EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000154269 (Gene tree)
Gene ID: 5169
Gene Symbol: ENPP3
Alias: PD-IBETA|gp130RB13-6|B10|CD203c|PDNP3
Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 118,977 bases
Position: chr6:131,628,442-131,747,418
Accession: 3358
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000350265	Endonuclease_NS	PF01223.23	8e-06	1	1
ENSP00000406261	Endonuclease_NS	PF01223.23	8e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000358229	ENPP3-202	3026	-	ENSP00000350964	663 (aa)	-	F8W6H5
ENST00000494023	ENPP3-207	632	-	-	- (aa)	-	-
ENST00000357639	ENPP3-201	3162	XM_011535897	ENSP00000350265	875 (aa)	XP_011534199	O14638
ENST00000423831	ENPP3-204	598	-	ENSP00000408642	53 (aa)	-	E9PDB4
ENST00000470930	ENPP3-206	550	-	-	- (aa)	-	-
ENST00000427707	ENPP3-205	1536	-	ENSP00000415589	53 (aa)	-	E7ETI7
ENST00000414305	ENPP3-203	3418	-	ENSP00000406261	875 (aa)	-	O14638

Gene Model

Click here to download ENSG00000154269's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00240	Pyrimidine metabolism	KEGG
hsa00500	Starch and sucrose metabolism	KEGG
hsa00740	Riboflavin metabolism	KEGG
hsa00760	Nicotinate and nicotinamide metabolism	KEGG
hsa00770	Pantothenate and CoA biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000154269	Platelet Function Tests	1.0655200E-005	-
ENSG00000154269	Lung Neoplasms	2E-6	28044437
ENSG00000154269	Body Mass Index	2E-6	28044437
ENSG00000154269	Fenofibrate	5E-6	23149075

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000154269	rs12199015	6	131737807	?	Response to fenofibrate (adiponectin levels)	23149075	[0.051-0.129] ng/dL increase	0.09	GO_1901557
ENSG00000154269	rs17601580	6	131740280	?	Body mass index (change over time) in lung cancer	28044437	[0.069-0.155] unit decrease	0.112	EFO_0001071\|EFO_0005937
ENSG00000154269	rs7766061	6	131645893	?	Reaction time	29844566	[0.0047-0.0116] unit decrease	0.0081433	EFO_0008393
ENSG00000154269	rs9321309	6	131726105	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000154269's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000154269	ENPP3	100	83.580	ENSAMEG00000010324	ENPP3	100	83.580	Ailuropoda_melanoleuca
ENSG00000154269	ENPP3	99	66.858	ENSAPLG00000009807	ENPP3	99	66.628	Anas_platyrhynchos
ENSG00000154269	ENPP3	97	67.488	ENSACAG00000001394	ENPP3	97	67.488	Anolis_carolinensis
ENSG00000154269	ENPP3	100	94.171	ENSANAG00000029995	ENPP3	100	94.171	Aotus_nancymaae
ENSG00000154269	ENPP3	100	81.829	ENSBTAG00000020196	ENPP3	100	81.829	Bos_taurus
ENSG00000154269	ENPP3	100	94.171	ENSCJAG00000003044	ENPP3	100	94.171	Callithrix_jacchus
ENSG00000154269	ENPP3	100	84.949	ENSCAFG00000000367	ENPP3	100	84.949	Canis_familiaris
ENSG00000154269	ENPP3	98	82.305	ENSCAFG00020017451	ENPP3	99	82.189	Canis_lupus_dingo
ENSG00000154269	ENPP3	100	81.600	ENSCHIG00000000508	ENPP3	100	81.600	Capra_hircus
ENSG00000154269	ENPP3	100	86.057	ENSTSYG00000006067	ENPP3	100	86.057	Carlito_syrichta
ENSG00000154269	ENPP3	95	64.881	ENSCAPG00000015290	ENPP3	100	64.881	Cavia_aperea
ENSG00000154269	ENPP3	95	68.585	ENSCPOG00000038769	ENPP3	100	68.705	Cavia_porcellus
ENSG00000154269	ENPP3	100	94.312	ENSCCAG00000036027	ENPP3	100	94.312	Cebus_capucinus
