EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000155438 (Gene tree)
Gene ID: 84365
Gene Symbol: NIFK
Alias: Nopp34|hNIFK|MKI67IP
Full Name: nucleolar protein interacting with the FHA domain of MKI67
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 9,983 bases
Position: chr2:121,726,945-121,736,927
Accession: 17838
RBP type: canonical RBP
Summary: This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000285814	RRM_1	PF00076.22	2.9e-16	1	1
ENSP00000398116	RRM_1	PF00076.22	1.4e-10	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11342549	A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis.	J Biol Chem	2001 Jul 6	Takagi M	-
20629179	Genome-wide gain-of-function screen identifies novel regulators of pluripotency.	Stem Cells	2010 Sep	Abujarour R	doi: 10.1002/stem.472.
25826659	The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression.	RNA Biol	2015	Pan WA	doi: 10.1080/15476286.2015.1017221.
14703492	[Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro].	Zhonghua Yu Fang Yi Xue Za Zhi	2003 Nov	Zhang YX	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000423105	NIFK-202	686	-	ENSP00000390174	102 (aa)	-	H7BZL0
ENST00000498570	NIFK-207	374	-	-	- (aa)	-	-
ENST00000477693	NIFK-205	1096	-	-	- (aa)	-	-
ENST00000447132	NIFK-203	759	-	ENSP00000406227	164 (aa)	-	C9J808
ENST00000285814	NIFK-201	1734	-	ENSP00000285814	293 (aa)	-	Q9BYG3
ENST00000451734	NIFK-204	559	-	ENSP00000398116	166 (aa)	-	C9J6C5
ENST00000481978	NIFK-206	663	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000155438's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000155438's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000155438	NIFK	98	47.205	ENSAPOG00000005547	nifk	83	52.308	Acanthochromis_polyacanthus
ENSG00000155438	NIFK	99	77.108	ENSAMEG00000005074	NIFK	100	76.768	Ailuropoda_melanoleuca
ENSG00000155438	NIFK	98	46.584	ENSACIG00000018626	nifk	82	49.275	Amphilophus_citrinellus
ENSG00000155438	NIFK	98	47.826	ENSAOCG00000012662	nifk	84	51.136	Amphiprion_ocellaris
ENSG00000155438	NIFK	98	48.447	ENSAPEG00000002123	nifk	84	51.515	Amphiprion_percula
ENSG00000155438	NIFK	99	46.626	ENSATEG00000006206	nifk	89	51.119	Anabas_testudineus
ENSG00000155438	NIFK	99	52.761	ENSACAG00000004655	NIFK	87	55.147	Anolis_carolinensis
ENSG00000155438	NIFK	100	79.181	ENSANAG00000032684	-	100	79.181	Aotus_nancymaae
ENSG00000155438	NIFK	100	92.150	ENSANAG00000029859	-	98	92.150	Aotus_nancymaae
ENSG00000155438	NIFK	98	43.478	ENSACLG00000000228	nifk	89	46.570	Astatotilapia_calliptera
ENSG00000155438	NIFK	90	49.432	ENSAMXG00000029665	nifk	82	50.000	Astyanax_mexicanus
ENSG00000155438	NIFK	100	73.649	ENSBTAG00000019387	NIFK	100	73.649	Bos_taurus
ENSG00000155438	NIFK	100	88.055	ENSCJAG00000013386	NIFK	100	88.055	Callithrix_jacchus
