EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000156414 (Gene tree)
Gene ID: 122402
Gene Symbol: TDRD9
Alias: DKFZp434N0820|FLJ36164|NET54|C14orf75
Full Name: tudor domain containing 9
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 124,230 bases
Position: chr14:103,928,438-104,052,667
Accession: 20122
RBP type: canonical RBP
Summary: (Tudor Domain Containing 9) is a Protein Coding gene. Diseases associated with TDRD9 include Spermatogenic Failure 30. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX9.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000343545	TUDOR	PF00567.24	3e-14	1	1
ENSP00000451637	TUDOR	PF00567.24	3.1e-14	1	1
ENSP00000387303	TUDOR	PF00567.24	4.6e-14	1	1
ENSP00000387303	DEAD	PF00270.29	2.2e-08	1	1
ENSP00000343545	HA2	PF04408.23	2.7e-13	1	1
ENSP00000451637	HA2	PF04408.23	2.8e-13	1	1
ENSP00000387303	HA2	PF04408.23	4.5e-13	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409874	TDRD9-202	4782	XM_005267309	ENSP00000387303	1382 (aa)	XP_005267366	Q8NDG6
ENST00000554571	TDRD9-207	637	-	-	- (aa)	-	-
ENST00000462273	TDRD9-203	948	-	-	- (aa)	-	-
ENST00000339063	TDRD9-201	3447	-	ENSP00000343545	877 (aa)	-	A0A0C4DFS5
ENST00000557332	TDRD9-208	3338	XM_017020955	ENSP00000451637	918 (aa)	XP_016876444	H0YJJ2
ENST00000466378	TDRD9-204	565	-	-	- (aa)	-	-
ENST00000481318	TDRD9-205	630	-	-	- (aa)	-	-
ENST00000496087	TDRD9-206	581	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000156414's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000156414	Blood Pressure	2.5347984E-005	-
ENSG00000156414	Arterial Pressure	4.7969713E-005	-
ENSG00000156414	Bipolar Disorder	8E-6	17554300
ENSG00000156414	Bipolar Disorder	2E-6	21254220

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000156414	rs35337422	14	103940906	A	Spherical equivalent	29808027	[0.086-0.178] unit increase	0.1322	EFO_0007814
ENSG00000156414	rs35337422	14	103940906	A	Spherical equivalent or myopia (age of diagnosis)	29808027	[NR] z score increase	6.347	EFO_0004847\|HP_0000545\|EFO_0007814
ENSG00000156414	rs11622475	14	104042739	?	Bipolar disorder	21254220			EFO_0000289
ENSG00000156414	rs11622475	14	104042739	C	Bipolar disorder	17554300	[0.89-1.44]	1.13	EFO_0000289

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000156414's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000156414	TDRD9	99	55.596	ENSAPOG00000015220	tdrd9	97	54.783	Acanthochromis_polyacanthus
ENSG00000156414	TDRD9	99	90.488	ENSAMEG00000018095	TDRD9	100	87.734	Ailuropoda_melanoleuca
ENSG00000156414	TDRD9	99	49.376	ENSACIG00000024299	tdrd9	98	52.377	Amphilophus_citrinellus
ENSG00000156414	TDRD9	99	52.381	ENSAOCG00000007386	tdrd9	99	53.543	Amphiprion_ocellaris
ENSG00000156414	TDRD9	99	52.857	ENSAPEG00000023023	tdrd9	97	53.555	Amphiprion_percula
ENSG00000156414	TDRD9	99	55.231	ENSATEG00000015827	tdrd9	97	55.529	Anabas_testudineus
ENSG00000156414	TDRD9	99	67.399	ENSAPLG00000007429	TDRD9	99	65.628	Anas_platyrhynchos
ENSG00000156414	TDRD9	99	69.353	ENSACAG00000010862	TDRD9	100	64.595	Anolis_carolinensis
ENSG00000156414	TDRD9	99	94.731	ENSANAG00000020949	TDRD9	100	92.414	Aotus_nancymaae
ENSG00000156414	TDRD9	99	52.848	ENSACLG00000020660	tdrd9	94	53.925	Astatotilapia_calliptera
ENSG00000156414	TDRD9	99	57.767	ENSAMXG00000021360	tdrd9	93	56.500	Astyanax_mexicanus
ENSG00000156414	TDRD9	99	87.424	ENSBTAG00000020402	TDRD9	100	82.200	Bos_taurus
ENSG00000156414	TDRD9	98	94.774	ENSCJAG00000017235	TDRD9	99	92.513	Callithrix_jacchus
