EuRBPDB

Description

Ensembl ID: ENSG00000155393 (Gene tree)
Gene ID: 55027
Gene Symbol: HEATR3
Alias: FLJ20718
Full Name: HEAT repeat containing 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 40,447 bases
Position: chr16:50,065,941-50,106,387
Accession: 26087
RBP type: non-canonical RBP
Summary: The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25849277	Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.	Nat Commun	2015 Apr 7	Calvino FR	doi: 10.1038/ncomms7510.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000569324	HEATR3-205	746	-	-	- (aa)	-	-
ENST00000561819	HEATR3-203	468	-	-	- (aa)	-	-
ENST00000299192	HEATR3-201	3560	XM_005256013	ENSP00000299192	680 (aa)	XP_005256070	Q7Z4Q2
ENST00000564942	HEATR3-204	801	-	-	- (aa)	-	-
ENST00000561525	HEATR3-202	402	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000155393	Carcinoma, Squamous Cell	2E-20	22960999
ENSG00000155393	Esophageal Neoplasms	2E-20	22960999

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000155393	rs4785204	16	50069823	T	Esophageal cancer (squamous cell)	22960999	[1.18-1.29]	1.24	EFO_0000707\|EFO_0002916
ENSG00000155393	rs10852606	16	50094961	C	Glioblastoma	28346443	1.13-1.24	1.18	EFO_0000326\|EFO_0000519
ENSG00000155393	rs71138029	16	50074982	CA	Red cell distribution width	28957414	[0.023-0.04] unit increase	0.0313909	EFO_0005192
ENSG00000155393	rs2287197	16	50072683	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005623	cell	-	IEA	Component
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0042273	ribosomal large subunit biogenesis	21873635.	IBA	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function