ENSG00000155438	NIFK	100	73.737	ENSCAFG00000004710	NIFK	100	73.737	Canis_familiaris
ENSG00000155438	NIFK	100	69.966	ENSCAFG00020011751	NIFK	100	69.966	Canis_lupus_dingo
ENSG00000155438	NIFK	100	72.973	ENSCHIG00000010512	NIFK	100	72.973	Capra_hircus
ENSG00000155438	NIFK	99	72.393	ENSTSYG00000001411	NIFK	99	71.918	Carlito_syrichta
ENSG00000155438	NIFK	100	65.680	ENSCPOG00000007472	NIFK	98	69.048	Cavia_porcellus
ENSG00000155438	NIFK	100	85.366	ENSCCAG00000025869	NIFK	100	88.372	Cebus_capucinus
ENSG00000155438	NIFK	100	96.951	ENSCATG00000015239	NIFK	100	95.222	Cercocebus_atys
ENSG00000155438	NIFK	95	73.418	ENSCLAG00000006296	NIFK	98	69.767	Chinchilla_lanigera
ENSG00000155438	NIFK	100	96.951	ENSCSAG00000016704	NIFK	100	96.246	Chlorocebus_sabaeus
ENSG00000155438	NIFK	98	71.777	ENSCSAG00000017231	-	100	71.777	Chlorocebus_sabaeus
ENSG00000155438	NIFK	99	69.880	ENSCHOG00000002227	NIFK	100	71.429	Choloepus_hoffmanni
ENSG00000155438	NIFK	98	51.553	ENSCPBG00000013739	NIFK	93	53.430	Chrysemys_picta_bellii
ENSG00000155438	NIFK	78	41.667	ENSCSAVG00000001363	-	61	37.634	Ciona_savignyi
ENSG00000155438	NIFK	100	96.341	ENSCANG00000036234	NIFK	100	94.881	Colobus_angolensis_palliatus
ENSG00000155438	NIFK	95	63.684	ENSCGRG00001016466	Nifk	98	61.392	Cricetulus_griseus_chok1gshd
ENSG00000155438	NIFK	99	42.945	ENSCSEG00000015419	nifk	88	46.403	Cynoglossus_semilaevis
ENSG00000155438	NIFK	98	40.373	ENSCVAG00000018411	nifk	71	48.047	Cyprinodon_variegatus
ENSG00000155438	NIFK	90	52.667	ENSDARG00000040666	nifk	94	52.667	Danio_rerio
ENSG00000155438	NIFK	100	71.687	ENSDNOG00000046092	-	98	71.280	Dasypus_novemcinctus
ENSG00000155438	NIFK	100	71.864	ENSDNOG00000005017	-	100	71.864	Dasypus_novemcinctus
ENSG00000155438	NIFK	78	55.385	ENSEBUG00000006979	nifk	69	54.795	Eptatretus_burgeri
ENSG00000155438	NIFK	98	65.979	ENSEASG00005004772	NIFK	94	74.138	Equus_asinus_asinus
ENSG00000155438	NIFK	99	73.780	ENSECAG00000018478	NIFK	100	73.469	Equus_caballus
ENSG00000155438	NIFK	96	63.021	ENSEEUG00000008535	-	100	69.231	Erinaceus_europaeus
ENSG00000155438	NIFK	98	45.000	ENSELUG00000007718	nifk	80	49.808	Esox_lucius
ENSG00000155438	NIFK	100	75.000	ENSFCAG00000010787	NIFK	100	75.000	Felis_catus
ENSG00000155438	NIFK	80	65.909	ENSFALG00000013238	NIFK	90	54.472	Ficedula_albicollis
ENSG00000155438	NIFK	100	64.570	ENSFDAG00000021146	NIFK	100	64.901	Fukomys_damarensis
ENSG00000155438	NIFK	98	40.994	ENSFHEG00000020455	nifk	81	48.263	Fundulus_heteroclitus
ENSG00000155438	NIFK	99	39.634	ENSGMOG00000003166	nifk	97	44.484	Gadus_morhua
ENSG00000155438	NIFK	98	47.205	ENSGALG00000011650	NIFK	91	52.190	Gallus_gallus
ENSG00000155438	NIFK	98	42.857	ENSGAFG00000011462	nifk	80	50.000	Gambusia_affinis
ENSG00000155438	NIFK	96	48.043	ENSGACG00000001551	nifk	94	48.043	Gasterosteus_aculeatus
ENSG00000155438	NIFK	100	69.625	ENSGGOG00000025617	-	100	69.283	Gorilla_gorilla
