EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000152818 (Gene tree)
Gene ID: 7402
Gene Symbol: UTRN
Alias: DRP|DRP1|DMDL
Full Name: utrophin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 567,737 bases
Position: chr6:144,285,298-144,853,034
Accession: 12635
RBP type: non-canonical RBP
Summary: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11755781	Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy.	J Physiol Paris	2002 Jan-Mar	Jasmin BJ	-
11546668	Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events.	Am J Physiol Cell Physiol	2001 Oct	Gramolini AO	-
24371285	Converging pathways involving microRNA-206 and the RNA-binding protein KSRP control post-transcriptionally utrophin A expression in skeletal muscle.	Nucleic Acids Res	2014 Apr	Amirouche A	doi: 10.1093/nar/gkt1350
23575223	Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics.	Hum Mol Genet	2013 Aug 1	Amirouche A	doi: 10.1093/hmg/ddt165
26494902	Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles.	Hum Mol Genet	2016 Jan 1	Peladeau C	doi: 10.1093/hmg/ddv444

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000465299	UTRN-211	372	-	-	- (aa)	-	-
ENST00000367526	UTRN-203	3220	XM_006715560	ENSP00000356496	988 (aa)	XP_006715623	Q5T097
ENST00000367524	UTRN-201	753	-	ENSP00000356494	251 (aa)	-	H0Y337
ENST00000367525	UTRN-202	579	-	ENSP00000356495	66 (aa)	-	Q5T098
ENST00000421035	UTRN-206	572	-	ENSP00000396276	154 (aa)	-	A0A0A0MSM3
ENST00000628146	UTRN-213	597	-	ENSP00000487153	150 (aa)	-	A0A0D9SG57
ENST00000367545	UTRN-204	12339	XM_005267127	ENSP00000356515	3433 (aa)	XP_005267184	P46939
ENST00000460618	UTRN-210	347	-	-	- (aa)	-	-
ENST00000417142	UTRN-205	678	-	ENSP00000404205	184 (aa)	-	Q5JT44
ENST00000432686	UTRN-207	666	-	ENSP00000398923	180 (aa)	-	Q5JT45
ENST00000433557	UTRN-208	354	-	ENSP00000390879	47 (aa)	-	Q5SYY2
ENST00000480333	UTRN-212	467	-	-	- (aa)	-	-
ENST00000455022	UTRN-209	633	-	ENSP00000387927	186 (aa)	-	Q5JT49

Gene Model

Click here to download ENSG00000152818's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000152818	Echocardiography	9.15349118766388E-5	17903301
ENSG00000152818	Hip	9.94212450016185E-5	17903296
ENSG00000152818	Antihypertensive Agents	8.4620000E-005	-
ENSG00000152818	Albumins	6.8790000E-005	-
ENSG00000152818	Leukocyte Count	1.9750000E-005	-
ENSG00000152818	Leukocyte Count	1.8840000E-005	-
ENSG00000152818	Leukocyte Count	7.1450000E-006	-
ENSG00000152818	Leukocyte Count	8.6510000E-006	-
ENSG00000152818	Blood Pressure	5.2073509E-005	-
ENSG00000152818	Blood Pressure	5.9820197E-005	-
ENSG00000152818	Platelet Function Tests	8.4158335E-007	-
ENSG00000152818	Platelet Function Tests	3.7456513E-006	-
ENSG00000152818	Platelet Function Tests	3.7456513E-006	-
ENSG00000152818	Platelet Function Tests	1.7837600E-005	-
ENSG00000152818	Platelet Function Tests	6.0779281E-006	-
ENSG00000152818	Child Development Disorders, Pervasive	1.5000000E-005	-
ENSG00000152818	Child Development Disorders, Pervasive	4.4000000E-005	-
ENSG00000152818	C-Reactive Protein	6.2160000E-005	-
ENSG00000152818	C-Reactive Protein	2.3530000E-005	-
ENSG00000152818	Eye Movements	3E-6	26242244
ENSG00000152818	Loneliness	2E-6	27629369

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000152818	rs11155372	6	144698602	T	Remission after SSRI treatment in MDD or openness	29559929			EFO_0003761\|EFO_0005658\|EFO_0007914
ENSG00000152818	rs4895650	6	144702986	T	Educational attainment (MTAG)	30038396	[0.0064-0.0114] unit increase	0.0089	EFO_0004784
ENSG00000152818	rs4895650	6	144702986	T	Highest math class taken (MTAG)	30038396	[0.006-0.0126] unit increase	0.0093	EFO_0004875
ENSG00000152818	rs6570628	6	144428223	G	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[20.2-23.34]	21.77	EFO_0004265\|EFO_0007908
ENSG00000152818	rs4530873	6	144666027	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000152818	rs4895650	6	144702986	T	Educational attainment (years of education)	30038396	[0.0066-0.012] unit increase	0.0093	EFO_0004784
ENSG00000152818	rs7738842	6	144550577	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000152818	rs2876586	6	144541862	A	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.004-0.0083] unit increase	0.00617405	EFO_0006527
ENSG00000152818	rs9321987	6	144709148	A	Response to SSRI in MDD or openness	29559929			EFO_0003761\|EFO_0005658\|EFO_0007914

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000152818's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001954	positive regulation of cell-matrix adhesion	19786618.	IMP	Process
GO:0003779	actin binding	16803572.	IDA	Function
GO:0005178	integrin binding	16803572.	IPI	Function
GO:0005515	protein binding	10767429.16777071.18838687.19786618.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	19786618.	IDA	Component
GO:0005856	cytoskeleton	8977119.	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006936	muscle contraction	9288751.	TAS	Process
GO:0007517	muscle organ development	9288751.	TAS	Process
GO:0007528	neuromuscular junction development	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0014894	response to denervation involved in regulation of muscle adaptation	-	IEA	Process
GO:0016010	dystrophin-associated glycoprotein complex	-	IEA	Component
GO:0016020	membrane	1426262.	TAS	Component
GO:0017166	vinculin binding	16803572.	IPI	Function
GO:0019901	protein kinase binding	16803572.	IPI	Function
GO:0030054	cell junction	-	IEA	Component
GO:0030175	filopodium	16803572.	IDA	Component
GO:0030426	growth cone	-	IEA	Component
GO:0030864	cortical actin cytoskeleton	-	IEA	Component
GO:0031527	filopodium membrane	16803572.	IDA	Component
GO:0031594	neuromuscular junction	-	IEA	Component
GO:0032991	protein-containing complex	18468998.	IDA	Component
GO:0042383	sarcolemma	-	IEA	Component
GO:0045211	postsynaptic membrane	-	IEA	Component
GO:0051015	actin filament binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070938	contractile ring	16803572.	IDA	Component
