EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000153147 (Gene tree)
Gene ID: 8467
Gene Symbol: SMARCA5
Alias: hSNF2H|hISWI|ISWI
Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 44,027 bases
Position: chr4:143,513,463-143,557,489
Accession: 11101
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000283131	ResIII	PF04851.15	2.5e-10	1	1
ENSP00000283131	DEAD	PF00270.29	1.5e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16603771	The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.	J Biol Chem	2006 Jun 16	Cavellan E	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508573	SMARCA5-202	363	-	-	- (aa)	-	-
ENST00000515531	SMARCA5-203	529	-	-	- (aa)	-	-
ENST00000283131	SMARCA5-201	7923	-	ENSP00000283131	1052 (aa)	-	O60264

Gene Model

Click here to download ENSG00000153147's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000153147's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000153147	SMARCA5	52	42.637	ENSG00000127616	SMARCA4	94	42.986

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000153147	SMARCA5	100	98.764	ENSAMEG00000009585	SMARCA5	100	98.764	Ailuropoda_melanoleuca
ENSG00000153147	SMARCA5	91	96.612	ENSAPLG00000009206	SMARCA5	100	96.612	Anas_platyrhynchos
ENSG00000153147	SMARCA5	98	93.986	ENSACAG00000003038	SMARCA5	99	93.986	Anolis_carolinensis
ENSG00000153147	SMARCA5	100	99.335	ENSANAG00000019345	SMARCA5	100	99.335	Aotus_nancymaae
ENSG00000153147	SMARCA5	100	98.194	ENSBTAG00000003399	SMARCA5	100	98.194	Bos_taurus
ENSG00000153147	SMARCA5	100	99.525	ENSCJAG00000002735	SMARCA5	100	99.525	Callithrix_jacchus
ENSG00000153147	SMARCA5	100	98.574	ENSCAFG00000007525	SMARCA5	100	98.574	Canis_familiaris
ENSG00000153147	SMARCA5	98	98.547	ENSCAFG00020025641	SMARCA5	99	98.547	Canis_lupus_dingo
ENSG00000153147	SMARCA5	100	98.669	ENSCHIG00000013730	-	100	98.669	Capra_hircus
ENSG00000153147	SMARCA5	100	96.958	ENSCHIG00000016375	-	100	96.958	Capra_hircus
ENSG00000153147	SMARCA5	97	97.363	ENSTSYG00000009954	SMARCA5	99	99.597	Carlito_syrichta
ENSG00000153147	SMARCA5	92	98.967	ENSCAPG00000013747	SMARCA5	95	98.967	Cavia_aperea
ENSG00000153147	SMARCA5	100	97.909	ENSCPOG00000002259	SMARCA5	100	97.909	Cavia_porcellus
ENSG00000153147	SMARCA5	100	99.525	ENSCCAG00000027215	SMARCA5	100	99.525	Cebus_capucinus
ENSG00000153147	SMARCA5	100	99.810	ENSCATG00000044917	SMARCA5	100	99.810	Cercocebus_atys
ENSG00000153147	SMARCA5	99	95.115	ENSCLAG00000006153	SMARCA5	100	99.194	Chinchilla_lanigera
ENSG00000153147	SMARCA5	92	100.000	ENSCSAG00000003448	SMARCA5	100	100.000	Chlorocebus_sabaeus
ENSG00000153147	SMARCA5	90	98.292	ENSCHOG00000011724	SMARCA5	90	98.292	Choloepus_hoffmanni
ENSG00000153147	SMARCA5	95	97.994	ENSCPBG00000027535	SMARCA5	96	97.994	Chrysemys_picta_bellii
ENSG00000153147	SMARCA5	100	99.620	ENSCANG00000041629	SMARCA5	100	99.620	Colobus_angolensis_palliatus