ENSG00000155438	NIFK	98	72.222	ENSGGOG00000041210	-	99	72.222	Gorilla_gorilla
ENSG00000155438	NIFK	100	98.976	ENSGGOG00000023498	NIFK	100	98.976	Gorilla_gorilla
ENSG00000155438	NIFK	98	43.478	ENSHBUG00000001209	nifk	89	46.570	Haplochromis_burtoni
ENSG00000155438	NIFK	96	68.905	ENSHGLG00000008673	NIFK	98	68.729	Heterocephalus_glaber_female
ENSG00000155438	NIFK	95	72.785	ENSHGLG00100003651	NIFK	100	68.013	Heterocephalus_glaber_male
ENSG00000155438	NIFK	98	47.205	ENSHCOG00000007721	nifk	88	50.179	Hippocampus_comes
ENSG00000155438	NIFK	98	42.857	ENSIPUG00000023690	nifk	82	49.817	Ictalurus_punctatus
ENSG00000155438	NIFK	99	69.091	ENSSTOG00000026392	NIFK	97	69.416	Ictidomys_tridecemlineatus
ENSG00000155438	NIFK	99	65.294	ENSJJAG00000008547	Nifk	98	64.527	Jaculus_jaculus
ENSG00000155438	NIFK	98	43.478	ENSKMAG00000005871	nifk	85	49.035	Kryptolebias_marmoratus
ENSG00000155438	NIFK	99	46.626	ENSLBEG00000027125	nifk	86	50.000	Labrus_bergylta
ENSG00000155438	NIFK	99	46.626	ENSLBEG00000003213	nifk	86	50.000	Labrus_bergylta
ENSG00000155438	NIFK	97	50.314	ENSLOCG00000002155	nifk	89	54.724	Lepisosteus_oculatus
ENSG00000155438	NIFK	96	67.138	ENSLAFG00000030731	NIFK	98	67.010	Loxodonta_africana
ENSG00000155438	NIFK	100	94.539	ENSMFAG00000031270	NIFK	100	94.539	Macaca_fascicularis
ENSG00000155438	NIFK	100	94.539	ENSMMUG00000020928	NIFK	100	94.539	Macaca_mulatta
ENSG00000155438	NIFK	100	95.122	ENSMNEG00000035940	NIFK	100	94.881	Macaca_nemestrina
ENSG00000155438	NIFK	98	45.342	ENSMAMG00000008963	nifk	84	50.769	Mastacembelus_armatus
ENSG00000155438	NIFK	98	43.478	ENSMZEG00005013057	nifk	88	46.570	Maylandia_zebra
ENSG00000155438	NIFK	98	47.904	ENSMGAG00000011953	NIFK	95	51.601	Meleagris_gallopavo
ENSG00000155438	NIFK	96	68.750	ENSMAUG00000021255	Nifk	100	62.252	Mesocricetus_auratus
ENSG00000155438	NIFK	100	78.302	ENSMICG00000037600	NIFK	100	71.717	Microcebus_murinus
ENSG00000155438	NIFK	99	57.407	ENSMOCG00000001962	Nifk	99	57.432	Microtus_ochrogaster
ENSG00000155438	NIFK	95	42.162	ENSMMOG00000019220	nifk	78	44.151	Mola_mola
ENSG00000155438	NIFK	98	60.366	ENSMODG00000000152	-	89	59.859	Monodelphis_domestica
ENSG00000155438	NIFK	83	63.768	ENSMODG00000008447	-	95	55.794	Monodelphis_domestica
ENSG00000155438	NIFK	92	46.448	ENSMALG00000008759	nifk	85	48.496	Monopterus_albus
ENSG00000155438	NIFK	99	61.212	MGP_CAROLIEiJ_G0014507	Nifk	91	72.826	Mus_caroli
ENSG00000155438	NIFK	99	62.424	ENSMUSG00000026377	Nifk	91	73.913	Mus_musculus
ENSG00000155438	NIFK	96	64.375	MGP_PahariEiJ_G0027743	Nifk	100	68.000	Mus_pahari
ENSG00000155438	NIFK	99	63.030	MGP_SPRETEiJ_G0015314	Nifk	91	73.913	Mus_spretus
ENSG00000155438	NIFK	99	74.556	ENSMPUG00000001052	NIFK	100	76.333	Mustela_putorius_furo
ENSG00000155438	NIFK	100	72.483	ENSMLUG00000006481	NIFK	100	72.483	Myotis_lucifugus
