EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000156304 (Gene tree)
Gene ID: 57466
Gene Symbol: SCAF4
Alias: KIAA1172|DKFZp434E098|SRA4|SFRS15
Full Name: SR-related CTD associated factor 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 61,119 bases
Position: chr21:31,671,000-31,732,118
Accession: 19304
RBP type: canonical RBP
Summary: This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000402377	RRM_1	PF00076.22	9.8e-09	1	1
ENSP00000382703	RRM_1	PF00076.22	1.1e-08	1	1
ENSP00000286835	RRM_1	PF00076.22	1.1e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000286835	SCAF4-201	4193	XM_005261017	ENSP00000286835	1147 (aa)	XP_005261074	O95104
ENST00000399804	SCAF4-202	4127	XM_006724036	ENSP00000382703	1125 (aa)	XP_006724099	O95104
ENST00000472318	SCAF4-205	796	-	-	- (aa)	-	-
ENST00000485790	SCAF4-206	1282	-	-	- (aa)	-	-
ENST00000434667	SCAF4-203	3846	-	ENSP00000402377	1132 (aa)	-	O95104
ENST00000467731	SCAF4-204	2976	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000156304's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000156304	rs2833483	21	31703091	T	Educational attainment (MTAG)	30038396	[0.0099-0.0201] unit decrease	0.015	EFO_0004784
ENSG00000156304	rs59300999	21	31700050	T	Educational attainment (years of education)	30038396	[0.011-0.022] unit decrease	0.0164	EFO_0004784
ENSG00000156304	rs1544	21	31713272	A	Educational attainment (years of education)	30038396	[0.0065-0.0127] unit decrease	0.0096	EFO_0004784
ENSG00000156304	rs17660708	21	31687518	T	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.044	EFO_0004611
ENSG00000156304	rs17660708	21	31687518	T	Total cholesterol levels	29507422	unit decrease	0.037	EFO_0004574

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000156304's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000156304	SCAF4	79	54.973	ENSAPOG00000002946	scaf4a	55	57.251	Acanthochromis_polyacanthus
ENSG00000156304	SCAF4	73	93.381	ENSAMEG00000014987	SCAF4	96	94.224	Ailuropoda_melanoleuca
ENSG00000156304	SCAF4	69	57.031	ENSAOCG00000000615	scaf4a	55	58.761	Amphiprion_ocellaris
ENSG00000156304	SCAF4	69	57.031	ENSAPEG00000021229	scaf4a	55	58.610	Amphiprion_percula
ENSG00000156304	SCAF4	99	75.413	ENSAPLG00000002509	SCAF4	59	83.308	Anas_platyrhynchos
ENSG00000156304	SCAF4	96	69.161	ENSACAG00000002569	SCAF4	52	84.146	Anolis_carolinensis
ENSG00000156304	SCAF4	100	98.433	ENSANAG00000037494	SCAF4	100	98.433	Aotus_nancymaae
ENSG00000156304	SCAF4	93	50.821	ENSAMXG00000008585	scaf4a	60	63.102	Astyanax_mexicanus
ENSG00000156304	SCAF4	100	92.515	ENSBTAG00000018855	SCAF4	100	92.254	Bos_taurus
