EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000152700 (Gene tree)
Gene ID: 51128
Gene Symbol: SAR1B
Alias: SARA2
Full Name: secretion associated Ras related GTPase 1B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 48,128 bases
Position: chr5:134,601,144-134,649,271
Accession: 10535
RBP type: canonical RBP
Summary: The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000425466	MMR_HSR1	PF01926.23	1.3e-05	1	1
ENSP00000385432	MMR_HSR1	PF01926.23	2e-05	1	1
ENSP00000404997	MMR_HSR1	PF01926.23	2e-05	1	1
ENSP00000423005	MMR_HSR1	PF01926.23	0.00057	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000402673	SAR1B-201	6682	-	ENSP00000385432	198 (aa)	-	Q9Y6B6
ENST00000508363	SAR1B-209	3086	-	-	- (aa)	-	-
ENST00000439578	SAR1B-202	929	-	ENSP00000404997	198 (aa)	-	Q9Y6B6
ENST00000509937	SAR1B-211	455	-	ENSP00000424673	130 (aa)	-	Q9H029
ENST00000505758	SAR1B-207	670	-	ENSP00000425466	170 (aa)	-	D6RD69
ENST00000503318	SAR1B-205	733	-	ENSP00000425367	144 (aa)	-	D6RDB2
ENST00000507419	SAR1B-208	2287	-	ENSP00000425339	130 (aa)	-	Q9H029
ENST00000502286	SAR1B-203	548	-	ENSP00000423005	103 (aa)	-	D6RAA2
ENST00000502539	SAR1B-204	708	-	ENSP00000426335	130 (aa)	-	Q9H029
ENST00000504242	SAR1B-206	676	-	-	- (aa)	-	-
ENST00000509730	SAR1B-210	506	-	ENSP00000423197	118 (aa)	-	D6R9R5

Gene Model

Click here to download ENSG00000152700's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa05134	Legionellosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000152700	Child Development Disorders, Pervasive	2.1897300E-006	-
ENSG00000152700	Child Development Disorders, Pervasive	2.0278300E-006	-
ENSG00000152700	Child Development Disorders, Pervasive	4.0673100E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152700's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152700	SAR1B	100	100.000	ENSAMEG00000017849	SAR1B	100	98.990	Ailuropoda_melanoleuca
ENSG00000152700	SAR1B	100	93.204	ENSAPLG00000007369	SAR1A	100	88.442	Anas_platyrhynchos
ENSG00000152700	SAR1B	100	98.058	ENSACAG00000001850	SAR1B	100	93.434	Anolis_carolinensis
ENSG00000152700	SAR1B	100	100.000	ENSANAG00000032734	SAR1B	81	100.000	Aotus_nancymaae
ENSG00000152700	SAR1B	100	100.000	ENSBTAG00000021226	SAR1B	100	98.485	Bos_taurus
ENSG00000152700	SAR1B	100	100.000	ENSCJAG00000004819	SAR1B	100	99.495	Callithrix_jacchus
ENSG00000152700	SAR1B	100	100.000	ENSCAFG00000031992	SAR1B	100	98.990	Canis_familiaris
ENSG00000152700	SAR1B	100	100.000	ENSCAFG00020001469	SAR1B	100	98.990	Canis_lupus_dingo
ENSG00000152700	SAR1B	100	100.000	ENSCHIG00000022509	SAR1B	100	98.485	Capra_hircus
ENSG00000152700	SAR1B	100	100.000	ENSTSYG00000011867	SAR1B	100	98.990	Carlito_syrichta
ENSG00000152700	SAR1B	100	97.458	ENSCAPG00000015216	SAR1B	98	93.299	Cavia_aperea
ENSG00000152700	SAR1B	100	100.000	ENSCPOG00000038655	SAR1B	100	97.980	Cavia_porcellus
ENSG00000152700	SAR1B	100	100.000	ENSCCAG00000037282	SAR1B	100	98.990	Cebus_capucinus
ENSG00000152700	SAR1B	100	100.000	ENSCATG00000022601	SAR1B	100	99.495	Cercocebus_atys
ENSG00000152700	SAR1B	100	100.000	ENSCLAG00000015791	-	100	98.990	Chinchilla_lanigera
ENSG00000152700	SAR1B	100	100.000	ENSCSAG00000013578	SAR1B	100	98.990	Chlorocebus_sabaeus
