EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000155827 (Gene tree)
Gene ID: 56254
Gene Symbol: RNF20
Alias: FLJ20382|FLJ11189|KAIA2779|BRE1A|hBRE1|BRE1
Full Name: ring finger protein 20
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 29,496 bases
Position: chr9:101,533,849-101,563,344
Accession: 10062
RBP type: non-canonical RBP
Summary: The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000479306	RNF20-205	387	-	ENSP00000419201	99 (aa)	-	C9JWJ4
ENST00000389120	RNF20-202	3940	XM_011518862	ENSP00000373772	975 (aa)	XP_011517164	Q5VTR2
ENST00000374819	RNF20-201	596	-	ENSP00000363952	181 (aa)	-	C9JXC9
ENST00000466817	RNF20-203	784	-	ENSP00000418924	145 (aa)	-	C9J0A5
ENST00000481046	RNF20-206	601	-	-	- (aa)	-	-
ENST00000478072	RNF20-204	609	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000155827's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000155827's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000155827	RNF20	99	42.007	FBgn0086694	Bre1	50	40.072	Drosophila_melanogaster
ENSG00000155827	RNF20	100	70.297	ENSG00000103549	RNF40	99	66.667	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	16307923.	IDA	Component
GO:0000209	protein polyubiquitination	19037095.	IDA	Process
GO:0002039	p53 binding	16337599.	IDA	Function
GO:0003682	chromatin binding	-	IEA	Function
GO:0003713	transcription coactivator activity	16337599.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	19575011.	IDA	Function
GO:0004842	ubiquitin-protein transferase activity	19037095.	IDA	Function
GO:0004842	ubiquitin-protein transferase activity	16307923.	IDA	Function
GO:0005515	protein binding	16307923.17500595.19037095.19214193.19410543.21329877.23275563.25416956.25640309.	IPI	Function
GO:0005634	nucleus	16307923.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	19037095.	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	18832071.	IMP	Process
GO:0006511	ubiquitin-dependent protein catabolic process	19037095.	IMP	Process
GO:0007346	regulation of mitotic cell cycle	19575011.	IMP	Process
GO:0010390	histone monoubiquitination	16307923.16337599.	IDA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0030336	negative regulation of cell migration	18832071.	IDA	Process
GO:0031062	positive regulation of histone methylation	-	IEA	Process
GO:0031625	ubiquitin protein ligase binding	16307923.	IPI	Function
GO:0033503	HULC complex	19410543.	IDA	Component
GO:0033523	histone H2B ubiquitination	16307923.16337599.	IDA	Process
GO:0042393	histone binding	16337599.	IDA	Function
GO:0045893	positive regulation of transcription, DNA-templated	16713563.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:1900364	negative regulation of mRNA polyadenylation	19575011.	IMP	Process
GO:2001168	positive regulation of histone H2B ubiquitination	19575011.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19037095	Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.	Mol Biol Cell	2009 Feb	Liu Z	doi: 10.1091/mbc.E08-09-0983
28157208	RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.	Cell Death Differ	2017 Apr	Tarcic O	doi: 10.1038/cdd.2016.126