GO:2000649	regulation of sodium ion transmembrane transporter activity	21677768.	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16049973	Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients.	Int J Cancer	2006 Jan 15	Lomnytska M	-
25434519	Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells.	Int J Oncol	2015 Feb	Han XJ	doi: 10.3892/ijo.2014.2781

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	144839195	Missense_Mutation	rs775875409	N3363S	0.37
ACC	chr6	144557229	Missense_Mutation	novel	E2403Q	0.07
BLCA	chr6	144448705	Missense_Mutation	novel	E670K	0.12
BLCA	chr6	144462741	Missense_Mutation	novel	D981H	0.73
BLCA	chr6	144461304	Missense_Mutation	novel	D939N	0.18
BLCA	chr6	144499313	Silent	NA	K1550K	0.19
BLCA	chr6	144482243	Missense_Mutation	NA	R1181K	0.23
BLCA	chr6	144820940	Missense_Mutation	NA	S3139L	0.52
BLCA	chr6	144493316	Missense_Mutation	novel	L1485V	0.27
BLCA	chr6	144835864	Missense_Mutation	novel	Q3250H	0.15
BLCA	chr6	144577190	Missense_Mutation	NA	E2461K	0.52
BLCA	chr6	144514775	Silent	novel	L1733L	0.22
BLCA	chr6	144522029	Missense_Mutation	novel	R1864T	0.15
BLCA	chr6	144458907	Missense_Mutation	novel	D808H	0.09
BLCA	chr6	144531179	Missense_Mutation	novel	E2012Q	0.17
BLCA	chr6	144291888	Silent	NA	D20D	0.66
BLCA	chr6	144479839	Nonsense_Mutation	novel	E1122*	0.04
BLCA	chr6	144491049	Missense_Mutation	novel	D1462H	0.98
BLCA	chr6	144482268	Silent	novel	I1189I	0.28
BLCA	chr6	144447663	Missense_Mutation	rs371533335	Q595R	0.17
BLCA	chr6	144461196	Splice_Site	novel	X903_splice	0.46
BLCA	chr6	144511049	Nonsense_Mutation	novel	E1624*	0.39
BLCA	chr6	144513933	Missense_Mutation	novel	F1657V	0.55
BLCA	chr6	144539367	Missense_Mutation	novel	S2148L	0.35
BLCA	chr6	144839261	Missense_Mutation	novel	S3385F	0.1
BLCA	chr6	144539332	Silent	NA	L2136L	0.25
BLCA	chr6	144482256	Silent	NA	L1185L	0.21
BLCA	chr6	144793913	Missense_Mutation	novel	Q3000H	0.48
BLCA	chr6	144542802	Missense_Mutation	NA	R2176K	0.48
BLCA	chr6	144516827	Missense_Mutation	rs777524827	A1807V	0.32
BLCA	chr6	144551060	Missense_Mutation	novel	M2302I	0.18
BLCA	chr6	144551033	Missense_Mutation	NA	L2293F	0.46
BLCA	chr6	144488801	Missense_Mutation	novel	R1367S	0.23
BLCA	chr6	144537658	Missense_Mutation	NA	E2104K	0.1
BLCA	chr6	144482353	In_Frame_Ins	novel	C1218delinsFFLFFSS	0.04
BLCA	chr6	144438815	Missense_Mutation	novel	E438K	0.15
BLCA	chr6	144447641	Missense_Mutation	novel	D588Y	0.41
BLCA	chr6	144678496	Nonsense_Mutation	novel	E2524*	0.53
BLCA	chr6	144835829	Missense_Mutation	novel	E3239Q	0.29
BLCA	chr6	144548770	Silent	novel	L2242L	0.28
BLCA	chr6	144548771	Missense_Mutation	novel	V2243L	0.27
BLCA	chr6	144523057	Silent	novel	A1925A	0.36
BLCA	chr6	144473723	Missense_Mutation	rs370435884	D1024N	0.47
BLCA	chr6	144678572	Missense_Mutation	novel	S2549I	0.24
BLCA	chr6	144730432	Missense_Mutation	NA	D2629N	0.31
BLCA	chr6	144730398	Silent	novel	L2617L	0.35
BLCA	chr6	144839228	Missense_Mutation	novel	S3374F	0.32
BLCA	chr6	144493424	Silent	NA	L1521L	0.42
BLCA	chr6	144438752	Missense_Mutation	NA	D417N	0.24
BLCA	chr6	144499359	Missense_Mutation	rs142782123	E1566K	0.38
BLCA	chr6	144839235	Silent	NA	L3376L	0.33
BLCA	chr6	144448666	Missense_Mutation	rs770003496	R657C	0.32
BLCA	chr6	144479974	Missense_Mutation	novel	E1167K	0.35
BLCA	chr6	144462864	Nonsense_Mutation	novel	E1022*	0.24
BRCA	chr6	144514808	Missense_Mutation	NA	I1744M	0.16
BRCA	chr6	144839235	Silent	NA	L3376L	0.23
BRCA	chr6	144428870	Missense_Mutation	NA	I224S	0.29
BRCA	chr6	144774335	Missense_Mutation	NA	K2868T	0.42
BRCA	chr6	144458924	Silent	NA	V813V	0.11
BRCA	chr6	144490132	Missense_Mutation	rs151173089	R1399H	0.18
BRCA	chr6	144835901	Missense_Mutation	novel	L3263V	0.19
BRCA	chr6	144440351	Splice_Site	NA	X465_splice	0.2
BRCA	chr6	144846820	Missense_Mutation	NA	R3429T	0.21
BRCA	chr6	144453833	Missense_Mutation	novel	Q750E	0.09
BRCA	chr6	144751813	Missense_Mutation	novel	R2739T	0.3
BRCA	chr6	144516265	Missense_Mutation	NA	V1761F	0.23
BRCA	chr6	144447307	Nonsense_Mutation	rs764291295	R571*	0.45
BRCA	chr6	144458907	Missense_Mutation	novel	D808H	0.12
BRCA	chr6	144781951	Missense_Mutation	NA	E2888K	0.14
BRCA	chr6	144539332	Silent	NA	L2136L	0.3
BRCA	chr6	144748437	Nonsense_Mutation	NA	E2711*	0.5
BRCA	chr6	144554707	Silent	novel	Q2316Q	0.06
BRCA	chr6	144462854	Silent	NA	L1018L	0.2
BRCA	chr6	144513915	Missense_Mutation	novel	Q1651E	0.06
BRCA	chr6	144754732	Missense_Mutation	novel	D2790N	0.1
BRCA	chr6	144827655	Missense_Mutation	NA	R3193T	0.32
BRCA	chr6	144513915	Nonsense_Mutation	NA	Q1651*	0.17
BRCA	chr6	144797850	Silent	NA	V3035V	0.17
BRCA	chr6	144516949	Splice_Site	NA	X1847_splice	0.15
BRCA	chr6	144514003	Nonsense_Mutation	novel	K1681*	0.04
BRCA	chr6	144678565	Nonsense_Mutation	novel	S2547delins*	0.1
BRCA	chr6	144458978	Silent	rs115499045	R831R	0.47
BRCA	chr6	144523178	Missense_Mutation	NA	D1966N	0.33
BRCA	chr6	144551004	Missense_Mutation	novel	D2284N	0.04
BRCA	chr6	144462864	Missense_Mutation	rs200897894	E1022K	0.41
BRCA	chr6	144521991	Missense_Mutation	NA	I1851M	0.28
BRCA	chr6	144781951	Nonsense_Mutation	novel	E2888*	0.09
BRCA	chr6	144851067	3'UTR	novel		0.3
BRCA	chr6	144514026	Missense_Mutation	NA	E1688Q	0.18
BRCA	chr6	144511116	Missense_Mutation	NA	T1646S	0.18
BRCA	chr6	144459234	Missense_Mutation	NA	S863P	0.2
BRCA	chr6	144499420	Nonsense_Mutation	novel	W1586*	0.12
BRCA	chr6	144548696	Missense_Mutation	NA	Q2218K	0.22
CESC	chr6	144437743	Missense_Mutation	novel	S413F	0.13
CESC	chr6	144403167	Missense_Mutation	NA	N42H	0.31
CESC	chr6	144793877	Missense_Mutation	novel	Q2988H	0.33
CESC	chr6	144774318	Silent	novel	A2862A	0.15
CESC	chr6	144748257	Missense_Mutation	NA	E2651K	0.61
CESC	chr6	144458838	Nonsense_Mutation	novel	Q785*	0.63
CESC	chr6	144757987	Splice_Region	NA	I2831I	0.25
CESC	chr6	144554826	Missense_Mutation	rs754193488	E2356G	0.11
CESC	chr6	144730470	Missense_Mutation	NA	N2641K	0.25
CESC	chr6	144462846	Missense_Mutation	NA	L1016F	0.31
CESC	chr6	144423608	Silent	novel	Q98Q	0.45
CESC	chr6	144793905	Missense_Mutation	novel	A2998T	0.44
CESC	chr6	144771959	Nonsense_Mutation	NA	Q2850*	0.63