ENSG00000154269	ENPP3	100	94.749	ENSCATG00000044442	ENPP3	100	94.749	Cercocebus_atys
ENSG00000154269	ENPP3	100	78.107	ENSCLAG00000009551	ENPP3	99	78.107	Chinchilla_lanigera
ENSG00000154269	ENPP3	100	96.686	ENSCSAG00000016657	ENPP3	93	96.686	Chlorocebus_sabaeus
ENSG00000154269	ENPP3	99	68.270	ENSCPBG00000017819	ENPP3	98	68.270	Chrysemys_picta_bellii
ENSG00000154269	ENPP3	100	95.314	ENSCANG00000034260	ENPP3	100	95.314	Colobus_angolensis_palliatus
ENSG00000154269	ENPP3	100	81.849	ENSCGRG00001001049	Enpp3	100	81.849	Cricetulus_griseus_chok1gshd
ENSG00000154269	ENPP3	100	82.098	ENSDNOG00000014248	ENPP3	100	82.098	Dasypus_novemcinctus
ENSG00000154269	ENPP3	100	78.977	ENSDORG00000008720	Enpp3	100	78.977	Dipodomys_ordii
ENSG00000154269	ENPP3	76	79.455	ENSETEG00000007816	-	76	79.455	Echinops_telfairi
ENSG00000154269	ENPP3	100	83.886	ENSECAG00000007018	ENPP3	100	83.886	Equus_caballus
ENSG00000154269	ENPP3	100	82.286	ENSECAG00000012424	-	100	82.286	Equus_caballus
ENSG00000154269	ENPP3	70	85.268	ENSEEUG00000000695	-	72	85.268	Erinaceus_europaeus
ENSG00000154269	ENPP3	100	84.571	ENSFCAG00000014130	ENPP3	100	84.571	Felis_catus
ENSG00000154269	ENPP3	83	62.364	ENSFALG00000011732	ENPP3	99	62.364	Ficedula_albicollis
ENSG00000154269	ENPP3	100	75.000	ENSFDAG00000011940	ENPP3	100	75.000	Fukomys_damarensis
ENSG00000154269	ENPP3	99	66.551	ENSGALG00000037587	ENPP3	97	66.319	Gallus_gallus
ENSG00000154269	ENPP3	97	66.470	ENSGAGG00000022901	ENPP3	99	70.325	Gopherus_agassizii
ENSG00000154269	ENPP3	100	78.539	ENSHGLG00000013966	ENPP3	100	78.539	Heterocephalus_glaber_female
ENSG00000154269	ENPP3	100	78.539	ENSHGLG00100018706	ENPP3	100	78.539	Heterocephalus_glaber_male
ENSG00000154269	ENPP3	100	81.829	ENSJJAG00000019911	Enpp3	100	81.829	Jaculus_jaculus
ENSG00000154269	ENPP3	100	83.771	ENSLAFG00000003881	ENPP3	100	83.771	Loxodonta_africana
ENSG00000154269	ENPP3	100	97.029	ENSMFAG00000040950	ENPP3	100	97.029	Macaca_fascicularis
ENSG00000154269	ENPP3	100	97.143	ENSMMUG00000017549	ENPP3	100	97.143	Macaca_mulatta
ENSG00000154269	ENPP3	100	96.800	ENSMNEG00000034089	ENPP3	100	96.800	Macaca_nemestrina
ENSG00000154269	ENPP3	100	96.914	ENSMLEG00000028918	ENPP3	100	96.914	Mandrillus_leucophaeus
ENSG00000154269	ENPP3	99	65.358	ENSMGAG00000013156	ENPP3	99	66.166	Meleagris_gallopavo
ENSG00000154269	ENPP3	100	74.315	ENSMAUG00000001245	Enpp3	100	74.315	Mesocricetus_auratus
ENSG00000154269	ENPP3	100	88.000	ENSMICG00000002944	ENPP3	100	88.000	Microcebus_murinus
ENSG00000154269	ENPP3	100	76.444	ENSMOCG00000003824	Enpp3	100	76.444	Microtus_ochrogaster
ENSG00000154269	ENPP3	98	70.788	ENSMODG00000017569	ENPP3	100	69.575	Monodelphis_domestica
ENSG00000154269	ENPP3	100	80.251	MGP_CAROLIEiJ_G0015190	Enpp3	100	80.251	Mus_caroli
ENSG00000154269	ENPP3	100	80.708	ENSMUSG00000019989	Enpp3	100	80.708	Mus_musculus
ENSG00000154269	ENPP3	98	76.117	MGP_PahariEiJ_G0023812	Enpp3	100	73.378	Mus_pahari
ENSG00000154269	ENPP3	100	80.708	MGP_SPRETEiJ_G0015999	Enpp3	96	84.713	Mus_spretus
ENSG00000154269	ENPP3	100	84.055	ENSMPUG00000014671	ENPP3	100	84.055	Mustela_putorius_furo
ENSG00000154269	ENPP3	100	80.914	ENSMLUG00000016827	ENPP3	100	80.914	Myotis_lucifugus
ENSG00000154269	ENPP3	99	82.503	ENSNGAG00000015161	Enpp3	99	82.503	Nannospalax_galili
