EuRBPDB

Description

Ensembl ID: ENSG00000152778 (Gene tree)
Gene ID: 24138
Gene Symbol: IFIT5
Alias: RI58
Full Name: interferon induced protein with tetratricopeptide repeats 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 6,435 bases
Position: chr10:89,414,568-89,421,002
Accession: 13328
RBP type: non-canonical RBP
Summary: (Interferon Induced Protein With Tetratricopeptide Repeats 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is IFIT1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23317505	tRNA binding, structure, and localization of the human interferon-induced protein IFIT5.	Mol Cell	2013 Feb 21	Katibah GE	doi: 10.1016/j.molcel.2012.12.015
23334420	Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.	Nature	2013 Feb 7	Abbas YM	doi: 10.1038/nature11783
31040842	IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells.	Front Immunol	2019 Apr 16	Chico V	doi: 10.3389/fimmu.2019.00613
25092312	Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5.	Proc Natl Acad Sci U S A	2014 Aug 19	Katibah GE	doi: 10.1073/pnas.1412842111

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000371795	IFIT5-201	4015	-	ENSP00000360860	482 (aa)	-	Q13325

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000152778	IFIT5	96	46.237	ENSG00000119922	IFIT2	97	46.237	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	23317505.	IDA	Function
GO:0000339	RNA cap binding	25092312.	IDA	Function
GO:0003690	double-stranded DNA binding	23774268.	IDA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003723	RNA binding	21642987.	IDA	Function
GO:0003727	single-stranded RNA binding	23334420.23774268.25092312.	IDA	Function
GO:0005515	protein binding	26334375.	IPI	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0008266	poly(U) RNA binding	25092312.	IDA	Function
GO:0008385	IkappaB kinase complex	26334375.	IMP	Component
GO:0015629	actin cytoskeleton	23317505.	IDA	Component
GO:0032587	ruffle membrane	23317505.	IDA	Component
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	26334375.	IMP	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0045071	negative regulation of viral genome replication	23774268.	IDA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045177	apical part of cell	23317505.	IDA	Component
GO:0051607	defense response to virus	21873635.	IBA	Process
GO:0051607	defense response to virus	23334420.	IMP	Process