ENSG00000156304	SCAF4	100	98.348	ENSCJAG00000008993	SCAF4	100	98.348	Callithrix_jacchus
ENSG00000156304	SCAF4	99	94.732	ENSCAFG00000008863	SCAF4	99	94.732	Canis_familiaris
ENSG00000156304	SCAF4	99	91.262	ENSCAFG00020026019	SCAF4	100	94.187	Canis_lupus_dingo
ENSG00000156304	SCAF4	100	91.934	ENSCHIG00000008385	SCAF4	100	91.847	Capra_hircus
ENSG00000156304	SCAF4	91	96.141	ENSTSYG00000011344	SCAF4	99	96.141	Carlito_syrichta
ENSG00000156304	SCAF4	100	91.388	ENSCPOG00000012443	SCAF4	100	91.652	Cavia_porcellus
ENSG00000156304	SCAF4	100	98.518	ENSCCAG00000033727	SCAF4	100	98.518	Cebus_capucinus
ENSG00000156304	SCAF4	100	98.094	ENSCATG00000030379	SCAF4	100	98.094	Cercocebus_atys
ENSG00000156304	SCAF4	99	90.712	ENSCLAG00000006298	SCAF4	100	91.927	Chinchilla_lanigera
ENSG00000156304	SCAF4	100	98.523	ENSCSAG00000009438	SCAF4	100	98.523	Chlorocebus_sabaeus
ENSG00000156304	SCAF4	100	98.780	ENSCANG00000029847	SCAF4	100	98.780	Colobus_angolensis_palliatus
ENSG00000156304	SCAF4	99	83.099	ENSCGRG00001020821	Scaf4	100	82.850	Cricetulus_griseus_chok1gshd
ENSG00000156304	SCAF4	99	82.876	ENSCGRG00000014360	Scaf4	99	85.783	Cricetulus_griseus_crigri
ENSG00000156304	SCAF4	79	53.587	ENSCSEG00000019549	scaf4a	53	54.697	Cynoglossus_semilaevis
ENSG00000156304	SCAF4	58	56.849	ENSCSEG00000012808	-	55	68.354	Cynoglossus_semilaevis
ENSG00000156304	SCAF4	100	90.410	ENSDNOG00000019014	SCAF4	94	90.497	Dasypus_novemcinctus
ENSG00000156304	SCAF4	92	97.436	ENSETEG00000000583	SCAF4	94	97.436	Echinops_telfairi
ENSG00000156304	SCAF4	100	93.723	ENSEASG00005007756	SCAF4	100	93.897	Equus_asinus_asinus
ENSG00000156304	SCAF4	100	94.071	ENSECAG00000014248	SCAF4	100	93.984	Equus_caballus
ENSG00000156304	SCAF4	58	52.703	ENSELUG00000002779	SCAF8	61	68.116	Esox_lucius
ENSG00000156304	SCAF4	100	94.118	ENSFCAG00000002228	SCAF4	100	94.118	Felis_catus
ENSG00000156304	SCAF4	99	89.741	ENSFDAG00000017780	SCAF4	100	89.569	Fukomys_damarensis
ENSG00000156304	SCAF4	59	58.696	ENSFHEG00000007634	scaf4b	55	71.519	Fundulus_heteroclitus
ENSG00000156304	SCAF4	100	76.537	ENSGALG00000033965	SCAF4	59	83.537	Gallus_gallus
ENSG00000156304	SCAF4	70	55.270	ENSGACG00000020580	scaf4a	54	70.122	Gasterosteus_aculeatus
ENSG00000156304	SCAF4	93	96.556	ENSGGOG00000015557	SCAF4	100	100.000	Gorilla_gorilla
ENSG00000156304	SCAF4	100	90.870	ENSHGLG00000010582	SCAF4	100	91.559	Heterocephalus_glaber_female
ENSG00000156304	SCAF4	99	90.759	ENSHGLG00100009441	SCAF4	100	91.456	Heterocephalus_glaber_male
ENSG00000156304	SCAF4	69	49.770	ENSIPUG00000011285	scaf4	63	63.514	Ictalurus_punctatus
ENSG00000156304	SCAF4	53	53.333	ENSIPUG00000019311	-	57	66.901	Ictalurus_punctatus