ENSG00000153147	SMARCA5	99	97.814	ENSCGRG00001012719	Smarca5	99	97.814	Cricetulus_griseus_chok1gshd
ENSG00000153147	SMARCA5	95	98.997	ENSCGRG00000001417	Smarca5	99	99.396	Cricetulus_griseus_crigri
ENSG00000153147	SMARCA5	98	95.358	ENSDNOG00000009158	SMARCA5	98	95.358	Dasypus_novemcinctus
ENSG00000153147	SMARCA5	99	82.342	ENSDORG00000003466	Smarca5	97	90.612	Dipodomys_ordii
ENSG00000153147	SMARCA5	92	85.744	ENSEBUG00000014773	SMARCA5	96	85.744	Eptatretus_burgeri
ENSG00000153147	SMARCA5	100	98.954	ENSEASG00005001866	SMARCA5	100	98.954	Equus_asinus_asinus
ENSG00000153147	SMARCA5	100	98.954	ENSECAG00000002676	SMARCA5	100	98.954	Equus_caballus
ENSG00000153147	SMARCA5	94	94.965	ENSEEUG00000013176	SMARCA5	100	94.965	Erinaceus_europaeus
ENSG00000153147	SMARCA5	92	89.485	ENSELUG00000014653	SMARCA5	99	89.485	Esox_lucius
ENSG00000153147	SMARCA5	100	98.764	ENSFCAG00000004544	SMARCA5	100	98.764	Felis_catus
ENSG00000153147	SMARCA5	92	97.216	ENSFALG00000004987	SMARCA5	100	97.216	Ficedula_albicollis
ENSG00000153147	SMARCA5	99	95.706	ENSFDAG00000021016	SMARCA5	100	99.396	Fukomys_damarensis
ENSG00000153147	SMARCA5	99	85.043	ENSGMOG00000007519	SMARCA5	94	89.560	Gadus_morhua
ENSG00000153147	SMARCA5	97	95.976	ENSGALG00000009913	SMARCA5	96	97.490	Gallus_gallus
ENSG00000153147	SMARCA5	93	90.686	ENSGACG00000017238	SMARCA5	95	90.686	Gasterosteus_aculeatus
ENSG00000153147	SMARCA5	96	96.940	ENSGAGG00000019882	SMARCA5	96	98.094	Gopherus_agassizii
ENSG00000153147	SMARCA5	100	100.000	ENSGGOG00000012595	SMARCA5	100	100.000	Gorilla_gorilla
ENSG00000153147	SMARCA5	96	89.275	ENSHGLG00000000317	-	95	89.558	Heterocephalus_glaber_female
ENSG00000153147	SMARCA5	100	97.909	ENSHGLG00000000816	-	99	97.909	Heterocephalus_glaber_female
ENSG00000153147	SMARCA5	96	98.310	ENSHGLG00100018421	-	100	99.295	Heterocephalus_glaber_male
ENSG00000153147	SMARCA5	100	98.575	ENSSTOG00000010683	SMARCA5	99	98.575	Ictidomys_tridecemlineatus
ENSG00000153147	SMARCA5	100	97.433	ENSJJAG00000014965	Smarca5	100	97.433	Jaculus_jaculus
ENSG00000153147	SMARCA5	94	95.358	ENSLACG00000007091	SMARCA5	97	95.358	Latimeria_chalumnae
ENSG00000153147	SMARCA5	94	92.284	ENSLOCG00000008966	SMARCA5	96	92.284	Lepisosteus_oculatus
ENSG00000153147	SMARCA5	100	98.574	ENSLAFG00000007795	SMARCA5	100	98.574	Loxodonta_africana
ENSG00000153147	SMARCA5	100	99.810	ENSMFAG00000043649	SMARCA5	100	99.810	Macaca_fascicularis
ENSG00000153147	SMARCA5	100	99.810	ENSMMUG00000000829	SMARCA5	100	99.810	Macaca_mulatta
ENSG00000153147	SMARCA5	100	99.810	ENSMNEG00000031916	SMARCA5	100	99.810	Macaca_nemestrina
ENSG00000153147	SMARCA5	100	99.810	ENSMLEG00000042393	SMARCA5	100	99.810	Mandrillus_leucophaeus
ENSG00000153147	SMARCA5	95	97.100	ENSMGAG00000003517	SMARCA5	99	97.100	Meleagris_gallopavo
ENSG00000153147	SMARCA5	94	99.396	ENSMAUG00000015902	Smarca5	98	99.396	Mesocricetus_auratus