ENSG00000154269	ENPP3	100	97.029	ENSNLEG00000014455	ENPP3	100	97.029	Nomascus_leucogenys
ENSG00000154269	ENPP3	99	70.183	ENSOPRG00000002617	ENPP3	100	70.183	Ochotona_princeps
ENSG00000154269	ENPP3	100	82.743	ENSOCUG00000014432	ENPP3	100	82.743	Oryctolagus_cuniculus
ENSG00000154269	ENPP3	100	81.486	ENSOARG00000014082	ENPP3	97	81.486	Ovis_aries
ENSG00000154269	ENPP3	100	99.200	ENSPPAG00000003107	ENPP3	100	99.200	Pan_paniscus
ENSG00000154269	ENPP3	100	84.800	ENSPPRG00000023946	ENPP3	100	84.800	Panthera_pardus
ENSG00000154269	ENPP3	100	84.800	ENSPTIG00000012163	ENPP3	100	84.800	Panthera_tigris_altaica
ENSG00000154269	ENPP3	100	99.314	ENSPTRG00000023128	ENPP3	100	99.314	Pan_troglodytes
ENSG00000154269	ENPP3	100	96.914	ENSPANG00000006092	ENPP3	93	96.914	Papio_anubis
ENSG00000154269	ENPP3	82	70.694	ENSPSIG00000006898	ENPP3	98	70.694	Pelodiscus_sinensis
ENSG00000154269	ENPP3	100	80.844	ENSPEMG00000022836	Enpp3	100	80.844	Peromyscus_maniculatus_bairdii
ENSG00000154269	ENPP3	97	52.693	ENSPMAG00000002458	ENPP3	100	52.693	Petromyzon_marinus
ENSG00000154269	ENPP3	98	73.457	ENSPCIG00000008801	ENPP3	96	73.138	Phascolarctos_cinereus
ENSG00000154269	ENPP3	100	83.543	ENSPPYG00000017009	ENPP3	100	83.543	Pongo_abelii
ENSG00000154269	ENPP3	100	74.514	ENSPCOG00000017134	ENPP3	100	74.514	Propithecus_coquereli
ENSG00000154269	ENPP3	100	74.800	ENSPVAG00000013515	ENPP3	100	74.800	Pteropus_vampyrus
ENSG00000154269	ENPP3	100	81.393	ENSRNOG00000013791	Enpp3	100	81.393	Rattus_norvegicus
ENSG00000154269	ENPP3	100	96.114	ENSRBIG00000030207	ENPP3	99	96.114	Rhinopithecus_bieti
ENSG00000154269	ENPP3	100	96.571	ENSRROG00000035272	ENPP3	100	96.571	Rhinopithecus_roxellana
ENSG00000154269	ENPP3	100	94.057	ENSSBOG00000034636	ENPP3	100	94.057	Saimiri_boliviensis_boliviensis
ENSG00000154269	ENPP3	99	72.426	ENSSHAG00000008503	ENPP3	99	72.426	Sarcophilus_harrisii
ENSG00000154269	ENPP3	96	62.500	ENSSPUG00000007266	ENPP3	97	64.295	Sphenodon_punctatus
ENSG00000154269	ENPP3	100	83.314	ENSSSCG00000025992	ENPP3	100	83.314	Sus_scrofa
ENSG00000154269	ENPP3	99	66.246	ENSTGUG00000011640	ENPP3	99	66.016	Taeniopygia_guttata
ENSG00000154269	ENPP3	100	75.228	ENSTBEG00000009399	ENPP3	100	75.228	Tupaia_belangeri
ENSG00000154269	ENPP3	100	82.286	ENSTTRG00000011371	ENPP3	100	82.286	Tursiops_truncatus
ENSG00000154269	ENPP3	100	81.257	ENSUAMG00000022974	ENPP3	100	82.195	Ursus_americanus
ENSG00000154269	ENPP3	100	84.114	ENSUMAG00000024546	ENPP3	100	84.114	Ursus_maritimus
ENSG00000154269	ENPP3	100	80.571	ENSVPAG00000005657	ENPP3	100	80.571	Vicugna_pacos
ENSG00000154269	ENPP3	97	82.629	ENSVVUG00000009079	-	99	84.727	Vulpes_vulpes
ENSG00000154269	ENPP3	97	61.702	ENSXETG00000008244	enpp3	99	61.910	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002276	basophil activation involved in immune response	-	ISS	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004528	phosphodiesterase I activity	11342463.	IMP	Function
GO:0005044	scavenger receptor activity	-	IEA	Function
GO:0005509	calcium ion binding	29717535.	IDA	Function
GO:0006220	pyrimidine nucleotide metabolic process	11342463.	IMP	Process
GO:0006796	phosphate-containing compound metabolic process	10513816.	IDA	Process