ENSG00000156304	SCAF4	99	87.811	ENSSTOG00000004450	SCAF4	100	88.167	Ictidomys_tridecemlineatus
ENSG00000156304	SCAF4	99	88.938	ENSJJAG00000019447	Scaf4	99	89.464	Jaculus_jaculus
ENSG00000156304	SCAF4	60	57.971	ENSKMAG00000005742	scaf4b	54	73.885	Kryptolebias_marmoratus
ENSG00000156304	SCAF4	98	60.351	ENSLACG00000013913	SCAF4	59	69.749	Latimeria_chalumnae
ENSG00000156304	SCAF4	95	57.988	ENSLOCG00000009162	scaf4a	59	67.953	Lepisosteus_oculatus
ENSG00000156304	SCAF4	99	92.935	ENSLAFG00000010710	SCAF4	100	92.032	Loxodonta_africana
ENSG00000156304	SCAF4	100	98.268	ENSMFAG00000037668	SCAF4	100	98.268	Macaca_fascicularis
ENSG00000156304	SCAF4	100	98.182	ENSMMUG00000001712	SCAF4	100	98.182	Macaca_mulatta
ENSG00000156304	SCAF4	100	98.097	ENSMNEG00000032966	SCAF4	100	98.097	Macaca_nemestrina
ENSG00000156304	SCAF4	99	98.338	ENSMLEG00000039674	SCAF4	100	98.338	Mandrillus_leucophaeus
ENSG00000156304	SCAF4	99	76.281	ENSMGAG00000014515	SCAF4	59	83.462	Meleagris_gallopavo
ENSG00000156304	SCAF4	99	88.370	ENSMAUG00000013307	Scaf4	100	88.811	Mesocricetus_auratus
ENSG00000156304	SCAF4	100	96.949	ENSMICG00000005256	SCAF4	100	96.949	Microcebus_murinus
ENSG00000156304	SCAF4	100	85.702	ENSMOCG00000012087	Scaf4	95	92.218	Microtus_ochrogaster
ENSG00000156304	SCAF4	100	84.609	ENSMODG00000021040	SCAF4	100	83.739	Monodelphis_domestica
ENSG00000156304	SCAF4	100	83.510	MGP_CAROLIEiJ_G0020944	Scaf4	95	90.464	Mus_caroli
ENSG00000156304	SCAF4	100	83.470	ENSMUSG00000022983	Scaf4	95	89.909	Mus_musculus
ENSG00000156304	SCAF4	100	82.792	MGP_PahariEiJ_G0016649	Scaf4	100	86.667	Mus_pahari
ENSG00000156304	SCAF4	100	84.319	MGP_SPRETEiJ_G0021850	Scaf4	100	86.091	Mus_spretus
ENSG00000156304	SCAF4	100	92.641	ENSMPUG00000001078	SCAF4	100	92.554	Mustela_putorius_furo
ENSG00000156304	SCAF4	99	77.639	ENSMLUG00000011472	SCAF4	79	83.424	Myotis_lucifugus
ENSG00000156304	SCAF4	99	91.579	ENSNGAG00000005214	Scaf4	99	91.339	Nannospalax_galili
ENSG00000156304	SCAF4	100	99.303	ENSNLEG00000003569	SCAF4	100	99.303	Nomascus_leucogenys
ENSG00000156304	SCAF4	78	90.761	ENSOPRG00000007016	SCAF4	77	90.217	Ochotona_princeps
ENSG00000156304	SCAF4	100	89.316	ENSODEG00000002718	SCAF4	100	89.060	Octodon_degus
ENSG00000156304	SCAF4	71	59.690	ENSONIG00000004687	scaf4a	51	73.780	Oreochromis_niloticus
ENSG00000156304	SCAF4	100	90.829	ENSOCUG00000008336	SCAF4	100	90.917	Oryctolagus_cuniculus
ENSG00000156304	SCAF4	53	57.480	ENSORLG00000003420	scaf4b	67	58.650	Oryzias_latipes
ENSG00000156304	SCAF4	99	89.583	ENSOGAG00000014653	SCAF4	94	95.586	Otolemur_garnettii
ENSG00000156304	SCAF4	99	91.339	ENSOARG00000013894	SCAF4	99	90.964	Ovis_aries
ENSG00000156304	SCAF4	100	100.000	ENSPPAG00000028535	SCAF4	100	100.000	Pan_paniscus