ENSG00000155438	NIFK	99	68.485	ENSNGAG00000014831	Nifk	98	69.310	Nannospalax_galili
ENSG00000155438	NIFK	98	42.857	ENSNBRG00000011444	nifk	88	46.377	Neolamprologus_brichardi
ENSG00000155438	NIFK	98	72.822	ENSNLEG00000028987	-	95	72.822	Nomascus_leucogenys
ENSG00000155438	NIFK	100	98.171	ENSNLEG00000001163	NIFK	100	97.952	Nomascus_leucogenys
ENSG00000155438	NIFK	64	73.832	ENSMEUG00000001680	-	100	60.927	Notamacropus_eugenii
ENSG00000155438	NIFK	95	69.730	ENSODEG00000006240	-	98	69.333	Octodon_degus
ENSG00000155438	NIFK	98	43.478	ENSONIG00000007903	nifk	87	47.101	Oreochromis_niloticus
ENSG00000155438	NIFK	98	51.630	ENSOANG00000007522	-	92	55.859	Ornithorhynchus_anatinus
ENSG00000155438	NIFK	99	73.684	ENSOCUG00000007451	-	99	76.190	Oryctolagus_cuniculus
ENSG00000155438	NIFK	92	49.143	ENSOMEG00000018272	nifk	91	47.212	Oryzias_melastigma
ENSG00000155438	NIFK	92	75.789	ENSOGAG00000016968	NIFK	100	70.656	Otolemur_garnettii
ENSG00000155438	NIFK	100	72.973	ENSOARG00000013327	NIFK	100	72.973	Ovis_aries
ENSG00000155438	NIFK	98	70.000	ENSPPAG00000033086	-	99	72.830	Pan_paniscus
ENSG00000155438	NIFK	100	70.648	ENSPPAG00000040912	-	100	70.307	Pan_paniscus
ENSG00000155438	NIFK	100	99.390	ENSPPAG00000034981	NIFK	100	98.635	Pan_paniscus
ENSG00000155438	NIFK	98	71.181	ENSPPAG00000028694	-	99	71.181	Pan_paniscus
ENSG00000155438	NIFK	100	75.676	ENSPPRG00000006683	NIFK	100	75.676	Panthera_pardus
ENSG00000155438	NIFK	99	73.939	ENSPTIG00000012086	NIFK	100	76.604	Panthera_tigris_altaica
ENSG00000155438	NIFK	100	69.625	ENSPTRG00000049930	-	100	69.283	Pan_troglodytes
ENSG00000155438	NIFK	98	70.000	ENSPTRG00000043623	-	99	72.830	Pan_troglodytes
ENSG00000155438	NIFK	100	99.390	ENSPTRG00000012419	NIFK	100	98.976	Pan_troglodytes
ENSG00000155438	NIFK	100	95.732	ENSPANG00000009239	NIFK	100	94.881	Papio_anubis
ENSG00000155438	NIFK	90	47.753	ENSPKIG00000020011	nifk	79	49.213	Paramormyrops_kingsleyae
ENSG00000155438	NIFK	98	42.236	ENSPMGG00000016653	nifk	87	48.438	Periophthalmus_magnuspinnatus
ENSG00000155438	NIFK	96	65.000	ENSPEMG00000023356	Nifk	100	59.365	Peromyscus_maniculatus_bairdii
ENSG00000155438	NIFK	78	62.791	ENSPMAG00000007316	nifk	92	51.913	Petromyzon_marinus
ENSG00000155438	NIFK	99	44.172	ENSPFOG00000000517	nifk	85	50.775	Poecilia_formosa
ENSG00000155438	NIFK	99	43.558	ENSPLAG00000015839	nifk	85	50.388	Poecilia_latipinna
ENSG00000155438	NIFK	99	43.558	ENSPMEG00000008828	nifk	85	50.388	Poecilia_mexicana
ENSG00000155438	NIFK	99	42.331	ENSPREG00000008485	nifk	85	49.612	Poecilia_reticulata
ENSG00000155438	NIFK	100	97.561	ENSPPYG00000018557	-	100	96.246	Pongo_abelii
ENSG00000155438	NIFK	100	98.171	ENSPPYG00000025875	-	100	97.674	Pongo_abelii
ENSG00000155438	NIFK	99	61.350	ENSPCOG00000023378	NIFK	91	66.981	Propithecus_coquereli
