EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000153187 (Gene tree)
Gene ID: 3192
Gene Symbol: HNRNPU
Alias: SAF-A|hnRNPU|FLJ37978|FLJ30202|HNRPU|HNRNPU-AS1|C1orf199|NCRNA00201
Full Name: heterogeneous nuclear ribonucleoprotein U
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 23,923 bases
Position: chr1:244,840,638-244,864,560
Accession: 5048
RBP type: canonical RBP
Summary: This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. [provided by RefSeq, Jun 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000283179	SAP	PF02037.27	1e-09	1	1
ENSP00000491215	SAP	PF02037.27	1.1e-09	1	1
ENSP00000393151	SAP	PF02037.27	1.1e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11431691	Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.	Nat Genet	2001 Jul	Ma Z	-
10214968	A potential NES of the Epstein-Barr virus nuclear antigen 1 (EBNA1) does not confer shuttling.	FEBS Lett	1999 Mar 26	Fischer N	-
14608463	Scaffold attachment factor A (SAF-A) is concentrated in inactive X chromosome territories through its RGG domain.	Chromosoma	2003 Dec	Helbig R	-
27001848	Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X.	Proc Natl Acad Sci U S A	2016 Apr 5	Wang J	doi: 10.1073/pnas.1520113113
9731709	The DNA-binding and tau2 transactivation domains of the rat glucocorticoid receptor constitute a nuclear matrix-targeting signal.	Mol Endocrinol	1998 Sep	Tang Y	-
1628625	Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.	EMBO J	1992 Jul	Kiledjian M	-
7993898	Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins.	Biochemistry	1994 Dec 13	Jordan P	-
9733834	E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs.	J Virol	1998 Oct	Gabler S	-
9353307	The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U.	J Biol Chem	1997 Nov 7	Eggert M	-
15096513	Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription.	J Biol Chem	2004 Jun 18	Howell M	-
19617346	Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.	J Biol Chem	2009 Oct 9	Ameyar-Zazoua M	doi: 10.1074/jbc.M109.037929
20554522	Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U).	J Biol Chem	2010 Aug 20	Kawano S	doi: 10.1074/jbc.M110.112979
25030905	DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal.	Nucleic Acids Res	2014 Aug	Britton S	doi: 10.1093/nar/gku601
28123941	Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation.	Mol Metab	2016 Nov 3	Mi L	doi: 10.1016/j.molmet.2016.10.010
28575444	Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding.	Nucleic Acids Res	2017 Jul 27	Ozdilek BA	doi: 10.1093/nar/gkx460.
29217678	HRPU-2, a Homolog of Mammalian hnRNP U, Regulates Synaptic Transmission by Controlling the Expression of SLO-2 Potassium Channel in Caenorhabditis elegans.	J Neurosci	2018 Jan 31	Liu P	doi: 10.1523/JNEUROSCI.1991-17.2017
31035352	Telomere Function and the G-Quadruplex Formation are Regulated by hnRNP U.	Cells	2019 Apr 28	Izumi H	doi: 10.3390/cells8050390.
