EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000153113 (Gene tree)
Gene ID: 831
Gene Symbol: CAST
Alias: N
Full Name: calpastatin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 254,329 bases
Position: chr5:96,525,267-96,779,595
Accession: 1515
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000348386	CAST-205	2272	-	-	- (aa)	-	-
ENST00000512191	CAST-237	406	-	-	- (aa)	-	-
ENST00000395813	CAST-207	4356	-	ENSP00000379158	708 (aa)	-	P20810
ENST00000395812	CAST-206	4506	-	ENSP00000379157	750 (aa)	-	P20810
ENST00000338252	CAST-203	2972	-	ENSP00000343421	695 (aa)	-	P20810
ENST00000511782	CAST-236	2466	-	ENSP00000423638	694 (aa)	-	B7Z574
ENST00000514845	CAST-241	588	-	ENSP00000422612	150 (aa)	-	D6RBR1
ENST00000503828	CAST-211	499	-	ENSP00000422807	78 (aa)	-	D6RAA8
ENST00000504465	CAST-213	2336	-	ENSP00000425670	636 (aa)	-	E9PDE4
ENST00000504221	CAST-212	578	-	-	- (aa)	-	-
ENST00000325674	CAST-202	3356	-	ENSP00000320319	430 (aa)	-	A0A0A0MR45
ENST00000515160	CAST-243	617	-	-	- (aa)	-	-
ENST00000515663	CAST-244	1473	-	ENSP00000422929	431 (aa)	-	E7EQA0
ENST00000515063	CAST-242	654	-	-	- (aa)	-	-
ENST00000509903	CAST-228	2171	-	ENSP00000426946	673 (aa)	-	E9PCH5
ENST00000513666	CAST-239	1539	-	-	- (aa)	-	-
ENST00000505143	CAST-215	864	-	ENSP00000422957	288 (aa)	-	H0Y944
ENST00000507836	CAST-219	449	-	-	- (aa)	-	-
ENST00000508579	CAST-222	1758	-	ENSP00000425787	423 (aa)	-	E7EQ12
ENST00000508608	CAST-223	2425	-	ENSP00000422677	754 (aa)	-	A0A0C4DGB5
ENST00000484552	CAST-210	1767	-	ENSP00000432878	450 (aa)	-	H0YD33
ENST00000309190	CAST-201	4282	-	ENSP00000312523	686 (aa)	-	P20810
ENST00000341926	CAST-204	2487	-	ENSP00000339914	708 (aa)	-	P20810
ENST00000421689	CAST-208	913	-	ENSP00000396558	304 (aa)	-	E9PSG1
ENST00000510245	CAST-231	561	-	-	- (aa)	-	-
ENST00000437034	CAST-209	3377	-	ENSP00000412374	436 (aa)	-	H0Y7F0
ENST00000509602	CAST-227	557	-	-	- (aa)	-	-
ENST00000508117	CAST-220	571	-	ENSP00000422466	82 (aa)	-	D6RBZ8
ENST00000506811	CAST-217	582	-	ENSP00000427092	156 (aa)	-	E7EN75
ENST00000511097	CAST-235	1399	-	ENSP00000422951	393 (aa)	-	F8W7E0
ENST00000507487	CAST-218	396	-	-	- (aa)	-	-
ENST00000509259	CAST-225	565	-	ENSP00000423846	91 (aa)	-	D6RC54
ENST00000511049	CAST-234	3273	-	ENSP00000421130	693 (aa)	-	E7EVY3
ENST00000510098	CAST-229	1323	-	ENSP00000427195	203 (aa)	-	A0A0C4DGD1
ENST00000512620	CAST-238	904	-	ENSP00000426422	301 (aa)	-	H0YA91
ENST00000510156	CAST-230	2079	-	ENSP00000422325	642 (aa)	-	E7ES10
ENST00000510500	CAST-232	1835	-	ENSP00000424160	465 (aa)	-	H0Y9H6
ENST00000509529	CAST-226	3066	-	-	- (aa)	-	-
ENST00000504532	CAST-214	714	-	-	- (aa)	-	-
ENST00000508197	CAST-221	567	-	ENSP00000422831	156 (aa)	-	E7EQK6
ENST00000510756	CAST-233	2310	-	ENSP00000422176	769 (aa)	-	P20810
ENST00000508830	CAST-224	2539	-	ENSP00000425721	791 (aa)	-	P20810
ENST00000514055	CAST-240	559	-	ENSP00000421230	149 (aa)	-	D6RGF7
ENST00000505402	CAST-216	362	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000153113's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000153113	Parkinson Disease	6.761E-5	17052657
ENSG00000153113	Parkinson Disease	2.189E-5	17052657
ENSG00000153113	Respiratory Function Tests	9.00302475512798E-5	17903307
ENSG00000153113	Blood Pressure	4.9170000E-005	-
ENSG00000153113	Psoriasis	3E-11	20953190
ENSG00000153113	Hodgkin Disease	7E-6	22286212
ENSG00000153113	Psoriasis	2E-8	25574825

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000153113	rs27033	5	96771195	A	Blood protein levels	29875488	[0.13-0.25] unit decrease	0.19	EFO_0007937
ENSG00000153113	rs27524	5	96766240	A	Psoriasis	25574825	[1.157-1.234]	1.195	EFO_0000676
ENSG00000153113	rs13160562	5	96775667	G	Alcohol dependence	19581569	[1.14-1.41]	1.27	EFO_0003829
ENSG00000153113	rs6556937	5	96649578	T	Blood protein levels	28240269	[0.36-0.6] unit increase	0.4792	EFO_0008119
ENSG00000153113	rs149313	5	96734501	T	Blood protein levels	28240269	[0.44-0.61] unit increase	0.5227	EFO_0008119
ENSG00000153113	rs10062657	5	96532204	A	Body mass index	28892062	[0.03-0.046] kg/m2 decrease	0.038	EFO_0004340
ENSG00000153113	rs27524	5	96766240	A	Psoriasis	20953190	[1.05-1.22]	1.13	EFO_0000676
ENSG00000153113	rs27524	5	96766240	?	Hodgkin's lymphoma	22286212	[1.11-1.33]	1.22	EFO_0000183
ENSG00000153113	rs72772090	5	96700607	G	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)	28090653	[1.3-20]	5.263158	EFO_0004735\|EFO_0007965\|EFO_0000220
ENSG00000153113	rs10055259	5	96548143	A	Telomere length	30185882	[0.118-0.268] unit decrease	0.193	EFO_0004505
ENSG00000153113	rs3822683	5	96745179	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000153113's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002020	protease binding	21873635.	IBA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004866	endopeptidase inhibitor activity	7638179.	TAS	Function
GO:0005515	protein binding	17474147.24462690.	IPI	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005829	cytosol	14559243.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity	21873635.	IBA	Function
GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity	2407243.	IMP	Function
GO:0016020	membrane	21873635.	IBA	Component
GO:0016020	membrane	14559243.	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0097340	inhibition of cysteine-type endopeptidase activity	21873635.	IBA	Process
GO:0097340	inhibition of cysteine-type endopeptidase activity	2407243.	IMP	Process
GO:1990709	presynaptic active zone organization	27626661.	TAS	Process
GO:2000675	negative regulation of type B pancreatic cell apoptotic process	15044459.	IDA	Process