26854224	RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer.	Cell Rep	2016 Feb 16	Tarcic O	doi: 10.1016/j.celrep.2016.01.020
22155569	Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.	Mol Cell Endocrinol	2012 Mar 5	Jskelinen T	doi: 10.1016/j.mce.2011.11.025
27798111	The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.	Hum Mol Genet	2016 Dec 15	Dickson KA	doi: 10.1093/hmg/ddw362.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr9	101540346	Silent	novel	L91L	0.08
BLCA	chr9	101540525	Nonsense_Mutation	novel	Y111*	0.5
BLCA	chr9	101540821	Silent	novel	F158F	0.36
BRCA	chr9	101540316	Silent	rs775041387	R81R	0.21
BRCA	chr9	101540339	Missense_Mutation	novel	S89L	0.09
BRCA	chr9	101552732	Missense_Mutation	NA	K627R	0.34
BRCA	chr9	101552169	Silent	novel	L479L	0.08
BRCA	chr9	101550783	Missense_Mutation	NA	E424K	0.12
BRCA	chr9	101552434	Missense_Mutation	NA	D528Y	0.16
BRCA	chr9	101552392	Missense_Mutation	NA	R514C	0.24
BRCA	chr9	101561144	Missense_Mutation	NA	Q855E	0.31
BRCA	chr9	101551702	Missense_Mutation	NA	H431Y	0.28
CESC	chr9	101552393	Missense_Mutation	rs201929039	R514H	0.36
CESC	chr9	101561096	Missense_Mutation	novel	E839K	0.27
CESC	chr9	101562339	Missense_Mutation	novel	R949C	0.26
COAD	chr9	101546964	Missense_Mutation	rs753765875	R298W	0.2
COAD	chr9	101546817	Splice_Region	NA		0.5
COAD	chr9	101560921	Missense_Mutation	rs769326539	R835C	0.26
COAD	chr9	101550616	Missense_Mutation	rs368721473	R368Q	0.38
COAD	chr9	101551771	Missense_Mutation	novel	M454V	0.57
COAD	chr9	101540834	Missense_Mutation	NA	A163T	0.27
COAD	chr9	101562340	Missense_Mutation	rs757082884	R949H	0.36
COAD	chr9	101552563	Nonsense_Mutation	rs142811207	R571*	0.15
COAD	chr9	101550616	Missense_Mutation	rs368721473	R368Q	0.37
COAD	chr9	101552557	Nonsense_Mutation	rs535787053	R569*	0.28
COAD	chr9	101547474	Missense_Mutation	rs761717076	R350W	0.13
COAD	chr9	101554107	Splice_Site	NA	X673_splice	0.32
COAD	chr9	101550681	Missense_Mutation	rs755745298	V390I	0.19
COAD	chr9	101550669	Missense_Mutation	novel	S386P	0.41
COAD	chr9	101540505	Missense_Mutation	NA	R105C	0.31
COAD	chr9	101546931	Nonsense_Mutation	rs759230038	R287*	0.29
ESCA	chr9	101547451	Missense_Mutation	rs779556011	R342H	0.35
ESCA	chr9	101552656	Nonsense_Mutation	novel	K602*	0.2
GBM	chr9	101547137	Missense_Mutation	novel	V299M	0.12
GBM	chr9	101540315	Missense_Mutation	NA	R81Q	0.24
GBM	chr9	101546900	Nonsense_Mutation	novel	W276*	0.41
GBM	chr9	101557510	Nonsense_Mutation	novel	E766*	0.19
GBM	chr9	101552249	Missense_Mutation	novel	S506F	0.3
HNSC	chr9	101552254	Missense_Mutation	novel	L508V	0.19
HNSC	chr9	101557512	Silent	novel	E766E	0.86
HNSC	chr9	101562262	Missense_Mutation	novel	P923L	0.33
HNSC	chr9	101540514	Missense_Mutation	novel	L108F	0.36
HNSC	chr9	101552669	Missense_Mutation	novel	S606C	0.18
HNSC	chr9	101557594	Nonsense_Mutation	novel	Q794*	0.18
HNSC	chr9	101540348	Missense_Mutation	novel	I92T	0.04
KIRC	chr9	101554078	Missense_Mutation	NA	M664I	0.38
KIRC	chr9	101547134	Splice_Region	novel		0.24
KIRP	chr9	101540286	Silent	rs150763272	E71E	0.56