31350345	Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA.	Proc Natl Acad Sci U S A	2019 Jul 26	Khyzha N	doi: 10.1073/pnas.1904108116
29616096	A comprehensive analysis of the predicted targets of miR-642b-3p associated with the long non-coding RNA HOXA11-AS in NSCLC cells.	Oncol Lett	2018 May	Zhang Y	doi: 10.3892/ol.2018.8105
8174554	Nucleic-acid-binding properties of hnRNP-U/SAF-A, a nuclear-matrix protein which binds DNA and RNA in vivo and in vitro.	Eur J Biochem	1994 Apr 15	Fackelmayer FO	-
23396972	hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.	J Biol Chem	2013 Mar 22	Vu NT	doi: 10.1074/jbc.M112.443333
19844162	Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers.	Cell Cycle	2009 Nov 15	Britton S	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000640306	HNRNPU-228	2917	-	ENSP00000491685	804 (aa)	-	A0A1W2PPS1
ENST00000638230	HNRNPU-212	1922	-	ENSP00000492010	527 (aa)	-	A0A1W2PQL0
ENST00000366525	HNRNPU-202	2851	-	-	- (aa)	-	-
ENST00000444376	HNRNPU-205	6827	-	ENSP00000393151	806 (aa)	-	Q00839
ENST00000476241	HNRNPU-209	4844	-	-	- (aa)	-	-
ENST00000366527	HNRNPU-203	12852	-	-	- (aa)	-	-
ENST00000468690	HNRNPU-207	5273	-	-	- (aa)	-	-
ENST00000639628	HNRNPU-219	4546	-	ENSP00000491340	549 (aa)	-	A0A1W2PPH7
ENST00000638952	HNRNPU-217	5678	-	-	- (aa)	-	-
ENST00000640657	HNRNPU-230	4323	-	-	- (aa)	-	-
ENST00000639667	HNRNPU-220	3940	-	-	- (aa)	-	-
ENST00000638301	HNRNPU-213	3650	-	ENSP00000491807	372 (aa)	-	A0A1W2PQ74
ENST00000638716	HNRNPU-216	2640	-	ENSP00000491601	547 (aa)	-	A0A1W2PPL4
ENST00000465881	HNRNPU-206	883	-	-	- (aa)	-	-
ENST00000640119	HNRNPU-225	461	-	ENSP00000491491	48 (aa)	-	A0A1W2PPE9
ENST00000640056	HNRNPU-224	2045	-	ENSP00000492620	128 (aa)	-	A0A1W2PRI6
ENST00000640218	HNRNPU-226	6858	-	ENSP00000491215	825 (aa)	-	Q00839
ENST00000638475	HNRNPU-214	2698	-	ENSP00000491305	728 (aa)	-	A0A1W2PP35
ENST00000283179	HNRNPU-201	3120	-	ENSP00000283179	744 (aa)	-	A0A1X7SBS1
ENST00000639064	HNRNPU-218	2625	-	-	- (aa)	-	-
ENST00000640440	HNRNPU-229	871	-	ENSP00000491263	181 (aa)	-	A0A1W2PP22
ENST00000440865	HNRNPU-204	3207	-	ENSP00000410728	602 (aa)	-	Q5RI18
ENST00000639824	HNRNPU-221	1450	-	ENSP00000491903	327 (aa)	-	A0A1W2PQD4
ENST00000649899	HNRNPU-231	13084	-	-	- (aa)	-	-
ENST00000639880	HNRNPU-222	4239	-	ENSP00000490988	70 (aa)	-	A0A1W2PNG3
ENST00000489705	HNRNPU-211	451	-	ENSP00000479468	17 (aa)	-	A0A087WVI9
ENST00000483966	HNRNPU-210	1069	-	ENSP00000492573	302 (aa)	-	A0A1W2PRZ7
ENST00000638589	HNRNPU-215	2225	-	-	- (aa)	-	-
ENST00000640264	HNRNPU-227	328	-	-	- (aa)	-	-
ENST00000640001	HNRNPU-223	4227	-	ENSP00000491294	546 (aa)	-	A0A1W2PP34
ENST00000475997	HNRNPU-208	5290	-	ENSP00000482621	152 (aa)	-	A0A087WZF3

Gene Model

Click here to download ENSG00000153187's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000153187	Parkinson Disease	5.748476E-5	17052657
ENSG00000153187	Platelet Function Tests	2.2204460E-016	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000153187's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000153187	HNRNPU	99	59.000	ENSG00000105323	HNRNPUL1	98	60.227
ENSG00000153187	HNRNPU	99	52.843	ENSG00000214753	HNRNPUL2	69	49.904

