EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000154743 (Gene tree)
Gene ID: 80746
Gene Symbol: TSEN2
Alias: SEN2|SEN2L|MGC2776
Full Name: tRNA splicing endonuclease subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 55,192 bases
Position: chr3:12,484,432-12,539,623
Accession: 28422
RBP type: canonical RBP
Summary: This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000392029	tRNA_int_endo	PF01974.17	4.6e-18	1	1
ENSP00000284995	tRNA_int_endo	PF01974.17	6e-18	1	1
ENSP00000385976	tRNA_int_endo	PF01974.17	6e-18	1	1
ENSP00000416510	tRNA_int_endo	PF01974.17	6e-18	1	1
ENSP00000407974	tRNA_int_endo	PF01974.17	6e-15	1	1
ENSP00000406238	tRNA_int_endo	PF01974.17	7.2e-10	1	1
ENSP00000406238	tRNA_int_endo_N	PF02778.14	5e-18	1	1
ENSP00000392029	tRNA_int_endo_N	PF02778.14	6.6e-18	1	1
ENSP00000284995	tRNA_int_endo_N	PF02778.14	9.5e-18	1	1
ENSP00000385976	tRNA_int_endo_N	PF02778.14	9.5e-18	1	1
ENSP00000407974	tRNA_int_endo_N	PF02778.14	7.1e-10	1	1
ENSP00000416510	tRNA_int_endo_N	PF02778.14	8.6e-10	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000455118	TSEN2-208	784	-	ENSP00000408744	81 (aa)	-	H7C301
ENST00000473755	TSEN2-209	3918	-	-	- (aa)	-	-
ENST00000412698	TSEN2-203	553	-	ENSP00000408528	101 (aa)	-	H7C2Z3
ENST00000415684	TSEN2-204	2279	XM_017007297	ENSP00000416510	439 (aa)	XP_016862786	Q8NCE0
ENST00000446004	TSEN2-206	1239	XM_024453784	ENSP00000406238	378 (aa)	XP_024309552	C9J7Z4
ENST00000444864	TSEN2-205	2697	-	ENSP00000407974	402 (aa)	-	Q8NCE0
ENST00000475595	TSEN2-210	830	-	-	- (aa)	-	-
ENST00000454502	TSEN2-207	1909	-	ENSP00000392029	406 (aa)	-	Q8NCE0
ENST00000490981	TSEN2-211	760	-	-	- (aa)	-	-
ENST00000402228	TSEN2-202	2149	XM_017007292	ENSP00000385976	465 (aa)	XP_016862781	Q8NCE0
ENST00000284995	TSEN2-201	2381	XM_011534139	ENSP00000284995	465 (aa)	XP_011532441	Q8NCE0

Gene Model

Click here to download ENSG00000154743's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000154743	Platelet Function Tests	2.1677700E-005	-
ENSG00000154743	Prostatic Neoplasms	2E-6	22219177

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000154743's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000154743	TSEN2	60	49.180	ENSG00000011376	LARS2	84	49.180
ENSG00000154743	TSEN2	68	52.113	ENSG00000196141	SPATS2L	61	52.113

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000154743	TSEN2	98	64.557	ENSAPOG00000019374	-	100	37.327	Acanthochromis_polyacanthus
ENSG00000154743	TSEN2	99	96.250	ENSAMEG00000004748	TSEN2	100	76.483	Ailuropoda_melanoleuca
ENSG00000154743	TSEN2	98	63.291	ENSACIG00000022861	tsen2	97	58.065	Amphilophus_citrinellus