ENSG00000152700	SAR1B	100	98.058	ENSCPBG00000008203	SAR1B	100	96.970	Chrysemys_picta_bellii
ENSG00000152700	SAR1B	100	99.029	ENSCGRG00001016339	SAR1B	100	98.990	Cricetulus_griseus_chok1gshd
ENSG00000152700	SAR1B	100	99.029	ENSCGRG00000016600	SAR1B	100	98.990	Cricetulus_griseus_crigri
ENSG00000152700	SAR1B	100	100.000	ENSDNOG00000044440	SAR1B	100	98.990	Dasypus_novemcinctus
ENSG00000152700	SAR1B	100	100.000	ENSDORG00000023516	Sar1b	100	99.495	Dipodomys_ordii
ENSG00000152700	SAR1B	100	97.980	ENSETEG00000016178	SAR1B	100	97.980	Echinops_telfairi
ENSG00000152700	SAR1B	100	100.000	ENSEASG00005018603	SAR1B	100	99.495	Equus_asinus_asinus
ENSG00000152700	SAR1B	100	100.000	ENSECAG00000012409	SAR1B	100	99.495	Equus_caballus
ENSG00000152700	SAR1B	100	100.000	ENSFCAG00000000338	SAR1B	100	99.495	Felis_catus
ENSG00000152700	SAR1B	100	94.915	ENSFALG00000007931	SAR1B	99	95.408	Ficedula_albicollis
ENSG00000152700	SAR1B	100	100.000	ENSFDAG00000010710	SAR1B	100	98.990	Fukomys_damarensis
ENSG00000152700	SAR1B	100	98.058	ENSGALG00000038753	SAR1B	100	97.475	Gallus_gallus
ENSG00000152700	SAR1B	100	98.058	ENSGAGG00000022935	SAR1B	100	95.960	Gopherus_agassizii
ENSG00000152700	SAR1B	100	99.029	ENSHGLG00000015553	SAR1B	100	97.980	Heterocephalus_glaber_female
ENSG00000152700	SAR1B	100	99.029	ENSHGLG00100014879	SAR1B	100	97.980	Heterocephalus_glaber_male
ENSG00000152700	SAR1B	100	100.000	ENSSTOG00000011326	-	100	98.990	Ictidomys_tridecemlineatus
ENSG00000152700	SAR1B	100	99.029	ENSJJAG00000000251	Sar1b	100	98.485	Jaculus_jaculus
ENSG00000152700	SAR1B	100	100.000	ENSLAFG00000001021	SAR1B	100	98.485	Loxodonta_africana
ENSG00000152700	SAR1B	100	100.000	ENSMFAG00000002947	SAR1B	100	99.495	Macaca_fascicularis
ENSG00000152700	SAR1B	100	100.000	ENSMMUG00000004417	SAR1B	100	99.495	Macaca_mulatta
ENSG00000152700	SAR1B	100	100.000	ENSMNEG00000045379	SAR1B	100	99.495	Macaca_nemestrina
ENSG00000152700	SAR1B	100	100.000	ENSMLEG00000038596	SAR1B	100	99.495	Mandrillus_leucophaeus
ENSG00000152700	SAR1B	100	98.058	ENSMGAG00000008340	SAR1B	100	97.980	Meleagris_gallopavo
ENSG00000152700	SAR1B	100	99.029	ENSMAUG00000014677	Sar1b	100	98.990	Mesocricetus_auratus
ENSG00000152700	SAR1B	100	96.923	ENSMICG00000011638	SAR1B	100	96.465	Microcebus_murinus
ENSG00000152700	SAR1B	100	99.231	MGP_CAROLIEiJ_G0016318	Sar1b	100	98.990	Mus_caroli
ENSG00000152700	SAR1B	100	99.231	ENSMUSG00000020386	Sar1b	100	98.990	Mus_musculus
ENSG00000152700	SAR1B	100	100.000	MGP_PahariEiJ_G0017453	Sar1b	100	99.495	Mus_pahari
ENSG00000152700	SAR1B	100	99.231	MGP_SPRETEiJ_G0017162	Sar1b	100	98.990	Mus_spretus
ENSG00000152700	SAR1B	100	100.000	ENSMPUG00000010087	SAR1B	100	98.990	Mustela_putorius_furo
ENSG00000152700	SAR1B	100	100.000	ENSMLUG00000016342	SAR1B	100	98.485	Myotis_lucifugus
ENSG00000152700	SAR1B	100	100.000	ENSNGAG00000016176	Sar1b	100	98.990	Nannospalax_galili
ENSG00000152700	SAR1B	100	100.000	ENSNLEG00000008118	SAR1B	100	100.000	Nomascus_leucogenys
ENSG00000152700	SAR1B	100	99.029	ENSODEG00000009764	SAR1B	100	96.970	Octodon_degus
ENSG00000152700	SAR1B	100	100.000	ENSOCUG00000008250	SAR1B	100	98.485	Oryctolagus_cuniculus