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000153187	HNRNPU	99	65.000	ENSAPOG00000017400	hnrnpub	87	77.083	Acanthochromis_polyacanthus
ENSG00000153187	HNRNPU	100	100.000	ENSAMEG00000009145	HNRNPU	100	95.737	Ailuropoda_melanoleuca
ENSG00000153187	HNRNPU	99	64.000	ENSACIG00000012138	hnrnpub	87	80.952	Amphilophus_citrinellus
ENSG00000153187	HNRNPU	99	65.667	ENSAOCG00000015843	hnrnpub	89	61.538	Amphiprion_ocellaris
ENSG00000153187	HNRNPU	99	65.667	ENSAPEG00000014679	hnrnpub	89	61.538	Amphiprion_percula
ENSG00000153187	HNRNPU	99	64.667	ENSATEG00000016178	hnrnpub	81	60.745	Anabas_testudineus
ENSG00000153187	HNRNPU	100	94.118	ENSACAG00000004511	HNRNPU	72	89.369	Anolis_carolinensis
ENSG00000153187	HNRNPU	100	100.000	ENSANAG00000033895	-	100	99.876	Aotus_nancymaae
ENSG00000153187	HNRNPU	99	64.667	ENSACLG00000008165	hnrnpub	85	83.333	Astatotilapia_calliptera
ENSG00000153187	HNRNPU	100	100.000	ENSBTAG00000007606	HNRNPU	100	98.545	Bos_taurus
ENSG00000153187	HNRNPU	100	100.000	ENSCJAG00000016914	HNRNPU	100	99.636	Callithrix_jacchus
ENSG00000153187	HNRNPU	100	100.000	ENSCAFG00020000918	HNRNPU	100	98.759	Canis_lupus_dingo
ENSG00000153187	HNRNPU	100	100.000	ENSCHIG00000004900	HNRNPU	100	98.511	Capra_hircus
ENSG00000153187	HNRNPU	100	100.000	ENSCPOG00000011887	HNRNPU	100	97.939	Cavia_porcellus
ENSG00000153187	HNRNPU	100	100.000	ENSCCAG00000037859	-	100	99.636	Cebus_capucinus
ENSG00000153187	HNRNPU	100	100.000	ENSCATG00000035273	HNRNPU	100	99.636	Cercocebus_atys
ENSG00000153187	HNRNPU	100	100.000	ENSCLAG00000007100	HNRNPU	100	98.182	Chinchilla_lanigera
ENSG00000153187	HNRNPU	100	100.000	ENSCSAG00000009219	HNRNPU	100	99.628	Chlorocebus_sabaeus
ENSG00000153187	HNRNPU	100	100.000	ENSCHOG00000001387	HNRNPU	79	100.000	Choloepus_hoffmanni
ENSG00000153187	HNRNPU	100	100.000	ENSCPBG00000009415	HNRNPU	88	91.532	Chrysemys_picta_bellii
ENSG00000153187	HNRNPU	100	100.000	ENSCANG00000022780	HNRNPU	100	96.569	Colobus_angolensis_palliatus
ENSG00000153187	HNRNPU	100	100.000	ENSCGRG00001020525	Hnrnpu	100	96.030	Cricetulus_griseus_chok1gshd
ENSG00000153187	HNRNPU	99	65.217	ENSCSEG00000010804	hnrnpub	89	64.062	Cynoglossus_semilaevis
ENSG00000153187	HNRNPU	99	63.087	ENSCVAG00000004280	hnrnpub	85	71.429	Cyprinodon_variegatus
ENSG00000153187	HNRNPU	99	68.667	ENSDARG00000004735	hnrnpub	90	59.459	Danio_rerio
ENSG00000153187	HNRNPU	99	65.436	ENSDARG00000015206	hnrnpua	89	62.319	Danio_rerio
ENSG00000153187	HNRNPU	100	100.000	ENSDNOG00000000215	HNRNPU	88	100.000	Dasypus_novemcinctus
ENSG00000153187	HNRNPU	100	100.000	ENSDORG00000015491	Hnrnpu	100	92.060	Dipodomys_ordii
ENSG00000153187	HNRNPU	100	100.000	ENSETEG00000014565	HNRNPU	100	93.176	Echinops_telfairi
ENSG00000153187	HNRNPU	100	100.000	ENSEASG00005003017	HNRNPU	100	97.891	Equus_asinus_asinus
ENSG00000153187	HNRNPU	100	100.000	ENSECAG00000007955	HNRNPU	100	97.643	Equus_caballus
ENSG00000153187	HNRNPU	94	81.250	ENSELUG00000011966	hnrnpua	67	72.973	Esox_lucius
ENSG00000153187	HNRNPU	99	67.667	ENSELUG00000010733	hnrnpub	68	62.270	Esox_lucius
ENSG00000153187	HNRNPU	100	100.000	ENSFCAG00000002156	HNRNPU	100	98.387	Felis_catus
ENSG00000153187	HNRNPU	100	100.000	ENSFDAG00000006026	HNRNPU	100	98.990	Fukomys_damarensis