CESC	chr6	144423593	Silent	novel	V93V	0.25
CESC	chr6	144797914	Nonsense_Mutation	rs373514468	R3057*	0.09
CESC	chr6	144474753	Silent	novel	S1110S	0.29
CESC	chr6	144851306	3'UTR	novel		0.41
CHOL	chr6	144423624	Missense_Mutation	novel	N104Y	0.71
COAD	chr6	144473825	Missense_Mutation	novel	Q1058K	0.15
COAD	chr6	144757976	Missense_Mutation	NA	P2828S	0.31
COAD	chr6	144429688	Missense_Mutation	NA	T268S	0.22
COAD	chr6	144482304	Missense_Mutation	NA	Q1201H	0.35
COAD	chr6	144516941	Missense_Mutation	NA	K1845T	0.27
COAD	chr6	144447630	Missense_Mutation	rs368046583	R584H	0.19
COAD	chr6	144423555	Missense_Mutation	novel	E81K	0.07
COAD	chr6	144438798	Missense_Mutation	novel	A432V	0.23
COAD	chr6	144447235	Missense_Mutation	rs778831647	E547K	0.24
COAD	chr6	144462806	Silent	novel	V1002V	0.21
COAD	chr6	144835833	Missense_Mutation	novel	S3240F	0.21
COAD	chr6	144499324	Missense_Mutation	novel	A1554V	0.39
COAD	chr6	144516300	Silent	novel	F1772F	0.29
COAD	chr6	144459239	Silent	novel	A864A	0.44
COAD	chr6	144490947	Missense_Mutation	novel	S1428P	0.43
COAD	chr6	144748446	Missense_Mutation	rs778217389	R2714W	0.33
COAD	chr6	144444312	Missense_Mutation	rs150084858	R515H	0.29
COAD	chr6	144479858	Missense_Mutation	NA	A1128E	0.08
COAD	chr6	144499412	Missense_Mutation	NA	E1583D	0.25
COAD	chr6	144821001	Frame_Shift_Del	novel	G3160*	0.03
COAD	chr6	144557200	Missense_Mutation	rs766462288	A2393V	0.13
COAD	chr6	144421936	Missense_Mutation	novel	L67S	0.29
COAD	chr6	144437652	Frame_Shift_Ins	novel	*D384Rfs6**	0.19
COAD	chr6	144438843	Frame_Shift_Ins	NA	*L449Pfs6**	0.44
COAD	chr6	144447254	Missense_Mutation	NA	N553S	0.47
COAD	chr6	144577118	Missense_Mutation	rs779829056	A2437T	0.32
COAD	chr6	144793915	Frame_Shift_Ins	NA	*R3003Pfs5**	0.27
COAD	chr6	144438822	Missense_Mutation	rs761620103	R440H	0.45
COAD	chr6	144557282	Frame_Shift_Del	novel	*T2422Hfs35**	0.47
COAD	chr6	144835884	Missense_Mutation	novel	R3257M	0.34
COAD	chr6	144839244	Silent	rs116654180	S3379S	0.33
COAD	chr6	144428826	Silent	NA	E209E	0.45
COAD	chr6	144789216	Missense_Mutation	novel	V2953L	0.41
COAD	chr6	144291860	Missense_Mutation	NA	P11H	0.43
COAD	chr6	144482390	Splice_Site	NA	X1229_splice	0.29
COAD	chr6	144461207	Silent	NA	G906G	0.2
COAD	chr6	144479907	Silent	NA	A1144A	0.26
COAD	chr6	144451473	Missense_Mutation	rs761628185	E726K	0.16
COAD	chr6	144458886	Missense_Mutation	NA	N801D	0.09
COAD	chr6	144462817	Missense_Mutation	novel	K1006T	0.07
COAD	chr6	144493300	Splice_Site	novel	X1480_splice	0.13
COAD	chr6	144537711	Missense_Mutation	rs772243941	E2121D	0.09
COAD	chr6	144542847	Missense_Mutation	NA	S2191Y	0.17
COAD	chr6	144493308	Missense_Mutation	rs774394926	Y1482C	0.08
COAD	chr6	144793974	Missense_Mutation	NA	R3021C	0.42
COAD	chr6	144840817	Missense_Mutation	novel	F3419V	0.24
COAD	chr6	144487616	Silent	NA	L1297L	0.35
COAD	chr6	144751901	Silent	novel	L2768L	0.43
COAD	chr6	144474674	Missense_Mutation	rs751133169	R1084Q	0.13
COAD	chr6	144461335	Frame_Shift_Del	NA	*K951Rfs32**	0.25
COAD	chr6	144533193	Nonsense_Mutation	NA	E2056*	0.28
COAD	chr6	144548671	Silent	rs114017467	V2209V	0.24
COAD	chr6	144835876	Silent	NA	S3254S	0.37
COAD	chr6	144462753	Frame_Shift_Ins	novel	*L985Wfs4**	0.07
COAD	chr6	144516945	Frame_Shift_Ins	novel	*K1847Ffs66**	0.07
COAD	chr6	144511076	Missense_Mutation	novel	W1633R	0.29
COAD	chr6	144513997	Missense_Mutation	novel	I1678N	0.34
COAD	chr6	144461335	Frame_Shift_Del	NA	*K951Rfs32**	0.18
DLBC	chr6	144827620	Silent	novel	Q3181Q	0.76
ESCA	chr6	144485395	Missense_Mutation	novel	S1233Y	0.18
ESCA	chr6	144828794	Missense_Mutation	novel	A3202T	0.09
ESCA	chr6	144473754	Missense_Mutation	novel	G1034A	0.07
ESCA	chr6	144852854	3'UTR	novel		0.12
ESCA	chr6	144458868	Missense_Mutation	novel	Q795E	0.13
ESCA	chr6	144852999	3'UTR	novel		0.36
ESCA	chr6	144803094	Nonsense_Mutation	NA	R3102*	0.49
ESCA	chr6	144493445	Silent	rs778079117	L1528L	0.21
ESCA	chr6	144479859	Silent	novel	A1128A	0.32
GBM	chr6	144514005	Missense_Mutation	novel	K1681Q	0.08
GBM	chr6	144793908	Missense_Mutation	NA	I2999V	0.05
GBM	chr6	144436130	Missense_Mutation	rs150684617	T351S	0.21
GBM	chr6	144437571	Missense_Mutation	novel	M356L	0.1
GBM	chr6	144437677	Missense_Mutation	novel	Q391L	0.12
GBM	chr6	144462784	Missense_Mutation	novel	G995V	0.21
GBM	chr6	144482388	Missense_Mutation	novel	E1229D	0.36
GBM	chr6	144522142	Missense_Mutation	novel	D1902Y	0.21
GBM	chr6	144577258	Silent	novel	I2483I	0.22
GBM	chr6	144797828	Missense_Mutation	novel	N3028S	0.46
GBM	chr6	144836378	Missense_Mutation	rs199713104	S3301L	0.55
GBM	chr6	144836512	Missense_Mutation	novel	L3346F	0.57
GBM	chr6	144474680	Missense_Mutation	novel	G1086A	0.34
GBM	chr6	144533219	Silent	novel	R2064R	0.08
GBM	chr6	144458901	Missense_Mutation	novel	Q806E	0.24
GBM	chr6	144459279	Frame_Shift_Ins	novel	*G878Efs4**	0.11
GBM	chr6	144438865	Missense_Mutation	novel	K454N	0.2
GBM	chr6	144451473	Missense_Mutation	rs761628185	E726K	0.15
GBM	chr6	144577154	Missense_Mutation	rs749768508	R2449C	0.37
GBM	chr6	144730366	Missense_Mutation	rs777256552	R2607W	0.11
GBM	chr6	144490189	Missense_Mutation	novel	D1418V	0.07
GBM	chr6	144462831	Missense_Mutation	novel	L1011F	0.45
HNSC	chr6	144490090	Missense_Mutation	NA	S1385L	0.14
HNSC	chr6	144774333	Silent	novel	I2867I	0.25
HNSC	chr6	144531091	Missense_Mutation	novel	H1982Q	0.37
HNSC	chr6	144426314	Missense_Mutation	novel	S145P	0.21
HNSC	chr6	144437586	Missense_Mutation	novel	A361P	0.21
HNSC	chr6	144514749	Missense_Mutation	novel	L1725I	0.61
HNSC	chr6	144700099	Silent	NA	E2555E	0.16
HNSC	chr6	144482353	In_Frame_Ins	novel	C1218delinsFFLFFSS	0.09
HNSC	chr6	144511122	Missense_Mutation	novel	M1648T	0.29
HNSC	chr6	144458826	Missense_Mutation	novel	K781Q	0.26
HNSC	chr6	144771961	Silent	NA	Q2850Q	0.25
HNSC	chr6	144448642	Nonsense_Mutation	NA	Q649*	0.11
HNSC	chr6	144516817	Nonsense_Mutation	novel	E1804*	0.36
HNSC	chr6	144436004	Missense_Mutation	novel	M309V	0.19
HNSC	chr6	144781959	Missense_Mutation	novel	F2890L	0.11
HNSC	chr6	144539407	Silent	novel	S2161S	0.39
HNSC	chr6	144539408	Nonsense_Mutation	novel	E2162*	0.39