ENSG00000156414	TDRD9	99	91.453	ENSCAFG00000018311	TDRD9	100	90.446	Canis_familiaris
ENSG00000156414	TDRD9	99	91.453	ENSCAFG00020008631	TDRD9	99	89.752	Canis_lupus_dingo
ENSG00000156414	TDRD9	99	86.735	ENSCHIG00000011541	TDRD9	100	84.226	Capra_hircus
ENSG00000156414	TDRD9	100	92.588	ENSTSYG00000003253	TDRD9	100	92.588	Carlito_syrichta
ENSG00000156414	TDRD9	99	80.412	ENSCAPG00000009518	TDRD9	99	77.633	Cavia_aperea
ENSG00000156414	TDRD9	99	88.278	ENSCPOG00000002760	TDRD9	99	85.072	Cavia_porcellus
ENSG00000156414	TDRD9	99	95.971	ENSCCAG00000022528	TDRD9	100	94.718	Cebus_capucinus
ENSG00000156414	TDRD9	100	97.612	ENSCATG00000032905	TDRD9	100	97.612	Cercocebus_atys
ENSG00000156414	TDRD9	99	86.827	ENSCLAG00000006616	TDRD9	99	84.855	Chinchilla_lanigera
ENSG00000156414	TDRD9	100	97.540	ENSCSAG00000009835	TDRD9	100	97.540	Chlorocebus_sabaeus
ENSG00000156414	TDRD9	86	70.414	ENSCHOG00000002226	-	90	81.250	Choloepus_hoffmanni
ENSG00000156414	TDRD9	88	73.756	ENSCPBG00000020203	TDRD9	95	84.615	Chrysemys_picta_bellii
ENSG00000156414	TDRD9	99	36.434	ENSCING00000019779	-	99	38.569	Ciona_intestinalis
ENSG00000156414	TDRD9	99	37.108	ENSCSAVG00000002146	-	100	39.086	Ciona_savignyi
ENSG00000156414	TDRD9	99	97.959	ENSCANG00000031870	TDRD9	100	97.176	Colobus_angolensis_palliatus
ENSG00000156414	TDRD9	99	89.744	ENSCGRG00001023336	Tdrd9	99	86.850	Cricetulus_griseus_chok1gshd
ENSG00000156414	TDRD9	99	89.744	ENSCGRG00000004013	Tdrd9	99	86.850	Cricetulus_griseus_crigri
ENSG00000156414	TDRD9	99	54.988	ENSCSEG00000001411	tdrd9	97	54.538	Cynoglossus_semilaevis
ENSG00000156414	TDRD9	99	46.909	ENSCVAG00000007427	tdrd9	99	48.186	Cyprinodon_variegatus
ENSG00000156414	TDRD9	99	56.813	ENSDARG00000013453	tdrd9	99	53.094	Danio_rerio
ENSG00000156414	TDRD9	99	89.390	ENSDORG00000015167	Tdrd9	99	84.237	Dipodomys_ordii
ENSG00000156414	TDRD9	93	31.707	FBgn0003483	spn-E	86	33.750	Drosophila_melanogaster
ENSG00000156414	TDRD9	92	83.871	ENSETEG00000015130	TDRD9	93	83.871	Echinops_telfairi
ENSG00000156414	TDRD9	99	45.085	ENSEBUG00000010711	tdrd9	92	46.204	Eptatretus_burgeri
ENSG00000156414	TDRD9	99	90.493	ENSEASG00005004203	TDRD9	100	88.061	Equus_asinus_asinus
ENSG00000156414	TDRD9	99	90.149	ENSECAG00000023843	TDRD9	100	87.844	Equus_caballus
ENSG00000156414	TDRD9	73	67.143	ENSEEUG00000003134	-	84	67.143	Erinaceus_europaeus
ENSG00000156414	TDRD9	99	58.202	ENSELUG00000010798	tdrd9	97	57.841	Esox_lucius
ENSG00000156414	TDRD9	99	89.377	ENSFCAG00000013807	TDRD9	99	87.246	Felis_catus
ENSG00000156414	TDRD9	99	62.637	ENSFALG00000002911	TDRD9	99	60.575	Ficedula_albicollis
ENSG00000156414	TDRD9	99	85.911	ENSFDAG00000004582	TDRD9	99	83.768	Fukomys_damarensis
ENSG00000156414	TDRD9	95	54.545	ENSFHEG00000008883	tdrd9	96	59.732	Fundulus_heteroclitus
ENSG00000156414	TDRD9	99	51.401	ENSGMOG00000010725	tdrd9	100	50.335	Gadus_morhua
ENSG00000156414	TDRD9	98	60.620	ENSGALG00000011565	TDRD9	99	60.690	Gallus_gallus
ENSG00000156414	TDRD9	99	54.126	ENSGACG00000008322	tdrd9	100	65.538	Gasterosteus_aculeatus
ENSG00000156414	TDRD9	100	98.770	ENSGGOG00000000812	TDRD9	100	98.770	Gorilla_gorilla
ENSG00000156414	TDRD9	73	51.042	ENSHBUG00000022779	tdrd9	100	49.427	Haplochromis_burtoni
ENSG00000156414	TDRD9	99	86.691	ENSHGLG00000007727	TDRD9	99	83.551	Heterocephalus_glaber_female
ENSG00000156414	TDRD9	99	86.691	ENSHGLG00100019237	TDRD9	99	83.551	Heterocephalus_glaber_male
ENSG00000156414	TDRD9	98	53.202	ENSHCOG00000020886	tdrd9	100	50.226	Hippocampus_comes
ENSG00000156414	TDRD9	99	53.602	ENSIPUG00000002814	tdrd9	97	50.724	Ictalurus_punctatus