ENSG00000153147	SMARCA5	100	98.954	ENSMICG00000003971	SMARCA5	100	98.954	Microcebus_murinus
ENSG00000153147	SMARCA5	99	97.433	ENSMOCG00000016986	-	99	97.433	Microtus_ochrogaster
ENSG00000153147	SMARCA5	100	95.735	ENSMODG00000000391	SMARCA5	98	96.418	Monodelphis_domestica
ENSG00000153147	SMARCA5	100	97.624	ENSMUSG00000031715	Smarca5	100	97.624	Mus_musculus
ENSG00000153147	SMARCA5	100	97.814	MGP_PahariEiJ_G0022862	Smarca5	100	97.814	Mus_pahari
ENSG00000153147	SMARCA5	100	98.764	ENSMLUG00000000468	SMARCA5	100	98.764	Myotis_lucifugus
ENSG00000153147	SMARCA5	100	97.909	ENSNGAG00000000441	Smarca5	100	97.909	Nannospalax_galili
ENSG00000153147	SMARCA5	100	99.810	ENSNLEG00000005383	SMARCA5	100	99.810	Nomascus_leucogenys
ENSG00000153147	SMARCA5	92	91.322	ENSMEUG00000001267	SMARCA5	100	91.322	Notamacropus_eugenii
ENSG00000153147	SMARCA5	85	98.429	ENSOPRG00000014427	SMARCA5	86	98.429	Ochotona_princeps
ENSG00000153147	SMARCA5	92	98.968	ENSOANG00000013921	SMARCA5	100	98.968	Ornithorhynchus_anatinus
ENSG00000153147	SMARCA5	92	99.587	ENSOCUG00000013042	SMARCA5	100	99.587	Oryctolagus_cuniculus
ENSG00000153147	SMARCA5	100	98.954	ENSOGAG00000009702	SMARCA5	100	98.954	Otolemur_garnettii
ENSG00000153147	SMARCA5	99	98.478	ENSOARG00000010589	SMARCA5	99	98.478	Ovis_aries
ENSG00000153147	SMARCA5	100	99.810	ENSPPAG00000028523	SMARCA5	100	99.810	Pan_paniscus
ENSG00000153147	SMARCA5	97	93.359	ENSPPRG00000004925	SMARCA5	98	93.907	Panthera_pardus
ENSG00000153147	SMARCA5	96	99.109	ENSPTIG00000020959	SMARCA5	97	99.109	Panthera_tigris_altaica
ENSG00000153147	SMARCA5	100	99.905	ENSPTRG00000016472	SMARCA5	100	99.905	Pan_troglodytes
ENSG00000153147	SMARCA5	100	99.810	ENSPANG00000001175	SMARCA5	100	99.810	Papio_anubis
ENSG00000153147	SMARCA5	93	90.779	ENSPKIG00000015699	SMARCA5	98	89.716	Paramormyrops_kingsleyae
ENSG00000153147	SMARCA5	93	91.002	ENSPKIG00000015885	SMARCA5	100	91.237	Paramormyrops_kingsleyae
ENSG00000153147	SMARCA5	95	95.988	ENSPSIG00000004177	SMARCA5	100	95.988	Pelodiscus_sinensis
ENSG00000153147	SMARCA5	92	90.226	ENSPMGG00000012316	SMARCA5	100	90.226	Periophthalmus_magnuspinnatus
ENSG00000153147	SMARCA5	97	97.642	ENSPEMG00000008060	Smarca5	99	97.642	Peromyscus_maniculatus_bairdii
ENSG00000153147	SMARCA5	96	69.882	ENSPMAG00000006011	SMARCA5	81	85.440	Petromyzon_marinus
ENSG00000153147	SMARCA5	61	86.739	ENSPMAG00000008026	SMARCA5	99	86.739	Petromyzon_marinus
ENSG00000153147	SMARCA5	100	95.459	ENSPCIG00000003926	SMARCA5	98	96.318	Phascolarctos_cinereus
ENSG00000153147	SMARCA5	100	99.715	ENSPPYG00000015091	SMARCA5	100	99.715	Pongo_abelii
ENSG00000153147	SMARCA5	86	90.390	ENSPCAG00000014230	SMARCA5	90	90.390	Procavia_capensis
ENSG00000153147	SMARCA5	100	96.198	ENSPCOG00000026744	SMARCA5	100	96.198	Propithecus_coquereli
ENSG00000153147	SMARCA5	99	98.478	ENSPVAG00000006482	SMARCA5	100	98.478	Pteropus_vampyrus