HNSC	chr6	144554836	Silent	novel	L2359L	0.19
HNSC	chr6	144836390	Missense_Mutation	novel	P3305R	0.19
HNSC	chr6	144523091	Nonsense_Mutation	novel	E1937*	0.23
HNSC	chr6	144851106	3'UTR	novel		0.25
HNSC	chr6	144451428	Missense_Mutation	novel	Q711E	0.18
HNSC	chr6	144487683	Missense_Mutation	novel	D1320H	0.25
HNSC	chr6	144797860	Missense_Mutation	novel	I3039L	0.14
HNSC	chr6	144771949	Silent	novel	T2846T	0.2
HNSC	chr6	144458805	Nonsense_Mutation	novel	E774*	0.53
HNSC	chr6	144487585	Missense_Mutation	rs373769853	R1287H	0.32
KIRC	chr6	144781955	Missense_Mutation	NA	I2889N	0.28
KIRC	chr6	144447637	Silent	NA	T586T	0.24
KIRC	chr6	144490085	Silent	NA	E1383E	0.24
KIRC	chr6	144459207	Missense_Mutation	novel	K854E	0.25
KIRC	chr6	144523121	Nonsense_Mutation	NA	R1947*	0.24
KIRC	chr6	144516945	Frame_Shift_Ins	novel	*K1847Ffs66**	0.06
KIRC	chr6	144781991	In_Frame_Ins	novel	L2902_S2903insKKQTHFYSYL	0.08
KIRC	chr6	144485467	Missense_Mutation	rs375665025	K1257R	0.24
KIRC	chr6	144490938	Missense_Mutation	NA	R1425G	0.29
KIRC	chr6	144487642	Frame_Shift_Ins	novel	*I1307Nfs3**	0.28
KIRP	chr6	144403167	Missense_Mutation	novel	N42Y	0.17
KIRP	chr6	144522053	Missense_Mutation	novel	Y1872C	0.3
KIRP	chr6	144423593	Silent	novel	V93V	0.36
KIRP	chr6	144490148	Silent	novel	T1404T	0.25
KIRP	chr6	144485438	Silent	novel	T1247T	0.4
LAML	chr6	144851262	3'UTR	novel		0.08
LAML	chr6	144522052	Missense_Mutation	novel	Y1872H	0.1
LAML	chr6	144851046	3'UTR	novel		0.04
LGG	chr6	144514699	Missense_Mutation	rs115466543	R1708H	0.15
LGG	chr6	144514651	Missense_Mutation	rs201062311	R1692L	0.09
LGG	chr6	144557244	Missense_Mutation	novel	D2408H	0.05
LGG	chr6	144499417	Missense_Mutation	NA	S1585F	0.29
LGG	chr6	144403174	Missense_Mutation	NA	R44Q	0.49
LGG	chr6	144426316	Silent	rs377032020	S145S	0.49
LGG	chr6	144448647	Missense_Mutation	novel	K650N	0.1
LGG	chr6	144482272	Silent	novel	L1191L	0.38
LGG	chr6	144490089	Missense_Mutation	novel	S1385A	0.06
LGG	chr6	144523109	Missense_Mutation	novel	A1943S	0.32
LGG	chr6	144557160	Missense_Mutation	novel	L2380M	0.17
LGG	chr6	144820984	Missense_Mutation	novel	V3154I	0.15
LGG	chr6	144550989	Missense_Mutation	rs114254210	R2279C	0.28
LIHC	chr6	144462780	Nonsense_Mutation	NA	Q994*	0.26
LIHC	chr6	144554858	Silent	NA	R2367R	0.23
LIHC	chr6	144548717	Frame_Shift_Del	novel	*S2226Kfs3**	0.25
LIHC	chr6	144542793	Splice_Site	novel	X2174_splice	0.63
LIHC	chr6	144462725	Missense_Mutation	novel	E975D	0.42
LIHC	chr6	144487547	Splice_Site	novel	X1275_splice	0.46
LIHC	chr6	144437571	Missense_Mutation	NA	M356V	0.36
LIHC	chr6	144444374	Nonsense_Mutation	NA	E536*	0.72
LUAD	chr6	144748413	Silent	NA	L2703L	0.09
LUAD	chr6	144782109	Silent	NA	L2940L	0.33
LUAD	chr6	144482360	Missense_Mutation	NA	R1220K	0.28
LUAD	chr6	144437747	Splice_Site	novel	X414_splice	0.09
LUAD	chr6	144840799	Missense_Mutation	NA	E3413Q	0.07
LUAD	chr6	144835852	Missense_Mutation	NA	Q3246H	0.07
LUAD	chr6	144516938	Missense_Mutation	rs778471797	N1844S	0.61
LUAD	chr6	144700230	Missense_Mutation	NA	Y2599C	0.14
LUAD	chr6	144557306	Silent	novel	K2428K	0.19
LUAD	chr6	144424005	Missense_Mutation	NA	G111V	0.11
LUAD	chr6	144542835	Missense_Mutation	NA	Q2187L	0.07
LUAD	chr6	144836343	Silent	novel	L3289L	0.15
LUAD	chr6	144485465	Frame_Shift_Ins	novel	*K1257Efs12**	0.04
LUAD	chr6	144523182	Missense_Mutation	NA	R1967L	0.43
LUAD	chr6	144448733	Missense_Mutation	novel	K679R	0.34
LUAD	chr6	144485471	Silent	novel	S1258S	0.32
LUAD	chr6	144474706	Missense_Mutation	novel	V1095L	0.06
LUAD	chr6	144836467	Missense_Mutation	novel	R3331G	0.28
LUAD	chr6	144473834	Splice_Site	novel	X1060_splice	0.13
LUAD	chr6	144438816	Missense_Mutation	novel	E438V	0.07
LUAD	chr6	144491100	Missense_Mutation	NA	M1479V	0.08
LUAD	chr6	144531063	Missense_Mutation	novel	R1973M	0.44
LUAD	chr6	144461278	Frame_Shift_Del	novel	*Q931Rfs4**	0.33
LUAD	chr6	144523079	Missense_Mutation	NA	D1933Y	0.28
LUAD	chr6	144730432	Missense_Mutation	NA	D2629N	0.28
LUAD	chr6	144485430	Nonsense_Mutation	novel	E1245*	0.37
LUAD	chr6	144482362	Missense_Mutation	rs760948472	I1221V	0.11
LUAD	chr6	144491091	Missense_Mutation	NA	D1476H	0.17
LUAD	chr6	144485518	Missense_Mutation	NA	E1274V	0.15
LUAD	chr6	144448626	Silent	NA	G643G	0.2
LUAD	chr6	144803095	Missense_Mutation	rs776348759	R3102Q	0.49
LUAD	chr6	144437670	Missense_Mutation	NA	E389Q	0.07
LUAD	chr6	144748447	Missense_Mutation	rs141157215	R2714Q	0.1
LUAD	chr6	144700086	Splice_Site	novel	X2551_splice	0.71
LUAD	chr6	144803035	Splice_Site	NA	X3082_splice	0.51
LUAD	chr6	144462676	Missense_Mutation	novel	N959I	0.11
LUAD	chr6	144793913	Missense_Mutation	novel	Q3000H	0.14
LUAD	chr6	144435955	Missense_Mutation	novel	E292D	0.19
LUAD	chr6	144533222	Missense_Mutation	NA	W2065C	0.22
LUSC	chr6	144438786	Missense_Mutation	novel	Q428L	0.21
LUSC	chr6	144797877	Missense_Mutation	NA	L3044F	0.34
LUSC	chr6	144459198	Missense_Mutation	novel	L851F	0.26
LUSC	chr6	144451388	Silent	novel	A697A	0.44
LUSC	chr6	144523056	Missense_Mutation	novel	A1925V	0.08
LUSC	chr6	144700117	Nonsense_Mutation	novel	W2561*	0.13
LUSC	chr6	144533183	Missense_Mutation	novel	S2052R	0.14
LUSC	chr6	144426323	Nonsense_Mutation	novel	Q148*	0.13
LUSC	chr6	144474642	Silent	novel	L1073L	0.37
LUSC	chr6	144516902	Frame_Shift_Ins	novel	*N1844Tfs79**	0.17
LUSC	chr6	144533088	Missense_Mutation	novel	L2021I	0.37
LUSC	chr6	144803067	Missense_Mutation	NA	V3093I	0.37
LUSC	chr6	144499291	Nonsense_Mutation	NA	S1543*	0.21
LUSC	chr6	144678578	Frame_Shift_Del	novel		0.14
LUSC	chr6	144291836	Missense_Mutation	novel	K3M	0.29
LUSC	chr6	144514772	Missense_Mutation	novel	E1732D	0.28
LUSC	chr6	144522117	Silent	novel	P1893P	0.11
LUSC	chr6	144448666	Missense_Mutation	rs770003496	R657C	0.39
LUSC	chr6	144550998	Nonsense_Mutation	novel	Q2282*	0.24
LUSC	chr6	144513984	Silent	NA	L1674L	0.32
LUSC	chr6	144447632	Nonsense_Mutation	NA	Q585*	0.31
LUSC	chr6	144577256	Missense_Mutation	NA	I2483V	0.47
LUSC	chr6	144487551	Missense_Mutation	NA	L1276V	0.06
LUSC	chr6	144438845	Missense_Mutation	rs545375734	P448S	0.09
