EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000154305 (Gene tree)
Gene ID: 375056
Gene Symbol: MIA3
Alias: UNQ6077|FLJ39207|KIAA0268|TANGO|TANGO1
Full Name: MIA SH3 domain ER export factor 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 49,927 bases
Position: chr1:222,618,086-222,668,012
Accession: 24008
RBP type: non-canonical RBP
Summary: (MIA SH3 Domain ER Export Factor 3) is a Protein Coding gene. Diseases associated with MIA3 include Inflammatory And Toxic Neuropathy and Alcoholic Neuropathy. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification. An important paralog of this gene is MIA2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000495210	MIA3-212	731	-	-	- (aa)	-	-
ENST00000467190	MIA3-206	553	-	-	- (aa)	-	-
ENST00000477519	MIA3-210	401	-	-	- (aa)	-	-
ENST00000344922	MIA3-203	8142	XM_006711304	ENSP00000340900	1907 (aa)	XP_006711367	Q5JRA6
ENST00000475451	MIA3-208	552	-	-	- (aa)	-	-
ENST00000479370	MIA3-211	298	-	-	- (aa)	-	-
ENST00000344507	MIA3-202	2026	-	ENSP00000341348	500 (aa)	-	Q5JRA6
ENST00000354906	MIA3-204	3045	XM_011509513	ENSP00000355062	1015 (aa)	XP_011507815	A0A0A0MRH6
ENST00000470521	MIA3-207	4071	-	-	- (aa)	-	-
ENST00000476400	MIA3-209	435	-	-	- (aa)	-	-
ENST00000450260	MIA3-205	605	-	ENSP00000396598	107 (aa)	-	H7C0T4
ENST00000340535	MIA3-201	2735	-	ENSP00000345866	785 (aa)	-	Q5JRA6

Gene Model

Click here to download ENSG00000154305's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000154305	Myocardial Infarction	1E-9	19198609
ENSG00000154305	Coronary Disease	1E-8	21378990
ENSG00000154305	Coronary Artery Disease	1E-12	26343387
ENSG00000154305	Coronary Disease	1E-6	17634449
ENSG00000154305	Myocardial Infarction	2E-11	26343387

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000154305	rs67180937	1	222650401	G	Coronary artery disease	26343387	[1.06- 1.11]	1.08	EFO_0000378
ENSG00000154305	rs35700460	1	222638065	G	Myocardial infarction	26343387	[1.06-1.11]	1.09	EFO_0000612
ENSG00000154305	rs17465637	1	222650187	C	Myocardial infarction (early onset)	19198609	[1.10-1.19]	1.14	EFO_0000612
ENSG00000154305	rs17465982	1	222664597	A	Coronary artery disease	29212778	[0.065-0.093] unit increase	0.079	EFO_0000378
ENSG00000154305	rs17465637	1	222650187	A	Coronary artery disease	29212778	[0.068-0.096] unit decrease	0.0817	EFO_0000378
ENSG00000154305	rs35158675	1	222656208	A	Coronary artery disease	29212778	[0.057-0.082] unit increase	0.0699	EFO_0000378
ENSG00000154305	rs17465637	1	222650187	C	Coronary heart disease	17634449	[1.12-1.30]	1.2	EFO_0001645
ENSG00000154305	rs17465637	1	222650187	C	Coronary heart disease	21378990	[1.09-1.20]	1.14	EFO_0001645

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000154305's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0002042	cell migration involved in sprouting angiogenesis	28341552.	IMP	Process
GO:0002687	positive regulation of leukocyte migration	17726152.	IDA	Process
GO:0005515	protein binding	17726152.19269366.21525241.25202031.27138255.27170179.27551091.28442536.	IPI	Function
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	19269366.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0006887	exocytosis	19269366.	IMP	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	27138255.	IMP	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007029	endoplasmic reticulum organization	28442536.	IMP	Process
GO:0007162	negative regulation of cell adhesion	17726152.	IDA	Process
GO:0009306	protein secretion	21873635.	IBA	Process
GO:0015031	protein transport	19269366.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	19269366.	IDA	Component
GO:0030336	negative regulation of cell migration	17044017.	IDA	Process
GO:0035459	cargo loading into vesicle	21873635.	IBA	Process
GO:0042060	wound healing	17044017.	IDA	Process
GO:0042953	lipoprotein transport	27138255.	IMP	Process
GO:0042954	lipoprotein transporter activity	21873635.	IBA	Function
GO:0042954	lipoprotein transporter activity	27138255.	IMP	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0070971	endoplasmic reticulum exit site	21873635.	IBA	Component
GO:0070971	endoplasmic reticulum exit site	21525241.25202031.28442536.	IDA	Component
GO:0070973	protein localization to endoplasmic reticulum exit site	28442536.	IMP	Process
GO:0090110	cargo loading into COPII-coated vesicle	27138255.	IMP	Process
GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	28341552.	IMP	Process
GO:1903038	negative regulation of leukocyte cell-cell adhesion	28341552.	IMP	Process
GO:2000402	negative regulation of lymphocyte migration	28341552.	IMP	Process