ENSG00000153147	SMARCA5	97	88.039	ENSPNAG00000027824	SMARCA5	97	90.145	Pygocentrus_nattereri
ENSG00000153147	SMARCA5	95	99.196	ENSRNOG00000018149	Smarca5	100	99.196	Rattus_norvegicus
ENSG00000153147	SMARCA5	100	99.620	ENSRBIG00000044644	SMARCA5	100	99.620	Rhinopithecus_bieti
ENSG00000153147	SMARCA5	98	99.516	ENSRROG00000029591	SMARCA5	99	99.799	Rhinopithecus_roxellana
ENSG00000153147	SMARCA5	100	99.240	ENSSBOG00000036257	SMARCA5	100	99.240	Saimiri_boliviensis_boliviensis
ENSG00000153147	SMARCA5	94	98.892	ENSSHAG00000008464	SMARCA5	100	98.892	Sarcophilus_harrisii
ENSG00000153147	SMARCA5	99	85.918	ENSSFOG00015013252	SMARCA5	97	90.050	Scleropages_formosus
ENSG00000153147	SMARCA5	98	93.501	ENSSPUG00000007604	SMARCA5	99	96.181	Sphenodon_punctatus
ENSG00000153147	SMARCA5	100	98.099	ENSSSCG00000009047	SMARCA5	100	98.099	Sus_scrofa
ENSG00000153147	SMARCA5	96	95.929	ENSTGUG00000002408	SMARCA5	99	95.929	Taeniopygia_guttata
ENSG00000153147	SMARCA5	98	98.740	ENSUAMG00000023495	SMARCA5	99	98.740	Ursus_americanus
ENSG00000153147	SMARCA5	95	99.302	ENSUMAG00000015324	SMARCA5	97	99.302	Ursus_maritimus
ENSG00000153147	SMARCA5	100	98.194	ENSVPAG00000008982	SMARCA5	100	98.194	Vicugna_pacos
ENSG00000153147	SMARCA5	100	98.764	ENSVVUG00000017473	SMARCA5	100	98.764	Vulpes_vulpes
ENSG00000153147	SMARCA5	95	88.767	ENSXETG00000017566	smarca5	94	93.610	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000183	chromatin silencing at rDNA	-	IEA	Process
GO:0000793	condensed chromosome	12972596.	IDA	Component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001650	fibrillar center	-	IDA	Component
GO:0003677	DNA binding	12972596.	IDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	10655480.10662543.11980720.12972596.15543136.16514417.16917504.26100909.30021884.	IPI	Function
GO:0005524	ATP binding	12972596.	IDA	Function
GO:0005634	nucleus	12972596.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005677	chromatin silencing complex	-	IEA	Component
GO:0006334	nucleosome assembly	12972596.	IDA	Process
GO:0006338	chromatin remodeling	9836642.	IDA	Process
GO:0006352	DNA-templated transcription, initiation	9836642.	IDA	Process
GO:0006357	regulation of transcription by RNA polymerase II	9730600.	TAS	Process
GO:0016584	nucleosome positioning	9836642.	IDA	Process
GO:0016589	NURF complex	20850016.	IDA	Component
GO:0016887	ATPase activity	12972596.	IDA	Function
GO:0031213	RSF complex	9836642.	IPI	Component
GO:0031491	nucleosome binding	-	IEA	Function
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0042393	histone binding	12972596.	IDA	Function
GO:0043044	ATP-dependent chromatin remodeling	15543136.	IMP	Process
GO:0043596	nuclear replication fork	15543136.	IDA	Component
GO:0045815	positive regulation of gene expression, epigenetic	-	TAS	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	IEA	Process
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	Process