ENSG00000156414	TDRD9	99	91.697	ENSSTOG00000007890	TDRD9	99	89.265	Ictidomys_tridecemlineatus
ENSG00000156414	TDRD9	99	88.889	ENSJJAG00000022462	Tdrd9	99	85.673	Jaculus_jaculus
ENSG00000156414	TDRD9	99	53.528	ENSKMAG00000005523	tdrd9	99	53.583	Kryptolebias_marmoratus
ENSG00000156414	TDRD9	99	55.164	ENSLBEG00000022006	tdrd9	96	55.328	Labrus_bergylta
ENSG00000156414	TDRD9	99	64.242	ENSLACG00000002257	TDRD9	100	62.441	Latimeria_chalumnae
ENSG00000156414	TDRD9	99	57.818	ENSLOCG00000009992	tdrd9	99	58.088	Lepisosteus_oculatus
ENSG00000156414	TDRD9	99	88.927	ENSLAFG00000007580	TDRD9	100	91.136	Loxodonta_africana
ENSG00000156414	TDRD9	100	97.948	ENSMFAG00000001293	TDRD9	100	97.948	Macaca_fascicularis
ENSG00000156414	TDRD9	100	97.540	ENSMMUG00000006243	TDRD9	100	97.938	Macaca_mulatta
ENSG00000156414	TDRD9	100	97.902	ENSMNEG00000044098	TDRD9	100	97.902	Macaca_nemestrina
ENSG00000156414	TDRD9	99	97.959	ENSMLEG00000032473	TDRD9	100	97.786	Mandrillus_leucophaeus
ENSG00000156414	TDRD9	99	55.420	ENSMAMG00000002068	tdrd9	96	54.137	Mastacembelus_armatus
ENSG00000156414	TDRD9	99	55.623	ENSMZEG00005007746	tdrd9	94	55.721	Maylandia_zebra
ENSG00000156414	TDRD9	99	67.153	ENSMGAG00000013431	TDRD9	99	65.032	Meleagris_gallopavo
ENSG00000156414	TDRD9	89	88.843	ENSMAUG00000020617	Tdrd9	99	78.051	Mesocricetus_auratus
ENSG00000156414	TDRD9	99	93.356	ENSMICG00000000428	TDRD9	100	91.317	Microcebus_murinus
ENSG00000156414	TDRD9	99	89.133	ENSMOCG00000017012	Tdrd9	99	86.633	Microtus_ochrogaster
ENSG00000156414	TDRD9	99	52.657	ENSMMOG00000013849	tdrd9	97	52.636	Mola_mola
ENSG00000156414	TDRD9	73	84.211	ENSMODG00000013609	TDRD9	100	84.517	Monodelphis_domestica
ENSG00000156414	TDRD9	99	54.435	ENSMALG00000008927	tdrd9	100	51.007	Monopterus_albus
ENSG00000156414	TDRD9	99	88.767	MGP_CAROLIEiJ_G0018145	Tdrd9	98	90.892	Mus_caroli
ENSG00000156414	TDRD9	99	87.973	ENSMUSG00000054003	Tdrd9	97	91.651	Mus_musculus
ENSG00000156414	TDRD9	99	87.629	MGP_PahariEiJ_G0029902	Tdrd9	98	91.271	Mus_pahari
ENSG00000156414	TDRD9	99	87.973	MGP_SPRETEiJ_G0018994	Tdrd9	98	91.461	Mus_spretus
ENSG00000156414	TDRD9	99	89.744	ENSMPUG00000002286	TDRD9	100	88.899	Mustela_putorius_furo
ENSG00000156414	TDRD9	99	85.567	ENSMLUG00000011984	TDRD9	99	83.993	Myotis_lucifugus
ENSG00000156414	TDRD9	99	87.171	ENSNGAG00000021858	Tdrd9	99	85.072	Nannospalax_galili
ENSG00000156414	TDRD9	99	53.892	ENSNBRG00000008735	tdrd9	100	54.567	Neolamprologus_brichardi
ENSG00000156414	TDRD9	100	97.188	ENSNLEG00000016251	TDRD9	100	97.188	Nomascus_leucogenys
ENSG00000156414	TDRD9	99	72.185	ENSMEUG00000014017	-	100	72.185	Notamacropus_eugenii
ENSG00000156414	TDRD9	55	90.984	ENSOPRG00000002510	-	61	90.984	Ochotona_princeps
ENSG00000156414	TDRD9	99	85.714	ENSODEG00000002255	TDRD9	99	82.899	Octodon_degus
ENSG00000156414	TDRD9	99	56.227	ENSONIG00000020126	tdrd9	100	52.903	Oreochromis_niloticus
ENSG00000156414	TDRD9	99	71.886	ENSOANG00000000797	TDRD9	99	71.415	Ornithorhynchus_anatinus
ENSG00000156414	TDRD9	99	86.326	ENSOCUG00000014788	TDRD9	98	85.649	Oryctolagus_cuniculus
ENSG00000156414	TDRD9	97	49.013	ENSORLG00000015842	tdrd9	98	49.184	Oryzias_latipes
ENSG00000156414	TDRD9	97	50.875	ENSORLG00020009475	tdrd9	99	51.378	Oryzias_latipes_hni
ENSG00000156414	TDRD9	92	50.123	ENSORLG00015008417	tdrd9	97	47.797	Oryzias_latipes_hsok
ENSG00000156414	TDRD9	99	52.862	ENSOMEG00000006369	tdrd9	95	52.876	Oryzias_melastigma
ENSG00000156414	TDRD9	99	90.149	ENSOGAG00000007626	TDRD9	100	87.840	Otolemur_garnettii