ENSG00000155438	NIFK	99	76.506	ENSPVAG00000016707	NIFK	99	75.085	Pteropus_vampyrus
ENSG00000155438	NIFK	98	43.478	ENSPNYG00000016315	nifk	91	46.570	Pundamilia_nyererei
ENSG00000155438	NIFK	99	42.683	ENSPNAG00000017902	nifk	87	49.421	Pygocentrus_nattereri
ENSG00000155438	NIFK	99	57.669	ENSRNOG00000025701	Nifk	96	70.667	Rattus_norvegicus
ENSG00000155438	NIFK	100	95.732	ENSRBIG00000035094	NIFK	100	95.563	Rhinopithecus_bieti
ENSG00000155438	NIFK	100	95.732	ENSRROG00000039485	NIFK	100	95.563	Rhinopithecus_roxellana
ENSG00000155438	NIFK	100	91.468	ENSSBOG00000033603	NIFK	98	91.468	Saimiri_boliviensis_boliviensis
ENSG00000155438	NIFK	98	59.509	ENSSHAG00000011786	NIFK	94	55.629	Sarcophilus_harrisii
ENSG00000155438	NIFK	80	59.091	ENSSFOG00015012070	nifk	75	48.649	Scleropages_formosus
ENSG00000155438	NIFK	95	46.032	ENSSMAG00000001845	nifk	85	50.000	Scophthalmus_maximus
ENSG00000155438	NIFK	99	47.239	ENSSDUG00000005813	nifk	87	50.735	Seriola_dumerili
ENSG00000155438	NIFK	99	45.732	ENSSLDG00000003456	nifk	89	49.286	Seriola_lalandi_dorsalis
ENSG00000155438	NIFK	99	53.988	ENSSARG00000006252	NIFK	99	58.366	Sorex_araneus
ENSG00000155438	NIFK	98	47.239	ENSSPAG00000023399	nifk	92	54.386	Stegastes_partitus
ENSG00000155438	NIFK	99	71.515	ENSSSCG00000015730	NIFK	99	70.990	Sus_scrofa
ENSG00000155438	NIFK	98	51.553	ENSTGUG00000004461	NIFK	92	56.522	Taeniopygia_guttata
ENSG00000155438	NIFK	99	44.785	ENSTRUG00000005206	nifk	87	48.201	Takifugu_rubripes
ENSG00000155438	NIFK	80	60.606	ENSTNIG00000017831	nifk	95	48.235	Tetraodon_nigroviridis
ENSG00000155438	NIFK	100	71.515	ENSTBEG00000001123	NIFK	100	71.429	Tupaia_belangeri
ENSG00000155438	NIFK	99	75.152	ENSTTRG00000005849	NIFK	100	73.818	Tursiops_truncatus
ENSG00000155438	NIFK	99	77.108	ENSUAMG00000021620	NIFK	100	75.421	Ursus_americanus
ENSG00000155438	NIFK	99	72.840	ENSUMAG00000008522	NIFK	100	75.620	Ursus_maritimus
ENSG00000155438	NIFK	98	68.041	ENSVPAG00000005847	NIFK	100	73.820	Vicugna_pacos
ENSG00000155438	NIFK	99	66.049	ENSVVUG00000027544	NIFK	97	73.134	Vulpes_vulpes
ENSG00000155438	NIFK	78	60.465	ENSXETG00000000839	nifk	73	49.254	Xenopus_tropicalis
ENSG00000155438	NIFK	98	43.478	ENSXMAG00000023401	nifk	83	50.391	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000794	condensed nuclear chromosome	11342549.	IDA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	11342549.	IDA	Function
GO:0005515	protein binding	11342549.16244663.25416956.26949251.	IPI	Function
GO:0005654	nucleoplasm	11342549.	IDA	Component
GO:0005730	nucleolus	11342549.	IDA	Component
GO:0005737	cytoplasm	11342549.	IDA	Component
GO:0009303	rRNA transcription	11342549.	NAS	Process
GO:0016072	rRNA metabolic process	11342549.	NAS	Process