LUSC	chr6	144473762	Missense_Mutation	novel	D1037N	0.27
LUSC	chr6	144577233	Missense_Mutation	novel	R2475L	0.21
LUSC	chr6	144447665	Missense_Mutation	NA	D596N	0.18
LUSC	chr6	144482270	Missense_Mutation	novel	K1190R	0.29
LUSC	chr6	144462826	Missense_Mutation	rs766506915	H1009R	0.26
LUSC	chr6	144836345	Missense_Mutation	NA	R3290Q	0.38
LUSC	chr6	144487623	Frame_Shift_Del	novel	*I1302Sfs5**	0.24
LUSC	chr6	144423608	Missense_Mutation	novel	Q98H	0.15
LUSC	chr6	144539341	Silent	NA	L2139L	0.22
LUSC	chr6	144730378	Frame_Shift_Ins	novel	*Y2614Rfs17**	0.26
LUSC	chr6	144513972	Missense_Mutation	NA	Q1670E	0.13
LUSC	chr6	144521984	Missense_Mutation	NA	I1849S	0.04
LUSC	chr6	144440393	In_Frame_Ins	novel	S479dup	0.44
LUSC	chr6	144490145	Silent	novel	L1403L	0.22
LUSC	chr6	144840833	Splice_Site	NA	X3424_splice	0.12
LUSC	chr6	144782119	Missense_Mutation	novel	D2944Y	0.64
LUSC	chr6	144479935	Nonsense_Mutation	novel	E1154*	0.15
LUSC	chr6	144748433	Missense_Mutation	novel	E2709D	0.19
LUSC	chr6	144473762	Missense_Mutation	rs200581848	D1037H	0.08
LUSC	chr6	144479927	Missense_Mutation	novel	R1151L	0.23
LUSC	chr6	144423586	Missense_Mutation	novel	N91S	0.1
LUSC	chr6	144748492	Missense_Mutation	novel	Q2729R	0.43
LUSC	chr6	144516344	Missense_Mutation	novel	K1787R	0.1
LUSC	chr6	144423595	Missense_Mutation	novel	N94S	0.58
LUSC	chr6	144678566	Missense_Mutation	novel	S2547Y	0.27
LUSC	chr6	144793854	Missense_Mutation	novel	G2981R	0.49
LUSC	chr6	144557154	Splice_Region	novel		0.15
LUSC	chr6	144493387	Silent	novel	T1508T	0.52
LUSC	chr6	144435969	Missense_Mutation	novel	R297L	0.31
LUSC	chr6	144458924	Silent	NA	V813V	0.15
LUSC	chr6	144835840	Silent	novel	V3242V	0.11
LUSC	chr6	144459174	Splice_Region	NA	R843R	0.19
OV	chr6	144851375	3'UTR	novel		0.78
OV	chr6	144474673	Nonsense_Mutation	novel	R1084*	0.17
OV	chr6	144451458	Missense_Mutation	NA	M721V	1
OV	chr6	144447614	Missense_Mutation	novel	D579H	0.06
OV	chr6	144836477	Missense_Mutation	NA	I3334T	0.3
OV	chr6	144485464	Missense_Mutation	NA	M1256R	0.22
OV	chr6	144462662	Missense_Mutation	NA	D954E	0.38
OV	chr6	144462669	Missense_Mutation	NA	L957V	0.56
OV	chr6	144789248	Silent	novel	L2963L	0.48
OV	chr6	144774362	Missense_Mutation	novel	C2877S	0.08
OV	chr6	144577283	Missense_Mutation	novel	M2492L	0.06
OV	chr6	144474665	Missense_Mutation	NA	T1081N	0.54
OV	chr6	144438751	Silent	rs114118949	H416H	0.12
PAAD	chr6	144459299	Silent	novel	G884G	0.06
PAAD	chr6	144438863	Missense_Mutation	novel	K454Q	0.32
PAAD	chr6	144437619	Missense_Mutation	novel	A372T	0.14
PAAD	chr6	144447307	Nonsense_Mutation	rs764291295	R571*	0.12
PAAD	chr6	144458930	Silent	novel	K815K	0.19
PAAD	chr6	144754794	Silent	novel	L2810L	0.2
PCPG	chr6	144440374	Missense_Mutation	novel	A472V	0.2
PRAD	chr6	144462854	Silent	NA	L1018L	0.18
PRAD	chr6	144523182	Missense_Mutation	NA	R1967Q	0.21
PRAD	chr6	144836312	Missense_Mutation	novel	V3279A	0.18
PRAD	chr6	144447252	Missense_Mutation	novel	L552F	0.38
PRAD	chr6	144836399	Missense_Mutation	rs755338194	T3308M	0.08
PRAD	chr6	144488809	Missense_Mutation	novel	A1370D	0.52
PRAD	chr6	144516934	Missense_Mutation	novel	Y1843H	0.49
PRAD	chr6	144678462	Silent	novel	N2512N	0.29
PRAD	chr6	144748443	Missense_Mutation	rs751028495	V2713M	0.41
PRAD	chr6	144516336	Silent	NA	N1784N	0.41
READ	chr6	144820981	Missense_Mutation	novel	P3153S	0.2
READ	chr6	144291877	Missense_Mutation	rs764071312	E17K	0.24
READ	chr6	144429727	Missense_Mutation	NA	A281T	0.23
READ	chr6	144793974	Missense_Mutation	NA	R3021C	0.16
READ	chr6	144459339	Missense_Mutation	novel	Q898E	0.13
READ	chr6	144447655	Missense_Mutation	NA	E592D	0.27
READ	chr6	144751893	Missense_Mutation	novel	P2766T	0.34
READ	chr6	144548824	Silent	novel	E2260E	0.36
READ	chr6	144437710	Missense_Mutation	NA	E402G	0.68
READ	chr6	144522040	Missense_Mutation	NA	L1868F	0.09
READ	chr6	144436095	Missense_Mutation	novel	S339Y	0.43
READ	chr6	144447307	Nonsense_Mutation	rs764291295	R571*	0.32
READ	chr6	144447759	Missense_Mutation	NA	R627I	0.44
READ	chr6	144451473	Missense_Mutation	rs761628185	E726K	0.56
READ	chr6	144462708	Nonsense_Mutation	NA	E970*	0.4
READ	chr6	144474667	Missense_Mutation	novel	N1082H	0.36
READ	chr6	144522142	Missense_Mutation	novel	D1902Y	0.41
READ	chr6	144291877	Missense_Mutation	rs764071312	E17K	0.23
READ	chr6	144537688	Missense_Mutation	rs532277544	E2114K	0.19
SARC	chr6	144487680	Missense_Mutation	novel	E1319K	0.07
SARC	chr6	144700177	Missense_Mutation	novel	E2581D	0.08
SARC	chr6	144437715	Missense_Mutation	rs748920125	L404F	0.36
SARC	chr6	144835891	Silent	novel	E3259E	0.19
SARC	chr6	144852868	3'UTR	rs189788171		0.42
SKCM	chr6	144458958	Missense_Mutation	novel	S825A	0.3
SKCM	chr6	144462684	Missense_Mutation	novel	P962S	0.16
SKCM	chr6	144490104	Missense_Mutation	NA	T1390A	0.27
SKCM	chr6	144459333	Missense_Mutation	NA	R896C	0.36
SKCM	chr6	144491040	Missense_Mutation	NA	H1459Y	0.18
SKCM	chr6	144542817	Missense_Mutation	rs745518797	T2181I	0.34
SKCM	chr6	144542818	Silent	NA	T2181T	0.34
SKCM	chr6	144499274	Silent	NA	Q1537Q	0.65
SKCM	chr6	144522151	Missense_Mutation	novel	F1905I	0.11
SKCM	chr6	144448666	Missense_Mutation	rs770003496	R657C	0.13
SKCM	chr6	144548712	Missense_Mutation	rs746644873	S2223L	0.4
SKCM	chr6	144514709	Silent	NA	A1711A	0.47
SKCM	chr6	144748447	Missense_Mutation	rs141157215	R2714Q	0.22
SKCM	chr6	144757962	Missense_Mutation	NA	S2823L	0.57
SKCM	chr6	144511063	Silent	novel	V1628V	0.67
SKCM	chr6	144458983	Missense_Mutation	NA	S833F	0.35
SKCM	chr6	144748442	Silent	rs374773628	S2712S	0.26
SKCM	chr6	144479907	Silent	rs539874928	A1144A	0.65
SKCM	chr6	144438793	Silent	NA	L430L	0.33
SKCM	chr6	144426445	Silent	novel	V188V	0.56
SKCM	chr6	144511093	Silent	novel	T1638T	0.19
SKCM	chr6	144438750	Missense_Mutation	novel	H416L	0.25
SKCM	chr6	144438751	Silent	rs114118949	H416H	0.25
SKCM	chr6	144771963	Missense_Mutation	rs762992139	S2851F	0.1
SKCM	chr6	144459173	Splice_Site	NA	X843_splice	0.38
SKCM	chr6	144429675	Silent	NA	I263I	0.37
SKCM	chr6	144453811	Silent	NA	I742I	0.39
SKCM	chr6	144461204	Silent	novel	K905K	0.71
SKCM	chr6	144513911	Splice_Region	NA	N1649N	0.27