ENSG00000156414	TDRD9	99	86.254	ENSOARG00000006675	TDRD9	96	85.681	Ovis_aries
ENSG00000156414	TDRD9	99	99.427	ENSPPAG00000027180	TDRD9	100	99.466	Pan_paniscus
ENSG00000156414	TDRD9	99	89.133	ENSPPRG00000021286	TDRD9	99	87.101	Panthera_pardus
ENSG00000156414	TDRD9	95	87.871	ENSPTIG00000017411	TDRD9	96	84.798	Panthera_tigris_altaica
ENSG00000156414	TDRD9	100	99.349	ENSPTRG00000006765	TDRD9	100	99.349	Pan_troglodytes
ENSG00000156414	TDRD9	99	97.959	ENSPANG00000004811	TDRD9	99	95.028	Papio_anubis
ENSG00000156414	TDRD9	99	54.134	ENSPKIG00000017763	tdrd9	94	55.257	Paramormyrops_kingsleyae
ENSG00000156414	TDRD9	99	75.457	ENSPSIG00000010466	TDRD9	99	75.568	Pelodiscus_sinensis
ENSG00000156414	TDRD9	99	49.582	ENSPMGG00000010265	tdrd9	97	53.183	Periophthalmus_magnuspinnatus
ENSG00000156414	TDRD9	99	89.988	ENSPEMG00000012496	Tdrd9	99	87.572	Peromyscus_maniculatus_bairdii
ENSG00000156414	TDRD9	76	79.466	ENSPCIG00000016427	TDRD9	99	79.640	Phascolarctos_cinereus
ENSG00000156414	TDRD9	99	52.179	ENSPFOG00000002400	tdrd9	99	52.433	Poecilia_formosa
ENSG00000156414	TDRD9	99	52.317	ENSPLAG00000005202	tdrd9	99	51.580	Poecilia_latipinna
ENSG00000156414	TDRD9	99	52.317	ENSPMEG00000017922	tdrd9	99	51.494	Poecilia_mexicana
ENSG00000156414	TDRD9	97	48.066	ENSPREG00000015184	tdrd9	100	48.066	Poecilia_reticulata
ENSG00000156414	TDRD9	99	98.344	ENSPPYG00000006180	-	100	98.344	Pongo_abelii
ENSG00000156414	TDRD9	85	83.562	ENSPCAG00000015416	-	91	83.562	Procavia_capensis
ENSG00000156414	TDRD9	99	91.867	ENSPCOG00000015323	TDRD9	100	91.959	Propithecus_coquereli
ENSG00000156414	TDRD9	84	87.500	ENSPVAG00000011551	-	89	87.500	Pteropus_vampyrus
ENSG00000156414	TDRD9	99	54.096	ENSPNYG00000022319	tdrd9	99	53.774	Pundamilia_nyererei
ENSG00000156414	TDRD9	99	56.796	ENSPNAG00000010714	tdrd9	99	53.266	Pygocentrus_nattereri
ENSG00000156414	TDRD9	99	87.973	ENSRNOG00000053631	Tdrd9	99	85.890	Rattus_norvegicus
ENSG00000156414	TDRD9	99	96.939	ENSRBIG00000040614	TDRD9	99	95.028	Rhinopithecus_bieti
ENSG00000156414	TDRD9	100	96.961	ENSRROG00000037241	TDRD9	100	96.961	Rhinopithecus_roxellana
ENSG00000156414	TDRD9	99	94.960	ENSSBOG00000027466	TDRD9	100	94.809	Saimiri_boliviensis_boliviensis
ENSG00000156414	TDRD9	99	85.784	ENSSHAG00000013742	TDRD9	100	84.151	Sarcophilus_harrisii
ENSG00000156414	TDRD9	99	57.488	ENSSFOG00015012742	tdrd9	93	59.482	Scleropages_formosus
ENSG00000156414	TDRD9	99	54.655	ENSSMAG00000001831	tdrd9	99	53.828	Scophthalmus_maximus
ENSG00000156414	TDRD9	99	50.847	ENSSDUG00000000483	tdrd9	99	53.349	Seriola_dumerili
ENSG00000156414	TDRD9	99	55.772	ENSSLDG00000011875	tdrd9	97	55.608	Seriola_lalandi_dorsalis
ENSG00000156414	TDRD9	80	89.238	ENSSARG00000010748	-	84	89.238	Sorex_araneus
ENSG00000156414	TDRD9	96	72.727	ENSSPUG00000004504	TDRD9	92	75.207	Sphenodon_punctatus
ENSG00000156414	TDRD9	99	52.445	ENSSPAG00000012556	tdrd9	98	52.123	Stegastes_partitus
ENSG00000156414	TDRD9	99	85.417	ENSSSCG00000002552	TDRD9	99	80.825	Sus_scrofa
ENSG00000156414	TDRD9	99	62.515	ENSTGUG00000012887	-	99	61.163	Taeniopygia_guttata
ENSG00000156414	TDRD9	99	47.694	ENSTRUG00000009586	tdrd9	96	49.565	Takifugu_rubripes
ENSG00000156414	TDRD9	99	53.614	ENSTNIG00000017353	tdrd9	100	52.329	Tetraodon_nigroviridis
ENSG00000156414	TDRD9	60	93.304	ENSTBEG00000003593	-	65	93.304	Tupaia_belangeri
ENSG00000156414	TDRD9	99	88.852	ENSTTRG00000006405	TDRD9	100	88.852	Tursiops_truncatus
ENSG00000156414	TDRD9	99	90.171	ENSUAMG00000017361	TDRD9	99	90.304	Ursus_americanus
ENSG00000156414	TDRD9	99	90.171	ENSUMAG00000024822	TDRD9	99	90.304	Ursus_maritimus