ENSG00000153187	HNRNPU	99	63.333	ENSFHEG00000022639	hnrnpub	88	69.643	Fundulus_heteroclitus
ENSG00000153187	HNRNPU	99	65.667	ENSGMOG00000001755	hnrnpub	77	60.891	Gadus_morhua
ENSG00000153187	HNRNPU	100	100.000	ENSGALG00000010671	HNRNPU	99	78.356	Gallus_gallus
ENSG00000153187	HNRNPU	99	63.333	ENSGAFG00000009369	hnrnpub	84	78.261	Gambusia_affinis
ENSG00000153187	HNRNPU	99	64.333	ENSGACG00000004679	hnrnpub	72	77.083	Gasterosteus_aculeatus
ENSG00000153187	HNRNPU	100	100.000	ENSGGOG00000004061	HNRNPU	100	99.515	Gorilla_gorilla
ENSG00000153187	HNRNPU	99	64.667	ENSHBUG00000012290	hnrnpub	85	83.333	Haplochromis_burtoni
ENSG00000153187	HNRNPU	100	100.000	ENSHGLG00000010594	-	100	97.767	Heterocephalus_glaber_female
ENSG00000153187	HNRNPU	100	100.000	ENSHGLG00100015093	HNRNPU	100	99.328	Heterocephalus_glaber_male
ENSG00000153187	HNRNPU	99	63.333	ENSHCOG00000020091	hnrnpub	83	79.545	Hippocampus_comes
ENSG00000153187	HNRNPU	99	72.333	ENSIPUG00000007749	hnrnpu	92	72.549	Ictalurus_punctatus
ENSG00000153187	HNRNPU	100	100.000	ENSJJAG00000011371	Hnrnpu	100	96.614	Jaculus_jaculus
ENSG00000153187	HNRNPU	99	65.000	ENSKMAG00000004532	hnrnpub	88	59.155	Kryptolebias_marmoratus
ENSG00000153187	HNRNPU	99	66.000	ENSLBEG00000022520	hnrnpub	87	61.194	Labrus_bergylta
ENSG00000153187	HNRNPU	100	94.118	ENSLACG00000017463	HNRNPU	99	62.392	Latimeria_chalumnae
ENSG00000153187	HNRNPU	99	76.000	ENSLOCG00000016652	hnrnpua	77	66.304	Lepisosteus_oculatus
ENSG00000153187	HNRNPU	100	100.000	ENSLAFG00000021377	HNRNPU	100	97.939	Loxodonta_africana
ENSG00000153187	HNRNPU	100	100.000	ENSMFAG00000037308	HNRNPU	100	99.636	Macaca_fascicularis
ENSG00000153187	HNRNPU	100	100.000	ENSMMUG00000021098	HNRNPU	100	99.628	Macaca_mulatta
ENSG00000153187	HNRNPU	100	100.000	ENSMNEG00000043645	HNRNPU	100	99.636	Macaca_nemestrina
ENSG00000153187	HNRNPU	99	65.667	ENSMAMG00000007196	hnrnpub	86	73.077	Mastacembelus_armatus
ENSG00000153187	HNRNPU	99	64.667	ENSMZEG00005003185	hnrnpub	85	83.333	Maylandia_zebra
ENSG00000153187	HNRNPU	100	100.000	ENSMAUG00000008842	Hnrnpu	100	96.030	Mesocricetus_auratus
ENSG00000153187	HNRNPU	100	100.000	ENSMICG00000004616	HNRNPU	100	98.909	Microcebus_murinus
ENSG00000153187	HNRNPU	100	100.000	ENSMOCG00000015623	Hnrnpu	100	95.658	Microtus_ochrogaster
ENSG00000153187	HNRNPU	100	100.000	ENSMODG00000006515	HNRNPU	100	92.941	Monodelphis_domestica
ENSG00000153187	HNRNPU	99	66.333	ENSMALG00000018243	hnrnpub	84	61.486	Monopterus_albus
ENSG00000153187	HNRNPU	100	100.000	MGP_CAROLIEiJ_G0014962	Hnrnpu	100	96.283	Mus_caroli
ENSG00000153187	HNRNPU	100	100.000	ENSMUSG00000039630	Hnrnpu	100	96.406	Mus_musculus
ENSG00000153187	HNRNPU	100	100.000	MGP_PahariEiJ_G0028193	Hnrnpu	100	95.050	Mus_pahari
ENSG00000153187	HNRNPU	100	100.000	MGP_SPRETEiJ_G0015761	Hnrnpu	100	96.406	Mus_spretus
ENSG00000153187	HNRNPU	100	100.000	ENSMLUG00000000475	HNRNPU	100	89.246	Myotis_lucifugus
ENSG00000153187	HNRNPU	100	100.000	ENSNGAG00000019075	Hnrnpu	100	96.774	Nannospalax_galili
ENSG00000153187	HNRNPU	80	83.333	ENSNBRG00000017855	hnrnpub	85	83.333	Neolamprologus_brichardi
ENSG00000153187	HNRNPU	96	96.497	ENSMEUG00000000541	HNRNPU	100	90.097	Notamacropus_eugenii