ENSG00000154743	TSEN2	98	63.291	ENSAOCG00000007248	tsen2	100	39.301	Amphiprion_ocellaris
ENSG00000154743	TSEN2	98	62.025	ENSAPEG00000021947	tsen2	99	43.396	Amphiprion_percula
ENSG00000154743	TSEN2	98	67.089	ENSATEG00000009406	tsen2	99	43.678	Anabas_testudineus
ENSG00000154743	TSEN2	99	73.750	ENSAPLG00000014992	TSEN2	100	53.477	Anas_platyrhynchos
ENSG00000154743	TSEN2	85	72.464	ENSACAG00000013345	TSEN2	100	55.115	Anolis_carolinensis
ENSG00000154743	TSEN2	99	96.250	ENSANAG00000026891	TSEN2	100	91.379	Aotus_nancymaae
ENSG00000154743	TSEN2	98	62.025	ENSACLG00000014303	tsen2	99	42.424	Astatotilapia_calliptera
ENSG00000154743	TSEN2	98	62.025	ENSAMXG00000043484	tsen2	99	45.657	Astyanax_mexicanus
ENSG00000154743	TSEN2	99	88.750	ENSBTAG00000037980	TSEN2	100	71.591	Bos_taurus
ENSG00000154743	TSEN2	99	97.500	ENSCJAG00000039013	TSEN2	100	95.495	Callithrix_jacchus
ENSG00000154743	TSEN2	99	93.750	ENSCAFG00000004987	TSEN2	100	77.495	Canis_familiaris
ENSG00000154743	TSEN2	99	93.750	ENSCAFG00020007250	TSEN2	100	77.495	Canis_lupus_dingo
ENSG00000154743	TSEN2	99	90.000	ENSCHIG00000013772	TSEN2	100	72.103	Capra_hircus
ENSG00000154743	TSEN2	99	95.000	ENSTSYG00000010816	TSEN2	100	80.901	Carlito_syrichta
ENSG00000154743	TSEN2	99	82.500	ENSCPOG00000007932	-	100	67.167	Cavia_porcellus
ENSG00000154743	TSEN2	99	96.250	ENSCCAG00000037851	TSEN2	100	92.857	Cebus_capucinus
ENSG00000154743	TSEN2	99	96.250	ENSCATG00000031911	TSEN2	100	87.768	Cercocebus_atys
ENSG00000154743	TSEN2	99	81.250	ENSCLAG00000011090	TSEN2	100	67.167	Chinchilla_lanigera
ENSG00000154743	TSEN2	99	97.500	ENSCSAG00000009822	TSEN2	100	91.631	Chlorocebus_sabaeus
ENSG00000154743	TSEN2	99	92.500	ENSCHOG00000009111	TSEN2	74	85.027	Choloepus_hoffmanni
ENSG00000154743	TSEN2	99	72.500	ENSCPBG00000026359	TSEN2	100	56.416	Chrysemys_picta_bellii
ENSG00000154743	TSEN2	85	33.333	ENSCING00000013311	-	91	46.457	Ciona_intestinalis
ENSG00000154743	TSEN2	100	96.552	ENSCANG00000035550	TSEN2	100	96.552	Colobus_angolensis_palliatus
ENSG00000154743	TSEN2	99	88.750	ENSCGRG00001017681	Tsen2	100	71.642	Cricetulus_griseus_chok1gshd
ENSG00000154743	TSEN2	99	88.750	ENSCGRG00000010015	Tsen2	100	71.642	Cricetulus_griseus_crigri
ENSG00000154743	TSEN2	98	55.696	ENSCSEG00000020407	tsen2	99	42.518	Cynoglossus_semilaevis
ENSG00000154743	TSEN2	98	60.759	ENSCVAG00000014431	tsen2	100	60.135	Cyprinodon_variegatus
ENSG00000154743	TSEN2	98	56.962	ENSDARG00000091851	tsen2	99	63.441	Danio_rerio
ENSG00000154743	TSEN2	99	92.500	ENSDNOG00000038504	TSEN2	100	76.180	Dasypus_novemcinctus
ENSG00000154743	TSEN2	99	83.750	ENSDORG00000003395	Tsen2	100	65.665	Dipodomys_ordii
ENSG00000154743	TSEN2	99	92.500	ENSETEG00000003098	TSEN2	72	81.624	Echinops_telfairi