ENSG00000156414	TDRD9	99	91.575	ENSVVUG00000002584	TDRD9	99	90.552	Vulpes_vulpes
ENSG00000156414	TDRD9	99	67.971	ENSXETG00000023069	tdrd9	99	66.097	Xenopus_tropicalis
ENSG00000156414	TDRD9	99	52.311	ENSXCOG00000009311	tdrd9	99	52.126	Xiphophorus_couchianus
ENSG00000156414	TDRD9	99	52.311	ENSXMAG00000018300	tdrd9	99	52.205	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	28536242.	IDA	Component
GO:0005737	cytoplasm	28536242.	IDA	Component
GO:0007140	male meiotic nuclear division	-	ISS	Process
GO:0007141	male meiosis I	-	ISS	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007283	spermatogenesis	28536242.	IMP	Process
GO:0007283	spermatogenesis	-	ISS	Process
GO:0009566	fertilization	-	ISS	Process
GO:0010529	negative regulation of transposition	21873635.	IBA	Process
GO:0010529	negative regulation of transposition	-	ISS	Process
GO:0016887	ATPase activity	-	ISS	Function
GO:0030154	cell differentiation	-	IEA	Process
GO:0031047	gene silencing by RNA	-	IEA	Process
GO:0034459	ATP-dependent 3'-5' RNA helicase activity	21873635.	IBA	Function
GO:0034587	piRNA metabolic process	-	ISS	Process
GO:0043046	DNA methylation involved in gamete generation	-	ISS	Process
GO:0071547	piP-body	-	ISS	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr14	104014781	Silent	novel	V721V	0.83
BLCA	chr14	104005390	Silent	NA	I566I	0.33
BLCA	chr14	104008427	Nonsense_Mutation	novel	W689*	0.32
BLCA	chr14	103998691	Missense_Mutation	novel	L482F	0.12
BLCA	chr14	103998640	Missense_Mutation	NA	L465F	0.27
BLCA	chr14	104022249	Missense_Mutation	NA	S842L	0.23
BLCA	chr14	104025695	Silent	novel	V950V	0.05
BLCA	chr14	104024656	Silent	rs544648720	L898L	0.43
BRCA	chr14	104052150	3'UTR	novel		0.15
BRCA	chr14	104025669	Missense_Mutation	NA	P942S	0.23
BRCA	chr14	104018144	Missense_Mutation	NA	L795P	0.28
BRCA	chr14	104040284	Missense_Mutation	NA	D1269N	0.34
BRCA	chr14	104004310	Missense_Mutation	NA	P519R	0.14
BRCA	chr14	103970547	Missense_Mutation	rs376816009	E258K	0.09
BRCA	chr14	103986304	Missense_Mutation	NA	D367Y	0.25
BRCA	chr14	104025769	Missense_Mutation	novel	S975Y	0.09
BRCA	chr14	104026909	Silent	rs142825405	A1084A	0.13
CESC	chr14	104026101	Nonsense_Mutation	novel	E996*	0.19
CHOL	chr14	104005274	Missense_Mutation	rs199531888	R528C	0.1
COAD	chr14	104014760	Silent	NA	I714I	0.46
COAD	chr14	104025605	Missense_Mutation	novel	E920D	0.1
COAD	chr14	103986272	Missense_Mutation	novel	A356D	0.05
COAD	chr14	104006448	Missense_Mutation	NA	L591F	0.08	TUDOR
COAD	chr14	104040278	Missense_Mutation	NA	E1267K	0.28
COAD	chr14	103965409	Missense_Mutation	NA	P166L	0.45
COAD	chr14	104024634	Missense_Mutation	novel	R891K	0.38
COAD	chr14	103970551	Missense_Mutation	NA	R259Q	0.22
COAD	chr14	103975507	Missense_Mutation	novel	V322A	0.12
COAD	chr14	104022254	Missense_Mutation	NA	E844K	0.19
COAD	chr14	104007201	Silent	rs373747611	P683P	0.32
COAD	chr14	104040331	Silent	NA	V1284V	0.22
COAD	chr14	104024604	Missense_Mutation	novel	P881H	0.29
ESCA	chr14	104022266	Missense_Mutation	novel	H848Y	0.09
ESCA	chr14	103991197	Nonsense_Mutation	rs377183290	R385*	0.07
ESCA	chr14	103995781	Missense_Mutation	novel	S451F	0.19
GBM	chr14	104014791	Nonsense_Mutation	rs143367834	R725*	0.32
GBM	chr14	104022308	Missense_Mutation	rs201957950	V862I	0.19
GBM	chr14	103994372	Silent	rs567369483	S407S	0.33
GBM	chr14	104042175	Missense_Mutation	NA	Q1321P	0.28
GBM	chr14	104014748	Missense_Mutation	novel	L710F	0.09
GBM	chr14	104022262	Silent	rs140463535	S846S	0.56
