EuRBPDB

Description

Ensembl ID: ENSG00000155561 (Gene tree)
Gene ID: 23165
Gene Symbol: NUP205
Alias: KIAA0225|C7orf14
Full Name: nucleoporin 205
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 90,844 bases
Position: chr7:135,557,914-135,648,757
Accession: 18658
RBP type: non-canonical RBP
Summary: This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000491089	NUP205-209	553	-	-	- (aa)	-	-
ENST00000490439	NUP205-208	653	-	ENSP00000475877	42 (aa)	-	U3KQH5
ENST00000461255	NUP205-202	1447	-	-	- (aa)	-	-
ENST00000477620	NUP205-206	1800	-	ENSP00000475318	273 (aa)	-	U3KPX2
ENST00000285968	NUP205-201	6266	-	ENSP00000285968	2012 (aa)	-	Q92621
ENST00000472132	NUP205-205	553	-	ENSP00000475665	184 (aa)	-	U3KQ97
ENST00000462316	NUP205-203	571	-	-	- (aa)	-	-
ENST00000607647	NUP205-210	4518	-	-	- (aa)	-	-
ENST00000489493	NUP205-207	550	-	-	- (aa)	-	-
ENST00000463247	NUP205-204	570	-	ENSP00000475539	71 (aa)	-	U3KQ47

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000155561	Bronchodilator Agents	5E-6	26634245
ENSG00000155561	Lung Volume Measurements	5E-6	26634245
ENSG00000155561	Bronchodilator Agents	3E-6	26634245
ENSG00000155561	Forced Expiratory Volume	3E-6	26634245
ENSG00000155561	Erythrocyte Indices	3E-8	23222517
ENSG00000155561	Venous Thromboembolism	5E-7	28203683
ENSG00000155561	Osteitis Deformans	8E-10	21623375

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000155561	rs185746565	7	135575301	C	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.554	GO_0097366\|EFO_0004713
ENSG00000155561	rs185746565	7	135575301	C	Post bronchodilator FEV1	26634245	NR unit increase	2.84	EFO_0004314\|GO_0097366
ENSG00000155561	rs12530845	7	135645230	?	Red blood cell traits	23222517			EFO_0004527
ENSG00000155561	rs35061496	7	135569521	T	Educational attainment (MTAG)	30038396	[0.0066-0.0132] unit decrease	0.0099	EFO_0004784
ENSG00000155561	rs150498874	7	135619608	T	Venous thromboembolism adjusted for sickle cell variant rs77121243-T	28203683	[2.28-6.534]	3.86	EFO_0004286
ENSG00000155561	rs4294134	7	135608380	G	Paget's disease	21623375	[1.29-1.63]	1.45	EFO_0004261
ENSG00000155561	rs12530805	7	135594043	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000155561	rs4728358	7	135565522	?	Waist-hip ratio	30595370			EFO_0004343

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000155561	NUP205	100	93.244	ENSMUSG00000038759	Nup205	100	93.244	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	9348540.25210169.26878725.	IPI	Function
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005643	nuclear pore	12802065.15229283.	IDA	Component
GO:0005643	nuclear pore	9348540.	NAS	Component
GO:0006110	regulation of glycolytic process	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0006913	nucleocytoplasmic transport	9348540.	TAS	Process
GO:0006999	nuclear pore organization	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	TAS	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0017056	structural constituent of nuclear pore	21873635.	IBA	Function
GO:0017056	structural constituent of nuclear pore	15229283.	IMP	Function
GO:0019083	viral transcription	-	TAS	Process
GO:0031965	nuclear membrane	15229283.	IDA	Component
GO:0034399	nuclear periphery	15229283.	IDA	Component
GO:0043657	host cell	-	IEA	Component
GO:0044611	nuclear pore inner ring	21873635.	IBA	Component
GO:0051292	nuclear pore complex assembly	15229283.	IMP	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process