ENSG00000154743	TSEN2	81	56.061	ENSEBUG00000014614	TSEN2	99	35.498	Eptatretus_burgeri
ENSG00000154743	TSEN2	99	93.750	ENSEASG00005014763	TSEN2	100	80.043	Equus_asinus_asinus
ENSG00000154743	TSEN2	99	96.250	ENSECAG00000012813	TSEN2	100	79.828	Equus_caballus
ENSG00000154743	TSEN2	98	56.962	ENSELUG00000013262	tsen2	100	43.496	Esox_lucius
ENSG00000154743	TSEN2	99	96.250	ENSFCAG00000025500	TSEN2	100	83.498	Felis_catus
ENSG00000154743	TSEN2	99	73.750	ENSFALG00000000012	TSEN2	100	55.975	Ficedula_albicollis
ENSG00000154743	TSEN2	99	83.750	ENSFDAG00000008132	TSEN2	100	71.564	Fukomys_damarensis
ENSG00000154743	TSEN2	85	55.072	ENSGMOG00000000443	-	79	48.544	Gadus_morhua
ENSG00000154743	TSEN2	99	76.250	ENSGALG00000004981	TSEN2	100	54.025	Gallus_gallus
ENSG00000154743	TSEN2	88	61.972	ENSGAFG00000019542	tsen2	98	36.725	Gambusia_affinis
ENSG00000154743	TSEN2	98	63.291	ENSGACG00000003387	tsen2	99	44.186	Gasterosteus_aculeatus
ENSG00000154743	TSEN2	99	71.250	ENSGAGG00000022560	TSEN2	100	56.813	Gopherus_agassizii
ENSG00000154743	TSEN2	99	100.000	ENSGGOG00000012488	TSEN2	100	98.276	Gorilla_gorilla
ENSG00000154743	TSEN2	98	63.291	ENSHBUG00000009039	tsen2	99	42.657	Haplochromis_burtoni
ENSG00000154743	TSEN2	99	82.500	ENSHGLG00000000740	TSEN2	100	67.452	Heterocephalus_glaber_female
ENSG00000154743	TSEN2	99	82.500	ENSHGLG00100001532	TSEN2	100	67.452	Heterocephalus_glaber_male
ENSG00000154743	TSEN2	98	58.228	ENSHCOG00000014632	-	64	61.326	Hippocampus_comes
ENSG00000154743	TSEN2	98	58.228	ENSIPUG00000011651	tsen2	99	44.654	Ictalurus_punctatus
ENSG00000154743	TSEN2	99	92.500	ENSSTOG00000000538	TSEN2	100	73.876	Ictidomys_tridecemlineatus
ENSG00000154743	TSEN2	96	34.133	ENSKMAG00000014543	-	77	37.778	Kryptolebias_marmoratus
ENSG00000154743	TSEN2	99	63.750	ENSLACG00000008466	TSEN2	100	46.862	Latimeria_chalumnae
ENSG00000154743	TSEN2	98	56.962	ENSLOCG00000013958	tsen2	100	46.751	Lepisosteus_oculatus
ENSG00000154743	TSEN2	99	91.250	ENSLAFG00000009300	TSEN2	100	74.034	Loxodonta_africana
ENSG00000154743	TSEN2	99	97.500	ENSMFAG00000038583	TSEN2	100	96.059	Macaca_fascicularis
ENSG00000154743	TSEN2	99	97.500	ENSMMUG00000007195	TSEN2	100	96.059	Macaca_mulatta
ENSG00000154743	TSEN2	99	97.500	ENSMNEG00000025898	TSEN2	100	94.409	Macaca_nemestrina
ENSG00000154743	TSEN2	99	97.500	ENSMLEG00000038210	TSEN2	100	92.688	Mandrillus_leucophaeus
ENSG00000154743	TSEN2	98	63.291	ENSMAMG00000009733	tsen2	99	39.955	Mastacembelus_armatus
ENSG00000154743	TSEN2	98	62.025	ENSMZEG00005012081	-	65	65.193	Maylandia_zebra
ENSG00000154743	TSEN2	99	77.500	ENSMGAG00000005015	TSEN2	100	54.105	Meleagris_gallopavo
