense_Mutation	NA	D327Y	0.24	DEAD
COAD	chr5	55815083	Missense_Mutation	novel	R633H	0.36
COAD	chr5	55760259	Silent	NA	R63R	0.29
COAD	chr5	55760216	Silent	NA	P48P	0.28
COAD	chr5	55780044	Nonsense_Mutation	NA	G159*	0.22
COAD	chr5	55785444	Splice_Region	rs773268378		0.25
COAD	chr5	55790608	Missense_Mutation	NA	G402V	0.29	DEAD
COAD	chr5	55792640	Splice_Site	NA	X435_splice	0.12
COAD	chr5	55813745	Frame_Shift_Del	novel	*I565Yfs35**	0.1
COAD	chr5	55816588	3'UTR	novel		0.42
COAD	chr5	55815157	Missense_Mutation	novel	K658Q	0.34
COAD	chr5	55815007	Missense_Mutation	novel	N608H	0.04
ESCA	chr5	55815128	Missense_Mutation	NA	S648L	0.32
ESCA	chr5	55814947	Missense_Mutation	novel	F588I	0.43
GBM	chr5	55787875	Silent	NA	H349H	0.07
GBM	chr5	55787848	Splice_Region	NA	A340A	0.25
GBM	chr5	55815142	Missense_Mutation	novel	A653S	0.23
HNSC	chr5	55815055	Missense_Mutation	novel	Y624H	0.78
HNSC	chr5	55786647	Missense_Mutation	NA	A332T	0.06	DEAD
HNSC	chr5	55815128	Missense_Mutation	NA	S648L	0.05
HNSC	chr5	55760275	Missense_Mutation	novel	R68K	0.23
KIRC	chr5	55760208	Missense_Mutation	NA	D46N	0.25
KIRC	chr5	55790581	Missense_Mutation	NA	C393Y	0.15	DEAD
KIRP	chr5	55815074	Missense_Mutation	NA	R630H	0.06
KIRP	chr5	55792687	Missense_Mutation	rs768783395	R450L	0.41	DEAD
LAML	chr5	55798478	Missense_Mutation	novel	V508L	0.03
LGG	chr5	55767913	Missense_Mutation	rs374972771	R123W	0.33
LGG	chr5	55787939	Missense_Mutation	novel	V371L	0.47	DEAD
LGG	chr5	55780039	Missense_Mutation	rs766670152	R157H	0.24
LGG	chr5	55790631	Nonsense_Mutation	NA	R410*	0.38	DEAD
LIHC	chr5	55815397	Missense_Mutation	rs770112379	V691M	0.43
LIHC	chr5	55787871	Missense_Mutation	NA	A348V	0.24	DEAD
LIHC	chr5	55785802	Silent	novel	G265G	0.28
LIHC	chr5	55786533	Missense_Mutation	rs757404630	N294D	0.28
LUAD	chr5	55760257	Missense_Mutation	NA	G62V	0.77
LUAD	chr5	55787942	Missense_Mutation	novel	A372S	0.18	DEAD
LUAD	chr5	55780045	Missense_Mutation	novel	G159A	0.08
LUAD	chr5	55786572	Missense_Mutation	novel	G307C	0.22
LUAD	chr5	55786629	Nonsense_Mutation	NA	R326*	0.07	DEAD
LUAD	chr5	55787968	Silent	NA	Q380Q	0.11
LUAD	chr5	55787970	Missense_Mutation	novel	I381N	0.11	DEAD
LUAD	chr5	55792792	Missense_Mutation	novel	P485L	0.2	DEAD
LUAD	chr5	55815171	Splice_Region	novel	D662D	0.08
LUAD	chr5	55763216	Missense_Mutation	NA	G83C	0.08
LUAD	chr5	55815412	Missense_Mutation	NA	D696Y	0.15
LUAD	chr5	55763185	Missense_Mutation	NA	E72D	0.15
LUAD	chr5	55781939	Missense_Mutation	NA	G195S	0.26
LUAD	chr5	55790633	Silent	novel	R410R	0.57
LUSC	chr5	55785746	Missense_Mutation	NA	I247V	0.34
LUSC	chr5	55814959	Missense_Mutation	NA	P592T	0.28
LUSC	chr5	55814991	Missense_Mutation	novel	R602S	0.2
LUSC	chr5	55760276	Splice_Region	novel	R68R	0.27
LUSC	chr5	55816462	Splice_Site	novel	X700_splice	0.19
LUSC	chr5	55816463	Missense_Mutation	novel	G700C	0.19
LUSC	chr5	55798535	Missense_Mutation	novel	K527E	0.42
LUSC	chr5	55780008	Missense_Mutation	NA	R147G	0.19
LUSC	chr5	55813707	Frame_Shift_Ins	novel	*A553Sfs21**	0.09
OV	chr5	55738995	Missense_Mutation	NA	N11T	0.24
PAAD	chr5	55813741	Missense_Mutation	novel	Q562K	0.04
PAAD	chr5	55763213	Missense_Mutation	novel	M82L	0.17
PAAD	chr5	55781108	Missense_Mutation	NA	G180D	0.16