ENSG00000153187	HNRNPU	100	100.000	ENSODEG00000014458	-	100	97.087	Octodon_degus
ENSG00000153187	HNRNPU	99	64.667	ENSONIG00000001260	hnrnpub	88	83.333	Oreochromis_niloticus
ENSG00000153187	HNRNPU	99	99.666	ENSOCUG00000014469	HNRNPU	93	98.639	Oryctolagus_cuniculus
ENSG00000153187	HNRNPU	99	65.667	ENSORLG00000016114	hnrnpub	86	83.333	Oryzias_latipes
ENSG00000153187	HNRNPU	99	65.333	ENSORLG00020005363	hnrnpub	86	83.333	Oryzias_latipes_hni
ENSG00000153187	HNRNPU	99	65.000	ENSORLG00015001190	hnrnpub	86	83.333	Oryzias_latipes_hsok
ENSG00000153187	HNRNPU	99	64.667	ENSOMEG00000014951	hnrnpub	86	83.333	Oryzias_melastigma
ENSG00000153187	HNRNPU	100	100.000	ENSOGAG00000014024	HNRNPU	100	98.759	Otolemur_garnettii
ENSG00000153187	HNRNPU	100	100.000	ENSOARG00000004985	HNRNPU	91	98.658	Ovis_aries
ENSG00000153187	HNRNPU	100	100.000	ENSPPAG00000038652	HNRNPU	100	100.000	Pan_paniscus
ENSG00000153187	HNRNPU	100	100.000	ENSPPRG00000002662	HNRNPU	100	98.545	Panthera_pardus
ENSG00000153187	HNRNPU	100	100.000	ENSPTRG00000002182	HNRNPU	100	100.000	Pan_troglodytes
ENSG00000153187	HNRNPU	100	100.000	ENSPANG00000011643	HNRNPU	100	99.628	Papio_anubis
ENSG00000153187	HNRNPU	99	73.667	ENSPKIG00000022332	hnrnpub	85	71.698	Paramormyrops_kingsleyae
ENSG00000153187	HNRNPU	99	73.000	ENSPKIG00000006885	hnrnpua	78	66.667	Paramormyrops_kingsleyae
ENSG00000153187	HNRNPU	100	100.000	ENSPCIG00000008657	HNRNPU	100	95.227	Phascolarctos_cinereus
ENSG00000153187	HNRNPU	99	63.333	ENSPFOG00000002908	hnrnpub	89	60.811	Poecilia_formosa
ENSG00000153187	HNRNPU	99	63.333	ENSPLAG00000004160	hnrnpub	89	60.811	Poecilia_latipinna
ENSG00000153187	HNRNPU	100	100.000	ENSPCOG00000018655	-	100	98.788	Propithecus_coquereli
ENSG00000153187	HNRNPU	100	100.000	ENSPCOG00000003883	-	100	94.293	Propithecus_coquereli
ENSG00000153187	HNRNPU	100	100.000	ENSPVAG00000002581	HNRNPU	100	98.545	Pteropus_vampyrus
ENSG00000153187	HNRNPU	99	65.000	ENSPNYG00000021642	hnrnpub	85	83.333	Pundamilia_nyererei
ENSG00000153187	HNRNPU	99	74.333	ENSPNAG00000001055	hnrnpub	79	64.557	Pygocentrus_nattereri
ENSG00000153187	HNRNPU	100	100.000	ENSRNOG00000033790	Hnrnpu	100	96.030	Rattus_norvegicus
ENSG00000153187	HNRNPU	100	100.000	ENSRBIG00000031519	HNRNPU	100	97.767	Rhinopithecus_bieti
ENSG00000153187	HNRNPU	100	100.000	ENSRROG00000041642	HNRNPU	100	99.380	Rhinopithecus_roxellana
ENSG00000153187	HNRNPU	99	73.000	ENSSFOG00015019004	hnrnpu	77	67.412	Scleropages_formosus
ENSG00000153187	HNRNPU	99	75.000	ENSSFOG00015001124	hnrnpub	78	65.839	Scleropages_formosus
ENSG00000153187	HNRNPU	99	64.667	ENSSMAG00000003607	hnrnpub	83	70.588	Scophthalmus_maximus
ENSG00000153187	HNRNPU	99	64.667	ENSSDUG00000005912	hnrnpub	85	70.588	Seriola_dumerili
ENSG00000153187	HNRNPU	99	64.333	ENSSLDG00000004899	hnrnpub	85	70.588	Seriola_lalandi_dorsalis
ENSG00000153187	HNRNPU	100	100.000	ENSSPUG00000011393	HNRNPU	90	90.619	Sphenodon_punctatus
ENSG00000153187	HNRNPU	99	64.667	ENSSPAG00000011853	hnrnpub	86	78.261	Stegastes_partitus
ENSG00000153187	HNRNPU	100	100.000	ENSSSCG00000010877	HNRNPU	100	98.788	Sus_scrofa
ENSG00000153187	HNRNPU	99	65.333	ENSTRUG00000007759	hnrnpub	85	64.706	Takifugu_rubripes