GO:0006898	receptor-mediated endocytosis	-	IEA	Process
GO:0008270	zinc ion binding	29717535.	IDA	Function
GO:0009143	nucleoside triphosphate catabolic process	21873635.	IBA	Process
GO:0009143	nucleoside triphosphate catabolic process	10513816.	IDA	Process
GO:0009897	external side of plasma membrane	11342463.	IDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016324	apical plasma membrane	-	IEA	Component
GO:0030247	polysaccharide binding	-	IEA	Function
GO:0030505	inorganic diphosphate transport	10513816.	IDA	Process
GO:0033007	negative regulation of mast cell activation involved in immune response	-	ISS	Process
GO:0035529	NADH pyrophosphatase activity	-	IEA	Function
GO:0046034	ATP metabolic process	29717535.	IDA	Process
GO:0047429	nucleoside-triphosphate diphosphatase activity	21873635.	IBA	Function
GO:0047429	nucleoside-triphosphate diphosphatase activity	10513816.29717535.	IDA	Function
GO:0048471	perinuclear region of cytoplasm	10513816.	IDA	Component
GO:0050728	negative regulation of inflammatory response	-	ISS	Process
GO:0070062	extracellular exosome	19056867.19199708.	HDA	Component
GO:0070667	negative regulation of mast cell proliferation	-	ISS	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
14533006	Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma.	Int J Mol Med	2003 Nov	Yano Y	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	131740369	Missense_Mutation	novel	E816Q	0.14	Endonuclease_NS
BLCA	chr6	131658388	Nonsense_Mutation	novel	W177*	0.37
BLCA	chr6	131637429	Silent	novel	K15K	0.42
BLCA	chr6	131650040	Silent	NA	K56K	0.43
BLCA	chr6	131675282	Intron	novel		0.23
BLCA	chr6	131674327	Intron	novel		0.75
BLCA	chr6	131658362	Silent	NA	G168G	0.2
BLCA	chr6	131708664	Intron	novel		0.38
BLCA	chr6	131733603	Missense_Mutation	novel	L657V	0.34	Endonuclease_NS
BLCA	chr6	131637457	Splice_Site	novel	X25_splice	0.16
BRCA	chr6	131671288	Nonsense_Mutation	novel	*P207_N208insHQSSCPYIPTKTFP**	0.07
BRCA	chr6	131733599	Silent	rs747888819	S655S	0.41
BRCA	chr6	131693576	Missense_Mutation	novel	R455K	0.49
BRCA	chr6	131733705	Missense_Mutation	NA	G691R	0.37	Endonuclease_NS
BRCA	chr6	131708640	Intron	novel		0.36
BRCA	chr6	131652887	Missense_Mutation	NA	E154K	0.13
BRCA	chr6	131674303	Intron	NA		0.14
BRCA	chr6	131726088	Missense_Mutation	NA	R614K	0.29
BRCA	chr6	131693500	Missense_Mutation	NA	R430G	0.18
BRCA	chr6	131675375	Intron	novel		0.27
BRCA	chr6	131720300	Silent	NA	F496F	0.25
CESC	chr6	131676756	Missense_Mutation	NA	R298M	0.16
CESC	chr6	131674218	Silent	NA	L233L	0.39
CESC	chr6	131740344	Silent	NA	I807I	0.32
CESC	chr6	131693555	Missense_Mutation	NA	L448P	0.14
CESC	chr6	131746847	Missense_Mutation	rs201810317	R840H	0.37	Endonuclease_NS
CESC	chr6	131708449	Intron	novel		0.2
CESC	chr6	131708494	Intron	novel		0.08
CESC	chr6	131652569	Missense_Mutation	rs371115901	R102H	0.67
CESC	chr6	131683163	Splice_Site	NA	X374_splice	0.47
CESC	chr6	131641500	Missense_Mutation	NA	G42W	0.29
COAD	chr6	131675151	Frame_Shift_Del	NA	*N279Mfs25**	0.31
COAD	chr6	131652857	Missense_Mutation	novel	C144R	0.61
COAD	chr6	131674363	Intron	novel		0.17
COAD	chr6	131677936	Missense_Mutation	NA	A336D	0.14
COAD	chr6	131674303	Intron	NA		0.35
COAD	chr6	131693576	Missense_Mutation	novel	R455I	0.3