GBM	chr14	104026934	Missense_Mutation	NA	S1093P	0.07
HNSC	chr14	104014762	Missense_Mutation	rs757739389	S715L	0.13
HNSC	chr14	104008411	Splice_Site	novel	X685_splice	0.36
KICH	chr14	103965438	Missense_Mutation	novel	R176C	0.24
KIRC	chr14	104022326	Missense_Mutation	novel	T868S	0.31
KIRC	chr14	104052040	Frame_Shift_Del	novel	*F1370Sfs39**	0.11
KIRC	chr14	103998696	Missense_Mutation	NA	W484L	0.07
LAML	chr14	104004274	Missense_Mutation	novel	R507Q	0.06
LGG	chr14	104024595	Missense_Mutation	rs139118201	T878M	0.61
LGG	chr14	103994338	Missense_Mutation	novel	G396D	0.05
LGG	chr14	104026075	Missense_Mutation	novel	S987Y	0.29
LGG	chr14	104025706	Missense_Mutation	novel	P954L	0.08
LIHC	chr14	104022201	Missense_Mutation	NA	T826I	0.33
LIHC	chr14	104006667	Frame_Shift_Ins	novel	*A637Cfs12**	0.12	TUDOR
LIHC	chr14	103994332	Missense_Mutation	NA	G394V	0.38
LIHC	chr14	103966774	Silent	novel	L236L	0.35
LIHC	chr14	104040305	Missense_Mutation	NA	V1276I	0.28
LIHC	chr14	104016018	Missense_Mutation	novel	T754S	0.09
LIHC	chr14	103970553	Missense_Mutation	novel	T260A	0.13
LUAD	chr14	104042162	Missense_Mutation	novel	D1317Y	0.32
LUAD	chr14	104006514	Frame_Shift_Ins	novel	*G614Pfs10**	0.09	TUDOR
LUAD	chr14	104026820	Missense_Mutation	novel	H1055Y	0.17
LUAD	chr14	104042132	Missense_Mutation	NA	L1307I	0.2
LUAD	chr14	103986242	Missense_Mutation	rs763784398	P346L	0.15
LUAD	chr14	104004320	Silent	NA	V522V	0.11
LUAD	chr14	104042083	Missense_Mutation	novel	R1290S	0.4
LUAD	chr14	104025576	Nonsense_Mutation	rs761700524	G911*	0.08
LUAD	chr14	104024570	Missense_Mutation	NA	V870L	0.11
LUAD	chr14	104005329	Missense_Mutation	novel	P546Q	0.07
LUAD	chr14	104006654	Missense_Mutation	novel	L630V	0.16	TUDOR
LUSC	chr14	104026790	Missense_Mutation	novel	T1045A	0.19
LUSC	chr14	104006541	Silent	rs551622818	E622E	0.4
LUSC	chr14	104026826	Missense_Mutation	rs575819052	V1057I	0.25
LUSC	chr14	104016068	Missense_Mutation	novel	D771N	0.21
LUSC	chr14	104006522	In_Frame_Ins	novel	V616_F617insACSIHE	0.19	TUDOR
LUSC	chr14	104004327	Missense_Mutation	NA	E525Q	0.25
LUSC	chr14	104025720	Missense_Mutation	novel	D959H	0.38
LUSC	chr14	104005404	Nonsense_Mutation	novel	*E571Dfs8**	0.13	TUDOR
LUSC	chr14	104024660	Silent	novel	L900L	0.3
LUSC	chr14	104006681	Missense_Mutation	rs763546824	P639T	0.28	TUDOR
LUSC	chr14	104005383	Missense_Mutation	novel	R564L	0.29
LUSC	chr14	104026918	Silent	rs750015527	T1087T	0.37
LUSC	chr14	104006488	Missense_Mutation	NA	Q605E	0.18	TUDOR
LUSC	chr14	103998624	Missense_Mutation	novel	V460D	0.19
OV	chr14	104006421	Missense_Mutation	novel	E582D	0.05	TUDOR
OV	chr14	103991197	Nonsense_Mutation	rs377183290	R385*	0.63
OV	chr14	104006390	Missense_Mutation	novel	V572D	0.12	TUDOR
PAAD	chr14	104006680	Missense_Mutation	novel	M638I	0.14	TUDOR
PCPG	chr14	104006832	Missense_Mutation	novel	V665A	0.25
PRAD	chr14	104008412	Splice_Site	novel	X685_splice	0.13
READ	chr14	104004241	Missense_Mutation	rs772077271	R496H	0.16
READ	chr14	103970547	Missense_Mutation	NA	E258Q	0.3
READ	chr14	104040302	Missense_Mutation	NA	D1275N	0.41
READ	chr14	104014828	Missense_Mutation	rs764347895	R737Q	0.37
READ	chr14	103966720	Silent	NA	E218E	0.43
SARC	chr14	104042071	Splice_Region	novel	V1286V	0.48
SARC	chr14	104032059	Missense_Mutation	novel	H1161Y	0.07
SKCM	chr14	104025587	Nonsense_Mutation	NA	W914*	0.16
SKCM	chr14	104025589	Missense_Mutation	NA	G915E	0.18
SKCM	chr14	104024603	Missense_Mutation	NA	P881S	0.27
SKCM	chr14	104006390	Missense_Mutation	NA	V572A	0.29	TUDOR
SKCM	chr14	104026793	Missense_Mutation	novel	L1046F	0.67