ENSG00000153187	HNRNPU	99	63.667	ENSTNIG00000009725	hnrnpub	90	68.085	Tetraodon_nigroviridis
ENSG00000153187	HNRNPU	100	94.118	ENSTTRG00000005281	HNRNPU	71	100.000	Tursiops_truncatus
ENSG00000153187	HNRNPU	100	100.000	ENSUAMG00000021120	HNRNPU	100	98.788	Ursus_americanus
ENSG00000153187	HNRNPU	100	100.000	ENSUMAG00000012322	HNRNPU	98	96.396	Ursus_maritimus
ENSG00000153187	HNRNPU	100	100.000	ENSVPAG00000010520	HNRNPU	91	98.198	Vicugna_pacos
ENSG00000153187	HNRNPU	100	100.000	ENSVVUG00000026524	HNRNPU	100	98.759	Vulpes_vulpes
ENSG00000153187	HNRNPU	99	79.933	ENSXETG00000011386	hnrnpu	99	68.396	Xenopus_tropicalis
ENSG00000153187	HNRNPU	99	63.333	ENSXMAG00000010356	hnrnpub	97	78.261	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	9353307.	IMP	Process
GO:0000228	nuclear chromosome	11003645.	IDA	Component
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	22325991.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000776	kinetochore	21242313.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000922	spindle pole	-	IEA	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	ISS	Function
GO:0000993	RNA polymerase II complex binding	10490622.	IDA	Function
GO:0001097	TFIIH-class transcription factor complex binding	10490622.	IDA	Function
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0003677	DNA binding	9204873.	IDA	Function
GO:0003682	chromatin binding	9405365.11909954.28622508.	IDA	Function
GO:0003690	double-stranded DNA binding	8068679.8174554.	IDA	Function
GO:0003697	single-stranded DNA binding	1628625.8068679.8174554.	IDA	Function
GO:0003714	transcription corepressor activity	19617346.23811339.	IMP	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	23811339.26244333.28622508.	IDA	Function
GO:0003723	RNA binding	18082603.	IPI	Function
GO:0003725	double-stranded RNA binding	8174554.	IDA	Function
GO:0003727	single-stranded RNA binding	1628625.8068679.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	17174306.	IDA	Function
GO:0003779	actin binding	15711563.	IDA	Function
GO:0005515	protein binding	7753047.9105675.9353307.11909954.17289661.19174163.19617346.20858735.21242313.21988832.22365833.22720776.24965446.25616961.25986610.26496610.30021884.	IPI	Function
GO:0005524	ATP binding	28622508.	IDA	Function
GO:0005634	nucleus	9353307.9405365.11003645.14608463.19617346.21242313.22720776.	IDA	Component
GO:0005654	nucleoplasm	28221134.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005697	telomerase holoenzyme complex	18082603.	IDA	Component
GO:0005813	centrosome	25986610.	IDA	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006396	RNA processing	1628625.	TAS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007346	regulation of mitotic cell cycle	25986610.	IMP	Process
GO:0008143	poly(A) binding	8174554.	IDA	Function
GO:0009048	dosage compensation by inactivation of X chromosome	-	ISS	Process
GO:0009986	cell surface	7993898.	IDA	Component
GO:0016020	membrane	16210410.19946888.	HDA	Component
GO:0016070	RNA metabolic process	-	TAS	Process
GO:0016363	nuclear matrix	8174554.14608463.	IDA	Component
GO:0016607	nuclear speck	9353307.	IDA	Component
GO:0017069	snRNA binding	22325991.	IDA	Function