COAD	chr6	131726188	Silent	novel	T647T	0.36
COAD	chr6	131740285	Frame_Shift_Del	NA	*N789Tfs54**	0.21	Endonuclease_NS
COAD	chr6	131708667	Intron	novel		0.2
COAD	chr6	131652563	Missense_Mutation	NA	K100T	0.09
COAD	chr6	131652833	Nonsense_Mutation	novel	E136*	0.13
COAD	chr6	131637411	Silent	rs752225330	T9T	0.16
COAD	chr6	131747068	3'UTR	novel		0.3
COAD	chr6	131637454	Missense_Mutation	rs776696012	A24T	0.22
COAD	chr6	131683118	Missense_Mutation	rs747943081	R359Q	0.25
COAD	chr6	131746924	Frame_Shift_Ins	novel	*T866Sfs8**	0.12
COAD	chr6	131685451	Missense_Mutation	NA	A403V	0.15
ESCA	chr6	131733717	Missense_Mutation	novel	P695A	0.27	Endonuclease_NS
ESCA	chr6	131738080	Silent	rs769019983	E739E	0.38
ESCA	chr6	131747032	3'UTR	novel		0.17
ESCA	chr6	131722357	Silent	novel	N566N	0.08
GBM	chr6	131718737	Missense_Mutation	novel	E493G	0.09
GBM	chr6	131650136	Silent	novel	T88T	0.22
GBM	chr6	131737410	Silent	novel	V715V	0.06
GBM	chr6	131733589	Missense_Mutation	novel	G652E	0.1	Endonuclease_NS
GBM	chr6	131740285	Nonsense_Mutation	novel	K788*	0.05	Endonuclease_NS
GBM	chr6	131724066	Silent	NA	Q591Q	0.42
GBM	chr6	131738090	Missense_Mutation	novel	V743L	0.16	Endonuclease_NS
GBM	chr6	131693540	Missense_Mutation	novel	D443A	0.03
GBM	chr6	131722258	Missense_Mutation	novel	N533K	0.05
HNSC	chr6	131746863	Silent	novel	L845L	0.06
HNSC	chr6	131718698	Missense_Mutation	novel	G480E	0.27
HNSC	chr6	131746928	Missense_Mutation	novel	Y867C	0.24
HNSC	chr6	131738083	Missense_Mutation	novel	R740S	0.19	Endonuclease_NS
HNSC	chr6	131740314	Silent	rs777387463	C797C	0.38
HNSC	chr6	131683063	Missense_Mutation	novel	A341S	0.68
HNSC	chr6	131722244	Missense_Mutation	novel	P529T	0.55
HNSC	chr6	131677909	Missense_Mutation	novel	S327C	0.34
HNSC	chr6	131738104	Silent	novel	S747S	0.29
KIRC	chr6	131674248	Silent	NA	E243E	0.31
KIRC	chr6	131650108	Missense_Mutation	NA	G79A	0.33
KIRC	chr6	131746945	Frame_Shift_Ins	novel	*T873Kfs13**	0.1
KIRC	chr6	131746946	Frame_Shift_Ins	novel	*T874Hfs5**	0.07
KIRP	chr6	131637341	5'UTR	novel		0.48
KIRP	chr6	131738094	Missense_Mutation	NA	N744T	0.38	Endonuclease_NS
LAML	chr6	131740350	Silent	novel	P809P	0.07
LGG	chr6	131738090	Frame_Shift_Del	novel	V743*	0.24	Endonuclease_NS
LGG	chr6	131675092	Missense_Mutation	NA	A259T	0.23
LIHC	chr6	131746888	Missense_Mutation	NA	K854E	0.27
LIHC	chr6	131637346	5'UTR	novel		0.78
LIHC	chr6	131685422	Silent	NA	I393I	0.47
LIHC	chr6	131637330	5'UTR	novel		0.22
LIHC	chr6	131675099	Missense_Mutation	rs776096391	Y261C	0.27
LUAD	chr6	131718709	Missense_Mutation	novel	G484C	0.29
LUAD	chr6	131737372	Missense_Mutation	rs371282868	D703N	0.16	Endonuclease_NS
LUAD	chr6	131641489	Missense_Mutation	NA	G38E	0.1
LUAD	chr6	131708645	Intron	novel		0.18
LUAD	chr6	131737372	Missense_Mutation	NA	D703Y	0.22	Endonuclease_NS
LUAD	chr6	131740289	Missense_Mutation	NA	N789S	0.24	Endonuclease_NS
LUAD	chr6	131726101	Missense_Mutation	NA	K618N	0.26
LUAD	chr6	131685457	Missense_Mutation	NA	R405L	0.23
LUAD	chr6	131637399	Silent	rs754266041	L5L	0.35
LUAD	chr6	131740316	Missense_Mutation	novel	P798H	0.08	Endonuclease_NS
LUAD	chr6	131675193	Splice_Region	novel		0.21
LUAD	chr6	131693571	Missense_Mutation	novel	N453K	0.18