KIRP	chr9	101547432	Missense_Mutation	novel	K336E	0.39
KIRP	chr9	101540256	Missense_Mutation	NA	M61I	0.63
LIHC	chr9	101561176	Silent	rs767788496	I865I	0.03
LIHC	chr9	101540942	Missense_Mutation	novel	V199L	0.38
LIHC	chr9	101540567	Silent	novel	K125K	0.09
LIHC	chr9	101552525	Missense_Mutation	rs750558519	N558S	0.17
LIHC	chr9	101552748	Missense_Mutation	NA	E632D	0.04
LIHC	chr9	101552748	Missense_Mutation	NA	E632D	0.27
LUAD	chr9	101554788	Missense_Mutation	rs778771772	R705Q	0.43
LUAD	chr9	101544784	Missense_Mutation	novel	E216Q	0.38
LUAD	chr9	101561912	Splice_Region	novel	E884E	0.46
LUAD	chr9	101561223	Missense_Mutation	NA	R881P	0.28
LUAD	chr9	101557561	Missense_Mutation	NA	E783Q	0.1
LUAD	chr9	101554062	Missense_Mutation	NA	D659V	0.06
LUAD	chr9	101557521	Missense_Mutation	NA	K769N	0.36
LUAD	chr9	101546848	Missense_Mutation	NA	T259I	0.22
LUAD	chr9	101551726	Frame_Shift_Ins	novel	*Q440Sfs14**	0.08
LUAD	chr9	101551761	Missense_Mutation	novel	K450N	0.26
LUAD	chr9	101552410	Silent	rs191603421	L520L	0.07
LUAD	chr9	101552385	Splice_Region	novel	T511T	0.24
LUAD	chr9	101540976	Splice_Site	NA	X210_splice	0.45
LUAD	chr9	101552454	Silent	rs146044886	A534A	0.09
LUAD	chr9	101557426	Missense_Mutation	novel	A738S	0.19
LUAD	chr9	101540877	Missense_Mutation	novel	R177L	0.15
LUAD	chr9	101562265	Missense_Mutation	NA	C924F	0.15
LUAD	chr9	101544880	Nonsense_Mutation	NA	Q248*	0.12
LUAD	chr9	101554767	Missense_Mutation	NA	E698V	0.19
LUSC	chr9	101562353	Silent	novel	R953R	0.1
LUSC	chr9	101562354	Nonsense_Mutation	novel	Q954*	0.1
LUSC	chr9	101544813	Silent	rs763268347	L225L	0.43
LUSC	chr9	101554029	Missense_Mutation	NA	D648V	0.47
LUSC	chr9	101535510	Silent	NA	G29G	0.5
LUSC	chr9	101561948	Silent	NA	T896T	0.82
LUSC	chr9	101554819	Silent	NA	Q715Q	0.3
LUSC	chr9	101561919	Missense_Mutation	NA	S887P	0.18
LUSC	chr9	101544774	Silent	novel	L212L	0.68
LUSC	chr9	101552617	Missense_Mutation	novel	E589K	0.11
LUSC	chr9	101550744	Missense_Mutation	novel	G411C	0.32
LUSC	chr9	101562340	Missense_Mutation	novel	R949L	0.21
OV	chr9	101562469	3'UTR	novel		0.23
OV	chr9	101544783	Silent	rs754351898	E215E	0.2
OV	chr9	101550607	Missense_Mutation	NA	V365G	0.16
OV	chr9	101540314	Nonsense_Mutation	NA	R81*	0.12
OV	chr9	101560863	Missense_Mutation	NA	N815K	0.38
OV	chr9	101547498	Missense_Mutation	NA	T358P	0.46
OV	chr9	101547444	Nonsense_Mutation	novel	Q340*	0.17
OV	chr9	101551692	Missense_Mutation	NA	E427D	0.13
PAAD	chr9	101540882	Missense_Mutation	novel	E179K	0.15
PRAD	chr9	101551815	Silent	novel	Q468Q	0.4
PRAD	chr9	101552232	Missense_Mutation	NA	K500N	0.06
PRAD	chr9	101550681	Missense_Mutation	rs755745298	V390I	0.38
PRAD	chr9	101552160	Missense_Mutation	novel	M476I	0.47
PRAD	chr9	101561102	Missense_Mutation	novel	A841T	0.38
READ	chr9	101552497	Missense_Mutation	NA	A549T	0.26
READ	chr9	101560807	Missense_Mutation	NA	A797T	0.17
READ	chr9	101561223	Missense_Mutation	rs776618752	R881Q	0.35
READ	chr9	101540315	Missense_Mutation	NA	R81Q	0.32
SKCM	chr9	101540504	Silent	novel	I104I	0.19
SKCM	chr9	101540290	Missense_Mutation	rs200595234	R73C	0.22
SKCM	chr9	101550657	Missense_Mutation	NA	R382C	0.41
