EuRBPDB

Description

Ensembl ID: ENSG00000154473 (Gene tree)
Gene ID: 9184
Gene Symbol: BUB3
Alias: BUB3L
Full Name: BUB3 mitotic checkpoint protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 16,224 bases
Position: chr10:123,154,244-123,170,467
Accession: 1151
RBP type: non-canonical RBP
Summary: This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000407911	BUB3-204	895	-	ENSP00000383941	278 (aa)	-	J3QT28
ENST00000368859	BUB3-202	667	-	ENSP00000357852	145 (aa)	-	J3QSX4
ENST00000368858	BUB3-201	1361	-	ENSP00000357851	326 (aa)	-	O43684
ENST00000481952	BUB3-205	790	-	-	- (aa)	-	-
ENST00000368865	BUB3-203	7828	-	ENSP00000357858	328 (aa)	-	O43684

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000154473	BUB3	98	36.391	FBgn0034646	Rae1	96	36.391	Drosophila_melanogaster
ENSG00000154473	BUB3	98	34.911	ENSMUSG00000027509	Rae1	91	34.911	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000070	mitotic sister chromatid segregation	-	IEA	Process
GO:0000776	kinetochore	21873635.	IBA	Component
GO:0000776	kinetochore	9660858.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0005515	protein binding	9660858.10198256.11283619.12762840.15525512.17289665.19407811.21566117.21988832.22000412.24462186.24462187.25383541.25416956.25852190.26496610.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0007094	mitotic spindle assembly checkpoint	21873635.	IBA	Process
GO:0008608	attachment of spindle microtubules to kinetochore	18199686.	IDA	Process
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0033597	mitotic checkpoint complex	21873635.	IBA	Component
GO:0034501	protein localization to kinetochore	9660858.	IPI	Process
GO:0043130	ubiquitin binding	21873635.	IBA	Function
GO:0051301	cell division	-	IEA	Process
GO:0051321	meiotic cell cycle	-	IEA	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1990298	bub1-bub3 complex	21873635.	IBA	Component