PAAD	chr5	55798535	Missense_Mutation	novel	K527Q	0.19
PAAD	chr5	55815160	Missense_Mutation	NA	V659L	0.17
PAAD	chr5	55764020	Nonsense_Mutation	novel	S97*	0.04
PRAD	chr5	55798480	Silent	NA	V508V	0.21
READ	chr5	55785328	Silent	NA	I219I	0.22
READ	chr5	55815424	Splice_Site	NA	X699_splice	0.21
READ	chr5	55760201	Missense_Mutation	novel	E43D	0.4
READ	chr5	55760224	Missense_Mutation	novel	R51I	0.15
READ	chr5	55763250	Missense_Mutation	novel	R94I	0.11
READ	chr5	55792640	Splice_Site	NA	X435_splice	0.46
SARC	chr5	55779976	Missense_Mutation	novel	G136E	0.65
SKCM	chr5	55813674	Splice_Region	NA	G539G	0.3
SKCM	chr5	55787952	Missense_Mutation	NA	R375Q	0.44	DEAD
SKCM	chr5	55779969	Nonsense_Mutation	NA	R134*	0.12
SKCM	chr5	55813675	Missense_Mutation	NA	D540N	0.41
SKCM	chr5	55785317	Missense_Mutation	novel	E216K	0.31
SKCM	chr5	55786515	Splice_Region	novel		0.37
SKCM	chr5	55760237	Missense_Mutation	NA	M55I	0.31
SKCM	chr5	55738988	Missense_Mutation	NA	E9K	0.7
SKCM	chr5	55785767	Missense_Mutation	NA	D254N	0.54
SKCM	chr5	55786567	Frame_Shift_Del	novel	*K305Ifs3**	0.14
SKCM	chr5	55815128	Missense_Mutation	NA	S648L	0.37
SKCM	chr5	55738981	Nonsense_Mutation	novel	W6*	0.29
SKCM	chr5	55760269	Missense_Mutation	NA	G66E	0.33
SKCM	chr5	55814986	Missense_Mutation	novel	A601T	0.4
SKCM	chr5	55814944	Missense_Mutation	NA	R587C	0.59
SKCM	chr5	55785811	Silent	rs754067892	F268F	0.26
SKCM	chr5	55787894	Missense_Mutation	novel	T356A	0.24	DEAD
SKCM	chr5	55815328	Missense_Mutation	NA	P668S	0.37
SKCM	chr5	55814929	Missense_Mutation	novel	A582T	0.24
SKCM	chr5	55785729	Missense_Mutation	novel	G241E	0.24
SKCM	chr5	55792673	Silent	NA	L445L	0.14
SKCM	chr5	55798553	Missense_Mutation	novel	E533K	0.17
SKCM	chr5	55814922	Silent	novel	R579R	0.21
SKCM	chr5	55785820	Nonsense_Mutation	NA	Y271*	0.21
SKCM	chr5	55792745	Missense_Mutation	novel	M469I	0.36	DEAD
SKCM	chr5	55792726	Nonsense_Mutation	NA	L463*	0.09	DEAD
SKCM	chr5	55781942	Missense_Mutation	novel	D196N	0.14
SKCM	chr5	55815111	Silent	NA	S642S	0.37
SKCM	chr5	55763252	Missense_Mutation	novel	G95S	0.21
STAD	chr5	55792711	Missense_Mutation	novel	P458L	0.53	DEAD
STAD	chr5	55792750	Nonsense_Mutation	novel	S471*	0.22	DEAD
STAD	chr5	55815129	Silent	NA	S648S	0.36
STAD	chr5	55763252	Missense_Mutation	NA	G95C	0.37
STAD	chr5	55786527	Nonsense_Mutation	NA	E292*	0.39
STAD	chr5	55764048	Missense_Mutation	novel	S106R	0.33
STAD	chr5	55798470	Missense_Mutation	novel	V505A	0.26
STAD	chr5	55792787	Silent	novel	T483T	0.3
STAD	chr5	55798550	Missense_Mutation	rs777699581	V532I	0.13
STAD	chr5	55792660	Missense_Mutation	NA	K441T	0.08	DEAD
STAD	chr5	55785756	Missense_Mutation	NA	P250H	0.23
THCA	chr5	55792722	Nonsense_Mutation	NA	K462*	0.49	DEAD
THYM	chr5	55815065	Missense_Mutation	novel	R627L	0.09
UCEC	chr5	55798510	Silent	rs766204046	T518T	0.52
UCEC	chr5	55790587	Missense_Mutation	NA	R395I	0.26	DEAD
UCEC	chr5	55798436	Nonsense_Mutation	NA	E494*	0.35
UCEC	chr5	55815160	Missense_Mutation	NA	V659L	0.4
UCEC	chr5	55786632	Missense_Mutation	NA	D327Y	0.32	DEAD
UCEC	chr5	55816656	3'UTR	novel		0.21
UCEC	chr5	55798534	Silent	novel	S526S	0.35
UCEC	chr5	55815397	Missense_Mutation	rs770112379	V691M	0.22