SKCM	chr6	144448666	Missense_Mutation	rs770003496	R657C	0.38
SKCM	chr6	144522104	Missense_Mutation	rs144099534	S1889L	0.44
SKCM	chr6	144473789	Nonsense_Mutation	novel	Q1046*	0.21
SKCM	chr6	144531202	Splice_Region	NA	Q2019Q	0.52
SKCM	chr6	144516244	Missense_Mutation	novel	E1754K	0.33
SKCM	chr6	144839210	Nonsense_Mutation	novel	W3368*	0.1
SKCM	chr6	144754792	Missense_Mutation	NA	L2810F	0.53
SKCM	chr6	144523033	Silent	novel	L1917L	0.2
SKCM	chr6	144523034	Missense_Mutation	novel	D1918N	0.19
SKCM	chr6	144797864	Missense_Mutation	NA	D3040V	0.39
SKCM	chr6	144490958	Silent	novel	F1431F	0.38
SKCM	chr6	144513978	Missense_Mutation	NA	E1672K	0.52
SKCM	chr6	144757945	Silent	rs147309348	P2817P	0.08
SKCM	chr6	144522104	Missense_Mutation	rs144099534	S1889L	0.67
SKCM	chr6	144435999	Missense_Mutation	novel	V307A	0.26
SKCM	chr6	144459206	Silent	NA	P853P	0.58
SKCM	chr6	144490113	Missense_Mutation	NA	E1393K	0.64
SKCM	chr6	144827612	Missense_Mutation	novel	P3179S	0.36
SKCM	chr6	144836411	Missense_Mutation	NA	S3312L	0.35
SKCM	chr6	144485434	Missense_Mutation	NA	T1246N	0.42
SKCM	chr6	144840745	Missense_Mutation	NA	E3395K	0.55
STAD	chr6	144461335	Frame_Shift_Del	NA	*K951Rfs32**	0.34
STAD	chr6	144840811	Missense_Mutation	novel	S3417G	0.18
STAD	chr6	144537645	Missense_Mutation	NA	W2099C	0.2
STAD	chr6	144577141	Silent	rs754442261	T2444T	0.55
STAD	chr6	144447681	Missense_Mutation	NA	L601R	0.14
STAD	chr6	144479926	Missense_Mutation	rs375499592	R1151W	0.32
STAD	chr6	144511102	Missense_Mutation	NA	E1641D	0.2
STAD	chr6	144793926	Missense_Mutation	NA	L3005I	0.12
STAD	chr6	144493451	Missense_Mutation	rs771082025	A1530T	0.24
STAD	chr6	144516329	Missense_Mutation	NA	I1782K	0.16
STAD	chr6	144490132	Missense_Mutation	rs151173089	R1399H	0.1
STAD	chr6	144438822	Missense_Mutation	rs761620103	R440H	0.35
STAD	chr6	144835793	Missense_Mutation	rs746232110	A3227T	0.26
STAD	chr6	144754765	Missense_Mutation	novel	D2801H	0.16
STAD	chr6	144438844	Frame_Shift_Del	novel	*L449Wfs5**	0.18
STAD	chr6	144577154	Missense_Mutation	rs749768508	R2449C	0.15
STAD	chr6	144840833	Splice_Site	rs141700678	X3424_splice	0.26
STAD	chr6	144793841	Silent	NA	F2976F	0.24
STAD	chr6	144403136	Silent	rs754635241	D31D	0.27
STAD	chr6	144479929	Missense_Mutation	NA	D1152Y	0.38
STAD	chr6	144479952	Missense_Mutation	NA	E1159D	0.27
STAD	chr6	144487575	Missense_Mutation	NA	A1284T	0.33
STAD	chr6	144539400	Missense_Mutation	NA	K2159T	0.36
STAD	chr6	144548847	Missense_Mutation	rs150069642	R2268Q	0.43
STAD	chr6	144771892	Splice_Site	novel	X2832_splice	0.16
STAD	chr6	144678456	Silent	rs150099766	D2510D	0.17
STAD	chr6	144533093	Missense_Mutation	novel	E2022D	0.41
STAD	chr6	144782052	Missense_Mutation	novel	M2921I	0.14
STAD	chr6	144426337	Silent	NA	S152S	0.1
STAD	chr6	144429677	Missense_Mutation	rs750839546	R264H	0.24
STAD	chr6	144514699	Missense_Mutation	rs115466543	R1708H	0.2
STAD	chr6	144835789	Silent	NA	E3225E	0.07
STAD	chr6	144803095	Missense_Mutation	rs776348759	R3102Q	0.17
STAD	chr6	144793836	Missense_Mutation	NA	L2975F	0.33
STAD	chr6	144403136	Silent	rs754635241	D31D	0.16
STAD	chr6	144523041	Missense_Mutation	NA	L1920R	0.15
STAD	chr6	144557199	Missense_Mutation	novel	A2393T	0.06
STAD	chr6	144789236	Silent	novel	G2959G	0.11
STAD	chr6	144462739	Missense_Mutation	NA	P980H	0.43
STAD	chr6	144797944	Missense_Mutation	NA	Q3067K	0.12
STAD	chr6	144748482	Missense_Mutation	NA	D2726N	0.17
STAD	chr6	144751911	Missense_Mutation	NA	R2772C	0.08
STAD	chr6	144491019	Missense_Mutation	NA	D1452N	0.11
STAD	chr6	144435978	Missense_Mutation	NA	T300I	0.11
STAD	chr6	144479878	Missense_Mutation	rs757958729	A1135T	0.27
STAD	chr6	144437609	Silent	novel	S368S	0.28
STAD	chr6	144462684	Missense_Mutation	rs750447450	P962T	0.49
STAD	chr6	144482300	Missense_Mutation	NA	G1200D	0.47
STAD	chr6	144459285	Missense_Mutation	rs376535714	D880N	0.31
STAD	chr6	144827368	Missense_Mutation	novel	M3172K	0.43
STAD	chr6	144448605	Silent	NA	T636T	0.04
STAD	chr6	144482259	Silent	novel	K1186K	0.28
STAD	chr6	144836411	Missense_Mutation	NA	S3312L	0.26
STAD	chr6	144554876	Missense_Mutation	novel	Q2373K	0.12
STAD	chr6	144458927	Missense_Mutation	NA	I814M	0.54
STAD	chr6	144459334	Missense_Mutation	rs115273171	R896H	0.26
STAD	chr6	144479859	Silent	rs112708396	A1128A	0.17
STAD	chr6	144291864	Silent	rs181012386	D12D	0.08
TGCT	chr6	144774307	Missense_Mutation	rs748581554	R2859C	0.12
TGCT	chr6	144827372	Nonsense_Mutation	rs780974577	W3173*	0.14
TGCT	chr6	144458960	Silent	novel	S825S	0.29
THCA	chr6	144462864	Frame_Shift_Ins	novel	*E1022Vfs18**	0.09
THCA	chr6	144730396	Nonsense_Mutation	novel	*L2617Hfs3**	0.04
THCA	chr6	144516349	In_Frame_Ins	novel	V1789delinsDFPSL	0.07
THCA	chr6	144678490	In_Frame_Ins	novel	N2522delinsISISLY	0.11
THYM	chr6	144423606	Nonsense_Mutation	novel	Q98*	0.09
THYM	chr6	144748338	Missense_Mutation	novel	V2678L	0.07
UCEC	chr6	144444300	Missense_Mutation	NA	T511I	0.4
UCEC	chr6	144840740	Missense_Mutation	rs144906188	A3393V	0.51
UCEC	chr6	144458787	Nonsense_Mutation	NA	E768*	0.29
UCEC	chr6	144490931	Splice_Region	novel	R1422R	0.22
UCEC	chr6	144548822	Nonsense_Mutation	NA	E2260*	0.34
UCEC	chr6	144851208	3'UTR	novel		0.4
UCEC	chr6	144479816	Missense_Mutation	NA	A1114D	0.26
UCEC	chr6	144537688	Missense_Mutation	rs532277544	E2114K	0.26
UCEC	chr6	144435963	Missense_Mutation	novel	S295I	0.19
UCEC	chr6	144474674	Missense_Mutation	rs751133169	R1084Q	0.41
UCEC	chr6	144485495	Silent	rs781745538	T1266T	0.08
UCEC	chr6	144539346	Missense_Mutation	novel	R2141I	0.24
UCEC	chr6	144754738	Missense_Mutation	novel	L2792I	0.31
UCEC	chr6	144789198	Nonsense_Mutation	rs757056942	R2947*	0.31
UCEC	chr6	144803146	Missense_Mutation	novel	P3119H	0.14
UCEC	chr6	144557189	Silent	novel	G2389G	0.06
UCEC	chr6	144403185	Splice_Site	NA	X47_splice	0.34
UCEC	chr6	144447232	Missense_Mutation	rs764013545	T546A	0.37
UCEC	chr6	144482244	Silent	novel	R1181R	0.36
UCEC	chr6	144513946	Missense_Mutation	novel	V1661A	0.42
UCEC	chr6	144514692	Missense_Mutation	novel	N1706H	0.38
UCEC	chr6	144548797	Silent	novel	S2251S	0.2