LUAD	chr6	131746841	Missense_Mutation	novel	R838L	0.09	Endonuclease_NS
LUAD	chr6	131733692	Missense_Mutation	NA	K686N	0.05	Endonuclease_NS
LUAD	chr6	131726098	Missense_Mutation	novel	Q617H	0.18
LUAD	chr6	131722322	Nonsense_Mutation	NA	E555*	0.11
LUAD	chr6	131740303	Frame_Shift_Del	novel	*P794Gfs26**	0.44	Endonuclease_NS
LUAD	chr6	131674163	Missense_Mutation	novel	G215V	0.71
LUSC	chr6	131738034	Missense_Mutation	novel	M724T	0.18	Endonuclease_NS
LUSC	chr6	131737394	Missense_Mutation	rs757895652	I710N	0.35	Endonuclease_NS
LUSC	chr6	131683053	Splice_Site	NA	X338_splice	0.22
LUSC	chr6	131693616	Silent	NA	L468L	0.5
LUSC	chr6	131693551	Nonsense_Mutation	rs768656602	R447*	0.1
LUSC	chr6	131740322	Missense_Mutation	novel	W800L	0.13	Endonuclease_NS
LUSC	chr6	131724060	Silent	novel	V589V	0.19
LUSC	chr6	131740355	Missense_Mutation	novel	R811Q	0.33	Endonuclease_NS
LUSC	chr6	131720295	Missense_Mutation	novel	I495F	0.15
LUSC	chr6	131674261	Missense_Mutation	NA	A248S	0.17
LUSC	chr6	131652636	Silent	rs765294171	D124D	0.18
LUSC	chr6	131675292	Intron	novel		0.38
LUSC	chr6	131675120	Missense_Mutation	NA	T268N	0.25
LUSC	chr6	131722291	Missense_Mutation	novel	K544N	0.1
LUSC	chr6	131676777	Missense_Mutation	novel	W305L	0.14
LUSC	chr6	131652833	Missense_Mutation	novel	E136Q	0.14
LUSC	chr6	131733619	Missense_Mutation	novel	P662Q	0.29	Endonuclease_NS
LUSC	chr6	131650066	Missense_Mutation	NA	G65V	0.21
LUSC	chr6	131740278	Silent	novel	T785T	0.09
LUSC	chr6	131675155	Missense_Mutation	novel	G280R	0.09
LUSC	chr6	131675156	Missense_Mutation	rs772528200	G280V	0.17
LUSC	chr6	131637394	Missense_Mutation	novel	T4S	0.1
LUSC	chr6	131676768	Missense_Mutation	novel	L302Q	0.42
LUSC	chr6	131676769	Silent	novel	L302L	0.41
LUSC	chr6	131708648	Intron	novel		0.27
LUSC	chr6	131693618	Missense_Mutation	NA	A469V	0.5
OV	chr6	131685885	Missense_Mutation	novel	E421G	0.06
OV	chr6	131726198	Splice_Region	rs775710171	L651L	0.3
OV	chr6	131726171	Missense_Mutation	NA	M642L	0.18	Endonuclease_NS
OV	chr6	131674268	Nonsense_Mutation	NA	W250*	0.42
PAAD	chr6	131676795	Missense_Mutation	novel	A311V	0.19
PAAD	chr6	131722269	Missense_Mutation	rs762612558	G537D	0.2
PRAD	chr6	131652620	Missense_Mutation	NA	C119Y	0.26
READ	chr6	131637390	Missense_Mutation	novel	E2D	0.24
READ	chr6	131722228	Missense_Mutation	novel	D523E	0.06
READ	chr6	131674332	Intron	novel		0.18
READ	chr6	131685451	Frame_Shift_Del	NA	*R405Afs36**	0.26
READ	chr6	131652575	Missense_Mutation	novel	G104A	0.33
READ	chr6	131675105	Missense_Mutation	novel	G263D	0.41
READ	chr6	131674224	Missense_Mutation	NA	K235N	0.23
SARC	chr6	131693544	Silent	rs747144335	L444L	0.29
SKCM	chr6	131650117	Missense_Mutation	NA	C82F	0.3
SKCM	chr6	131733599	Silent	rs747888819	S655S	0.15
SKCM	chr6	131674258	Missense_Mutation	NA	P247S	0.3
SKCM	chr6	131708641	Intron	novel		0.43
SKCM	chr6	131671303	Silent	NA	F206F	0.55
SKCM	chr6	131652560	Missense_Mutation	novel	N99I	0.23
SKCM	chr6	131683119	Silent	novel	R359R	0.63
SKCM	chr6	131652568	Missense_Mutation	rs781156968	R102C	0.39
SKCM	chr6	131708652	Intron	novel		0.47
SKCM	chr6	131677881	Missense_Mutation	novel	T318A	0.73
SKCM	chr6	131652551	Nonsense_Mutation	rs150884645	W96*	0.26
SKCM	chr6	131724085	Missense_Mutation	NA	E598K	0.25