ENSG00000154743	TSEN2	99	96.250	ENSMICG00000016672	TSEN2	100	81.330	Microcebus_murinus
ENSG00000154743	TSEN2	99	88.750	ENSMOCG00000020824	Tsen2	100	69.936	Microtus_ochrogaster
ENSG00000154743	TSEN2	99	78.750	ENSMODG00000006249	TSEN2	100	63.383	Monodelphis_domestica
ENSG00000154743	TSEN2	98	64.557	ENSMALG00000020613	tsen2	83	42.733	Monopterus_albus
ENSG00000154743	TSEN2	99	86.250	MGP_CAROLIEiJ_G0028752	Tsen2	100	67.789	Mus_caroli
ENSG00000154743	TSEN2	99	86.250	ENSMUSG00000042389	Tsen2	100	68.220	Mus_musculus
ENSG00000154743	TSEN2	99	86.250	MGP_PahariEiJ_G0022503	Tsen2	100	68.856	Mus_pahari
ENSG00000154743	TSEN2	99	86.250	MGP_SPRETEiJ_G0029780	Tsen2	100	68.162	Mus_spretus
ENSG00000154743	TSEN2	99	92.500	ENSMPUG00000017182	TSEN2	100	74.681	Mustela_putorius_furo
ENSG00000154743	TSEN2	99	95.000	ENSMLUG00000017641	TSEN2	100	75.966	Myotis_lucifugus
ENSG00000154743	TSEN2	98	61.250	ENSNBRG00000007105	tsen2	99	58.621	Neolamprologus_brichardi
ENSG00000154743	TSEN2	99	98.750	ENSNLEG00000004696	TSEN2	100	93.103	Nomascus_leucogenys
ENSG00000154743	TSEN2	96	79.063	ENSNLEG00000033166	-	100	76.718	Nomascus_leucogenys
ENSG00000154743	TSEN2	99	80.000	ENSMEUG00000014148	-	62	85.106	Notamacropus_eugenii
ENSG00000154743	TSEN2	99	82.500	ENSOPRG00000003456	TSEN2	100	63.617	Ochotona_princeps
ENSG00000154743	TSEN2	99	78.750	ENSODEG00000002629	TSEN2	100	65.880	Octodon_degus
ENSG00000154743	TSEN2	98	63.291	ENSONIG00000000278	tsen2	99	41.048	Oreochromis_niloticus
ENSG00000154743	TSEN2	99	78.750	ENSOANG00000011648	-	100	61.048	Ornithorhynchus_anatinus
ENSG00000154743	TSEN2	99	83.750	ENSOCUG00000013203	TSEN2	96	70.386	Oryctolagus_cuniculus
ENSG00000154743	TSEN2	96	58.974	ENSORLG00000026661	-	99	42.155	Oryzias_latipes
ENSG00000154743	TSEN2	96	56.410	ENSORLG00020006129	-	99	42.417	Oryzias_latipes_hni
ENSG00000154743	TSEN2	96	58.974	ENSORLG00015000801	-	99	42.155	Oryzias_latipes_hsok
ENSG00000154743	TSEN2	98	56.962	ENSOMEG00000001692	tsen2	99	42.788	Oryzias_melastigma
ENSG00000154743	TSEN2	99	81.250	ENSOGAG00000028352	-	100	69.528	Otolemur_garnettii
ENSG00000154743	TSEN2	99	92.500	ENSOGAG00000002976	-	100	76.395	Otolemur_garnettii
ENSG00000154743	TSEN2	99	87.500	ENSOARG00000016087	TSEN2	91	71.245	Ovis_aries
ENSG00000154743	TSEN2	86	82.857	ENSPPAG00000034639	-	99	68.793	Pan_paniscus
ENSG00000154743	TSEN2	99	100.000	ENSPPAG00000035317	TSEN2	100	98.925	Pan_paniscus
ENSG00000154743	TSEN2	99	95.000	ENSPTIG00000021018	TSEN2	100	83.005	Panthera_tigris_altaica
ENSG00000154743	TSEN2	100	99.140	ENSPTRG00000014633	TSEN2	100	99.140	Pan_troglodytes
ENSG00000154743	TSEN2	88	83.099	ENSPTRG00000050820	-	100	72.273	Pan_troglodytes