UCEC	chr5	55813672	Splice_Site	novel	X539_splice	0.43
UCEC	chr5	55816682	3'UTR	novel		0.08
UCEC	chr5	55785820	Silent	rs146554855	Y271Y	0.33
UCEC	chr5	55813765	Missense_Mutation	novel	I570L	0.11
UCEC	chr5	55785306	Missense_Mutation	novel	K212T	0.35
UCEC	chr5	55787954	Nonsense_Mutation	novel	E376*	0.35	DEAD
UCEC	chr5	55767898	Missense_Mutation	rs757458025	E118K	0.41
UCEC	chr5	55780029	Nonsense_Mutation	novel	R154*	0.34
UCEC	chr5	55816505	Missense_Mutation	novel	A714S	0.33
UCEC	chr5	55786591	Missense_Mutation	novel	P313H	0.18	DEAD
UCEC	chr5	55816671	3'UTR	rs577314852		0.37
UCEC	chr5	55815082	Missense_Mutation	NA	R633C	0.06
UCEC	chr5	55815419	Missense_Mutation	novel	R698I	0.53
UCEC	chr5	55760199	Splice_Site	novel	X43_splice	0.45
UCEC	chr5	55779976	Missense_Mutation	novel	G136E	0.12
UCEC	chr5	55815059	Missense_Mutation	novel	V625A	0.37
UCEC	chr5	55814945	Missense_Mutation	NA	R587H	0.3
UCEC	chr5	55813692	Silent	novel	V545V	0.38
UCEC	chr5	55739018	Missense_Mutation	novel	P19S	0.54
UCEC	chr5	55815128	Missense_Mutation	NA	S648L	0.33
UCEC	chr5	55764015	Splice_Region	novel	G95G	0.18
UCEC	chr5	55815000	Silent	novel	D605D	0.08
UCEC	chr5	55767898	Missense_Mutation	rs757458025	E118K	0.15
UCEC	chr5	55785821	Missense_Mutation	rs140068018	D272N	0.38
UCEC	chr5	55790631	Nonsense_Mutation	NA	R410*	0.22	DEAD
UCEC	chr5	55815166	Missense_Mutation	novel	T661S	0.37
UCEC	chr5	55779967	Nonsense_Mutation	novel	Y133_R134delins*	0.47
UCEC	chr5	55781097	Silent	novel	Q176Q	0.42
UCEC	chr5	55767937	Missense_Mutation	novel	G131S	0.17
UCEC	chr5	55787968	Missense_Mutation	novel	Q380H	0.54	DEAD
UCEC	chr5	55798563	Missense_Mutation	NA	R536Q	0.22
UCEC	chr5	55816679	3'UTR	novel		0.42
UCEC	chr5	55814944	Missense_Mutation	NA	R587C	0.11
UCEC	chr5	55814945	Missense_Mutation	NA	R587H	0.27
UCEC	chr5	55815135	Silent	novel	N650N	0.31
UCEC	chr5	55781982	Splice_Site	novel	X209_splice	0.26
UCEC	chr5	55738949	Splice_Site	NA		0.39
UCEC	chr5	55787951	Nonsense_Mutation	NA	R375*	0.4	DEAD
UCEC	chr5	55790631	Nonsense_Mutation	NA	R410*	0.42	DEAD
UCEC	chr5	55790631	Nonsense_Mutation	NA	R410*	0.32	DEAD
UCEC	chr5	55798544	Missense_Mutation	NA	K530Q	0.4
UCEC	chr5	55815032	Missense_Mutation	NA	D616V	0.27
UCEC	chr5	55787997	Missense_Mutation	NA	F390C	0.35	DEAD
UCEC	chr5	55792776	Missense_Mutation	NA	F480L	0.38	DEAD
UCEC	chr5	55785767	Missense_Mutation	NA	D254N	0.27
UCEC	chr5	55798549	Silent	rs758573678	L531L	0.29
UCEC	chr5	55815326	Missense_Mutation	NA	V667A	0.26
UCEC	chr5	55816505	Missense_Mutation	NA	A714T	0.26
UCEC	chr5	55792687	Missense_Mutation	rs768783395	R450H	0.41	DEAD
UCS	chr5	55781099	Missense_Mutation	rs765470784	R177H	0.28
UCS	chr5	55785817	Missense_Mutation	novel	K270N	0.3
UCS	chr5	55813720	Missense_Mutation	novel	F555V	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2176	1.1352e-11
CHOL	DEL	0.1944	0.16947
MESO	DEL	0.0805	0.20184
PRAD	DEL	0.1829	3.125e-28
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.0075	Kaplan-Meier Survival Analysis
PRAD	0.02	Kaplan-Meier Survival Analysis
CESC	0.026	Kaplan-Meier Survival Analysis
LGG	0.0012	Kaplan-Meier Survival Analysis
CHOL	0.0068	Kaplan-Meier Survival Analysis
OV	0.04	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742