UCEC	chr6	144557193	Missense_Mutation	rs773392390	V2391I	0.4
UCEC	chr6	144577233	Missense_Mutation	rs771901189	R2475Q	0.34
UCEC	chr6	144491043	Missense_Mutation	rs145799060	V1460I	0.5
UCEC	chr6	144479857	Missense_Mutation	novel	A1128T	0.35
UCEC	chr6	144448736	Missense_Mutation	novel	R680I	0.04
UCEC	chr6	144462708	Nonsense_Mutation	NA	E970*	0.41
UCEC	chr6	144523182	Missense_Mutation	NA	R1967Q	0.4
UCEC	chr6	144789193	Splice_Site	NA	X2945_splice	0.19
UCEC	chr6	144447235	Missense_Mutation	rs778831647	E547K	0.3
UCEC	chr6	144459262	Missense_Mutation	novel	P872L	0.58
UCEC	chr6	144836417	Missense_Mutation	novel	L3314R	0.47
UCEC	chr6	144291877	Missense_Mutation	rs764071312	E17K	0.25
UCEC	chr6	144485508	Missense_Mutation	NA	E1271K	0.59
UCEC	chr6	144421938	Missense_Mutation	novel	D68N	0.46
UCEC	chr6	144435943	Silent	rs745647635	A288A	0.5
UCEC	chr6	144516900	Missense_Mutation	NA	K1831N	0.53
UCEC	chr6	144554807	Nonsense_Mutation	novel	E2350*	0.37
UCEC	chr6	144793881	Nonsense_Mutation	novel	Q2990*	0.33
UCEC	chr6	144291857	Missense_Mutation	novel	S10I	0.33
UCEC	chr6	144490992	Missense_Mutation	novel	R1443S	0.4
UCEC	chr6	144678503	Missense_Mutation	novel	A2526D	0.47
UCEC	chr6	144851446	3'UTR	novel		0.39
UCEC	chr6	144459320	Silent	novel	E891E	0.39
UCEC	chr6	144482250	Silent	novel	K1183K	0.47
UCEC	chr6	144751807	Missense_Mutation	novel	A2737V	0.21
UCEC	chr6	144782093	Missense_Mutation	novel	C2935Y	0.38
UCEC	chr6	144554743	Missense_Mutation	novel	Q2328H	0.2
UCEC	chr6	144516890	Missense_Mutation	novel	K1828T	0.1
UCEC	chr6	144447635	Missense_Mutation	NA	T586P	0.23
UCEC	chr6	144451450	Nonsense_Mutation	novel	Y718*	0.04
UCEC	chr6	144479823	Missense_Mutation	NA	Q1116H	0.17
UCEC	chr6	144539436	Missense_Mutation	NA	W2171L	0.37
UCEC	chr6	144771915	Missense_Mutation	NA	T2835K	0.41
UCEC	chr6	144548679	Missense_Mutation	novel	A2212V	0.32
UCEC	chr6	144291877	Missense_Mutation	rs764071312	E17K	0.28
UCEC	chr6	144423574	Missense_Mutation	novel	V87A	0.05
UCEC	chr6	144459284	Silent	NA	F879F	0.3
UCEC	chr6	144474638	Missense_Mutation	NA	S1072F	0.24
UCEC	chr6	144523181	Missense_Mutation	rs116699477	R1967W	0.26
UCEC	chr6	144751860	Missense_Mutation	novel	L2755V	0.09
UCEC	chr6	144836307	Silent	NA	L3277L	0.14
UCEC	chr6	144473783	Missense_Mutation	novel	A1044T	0.18
UCEC	chr6	144548669	Missense_Mutation	novel	V2209L	0.22
UCEC	chr6	144548825	Nonsense_Mutation	novel	E2261*	0.17
UCEC	chr6	144577118	Missense_Mutation	rs779829056	A2437T	0.29
UCEC	chr6	144771963	Missense_Mutation	rs762992139	S2851F	0.23
UCEC	chr6	144789244	Missense_Mutation	rs367549807	S2962Y	0.19
UCEC	chr6	144835849	Silent	rs375428730	P3245P	0.27
UCEC	chr6	144437658	Missense_Mutation	NA	E385K	0.35
UCEC	chr6	144462786	Missense_Mutation	novel	K996Q	0.3
UCEC	chr6	144479859	Silent	rs112708396	A1128A	0.37
UCEC	chr6	144700106	Missense_Mutation	rs374209033	A2558T	0.21
UCEC	chr6	144793942	Missense_Mutation	NA	A3010V	0.51
UCEC	chr6	144839188	Nonsense_Mutation	rs748796090	R3361*	0.47
UCEC	chr6	144451484	Missense_Mutation	novel	K729N	0.45
UCEC	chr6	144827348	Splice_Region	novel	T3165T	0.34
UCEC	chr6	144771937	Silent	NA	H2842H	0.33
UCEC	chr6	144487566	Missense_Mutation	rs770868827	R1281C	0.43
UCEC	chr6	144458828	Missense_Mutation	novel	K781N	0.65
UCEC	chr6	144793877	Silent	novel	Q2988Q	0.32
UCEC	chr6	144803084	Missense_Mutation	novel	F3098L	0.5
UCEC	chr6	144474674	Missense_Mutation	rs751133169	R1084Q	0.3
UCEC	chr6	144437605	Missense_Mutation	novel	G367D	0.34
UCEC	chr6	144493414	Silent	novel	Q1517Q	0.31
UCEC	chr6	144827614	Silent	rs752601858	P3179P	0.29
UCEC	chr6	144840746	Missense_Mutation	novel	E3395G	0.38
UCEC	chr6	144782024	Missense_Mutation	novel	T2912I	0.18
UCEC	chr6	144437613	Missense_Mutation	novel	L370M	0.29
UCEC	chr6	144438752	Missense_Mutation	NA	D417N	0.49
UCEC	chr6	144852793	3'UTR	novel		0.38
UCEC	chr6	144421938	Missense_Mutation	novel	D68Y	0.58
UCEC	chr6	144782071	Missense_Mutation	rs375664557	V2928I	0.44
UCEC	chr6	144440448	Missense_Mutation	rs762571654	A497T	0.39
UCEC	chr6	144473740	Missense_Mutation	novel	E1029D	0.13
UCEC	chr6	144539346	Missense_Mutation	novel	R2141I	0.31
UCEC	chr6	144836378	Missense_Mutation	rs199713104	S3301L	0.44
UCEC	chr6	144514650	Missense_Mutation	rs749647494	R1692C	0.33
UCEC	chr6	144537617	Missense_Mutation	novel	R2090M	0.45
UCEC	chr6	144852482	3'UTR	novel		0.39
UCEC	chr6	144852793	3'UTR	novel		0.5
UCEC	chr6	144459325	Missense_Mutation	rs774195329	V893A	0.14
UCEC	chr6	144482222	Missense_Mutation	NA	D1174V	0.36
UCEC	chr6	144554806	Missense_Mutation	novel	E2349D	0.41
UCEC	chr6	144577193	Missense_Mutation	novel	A2462S	0.42
UCEC	chr6	144836305	Missense_Mutation	novel	L3277I	0.35
UCEC	chr6	144852662	3'UTR	novel		0.57
UCEC	chr6	144730425	Missense_Mutation	NA	F2626L	0.46
UCEC	chr6	144493317	Frame_Shift_Del	novel	*S1486Kfs9**	0.31
UCEC	chr6	144448731	Missense_Mutation	NA	K678N	0.35
UCEC	chr6	144522105	Silent	rs751103582	S1889S	0.45
UCEC	chr6	144554832	Missense_Mutation	rs779151170	R2358Q	0.38
UCEC	chr6	144852793	3'UTR	novel		0.41
UCEC	chr6	144291748	5'Flank	novel		0.47
UCEC	chr6	144748295	Missense_Mutation	NA	K2663N	0.34
UCEC	chr6	144428828	Missense_Mutation	novel	R210I	0.32
UCEC	chr6	144447725	Missense_Mutation	rs780604221	E616K	0.32
UCEC	chr6	144533137	Missense_Mutation	rs766391697	R2037Q	0.29
UCEC	chr6	144678565	Missense_Mutation	novel	S2547P	0.63
UCEC	chr6	144751860	Missense_Mutation	novel	L2755V	0.42
UCEC	chr6	144429587	Missense_Mutation	novel	A234V	0.35
UCEC	chr6	144485429	Silent	novel	L1244L	0.33
UCEC	chr6	144782070	Silent	rs750707447	N2927N	0.33
UCEC	chr6	144820901	Missense_Mutation	novel	V3126A	0.29
UCEC	chr6	144828845	Missense_Mutation	novel	T3219A	0.2
UCEC	chr6	144748497	Missense_Mutation	NA	H2731N	0.26
UCEC	chr6	144473798	Missense_Mutation	rs757857244	D1049N	0.19
UCEC	chr6	144493336	Missense_Mutation	novel	E1491D	0.19
UCEC	chr6	144514699	Missense_Mutation	rs115466543	R1708H	0.21
UCEC	chr6	144516331	Nonsense_Mutation	novel	E1783*	0.15
UCEC	chr6	144548639	Splice_Site	novel	X2199_splice	0.2