ENSG00000156304	SCAF4	99	94.143	ENSPPRG00000000635	SCAF4	100	94.143	Panthera_pardus
ENSG00000156304	SCAF4	99	91.029	ENSPTIG00000021578	SCAF4	99	88.869	Panthera_tigris_altaica
ENSG00000156304	SCAF4	100	100.000	ENSPTRG00000013848	SCAF4	100	100.000	Pan_troglodytes
ENSG00000156304	SCAF4	100	98.268	ENSPANG00000017332	SCAF4	100	98.268	Papio_anubis
ENSG00000156304	SCAF4	66	64.512	ENSPKIG00000022408	scaf4a	90	66.966	Paramormyrops_kingsleyae
ENSG00000156304	SCAF4	99	77.145	ENSPSIG00000014242	SCAF4	57	84.520	Pelodiscus_sinensis
ENSG00000156304	SCAF4	66	61.011	ENSPMGG00000016741	scaf4a	54	61.429	Periophthalmus_magnuspinnatus
ENSG00000156304	SCAF4	99	84.664	ENSPCIG00000028183	SCAF4	91	83.498	Phascolarctos_cinereus
ENSG00000156304	SCAF4	100	99.477	ENSPPYG00000011355	SCAF4	100	99.477	Pongo_abelii
ENSG00000156304	SCAF4	100	95.917	ENSPCOG00000018710	SCAF4	100	96.177	Propithecus_coquereli
ENSG00000156304	SCAF4	100	92.677	ENSPVAG00000005220	SCAF4	100	92.851	Pteropus_vampyrus
ENSG00000156304	SCAF4	76	58.708	ENSPNAG00000016892	scaf4a	60	63.922	Pygocentrus_nattereri
ENSG00000156304	SCAF4	98	86.997	ENSRNOG00000002104	Scaf4	95	86.923	Rattus_norvegicus
ENSG00000156304	SCAF4	99	96.053	ENSRBIG00000040007	SCAF4	99	96.053	Rhinopithecus_bieti
ENSG00000156304	SCAF4	100	98.867	ENSRROG00000029488	SCAF4	100	98.867	Rhinopithecus_roxellana
ENSG00000156304	SCAF4	100	84.059	ENSSHAG00000001581	SCAF4	100	82.927	Sarcophilus_harrisii
ENSG00000156304	SCAF4	89	47.267	ENSSFOG00015006338	scaf4a	54	58.226	Scleropages_formosus
ENSG00000156304	SCAF4	65	58.423	ENSSMAG00000003738	scaf4b	54	71.519	Scophthalmus_maximus
ENSG00000156304	SCAF4	57	61.290	ENSSDUG00000012380	scaf4b	54	70.886	Seriola_dumerili
ENSG00000156304	SCAF4	57	61.290	ENSSLDG00000023152	-	54	70.886	Seriola_lalandi_dorsalis
ENSG00000156304	SCAF4	100	89.004	ENSSARG00000009994	SCAF4	100	89.177	Sorex_araneus
ENSG00000156304	SCAF4	100	92.436	ENSSSCG00000021023	SCAF4	100	92.700	Sus_scrofa
ENSG00000156304	SCAF4	74	72.570	ENSTGUG00000013464	SCAF4	57	86.047	Taeniopygia_guttata
ENSG00000156304	SCAF4	51	58.451	ENSTRUG00000009536	-	65	57.818	Takifugu_rubripes
ENSG00000156304	SCAF4	99	92.524	ENSTTRG00000010963	SCAF4	100	92.172	Tursiops_truncatus
ENSG00000156304	SCAF4	100	94.587	ENSUAMG00000008860	SCAF4	100	94.587	Ursus_americanus
ENSG00000156304	SCAF4	99	91.174	ENSUMAG00000016962	SCAF4	100	91.792	Ursus_maritimus
ENSG00000156304	SCAF4	99	94.797	ENSVVUG00000002953	SCAF4	100	94.797	Vulpes_vulpes
ENSG00000156304	SCAF4	99	56.585	ENSXETG00000007351	scaf4	63	66.619	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005654	nucleoplasm	-	IDA	Component