SKCM	chr6	131652568	Missense_Mutation	rs781156968	R102C	0.75
SKCM	chr6	131685457	Missense_Mutation	rs377322848	R405H	0.41
SKCM	chr6	131747018	3'UTR	novel		0.5
SKCM	chr6	131683146	Silent	novel	I368I	0.09
SKCM	chr6	131724066	Missense_Mutation	NA	Q591H	0.37
SKCM	chr6	131650126	Missense_Mutation	NA	F85S	0.41
SKCM	chr6	131685428	Silent	NA	F395F	0.56
SKCM	chr6	131693520	Missense_Mutation	NA	F436L	0.34
SKCM	chr6	131683102	Missense_Mutation	NA	E354K	0.11
SKCM	chr6	131746966	3'UTR	novel		0.33
SKCM	chr6	131652568	Missense_Mutation	rs781156968	R102C	0.21
SKCM	chr6	131733675	Missense_Mutation	novel	F681V	0.37	Endonuclease_NS
SKCM	chr6	131738030	Splice_Site	NA	X723_splice	0.36
SKCM	chr6	131724066	Silent	NA	Q591Q	0.24
SKCM	chr6	131675113	Missense_Mutation	NA	A266T	0.91
SKCM	chr6	131676743	Missense_Mutation	NA	P294S	0.3
SKCM	chr6	131637461	Missense_Mutation	NA	I26N	0.56
SKCM	chr6	131676797	Missense_Mutation	novel	E312K	0.27
SKCM	chr6	131726151	Missense_Mutation	novel	G635E	0.22	Endonuclease_NS
SKCM	chr6	131746855	Missense_Mutation	novel	E843K	0.4	Endonuclease_NS
STAD	chr6	131671269	Missense_Mutation	novel	K195R	0.09
STAD	chr6	131693500	Nonsense_Mutation	rs755811606	R430*	0.09
STAD	chr6	131683063	Missense_Mutation	rs762499320	A341T	0.16
STAD	chr6	131733705	Missense_Mutation	rs535729818	G691S	0.38	Endonuclease_NS
STAD	chr6	131671274	Missense_Mutation	NA	M197V	0.09
STAD	chr6	131683109	Missense_Mutation	novel	L356P	0.21
STAD	chr6	131693619	Silent	NA	A469A	0.19
STAD	chr6	131726102	Missense_Mutation	NA	N619D	0.22
STAD	chr6	131693551	Nonsense_Mutation	rs768656602	R447*	0.29
STAD	chr6	131724065	Missense_Mutation	NA	Q591R	0.22
STAD	chr6	131652557	Missense_Mutation	rs767163918	C98Y	0.15
STAD	chr6	131685433	Missense_Mutation	rs755872152	Y397C	0.17
STAD	chr6	131733623	Frame_Shift_Del	novel	*L665Gfs18**	0.15	Endonuclease_NS
TGCT	chr6	131650131	Missense_Mutation	novel	D87Y	0.25
THCA	chr6	131746945	Frame_Shift_Ins	novel	*T873Kfs13**	0.11
THCA	chr6	131746946	Frame_Shift_Ins	novel	*T874Qfs6**	0.09
UCEC	chr6	131708576	Intron	novel		0.44
UCEC	chr6	131674165	Missense_Mutation	NA	L216V	0.37
UCEC	chr6	131641458	Missense_Mutation	NA	L28I	0.11
UCEC	chr6	131652888	Missense_Mutation	NA	E154G	0.28
UCEC	chr6	131675198	Intron	novel		0.35
UCEC	chr6	131685441	Missense_Mutation	rs141972191	E400K	0.28
UCEC	chr6	131746923	Silent	NA	K865K	0.24
UCEC	chr6	131708537	Intron	novel		0.36
UCEC	chr6	131740301	Missense_Mutation	NA	T793I	0.45	Endonuclease_NS
UCEC	chr6	131652589	Missense_Mutation	NA	E109K	0.42
UCEC	chr6	131746816	Nonsense_Mutation	novel	E830*	0.09	Endonuclease_NS
UCEC	chr6	131641490	Silent	NA	G38G	0.3
UCEC	chr6	131683118	Missense_Mutation	rs747943081	R359Q	0.26
UCEC	chr6	131685429	Missense_Mutation	novel	F396V	0.38
UCEC	chr6	131738082	Missense_Mutation	novel	R740I	0.28	Endonuclease_NS
UCEC	chr6	131683103	Missense_Mutation	rs780456805	E354G	0.1
UCEC	chr6	131726157	Missense_Mutation	novel	A637D	0.54	Endonuclease_NS
UCEC	chr6	131746801	Missense_Mutation	novel	A825S	0.12	Endonuclease_NS
UCEC	chr6	131671313	Missense_Mutation	novel	Y210D	0.07
UCEC	chr6	131650064	Missense_Mutation	novel	R64S	0.06
UCEC	chr6	131675360	Intron	novel		0.3
UCEC	chr6	131658347	Silent	novel	L163L	0.21
UCEC	chr6	131685410	Nonsense_Mutation	novel	Y389*	0.13