GO:0017130	poly(C) RNA binding	8174554.	IDA	Function
GO:0030496	midbody	25986610.	IDA	Component
GO:0031490	chromatin DNA binding	11003645.	IDA	Function
GO:0032211	negative regulation of telomere maintenance via telomerase	18082603.	IMP	Process
GO:0032839	dendrite cytoplasm	-	IEA	Component
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0032991	protein-containing complex	8174554.9204873.11909954.19617346.	IDA	Component
GO:0033673	negative regulation of kinase activity	10490622.	IMP	Process
GO:0034046	poly(G) binding	8174554.	IDA	Function
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	10490622.	IMP	Process
GO:0036002	pre-mRNA binding	22325991.	IDA	Function
GO:0036464	cytoplasmic ribonucleoprotein granule	15121898.	IDA	Component
GO:0042802	identical protein binding	28622508.	IDA	Function
GO:0043021	ribonucleoprotein complex binding	19617346.	IDA	Function
GO:0044877	protein-containing complex binding	19617346.	IDA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	15711563.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0048255	mRNA stabilization	17174306.	IDA	Process
GO:0051301	cell division	-	IEA	Process
GO:0051457	maintenance of protein location in nucleus	19617346.	IMP	Process
GO:0055013	cardiac muscle cell development	-	IEA	Process
GO:0070034	telomerase RNA binding	18082603.	IPI	Function
GO:0070934	CRD-mediated mRNA stabilization	19029303.	IMP	Process
GO:0070937	CRD-mediated mRNA stability complex	19029303.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component
GO:0071385	cellular response to glucocorticoid stimulus	9353307.	IDA	Process
GO:0072686	mitotic spindle	21242313.25986610.	IDA	Component
GO:0090336	positive regulation of brown fat cell differentiation	-	ISS	Process
GO:0090575	RNA polymerase II transcription factor complex	10490622.	IDA	Component
GO:0098577	inactive sex chromosome	14608463.	IDA	Component
GO:0098963	dendritic transport of messenger ribonucleoprotein complex	-	IEA	Process
GO:0099122	RNA polymerase II C-terminal domain binding	-	ISS	Function
GO:1901673	regulation of mitotic spindle assembly	21242313.	IMP	Process
GO:1902275	regulation of chromatin organization	28622508.	IMP	Process
GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	21242313.	IMP	Process
GO:1902889	protein localization to spindle microtubule	21242313.	IMP	Process
GO:1990023	mitotic spindle midzone	21242313.	IDA	Component
GO:1990280	RNA localization to chromatin	-	ISS	Process
GO:1990498	mitotic spindle microtubule	21242313.	IDA	Component
GO:1990830	cellular response to leukemia inhibitory factor	-	ISS	Process
GO:1990837	sequence-specific double-stranded DNA binding	9405365.11003645.	IDA	Function
GO:1990841	promoter-specific chromatin binding	-	ISS	Function
GO:1990845	adaptive thermogenesis	-	ISS	Process
GO:1990904	ribonucleoprotein complex	9405365.11909954.17289661.19617346.	IDA	Component
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	-	ISS	Process
GO:2000648	positive regulation of stem cell proliferation	-	ISS	Process
GO:2000737	negative regulation of stem cell differentiation	21235343.	IMP	Process
GO:2000737	negative regulation of stem cell differentiation	-	ISS	Process