GO:0065003	protein-containing complex assembly	11342549.	NAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26984280	The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.	Elife	2016 Mar 17	Lin TC	doi: 10.7554/eLife.11288.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr2	121735713	Missense_Mutation	rs748810988	Y48C	0.26	RRM_1
BLCA	chr2	121728521	Missense_Mutation	NA	E194K	0.22
BLCA	chr2	121730935	Silent	novel	K174K	0.49
BLCA	chr2	121727744	Silent	novel	R288R	0.91
BLCA	chr2	121731087	Missense_Mutation	novel	E124K	0.13
BRCA	chr2	121727606	3'UTR	novel		0.16
BRCA	chr2	121735623	Missense_Mutation	NA	R78T	0.31	RRM_1
BRCA	chr2	121730802	Intron	novel		0.08
CESC	chr2	121727846	Missense_Mutation	rs756299604	D254N	0.31
CESC	chr2	121727986	Intron	novel		0.32
CESC	chr2	121732145	Silent	rs373704889	I101I	0.52
CESC	chr2	121727388	3'UTR	novel		0.38
CESC	chr2	121735707	Missense_Mutation	novel	R50H	0.27	RRM_1
CESC	chr2	121735684	Nonsense_Mutation	NA	E58*	0.53	RRM_1
COAD	chr2	121732146	Missense_Mutation	NA	I101T	0.32
COAD	chr2	121731054	Missense_Mutation	NA	N135H	0.29
COAD	chr2	121727704	3'UTR	novel		0.39
COAD	chr2	121730808	Intron	novel		0.08
COAD	chr2	121727509	3'UTR	novel		0.76
COAD	chr2	121730920	Frame_Shift_Del	NA	*G180Efs9**	0.37
COAD	chr2	121727747	Frame_Shift_Del	NA	*R287Dfs23**	0.41
COAD	chr2	121735708	Missense_Mutation	rs182886627	R50C	0.32	RRM_1
COAD	chr2	121728020	Intron	NA		0.29
COAD	chr2	121731100	Missense_Mutation	novel	H119Q	0.11
COAD	chr2	121727383	3'UTR	rs188800720		0.11
COAD	chr2	121730920	Frame_Shift_Del	NA	*G180Efs9**	0.33
COAD	chr2	121735731	Frame_Shift_Ins	novel	*L42Pfs14**	0.15	RRM_1
COAD	chr2	121735733	Frame_Shift_Ins	novel	*Q41Hfs15**	0.13	RRM_1
COAD	chr2	121727560	3'UTR	novel		0.17
ESCA	chr2	121728493	Missense_Mutation	rs377016579	T203M	0.33
ESCA	chr2	121727204	3'UTR	novel		0.67
ESCA	chr2	121735614	Missense_Mutation	novel	R81K	0.34	RRM_1
GBM	chr2	121730805	Intron	novel		0.46
HNSC	chr2	121727791	Missense_Mutation	novel	E272V	0.17
KIRC	chr2	121731067	Silent	NA	L130L	0.3
LAML	chr2	121730979	Missense_Mutation	rs779170193	R160W	0.19
LIHC	chr2	121727491	3'UTR	novel		0.24
LIHC	chr2	121727343	3'UTR	rs73950812		0.64
LIHC	chr2	121727649	3'UTR	novel		0.33
LIHC	chr2	121727551	3'UTR	rs575350480		0.32
LIHC	chr2	121728018	Intron	novel		0.14
LUAD	chr2	121730978	Missense_Mutation	rs185431138	R160Q	0.13
LUAD	chr2	121728530	Nonsense_Mutation	NA	Q191*	0.35
LUAD	chr2	121730939	Missense_Mutation	NA	R173T	0.1
LUAD	chr2	121735620	Missense_Mutation	NA	S79I	0.11	RRM_1
LUAD	chr2	121736779	Missense_Mutation	novel	K24N	0.09
LUSC	chr2	121731087	Nonsense_Mutation	novel	E124*	0.47
LUSC	chr2	121727780	Missense_Mutation	NA	E276Q	0.08
LUSC	chr2	121736893	5'UTR	novel		0.33
OV	chr2	121727893	Frame_Shift_Ins	novel	*T238Kfs17**	0.04
OV	chr2	121727895	Frame_Shift_Ins	novel	*T238Sfs23**	0.04
OV	chr2	121736746	Missense_Mutation	novel	Q35H	0.16	RRM_1
PAAD	chr2	121732140	Missense_Mutation	rs768177439	A103D	0.08