ENSG00000154743	TSEN2	99	97.500	ENSPANG00000013415	TSEN2	100	96.305	Papio_anubis
ENSG00000154743	TSEN2	99	62.500	ENSPKIG00000024801	tsen2	100	49.284	Paramormyrops_kingsleyae
ENSG00000154743	TSEN2	99	75.000	ENSPSIG00000010669	-	84	75.000	Pelodiscus_sinensis
ENSG00000154743	TSEN2	100	65.796	ENSPEMG00000013175	Tsen2	100	64.681	Peromyscus_maniculatus_bairdii
ENSG00000154743	TSEN2	99	80.000	ENSPCIG00000002191	TSEN2	100	64.331	Phascolarctos_cinereus
ENSG00000154743	TSEN2	90	60.274	ENSPFOG00000012459	tsen2	99	41.966	Poecilia_formosa
ENSG00000154743	TSEN2	90	60.274	ENSPLAG00000013787	tsen2	99	41.727	Poecilia_latipinna
ENSG00000154743	TSEN2	90	60.274	ENSPMEG00000002687	tsen2	79	57.595	Poecilia_mexicana
ENSG00000154743	TSEN2	99	97.500	ENSPPYG00000013647	TSEN2	100	94.194	Pongo_abelii
ENSG00000154743	TSEN2	99	75.000	ENSPCAG00000003542	TSEN2	100	64.301	Procavia_capensis
ENSG00000154743	TSEN2	99	96.250	ENSPCOG00000019328	TSEN2	100	81.330	Propithecus_coquereli
ENSG00000154743	TSEN2	99	97.500	ENSPVAG00000005820	TSEN2	82	88.938	Pteropus_vampyrus
ENSG00000154743	TSEN2	98	64.557	ENSPNAG00000008203	tsen2	99	45.625	Pygocentrus_nattereri
ENSG00000154743	TSEN2	99	87.500	ENSRNOG00000060175	Tsen2	100	69.296	Rattus_norvegicus
ENSG00000154743	TSEN2	99	97.500	ENSRBIG00000033133	TSEN2	100	95.054	Rhinopithecus_bieti
ENSG00000154743	TSEN2	99	97.500	ENSRROG00000041156	TSEN2	100	96.059	Rhinopithecus_roxellana
ENSG00000154743	TSEN2	99	97.500	ENSSBOG00000035499	TSEN2	100	88.177	Saimiri_boliviensis_boliviensis
ENSG00000154743	TSEN2	99	83.750	ENSSHAG00000010530	TSEN2	100	65.751	Sarcophilus_harrisii
ENSG00000154743	TSEN2	98	60.759	ENSSFOG00015001309	tsen2	100	49.203	Scleropages_formosus
ENSG00000154743	TSEN2	98	62.025	ENSSMAG00000006406	-	69	64.804	Scophthalmus_maximus
ENSG00000154743	TSEN2	98	63.291	ENSSDUG00000018175	tsen2	99	43.707	Seriola_dumerili
ENSG00000154743	TSEN2	58	62.195	ENSSLDG00000022171	-	93	35.359	Seriola_lalandi_dorsalis
ENSG00000154743	TSEN2	99	75.000	ENSSPUG00000018099	TSEN2	100	57.531	Sphenodon_punctatus
ENSG00000154743	TSEN2	93	56.000	ENSSPAG00000021756	-	99	39.806	Stegastes_partitus
ENSG00000154743	TSEN2	99	87.500	ENSSSCG00000011580	TSEN2	100	73.333	Sus_scrofa
ENSG00000154743	TSEN2	99	73.750	ENSTGUG00000004044	TSEN2	100	56.042	Taeniopygia_guttata
ENSG00000154743	TSEN2	95	41.667	ENSTRUG00000004124	-	98	42.065	Takifugu_rubripes
ENSG00000154743	TSEN2	98	60.759	ENSTNIG00000005222	-	99	39.024	Tetraodon_nigroviridis
ENSG00000154743	TSEN2	83	84.314	ENSTBEG00000011740	TSEN2	100	57.204	Tupaia_belangeri
ENSG00000154743	TSEN2	99	90.000	ENSTTRG00000016566	TSEN2	100	73.548	Tursiops_truncatus