SKCM	chr14	104049646	Missense_Mutation	NA	P1338L	0.3
SKCM	chr14	104052042	Missense_Mutation	novel	F1370C	0.63
SKCM	chr14	104049633	Missense_Mutation	novel	E1334K	0.35
SKCM	chr14	104006476	Missense_Mutation	NA	L601F	0.3	TUDOR
SKCM	chr14	104026805	Missense_Mutation	NA	V1050I	0.28
SKCM	chr14	104042188	Splice_Site	NA	X1325_splice	0.39
SKCM	chr14	104049669	Missense_Mutation	NA	E1346K	0.26
SKCM	chr14	104005356	Missense_Mutation	novel	S555Y	0.32
SKCM	chr14	104024657	Missense_Mutation	NA	L899F	0.24
SKCM	chr14	103986235	Missense_Mutation	novel	E344K	0.26
SKCM	chr14	104006699	Missense_Mutation	NA	D645N	0.83	TUDOR
SKCM	chr14	104005321	Missense_Mutation	NA	M543I	0.12
SKCM	chr14	104005322	Missense_Mutation	novel	G544S	0.12
SKCM	chr14	104049645	Missense_Mutation	NA	P1338S	0.57
SKCM	chr14	104026710	Missense_Mutation	NA	P1018L	0.18
SKCM	chr14	104004312	Missense_Mutation	NA	D520N	0.2
SKCM	chr14	103994588	Silent	NA	V435V	0.63
SKCM	chr14	104026134	Nonsense_Mutation	NA	Q1007*	0.17
SKCM	chr14	104018113	Missense_Mutation	novel	G785R	0.17
SKCM	chr14	103994360	Silent	NA	E403E	0.2
STAD	chr14	104052070	Silent	NA	V1379V	0.4
STAD	chr14	104018119	Missense_Mutation	NA	L787I	0.53
STAD	chr14	104005360	Silent	rs750571930	P556P	0.48
STAD	chr14	104014816	Missense_Mutation	rs148349259	I733T	0.07
STAD	chr14	104006655	Missense_Mutation	NA	L630P	0.1	TUDOR
STAD	chr14	104025725	Silent	NA	K960K	0.07
STAD	chr14	104006413	Frame_Shift_Ins	novel	*D583Kfs10**	0.32	TUDOR
STAD	chr14	104016046	Silent	NA	A763A	0.4
STAD	chr14	103994583	Missense_Mutation	NA	P434S	0.36
STAD	chr14	104042169	Missense_Mutation	NA	A1319V	0.15
STAD	chr14	104018153	Missense_Mutation	novel	Q798R	0.28
STAD	chr14	103991162	Missense_Mutation	NA	N373S	0.09
THYM	chr14	104022159	Missense_Mutation	NA	A812V	0.19
UCEC	chr14	104005383	Missense_Mutation	rs202014262	R564H	0.39
UCEC	chr14	104025656	Silent	novel	T937T	0.63
UCEC	chr14	104008456	Missense_Mutation	NA	R699I	0.24
UCEC	chr14	104049625	Missense_Mutation	NA	K1331T	0.33
UCEC	chr14	103970551	Missense_Mutation	NA	R259Q	0.39
UCEC	chr14	104005340	Silent	novel	L550L	0.22
UCEC	chr14	104040332	Missense_Mutation	rs780533314	E1285K	0.42
UCEC	chr14	103970551	Missense_Mutation	NA	R259Q	0.33
UCEC	chr14	103975484	Missense_Mutation	NA	E314D	0.41
UCEC	chr14	104004241	Missense_Mutation	novel	R496P	0.06
UCEC	chr14	104006448	Missense_Mutation	NA	L591F	0.33	TUDOR
UCEC	chr14	104025760	Missense_Mutation	novel	S972Y	0.16
UCEC	chr14	103970547	Missense_Mutation	rs376816009	E258K	0.56
UCEC	chr14	104042133	Missense_Mutation	novel	L1307P	0.38
UCEC	chr14	104032016	Splice_Site	novel	X1147_splice	0.23
UCEC	chr14	103991178	Silent	novel	G378G	0.38
UCEC	chr14	103970559	Nonsense_Mutation	novel	E262*	0.47
UCEC	chr14	104006536	Missense_Mutation	novel	D621N	0.49	TUDOR
UCEC	chr14	104018193	Splice_Site	novel	X811_splice	0.04
UCEC	chr14	104014827	Nonsense_Mutation	rs763145732	R737*	0.2
UCEC	chr14	104016069	Missense_Mutation	NA	D771G	0.23
UCEC	chr14	104026755	Missense_Mutation	NA	A1033V	0.31
UCEC	chr14	104006837	Missense_Mutation	NA	A667T	0.23
UCEC	chr14	104026081	Missense_Mutation	NA	V989A	0.13
UCEC	chr14	104040329	Missense_Mutation	novel	V1284I	0.09
UCEC	chr14	104052094	3'UTR	novel		0.14
UCEC	chr14	104005274	Missense_Mutation	rs199531888	R528C	0.34
UCEC	chr14	104026768	Silent	rs142715056	F1037F	0.46
UCEC	chr14	103955686	Nonsense_Mutation	novel	E80*	0.14
UCEC	chr14	104031224	Missense_Mutation	novel	E1133D	0.15
UCEC	chr14	104042162	Missense_Mutation	novel	D1317Y	0.4
