EuRBPDB

Description

Ensembl ID: ENSG00000153827 (Gene tree)
Gene ID: 9320
Gene Symbol: TRIP12
Alias: KIAA0045
Full Name: thyroid hormone receptor interactor 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 159,403 bases
Position: chr2:229,763,837-229,923,239
Accession: 12306
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23663701	Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells.	Skelet Muscle	2013 May 10	An CI	doi: 10.1186/2044-5040-3-11.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000459841	TRIP12-211	1009	-	-	- (aa)	-	-
ENST00000470302	TRIP12-213	487	-	-	- (aa)	-	-
ENST00000453485	TRIP12-210	652	-	ENSP00000400967	217 (aa)	-	H7C1L9
ENST00000389045	TRIP12-204	5355	-	ENSP00000373697	1722 (aa)	-	Q14669
ENST00000389044	TRIP12-203	6405	XM_017005283	ENSP00000373696	2040 (aa)	XP_016860772	Q14669
ENST00000495322	TRIP12-217	562	-	-	- (aa)	-	-
ENST00000435716	TRIP12-209	603	-	ENSP00000409460	154 (aa)	-	C9JSX9
ENST00000477441	TRIP12-214	581	-	-	- (aa)	-	-
ENST00000430954	TRIP12-208	719	-	ENSP00000389827	190 (aa)	-	C9JLD7
ENST00000487178	TRIP12-216	977	-	-	- (aa)	-	-
ENST00000461189	TRIP12-212	612	-	-	- (aa)	-	-
ENST00000409677	TRIP12-205	1507	-	ENSP00000386388	430 (aa)	-	G5E9G6
ENST00000428959	TRIP12-207	584	-	ENSP00000414385	149 (aa)	-	C9JLJ5
ENST00000283943	TRIP12-201	9874	XM_005246961	ENSP00000283943	1992 (aa)	XP_005247018	Q14669
ENST00000418123	TRIP12-206	562	-	ENSP00000408330	187 (aa)	-	H7C2Y1
ENST00000343290	TRIP12-202	583	-	ENSP00000342442	99 (aa)	-	F8W9P3
ENST00000479037	TRIP12-215	2938	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000153827	Interleukin-8	3.6000000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000153827	rs517261	2	229819388	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000153827	rs1044822	2	229764422	T	Systolic blood pressure	30224653	[0.16-0.3] mmHg decrease	0.2275	EFO_0006335

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000153827	TRIP12	100	100.000	ENSMUSG00000026219	Trip12	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0004842	ubiquitin-protein transferase activity	18627766.20208519.	IDA	Function
GO:0004842	ubiquitin-protein transferase activity	19028681.	IMP	Function
GO:0005515	protein binding	18627766.20208519.26514267.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	20208519.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	18627766.20208519.	IDA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	19028681.	IMP	Process
GO:0006974	cellular response to DNA damage stimulus	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	22884692.	IMP	Process
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0045995	regulation of embryonic development	-	ISS	Process
GO:0046966	thyroid hormone receptor binding	7776974.	IDA	Function
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	21873635.	IBA	Process
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	22884692.	IMP	Process
GO:2000780	negative regulation of double-strand break repair	22884692.	IMP	Process