SKCM	chr9	101546958	Silent	NA	L296L	0.41
SKCM	chr9	101535547	Missense_Mutation	novel	S42T	0.83
SKCM	chr9	101540956	Silent	NA	S203S	0.86
SKCM	chr9	101552707	Missense_Mutation	rs139776458	R619W	0.5
SKCM	chr9	101540555	Silent	rs757570520	L121L	0.33
SKCM	chr9	101550677	Silent	NA	F388F	0.06
SKCM	chr9	101544795	Silent	novel	Q219Q	0.26
SKCM	chr9	101557397	Missense_Mutation	novel	L728P	0.92
SKCM	chr9	101557597	Splice_Site	NA	X794_splice	0.24
SKCM	chr9	101550707	Silent	novel	L398L	0.32
SKCM	chr9	101535514	Missense_Mutation	NA	T31A	0.17
STAD	chr9	101550712	Missense_Mutation	NA	A400V	0.2
STAD	chr9	101550735	Missense_Mutation	novel	L408V	0.16
STAD	chr9	101562358	Missense_Mutation	NA	R955H	0.17
STAD	chr9	101535521	Missense_Mutation	novel	E33G	0.23
STAD	chr9	101554721	Missense_Mutation	NA	D683N	0.35
STAD	chr9	101557432	Missense_Mutation	novel	E740K	0.1
STAD	chr9	101550692	Silent	NA	N393N	0.09
STAD	chr9	101557414	Missense_Mutation	novel	V734I	0.2
STAD	chr9	101557403	Missense_Mutation	novel	S730F	0.17
STAD	chr9	101540265	Silent	NA	Q64Q	0.26
STAD	chr9	101552417	Missense_Mutation	novel	S522F	0.18
STAD	chr9	101562262	Missense_Mutation	novel	P923L	0.13
STAD	chr9	101546894	Silent	NA	L274L	0.13
STAD	chr9	101540497	Frame_Shift_Del	rs768858191	*N103Tfs87**	0.26
STAD	chr9	101540273	Missense_Mutation	NA	A67V	0.22
UCEC	chr9	101540357	Missense_Mutation	rs765010969	R95Q	0.34
UCEC	chr9	101552219	Missense_Mutation	NA	R496I	0.3
UCEC	chr9	101552687	Missense_Mutation	novel	K612T	0.33
UCEC	chr9	101562305	Silent	novel	C937C	0.44
UCEC	chr9	101563201	3'UTR	novel		0.46
UCEC	chr9	101552685	Missense_Mutation	NA	E611D	0.31
UCEC	chr9	101560839	Missense_Mutation	novel	E807D	0.09
UCEC	chr9	101562281	Missense_Mutation	NA	K929N	0.45
UCEC	chr9	101544837	Missense_Mutation	novel	Q233H	0.29
UCEC	chr9	101550614	Silent	NA	L367L	0.31
UCEC	chr9	101540628	Frame_Shift_Ins	NA	*G149Efs42**	0.39
UCEC	chr9	101547467	Missense_Mutation	novel	E347D	0.25
UCEC	chr9	101550658	Missense_Mutation	rs530650553	R382H	0.15
UCEC	chr9	101540290	Missense_Mutation	rs200595234	R73C	0.14
UCEC	chr9	101546853	Missense_Mutation	novel	E261K	0.05
UCEC	chr9	101554815	Frame_Shift_Ins	novel	*Q715Cfs13**	0.08
UCEC	chr9	101550783	Missense_Mutation	NA	E424K	0.06
UCEC	chr9	101550785	Frame_Shift_Ins	novel	*R425Lfs8**	0.06
UCEC	chr9	101535404	5'UTR	novel		0.31
UCEC	chr9	101554805	Frame_Shift_Ins	novel	*I711Tfs21**	0.1
UCEC	chr9	101540357	Missense_Mutation	rs765010969	R95Q	0.22
UCEC	chr9	101547467	Missense_Mutation	novel	E347D	0.23
UCEC	chr9	101561980	Missense_Mutation	novel	E907A	0.17
UCEC	chr9	101562564	3'UTR	novel		0.13
UCEC	chr9	101535427	Missense_Mutation	novel	S2P	0.37
UCEC	chr9	101540553	Missense_Mutation	NA	L121I	0.43
UCEC	chr9	101562299	Silent	novel	T935T	0.25
UCEC	chr9	101552557	Nonsense_Mutation	rs535787053	R569*	0.13
UCEC	chr9	101552162	Missense_Mutation	novel	R477H	0.41
UCEC	chr9	101544800	Missense_Mutation	novel	L221P	0.22
UCEC	chr9	101552563	Nonsense_Mutation	rs142811207	R571*	0.31
UCEC	chr9	101561087	Splice_Region	rs756590041		0.31
UCEC	chr9	101563239	3'UTR	novel		0.22
UCEC	chr9	101552212	Missense_Mutation	NA	V494I	0.22