UCEC	chr6	144557169	Nonsense_Mutation	novel	E2383*	0.08
UCEC	chr6	144774307	Missense_Mutation	rs748581554	R2859C	0.16
UCEC	chr6	144821018	Missense_Mutation	rs770453517	T3165I	0.1
UCEC	chr6	144836303	Missense_Mutation	novel	N3276I	0.15
UCEC	chr6	144851454	3'UTR	novel		0.27
UCEC	chr6	144523139	Silent	novel	L1953L	0.42
UCEC	chr6	144840799	Missense_Mutation	novel	E3413K	0.43
UCEC	chr6	144852787	3'UTR	novel		0.37
UCEC	chr6	144748419	Missense_Mutation	NA	A2705T	0.1
UCEC	chr6	144820963	Missense_Mutation	novel	P3147T	0.4
UCEC	chr6	144429658	Missense_Mutation	novel	V258F	0.16
UCEC	chr6	144479859	Silent	rs112708396	A1128A	0.33
UCEC	chr6	144522086	Missense_Mutation	novel	M1883T	0.29
UCEC	chr6	144513996	Missense_Mutation	NA	I1678L	0.45
UCEC	chr6	144426331	Silent	rs777393595	T150T	0.36
UCEC	chr6	144458930	Missense_Mutation	novel	K815N	0.31
UCEC	chr6	144485399	Silent	novel	C1234C	0.34
UCEC	chr6	144487585	Missense_Mutation	rs373769853	R1287H	0.77
UCEC	chr6	144490112	Missense_Mutation	novel	E1392D	0.33
UCEC	chr6	144493388	Missense_Mutation	novel	D1509N	0.31
UCEC	chr6	144522139	Missense_Mutation	rs780381364	E1901K	0.36
UCEC	chr6	144551080	Missense_Mutation	novel	K2309I	0.37
UCEC	chr6	144851460	3'UTR	novel		0.31
UCEC	chr6	144852794	3'UTR	novel		0.33
UCEC	chr6	144840768	Silent	rs145835486	H3402H	0.24
UCEC	chr6	144851008	3'UTR	rs199780135		0.3
UCEC	chr6	144403167	Missense_Mutation	NA	N42H	0.35
UCEC	chr6	144426317	Missense_Mutation	novel	D146N	0.44
UCEC	chr6	144577155	Missense_Mutation	rs771357033	R2449H	0.4
UCEC	chr6	144793974	Missense_Mutation	NA	R3021C	0.41
UCEC	chr6	144488778	Missense_Mutation	novel	L1360I	0.46
UCEC	chr6	144852793	3'UTR	novel		0.49
UCEC	chr6	144836369	Missense_Mutation	rs763690466	P3298L	0.42
UCEC	chr6	144291863	Missense_Mutation	NA	D12G	0.21
UCEC	chr6	144462747	Frame_Shift_Ins	novel	*L985Ifs3**	0.21
UCEC	chr6	144474674	Missense_Mutation	rs751133169	R1084Q	0.35
UCEC	chr6	144748383	Missense_Mutation	novel	L2693F	0.05
UCEC	chr6	144836378	Missense_Mutation	rs199713104	S3301L	0.19
UCEC	chr6	144577288	Splice_Region	novel	Q2493Q	0.13
UCEC	chr6	144782013	Silent	novel	I2908I	0.1
UCEC	chr6	144678520	Nonsense_Mutation	NA	R2532*	0.36
UCEC	chr6	144797961	Silent	novel	I3072I	0.26
UCEC	chr6	144426362	Missense_Mutation	NA	R161C	0.32
UCEC	chr6	144291775	5'Flank	novel		0.37
UCEC	chr6	144447661	Silent	novel	G594G	0.05
UCEC	chr6	144485382	Splice_Region	novel		0.17
UCEC	chr6	144438822	Missense_Mutation	rs761620103	R440H	0.45
UCEC	chr6	144748463	Silent	rs746080010	P2719P	0.47
UCEC	chr6	144840832	Missense_Mutation	rs11546880	P3424S	0.11
UCEC	chr6	144577258	Silent	novel	I2483I	0.22
UCEC	chr6	144774326	Missense_Mutation	novel	T2865I	0.09
UCEC	chr6	144803063	Silent	novel	Y3091Y	0.09
UCEC	chr6	144516349	Missense_Mutation	novel	V1789M	0.2
UCEC	chr6	144537618	Silent	rs374804526	R2090R	0.11
UCEC	chr6	144488791	Missense_Mutation	NA	L1364P	0.18
UCEC	chr6	144511056	Missense_Mutation	novel	L1626P	0.34
UCEC	chr6	144836338	Missense_Mutation	novel	H3288Y	0.54
UCEC	chr6	144424075	Nonsense_Mutation	novel	W134*	0.11
UCEC	chr6	144426331	Silent	rs777393595	T150T	0.52
UCEC	chr6	144438790	Silent	NA	Q429Q	0.19
UCEC	chr6	144447308	Missense_Mutation	rs181231692	R571Q	0.43
UCEC	chr6	144458787	Nonsense_Mutation	NA	E768*	0.39
UCEC	chr6	144730425	Missense_Mutation	NA	F2626L	0.57
UCEC	chr6	144551011	Frame_Shift_Del	novel	*F2287Lfs7**	0.49
UCEC	chr6	144291877	Missense_Mutation	rs764071312	E17K	0.29
UCEC	chr6	144453807	Missense_Mutation	NA	R741I	0.29
UCEC	chr6	144458886	Missense_Mutation	NA	N801H	0.28
UCEC	chr6	144499412	Missense_Mutation	NA	E1583D	0.11
UCEC	chr6	144516895	Nonsense_Mutation	NA	E1830*	0.4
UCEC	chr6	144539346	Missense_Mutation	novel	R2141I	0.27
UCEC	chr6	144577155	Missense_Mutation	rs771357033	R2449H	0.33
UCEC	chr6	144423591	Missense_Mutation	rs745802382	V93I	0.24
UCEC	chr6	144447289	Missense_Mutation	novel	E565K	0.25
UCEC	chr6	144700226	Missense_Mutation	novel	Q2598K	0.2
UCEC	chr6	144291877	Missense_Mutation	rs764071312	E17K	0.4
UCEC	chr6	144516942	Missense_Mutation	novel	K1845N	0.23
UCEC	chr6	144820903	Nonsense_Mutation	novel	R3127*	0.41
UCEC	chr6	144789220	Missense_Mutation	novel	Q2954R	0.31
UCEC	chr6	144516905	Missense_Mutation	rs140426320	R1833H	0.3
UCEC	chr6	144438751	Silent	rs114118949	H416H	0.4
UCEC	chr6	144493445	Silent	rs778079117	L1528L	0.25
UCEC	chr6	144531168	Missense_Mutation	NA	S2008I	0.19
UCEC	chr6	144782048	Missense_Mutation	novel	Q2920R	0.06
UCEC	chr6	144516273	Silent	NA	T1763T	0.29
UCEC	chr6	144479815	Missense_Mutation	novel	A1114T	0.3
UCEC	chr6	144490985	Silent	rs569844356	F1440F	0.52
UCEC	chr6	144522017	Missense_Mutation	novel	A1860V	0.5
UCEC	chr6	144771967	Splice_Region	novel	L2852L	0.49
UCEC	chr6	144782002	Missense_Mutation	rs144857275	P2905S	0.31
UCEC	chr6	144835892	Missense_Mutation	rs146824070	R3260C	0.26
UCEC	chr6	144839188	Nonsense_Mutation	rs748796090	R3361*	0.27
UCEC	chr6	144851121	3'UTR	novel		0.54
UCEC	chr6	144462819	Missense_Mutation	novel	D1007Y	0.26
UCEC	chr6	144487601	Missense_Mutation	novel	E1292D	0.44
UCEC	chr6	144491034	Missense_Mutation	novel	E1457K	0.3
UCS	chr6	144459211	Missense_Mutation	novel	I855T	0.15
UCS	chr6	144435955	Missense_Mutation	novel	E292D	0.24
UCS	chr6	144851146	3'UTR	novel		0.43
UVM	chr6	144493451	Missense_Mutation	rs771082025	A1530T	0.68

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
GBM	DEL	0.2409	1.056e-05
KIRC	DEL	0.2424	7.439e-11
KIRP	DEL	0.1007	0.054498
LGG	DEL	0.1481	0.0054594
MESO	DEL	0.4253	0.05642
PAAD	DEL	0.3587	0.11274
SKCM	DEL	0.5531	1.5442e-06
THYM	DEL	0.1301	0.10691
UVM	DEL	0.275	0.0054289

Survival Analysis

Cancer	P-value	Q-value
MESO	0.044	Kaplan-Meier Survival Analysis
HNSC	0.039	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
LUSC	0.033	Kaplan-Meier Survival Analysis
KIRP	0.04	Kaplan-Meier Survival Analysis
BLCA	0.04	Kaplan-Meier Survival Analysis
KICH	0.046	Kaplan-Meier Survival Analysis
UCEC	0.013	Kaplan-Meier Survival Analysis
LIHC	0.024	Kaplan-Meier Survival Analysis
LUAD	0.021	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742