ENSG00000152700	SAR1B	100	100.000	ENSOGAG00000013347	SAR1B	100	100.000	Otolemur_garnettii
ENSG00000152700	SAR1B	100	100.000	ENSOARG00000014231	SAR1B	100	98.485	Ovis_aries
ENSG00000152700	SAR1B	100	100.000	ENSPPAG00000033175	SAR1B	100	100.000	Pan_paniscus
ENSG00000152700	SAR1B	100	100.000	ENSPPRG00000008356	SAR1B	100	99.495	Panthera_pardus
ENSG00000152700	SAR1B	100	100.000	ENSPTIG00000001052	SAR1B	100	99.495	Panthera_tigris_altaica
ENSG00000152700	SAR1B	100	100.000	ENSPTRG00000017244	SAR1B	100	99.495	Pan_troglodytes
ENSG00000152700	SAR1B	100	99.231	ENSPANG00000005732	SAR1B	100	96.517	Papio_anubis
ENSG00000152700	SAR1B	100	98.058	ENSPSIG00000004800	SAR1B	100	96.970	Pelodiscus_sinensis
ENSG00000152700	SAR1B	100	99.029	ENSPEMG00000023610	Sar1b	100	98.990	Peromyscus_maniculatus_bairdii
ENSG00000152700	SAR1B	100	98.058	ENSPCIG00000014092	SAR1B	100	96.970	Phascolarctos_cinereus
ENSG00000152700	SAR1B	100	100.000	ENSPPYG00000015789	SAR1B	100	98.990	Pongo_abelii
ENSG00000152700	SAR1B	100	100.000	ENSPCAG00000002624	SAR1B	100	97.475	Procavia_capensis
ENSG00000152700	SAR1B	100	100.000	ENSPCOG00000025721	-	100	96.970	Propithecus_coquereli
ENSG00000152700	SAR1B	100	100.000	ENSPVAG00000012433	SAR1B	100	99.495	Pteropus_vampyrus
ENSG00000152700	SAR1B	100	99.029	ENSRNOG00000004820	Sar1b	100	98.990	Rattus_norvegicus
ENSG00000152700	SAR1B	100	100.000	ENSRBIG00000036918	SAR1B	100	99.495	Rhinopithecus_bieti
ENSG00000152700	SAR1B	100	100.000	ENSRROG00000028843	SAR1B	100	99.495	Rhinopithecus_roxellana
ENSG00000152700	SAR1B	100	98.058	ENSSHAG00000014991	SAR1B	100	96.970	Sarcophilus_harrisii
ENSG00000152700	SAR1B	100	100.000	ENSSARG00000002144	SAR1B	100	99.495	Sorex_araneus
ENSG00000152700	SAR1B	100	98.058	ENSSPUG00000009441	SAR1B	100	97.475	Sphenodon_punctatus
ENSG00000152700	SAR1B	100	100.000	ENSSSCG00000014305	SAR1B	100	98.990	Sus_scrofa
ENSG00000152700	SAR1B	100	100.000	ENSTTRG00000016864	SAR1B	100	98.990	Tursiops_truncatus
ENSG00000152700	SAR1B	100	100.000	ENSUAMG00000017620	SAR1B	100	98.485	Ursus_americanus
ENSG00000152700	SAR1B	100	100.000	ENSUMAG00000017678	SAR1B	100	98.485	Ursus_maritimus
ENSG00000152700	SAR1B	100	100.000	ENSVPAG00000001588	-	100	77.273	Vicugna_pacos
ENSG00000152700	SAR1B	100	100.000	ENSVVUG00000021294	SAR1B	100	98.990	Vulpes_vulpes
ENSG00000152700	SAR1B	100	90.291	ENSXETG00000010408	sar1b	99	84.772	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	TAS	Process
GO:0003400	regulation of COPII vesicle coating	21873635.	IBA	Process
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	-	TAS	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	Component
GO:0016050	vesicle organization	21873635.	IBA	Process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030127	COPII vesicle coat	21873635.	IBA	Component
GO:0032580	Golgi cisterna membrane	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0048208	COPII vesicle coating	-	TAS	Process
GO:0061024	membrane organization	21873635.	IBA	Process
GO:0070863	positive regulation of protein exit from endoplasmic reticulum	21873635.	IBA	Process
GO:0070971	endoplasmic reticulum exit site	21873635.	IBA	Component