ENSG00000154743	TSEN2	99	93.750	ENSUMAG00000017610	TSEN2	100	77.021	Ursus_maritimus
ENSG00000154743	TSEN2	76	72.189	ENSVPAG00000011061	-	74	72.189	Vicugna_pacos
ENSG00000154743	TSEN2	99	95.000	ENSVVUG00000015253	TSEN2	100	77.495	Vulpes_vulpes
ENSG00000154743	TSEN2	99	63.750	ENSXETG00000025146	tsen2	100	49.171	Xenopus_tropicalis
ENSG00000154743	TSEN2	85	63.768	ENSXCOG00000017262	tsen2	99	38.084	Xiphophorus_couchianus
ENSG00000154743	TSEN2	90	61.644	ENSXMAG00000012479	tsen2	77	59.459	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000213	tRNA-intron endonuclease activity	21873635.	IBA	Function
GO:0000214	tRNA-intron endonuclease complex	21873635.	IBA	Component
GO:0000379	tRNA-type intron splice site recognition and cleavage	21873635.	IBA	Process
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	17495927.	IDA	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	-	TAS	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0016829	lyase activity	-	IEA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	12529846	Missense_Mutation	novel	L407F	0.39
BLCA	chr3	12492164	Missense_Mutation	novel	R73K	0.24
BLCA	chr3	12489906	Missense_Mutation	novel	E36K	0.11
BLCA	chr3	12503572	Missense_Mutation	novel	E207Q	0.26
BLCA	chr3	12503639	Missense_Mutation	novel	I229N	0.21
BLCA	chr3	12531601	Missense_Mutation	novel	S427C	0.1
BLCA	chr3	12503688	Silent	novel	L245L	0.19
BLCA	chr3	12529806	Missense_Mutation	NA	S394C	0.31
BLCA	chr3	12519070	Silent	rs775135022	T324T	0.1
BRCA	chr3	12489909	Missense_Mutation	NA	F37L	0.35
BRCA	chr3	12503484	In_Frame_Ins	novel	K179_G181dup	0.35
BRCA	chr3	12532854	3'UTR	rs112696991		0.42
BRCA	chr3	12489982	Missense_Mutation	NA	Y61C	0.28
BRCA	chr3	12516656	Missense_Mutation	NA	E319Q	0.31
BRCA	chr3	12532784	3'UTR	rs577818131		0.13
CESC	chr3	12503381	Frame_Shift_Ins	novel	*R143Sfs32**	0.07
CESC	chr3	12503419	Missense_Mutation	NA	G156R	0.21
CESC	chr3	12503420	Missense_Mutation	rs750726691	G156E	0.2
CESC	chr3	12489974	Silent	novel	E58E	0.47
COAD	chr3	12503352	Silent	rs377321204	T133T	0.37
COAD	chr3	12516644	Missense_Mutation	novel	S315R	0.08
COAD	chr3	12519069	Missense_Mutation	rs772061041	T324M	0.14
COAD	chr3	12503292	Silent	NA	E113E	0.37
COAD	chr3	12503581	Missense_Mutation	NA	V210L	0.42
COAD	chr3	12503675	Missense_Mutation	NA	Q241L	0.16
COAD	chr3	12489906	Nonsense_Mutation	NA	E36*	0.29
COAD	chr3	12503352	Silent	rs377321204	T133T	0.3
COAD	chr3	12530079	Intron	novel		0.61
ESCA	chr3	12505189	Missense_Mutation	novel	N289K	0.33	tRNA_int_endo
GBM	chr3	12503474	Missense_Mutation	NA	N174I	0.11
GBM	chr3	12505201	Silent	novel	I293I	0.27
GBM	chr3	12503714	Missense_Mutation	novel	D254G	0.44
GBM	chr3	12529983	Intron	novel		0.13