UCEC	chr14	104042172	Missense_Mutation	rs571854129	R1320H	0.28
UCEC	chr14	103998728	Missense_Mutation	novel	G495S	0.24
UCEC	chr14	104005383	Missense_Mutation	rs202014262	R564H	0.32
UCEC	chr14	103970551	Missense_Mutation	NA	R259Q	0.48
UCEC	chr14	103994377	Missense_Mutation	novel	V409A	0.42
UCEC	chr14	104004240	Missense_Mutation	NA	R496G	0.09
UCEC	chr14	104018139	Missense_Mutation	novel	Q793H	0.45
UCEC	chr14	104005359	Missense_Mutation	rs781251895	P556L	0.25
UCEC	chr14	103965498	Missense_Mutation	rs779812910	A196T	0.48
UCEC	chr14	104018133	Silent	novel	Q791Q	0.38
UCEC	chr14	104040329	Missense_Mutation	novel	V1284I	0.39
UCEC	chr14	104033978	Missense_Mutation	novel	K1176N	0.19
UCEC	chr14	104006424	Missense_Mutation	novel	D583E	0.1	TUDOR
UCEC	chr14	104014747	Missense_Mutation	NA	L710S	0.38
UCEC	chr14	104026870	Silent	NA	A1071A	0.38
UCEC	chr14	104040284	Missense_Mutation	NA	D1269N	0.36
UCEC	chr14	103963084	Missense_Mutation	novel	R110W	0.47
UCEC	chr14	104006665	Missense_Mutation	novel	K633N	0.45	TUDOR
UCEC	chr14	104014744	Missense_Mutation	novel	E709G	0.29
UCEC	chr14	104006436	Silent	novel	H587H	0.3
UCEC	chr14	104025778	Splice_Site	novel	X977_splice	0.39
UCEC	chr14	104026844	Missense_Mutation	novel	Y1063H	0.34
UCEC	chr14	104026705	Missense_Mutation	novel	M1016I	0.4
UCEC	chr14	104035026	Missense_Mutation	novel	S1229N	0.35
UCEC	chr14	104007201	Silent	rs373747611	P683P	0.39
UCEC	chr14	103998629	Missense_Mutation	novel	D462Y	0.21
UCEC	chr14	104014822	Missense_Mutation	novel	K735T	0.28
UCEC	chr14	104035036	Silent	rs368732282	F1232F	0.38
UCEC	chr14	104008456	Missense_Mutation	NA	R699I	0.29
UCEC	chr14	103963132	Missense_Mutation	novel	T126P	0.09
UCEC	chr14	104025617	Missense_Mutation	novel	E924D	0.16
UCEC	chr14	104026679	Missense_Mutation	novel	A1008T	0.11
UCEC	chr14	103986316	Nonsense_Mutation	novel	*S371Ifs3**	0.05
UCEC	chr14	104006452	Missense_Mutation	novel	F593V	0.07	TUDOR
UCEC	chr14	103975514	Missense_Mutation	novel	E324D	0.18
UCEC	chr14	103986256	Frame_Shift_Ins	novel	*E354Mfs16**	0.22
UCEC	chr14	104005294	Silent	rs746659034	T534T	0.15
UCEC	chr14	104052021	Missense_Mutation	novel	S1363N	0.5
UCEC	chr14	103966720	Missense_Mutation	novel	E218D	0.3
UCEC	chr14	104026886	Missense_Mutation	rs770375180	V1077I	0.31
UCEC	chr14	104042139	Frame_Shift_Ins	novel	*V1312Efs14**	0.49
UCEC	chr14	103970611	Missense_Mutation	novel	R279H	0.4
UCEC	chr14	104006665	Missense_Mutation	novel	K633N	0.45	TUDOR
UCEC	chr14	104025623	Frame_Shift_Ins	novel	*L929Afs4**	0.33
UCEC	chr14	103975457	Silent	novel	N305N	0.37
UCEC	chr14	104033981	Missense_Mutation	novel	E1177D	0.38
UCS	chr14	104025585	Missense_Mutation	novel	W914G	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.237	1.4717e-06
CESC	DEL	0.1424	0.00086239
CHOL	DEL	0.5556	0.00040262
COAD	DEL	0.2882	0.050084
GBM	DEL	0.2461	5.7274e-07
HNSC	DEL	0.113	0.0057325
KIRC	DEL	0.3826	0.0074281
KIRP	DEL	0.1701	0.085174
LIHC	DEL	0.327	8.4799e-08
LUAD	DEL	0.2035	0.0018747
LUSC	AMP	0.2315	0.064655
MESO	DEL	0.4138	0.088547
PAAD	DEL	0.0761	0.11332
READ	DEL	0.3576	0.189
SKCM	DEL	0.2807	0.10277
STAD	DEL	0.2268	0.0031145

Survival Analysis

Cancer	P-value	Q-value
SARC	0.015	Kaplan-Meier Survival Analysis
MESO	0.026	Kaplan-Meier Survival Analysis
ACC	0.00077	Kaplan-Meier Survival Analysis
UCS	0.035	Kaplan-Meier Survival Analysis
KIRP	0.0079	Kaplan-Meier Survival Analysis
PAAD	0.00057	Kaplan-Meier Survival Analysis
LAML	0.00017	Kaplan-Meier Survival Analysis
LGG	0.023	Kaplan-Meier Survival Analysis
THCA	0.0043	Kaplan-Meier Survival Analysis