UCEC	chr6	131650138	Missense_Mutation	novel	C89Y	0.12
UCEC	chr6	131652855	Missense_Mutation	NA	N143S	0.2
UCEC	chr6	131674303	Intron	NA		0.26
UCEC	chr6	131675160	Silent	NA	S281S	0.44
UCEC	chr6	131674360	Intron	novel		0.48
UCEC	chr6	131685897	Missense_Mutation	NA	R425K	0.1
UCEC	chr6	131637333	5'UTR	novel		0.5
UCEC	chr6	131720358	Nonsense_Mutation	novel	E516*	0.24
UCEC	chr6	131722256	Missense_Mutation	novel	N533H	0.53
UCEC	chr6	131740355	Missense_Mutation	novel	R811Q	0.34	Endonuclease_NS
UCEC	chr6	131708474	Intron	novel		0.2
UCEC	chr6	131652548	Missense_Mutation	novel	I95T	0.33
UCEC	chr6	131677917	Missense_Mutation	novel	A330S	0.43
UCEC	chr6	131718674	Missense_Mutation	novel	S472I	0.43
UCEC	chr6	131675294	Intron	novel		0.4
UCEC	chr6	131722398	In_Frame_Ins	novel	L580_Q581insIESLLGSE	0.07
UCEC	chr6	131738108	Missense_Mutation	NA	P749T	0.1	Endonuclease_NS
UCEC	chr6	131674235	Missense_Mutation	NA	L239H	0.44
UCEC	chr6	131733698	Silent	novel	I688I	0.39
UCEC	chr6	131685393	Missense_Mutation	NA	E384K	0.32
UCEC	chr6	131674303	Intron	NA		0.11
UCEC	chr6	131722406	Splice_Site	novel	X582_splice	0.37
UCEC	chr6	131675213	Intron	rs755639995		0.36
UCEC	chr6	131677941	Splice_Site	rs140755651	X337_splice	0.35
UCEC	chr6	131722392	Missense_Mutation	novel	P578H	0.4
UCEC	chr6	131671280	Missense_Mutation	novel	A199S	0.46
UCEC	chr6	131737411	Missense_Mutation	novel	P716S	0.12	Endonuclease_NS
UCEC	chr6	131685451	Frame_Shift_Del	NA	*R405Afs36**	0.38
UCEC	chr6	131708482	Intron	novel		0.12
UCEC	chr6	131746984	3'UTR	novel		0.13
UCEC	chr6	131674303	Intron	NA		0.06
UCEC	chr6	131671327	Splice_Region	novel	T214T	0.33
UCEC	chr6	131637352	5'UTR	novel		0.41
UCEC	chr6	131738141	Missense_Mutation	NA	D760Y	0.62	Endonuclease_NS
UCEC	chr6	131650105	Missense_Mutation	rs759918276	R78Q	0.09
UCEC	chr6	131708469	Intron	novel		0.23
UCEC	chr6	131652618	Missense_Mutation	novel	D118E	0.32
UCEC	chr6	131658336	Missense_Mutation	novel	P160S	0.14
UCEC	chr6	131675082	Missense_Mutation	novel	M255I	0.11
UCEC	chr6	131708482	Intron	novel		0.22
UCEC	chr6	131722391	Missense_Mutation	novel	P578T	0.29
UCEC	chr6	131641466	Silent	novel	A30A	0.44
UCEC	chr6	131685486	Frame_Shift_Del	novel	*F416Lfs25**	0.08
UCEC	chr6	131650031	Missense_Mutation	NA	S53R	0.35
UCEC	chr6	131718723	Missense_Mutation	NA	E488D	0.24
UCEC	chr6	131733705	Missense_Mutation	rs535729818	G691S	0.06	Endonuclease_NS
UCEC	chr6	131652579	Silent	novel	E105E	0.34
UCEC	chr6	131737423	Nonsense_Mutation	novel	E720*	0.53	Endonuclease_NS
UCEC	chr6	131683071	Missense_Mutation	novel	Q343H	0.13
UCS	chr6	131685428	Missense_Mutation	novel	F395L	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.25	0.00052595
GBM	DEL	0.2357	1.056e-05
KIRC	DEL	0.2405	7.439e-11
LGG	DEL	0.1423	0.0054594
MESO	DEL	0.4138	0.05642
PAAD	DEL	0.3587	0.11274
SKCM	DEL	0.5368	1.5442e-06
THYM	DEL	0.1301	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.0054	Kaplan-Meier Survival Analysis
HNSC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
PAAD	0.00086	Kaplan-Meier Survival Analysis
BLCA	0.017	Kaplan-Meier Survival Analysis
UCEC	0.0061	Kaplan-Meier Survival Analysis
GBM	0.002	Kaplan-Meier Survival Analysis
LUAD	0.0062	Kaplan-Meier Survival Analysis