GBM	chr3	12489828	Nonsense_Mutation	novel	K10*	0.15
HNSC	chr3	12503734	Missense_Mutation	novel	E261K	0.35
KIRC	chr3	12503396	Missense_Mutation	NA	Q148P	0.08
KIRC	chr3	12503643	Silent	rs772295412	L230L	0.24
LGG	chr3	12503647	Missense_Mutation	rs553531943	R232C	0.5
LIHC	chr3	12503474	Missense_Mutation	NA	N174I	0.29
LUAD	chr3	12489906	Missense_Mutation	NA	E36Q	0.15
LUAD	chr3	12529771	Silent	novel	V382V	0.23
LUAD	chr3	12519163	Silent	NA	V355V	0.22
LUAD	chr3	12519067	Silent	novel	L323L	0.4
LUSC	chr3	12503659	Missense_Mutation	NA	H236Y	0.54
LUSC	chr3	12529816	Silent	novel	R397R	0.67
OV	chr3	12503784	Missense_Mutation	novel	E277D	0.07	tRNA_int_endo
OV	chr3	12505160	Nonsense_Mutation	novel	Q280*	0.05	tRNA_int_endo
OV	chr3	12496533	Missense_Mutation	novel	M96T	0.09
OV	chr3	12503734	Missense_Mutation	novel	E261K	0.06
PAAD	chr3	12528897	Missense_Mutation	rs750050383	R370Q	0.17
PAAD	chr3	12532791	3'UTR	novel		0.18
READ	chr3	12532784	3'UTR	rs577818131		0.41
SARC	chr3	12529793	Missense_Mutation	novel	H390Y	0.13
SKCM	chr3	12505191	Missense_Mutation	novel	P290L	0.57	tRNA_int_endo
SKCM	chr3	12489803	Translation_Start_Site	NA	M1?	0.19
SKCM	chr3	12532802	3'UTR	novel		0.27
SKCM	chr3	12532895	3'UTR	novel		0.24
SKCM	chr3	12532895	3'UTR	novel		0.48
SKCM	chr3	12516613	Splice_Region	NA	A304A	0.37
SKCM	chr3	12519166	Silent	novel	P356P	0.41
SKCM	chr3	12503708	Missense_Mutation	NA	G252E	0.25
STAD	chr3	12503682	Silent	NA	I243I	0.23
STAD	chr3	12496535	Missense_Mutation	NA	P97S	0.23
STAD	chr3	12519115	Missense_Mutation	NA	F339L	0.35
STAD	chr3	12519154	Missense_Mutation	NA	K352N	0.33
STAD	chr3	12503299	Missense_Mutation	rs777071802	R116C	0.23
STAD	chr3	12528916	Silent	NA	Y376Y	0.1
UCEC	chr3	12532818	3'UTR	novel		0.39
UCEC	chr3	12519146	Nonsense_Mutation	rs201467485	R350*	0.3
UCEC	chr3	12532692	Nonsense_Mutation	rs139032110	R457*	0.04
UCEC	chr3	12503750	Missense_Mutation	NA	A266V	0.22
UCEC	chr3	12532799	3'UTR	rs735640		0.33
UCEC	chr3	12489825	Missense_Mutation	novel	P9S	0.34
UCEC	chr3	12492155	Missense_Mutation	novel	I70S	0.1
UCEC	chr3	12492199	Missense_Mutation	NA	L85M	0.22
UCEC	chr3	12532808	3'UTR	novel		0.33
UCEC	chr3	12529772	In_Frame_Del	NA	I384del	0.2
UCEC	chr3	12530035	Intron	novel		0.21
UCEC	chr3	12531646	Missense_Mutation	novel	R442M	0.07
UCEC	chr3	12532848	3'UTR	novel		0.15
UCEC	chr3	12503320	Missense_Mutation	novel	S123R	0.2
UCEC	chr3	12503651	Missense_Mutation	novel	G233D	0.17
UCEC	chr3	12519197	Splice_Region	rs767804914	L367L	0.41
UCEC	chr3	12531599	Silent	novel	P426P	0.37
UCEC	chr3	12531641	Missense_Mutation	novel	M440I	0.38
UCEC	chr3	12532888	3'UTR	novel		0.5