UCEC	chr9	101544885	Missense_Mutation	novel	E249D	0.43
UCEC	chr9	101554053	Missense_Mutation	novel	E656G	0.33
UCEC	chr9	101562433	3'UTR	novel		0.52
UCEC	chr9	101540302	Missense_Mutation	novel	E77K	0.47
UCEC	chr9	101557549	Nonsense_Mutation	NA	E779*	0.29
UCEC	chr9	101561985	Missense_Mutation	rs772228228	L909M	0.2
UCEC	chr9	101561177	Missense_Mutation	rs78555934	V866M	0.41
UCEC	chr9	101562709	3'UTR	novel		0.5
UCEC	chr9	101552387	Missense_Mutation	novel	R512H	0.15
UCEC	chr9	101552617	Frame_Shift_Ins	novel	*E589Gfs13**	0.05
UCEC	chr9	101552619	Frame_Shift_Ins	novel	*R590Vfs22**	0.04
UCEC	chr9	101546853	Missense_Mutation	novel	E261K	0.22
UCEC	chr9	101563134	3'UTR	novel		0.44
UCEC	chr9	101540563	Missense_Mutation	novel	R124Q	0.53
UCEC	chr9	101562501	3'UTR	novel		0.46
UCEC	chr9	101563180	3'UTR	novel		0.5
UCEC	chr9	101544864	Missense_Mutation	novel	K242N	0.1
UCEC	chr9	101557514	Missense_Mutation	novel	R767H	0.36
UCEC	chr9	101540563	Missense_Mutation	novel	R124Q	0.4
UCEC	chr9	101561196	Missense_Mutation	novel	K872T	0.39
UCEC	chr9	101552722	Nonsense_Mutation	novel	E624*	0.06
UCEC	chr9	101540547	Missense_Mutation	novel	D119Y	0.33
UCEC	chr9	101544820	Missense_Mutation	NA	E228K	0.19
UCEC	chr9	101550711	Missense_Mutation	NA	A400T	0.27
UCEC	chr9	101552157	Silent	novel	E475E	0.04
UCEC	chr9	101562485	3'UTR	novel		0.15
UCEC	chr9	101540314	Nonsense_Mutation	NA	R81*	0.32
UCEC	chr9	101540234	Missense_Mutation	NA	K54T	0.44
UCEC	chr9	101554805	Frame_Shift_Ins	novel	*I711Tfs21**	0.09
UCEC	chr9	101540240	Missense_Mutation	novel	R56H	0.4
UCEC	chr9	101540506	Missense_Mutation	rs762616554	R105H	0.2
UCEC	chr9	101546878	Missense_Mutation	novel	S269Y	0.2
UCEC	chr9	101552162	Missense_Mutation	novel	R477H	0.2
UCEC	chr9	101552562	Silent	novel	E570E	0.24
UCEC	chr9	101561151	Missense_Mutation	novel	K857T	0.26
UCEC	chr9	101562670	3'UTR	novel		0.39
UCEC	chr9	101540289	Silent	novel	L72L	0.42
UCEC	chr9	101552161	Missense_Mutation	rs775924339	R477C	0.28
UCEC	chr9	101557549	Nonsense_Mutation	NA	E779*	0.27
UCEC	chr9	101561230	Missense_Mutation	NA	Q883H	0.25
UCEC	chr9	101562314	Silent	NA	V940V	0.14
UCEC	chr9	101552393	Missense_Mutation	rs201929039	R514H	0.39
UCEC	chr9	101540506	Missense_Mutation	rs762616554	R105H	0.36
UCEC	chr9	101554090	Missense_Mutation	novel	K668N	0.29
UCEC	chr9	101554741	Missense_Mutation	NA	K689N	0.48
UCEC	chr9	101544837	Missense_Mutation	novel	Q233H	0.39
UCEC	chr9	101562726	3'UTR	novel		0.25
UCS	chr9	101554087	Silent	rs147900751	E667E	0.31
UCS	chr9	101554703	Missense_Mutation	novel	L677I	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3725	0.11788
CHOL	DEL	0.4722	0.067545
LAML	DEL	0.0209	0.24147
LIHC	DEL	0.2622	0.12467
PRAD	AMP	0.0752	0.059049
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCS	DEL	0.6071	0.089783

Survival Analysis

Cancer	P-value	Q-value
ACC	0.00052	Kaplan-Meier Survival Analysis
PAAD	0.019	Kaplan-Meier Survival Analysis
PCPG	0.048	Kaplan-Meier Survival Analysis
BLCA	0.015	Kaplan-Meier Survival Analysis
LIHC	0.0081	Kaplan-Meier Survival Analysis
OV	0.039	Kaplan-Meier Survival Analysis