READ	chr2	121730920	Frame_Shift_Del	NA	*G180Efs9**	0.37
READ	chr2	121735746	Missense_Mutation	NA	K37T	0.45	RRM_1
READ	chr2	121730693	Intron	novel		0.6
READ	chr2	121727388	3'UTR	novel		0.36
SARC	chr2	121730901	Missense_Mutation	rs761077196	P186S	0.14
SKCM	chr2	121736919	5'UTR	novel		0.29
SKCM	chr2	121727704	3'UTR	novel		0.22
SKCM	chr2	121730932	Missense_Mutation	NA	K175N	0.23
SKCM	chr2	121736902	5'UTR	novel		0.2
SKCM	chr2	121728543	Splice_Region	novel		0.19
SKCM	chr2	121728318	Silent	novel	L221L	0.42
STAD	chr2	121736822	In_Frame_Del	novel	F4_P10delinsL	0.33
STAD	chr2	121730920	Frame_Shift_Del	NA	*G180Efs9**	0.15
STAD	chr2	121736780	Frame_Shift_Del	novel	*K24Rfs10**	0.25
STAD	chr2	121727986	Intron	novel		0.3
STAD	chr2	121735683	Missense_Mutation	NA	E58A	0.13	RRM_1
STAD	chr2	121736792	Missense_Mutation	NA	V20A	0.12
STAD	chr2	121727747	Frame_Shift_Del	NA	*R287Dfs23**	0.31
STAD	chr2	121727911	Missense_Mutation	novel	G232D	0.39
UCEC	chr2	121727755	Missense_Mutation	rs187635665	R284Q	0.39
UCEC	chr2	121727975	Intron	novel		0.27
UCEC	chr2	121731070	Silent	novel	E129E	0.13
UCEC	chr2	121727926	Intron	novel		0.36
UCEC	chr2	121728064	Intron	novel		0.21
UCEC	chr2	121728206	Intron	novel		0.42
UCEC	chr2	121728119	Intron	novel		1
UCEC	chr2	121732120	Missense_Mutation	novel	L110M	0.52
UCEC	chr2	121728301	Missense_Mutation	novel	T227N	0.44
UCEC	chr2	121728500	Missense_Mutation	rs374862911	R201C	0.38
UCEC	chr2	121728134	Intron	novel		0.48
UCEC	chr2	121731016	Silent	NA	K147K	0.44
UCEC	chr2	121735673	Silent	NA	I61I	0.26
UCEC	chr2	121730943	Missense_Mutation	novel	L172I	0.21
UCEC	chr2	121727916	Splice_Region	novel		0.05
UCEC	chr2	121727436	3'UTR	novel		0.46
UCEC	chr2	121732112	Silent	novel	G112G	0.34
UCEC	chr2	121728500	Missense_Mutation	rs374862911	R201C	0.53
UCEC	chr2	121730967	Nonsense_Mutation	rs145402818	R164*	0.34
UCEC	chr2	121727708	3'UTR	novel		0.33
UCEC	chr2	121727656	3'UTR	novel		0.37
UCEC	chr2	121728143	Intron	novel		0.48
UCEC	chr2	121731069	Missense_Mutation	novel	L130F	0.37
UCEC	chr2	121731085	Missense_Mutation	novel	E124D	0.39
UCEC	chr2	121732206	Splice_Site	rs749582401	X82_splice	0.23
UCEC	chr2	121727744	Nonsense_Mutation	rs147757149	R288*	0.12
UCEC	chr2	121727662	3'UTR	novel		0.2
UCEC	chr2	121732187	Silent	novel	G87G	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1889	0.15279
COAD	DEL	0.0222	0.13394
ESCA	AMP	0.2609	0.0043633
PAAD	DEL	0.038	0.2014

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0021	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.0017	Kaplan-Meier Survival Analysis
KIRP	0.00012	Kaplan-Meier Survival Analysis
PAAD	0.0017	Kaplan-Meier Survival Analysis
KICH	0.0024	Kaplan-Meier Survival Analysis
UCEC	0.0023	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0028	Kaplan-Meier Survival Analysis