UCEC	chr3	12532677	Nonsense_Mutation	rs376815626	R452*	0.46
UCEC	chr3	12532740	3'UTR	novel		0.13
UCEC	chr3	12530087	Intron	novel		0.25
UCEC	chr3	12530088	Intron	novel		0.25
UCEC	chr3	12503581	Missense_Mutation	rs186223564	V210M	0.35
UCEC	chr3	12532784	3'UTR	rs577818131		0.43
UCEC	chr3	12505167	Missense_Mutation	novel	N282I	0.45	tRNA_int_endo
UCEC	chr3	12532875	3'UTR	NA		0.33
UCEC	chr3	12528896	Missense_Mutation	rs148017012	R370W	0.19
UCEC	chr3	12532784	3'UTR	rs577818131		0.29
UCEC	chr3	12529905	Intron	novel		0.5
UCEC	chr3	12503758	Missense_Mutation	rs760427656	E269K	0.32
UCEC	chr3	12503459	Missense_Mutation	novel	R169I	0.36
UCEC	chr3	12532847	3'UTR	novel		0.58
UCEC	chr3	12519120	Missense_Mutation	novel	T341I	0.29
UCEC	chr3	12532677	Nonsense_Mutation	rs376815626	R452*	0.41
UCEC	chr3	12531645	Missense_Mutation	novel	R442G	0.08
UCEC	chr3	12519146	Nonsense_Mutation	rs201467485	R350*	0.21
UCEC	chr3	12503584	Nonsense_Mutation	NA	R211*	0.22
UCEC	chr3	12505221	Missense_Mutation	NA	S300I	0.16	tRNA_int_endo
UCEC	chr3	12503503	Missense_Mutation	novel	G184C	0.09
UCEC	chr3	12503571	Silent	novel	F206F	0.06
UCEC	chr3	12503476	Missense_Mutation	rs139755733	G175R	0.39
UCEC	chr3	12532799	3'UTR	rs735640		0.39
UCEC	chr3	12492157	Missense_Mutation	NA	L71F	0.19
UCEC	chr3	12530021	Intron	rs772137911		0.34
UCEC	chr3	12505185	Missense_Mutation	novel	R288I	0.36	tRNA_int_endo
UCEC	chr3	12532814	3'UTR	novel		0.4
UCEC	chr3	12503442	Silent	novel	G163G	0.49
UCEC	chr3	12503556	Silent	novel	P201P	0.37
UCEC	chr3	12532839	3'UTR	novel		0.21
UCEC	chr3	12528896	Missense_Mutation	rs148017012	R370W	0.35
UCEC	chr3	12529889	Intron	novel		0.39
UCEC	chr3	12503585	Missense_Mutation	rs570820022	R211Q	0.4
UCS	chr3	12489938	Silent	novel	N46N	0.44
UCS	chr3	12489892	Missense_Mutation	rs568361511	H31R	0.3
UCS	chr3	12489918	Missense_Mutation	novel	F40V	0.41
UCS	chr3	12503435	Missense_Mutation	novel	M161T	0.2
UCS	chr3	12529777	Silent	NA	I384I	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.75	0.02241
COAD	DEL	0.1264	0.010931
KIRC	DEL	0.8447	2.8873e-53
LUAD	DEL	0.3101	0.068154
SKCM	DEL	0.1526	0.13887
TGCT	DEL	0.2067	0.08422
THYM	DEL	0.0894	0.037527

Survival Analysis

Cancer	P-value	Q-value
THYM	0.047	Kaplan-Meier Survival Analysis
KIRC	0.00016	Kaplan-Meier Survival Analysis
SARC	0.033	Kaplan-Meier Survival Analysis
BLCA	0.0004	Kaplan-Meier Survival Analysis
READ	0.016	Kaplan-Meier Survival Analysis
LAML	0.03	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
LIHC	0.00044	Kaplan-Meier Survival Analysis
DLBC	0.049	Kaplan-Meier Survival Analysis
LGG	0.0019	Kaplan-Meier Survival Analysis
UVM	0.00048	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742