EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000156976 (Gene tree)
Gene ID: 1974
Gene Symbol: EIF4A2
Alias: DDX2B|EIF4A|BM-010|EIF4F
Full Name: eukaryotic translation initiation factor 4A2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 6,696 bases
Position: chr3:186,783,205-186,789,900
Accession: 3284
RBP type: canonical RBP
Summary: (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Diseases associated with EIF4A2 include Retinitis Pigmentosa 29 and X-Linked Hereditary Ataxia. Among its related pathways are TGF-Beta Pathway and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000326381	ResIII	PF04851.15	4.2e-07	1	1
ENSP00000398370	ResIII	PF04851.15	4.2e-07	1	1
ENSP00000462571	ResIII	PF04851.15	4.7e-05	1	1
ENSP00000326381	DEAD	PF00270.29	2.9e-43	1	1
ENSP00000398370	DEAD	PF00270.29	2.9e-43	1	1
ENSP00000462571	DEAD	PF00270.29	1e-14	1	1
ENSP00000415878	DEAD	PF00270.29	1.1e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24450646	The diverse roles of the eIF4A family: you are the company you keep.	Biochem Soc Trans	2014 Feb	Lu WT	doi: 10.1042/BST20130161.
16803875	Wheat eukaryotic initiation factor 4B organizes assembly of RNA and eIFiso4G, eIF4A, and poly(A)-binding protein.	J Biol Chem	2006 Aug 25	Cheng S	-
24895251	Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).	Int J Cancer	2015 Oct 15	Li-Weber M	doi: 10.1002/ijc.29013
27388680	eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation.	Plant Physiol	2016 Sep	Bush MS	doi: 10.1104/pp.16.00435
18977752	Translation initiation factor 4B homodimerization, RNA binding, and interaction with Poly(A)-binding protein are enhanced by zinc.	J Biol Chem	2008 Dec 26	Cheng S	doi: 10.1074/jbc.M807716200
19751846	Isolation and functional characterization of eIF4F components and poly(A)-binding protein from Plasmodium falciparum.	Parasitol Int	2009 Dec	Tuteja R	doi: 10.1016/j.parint.2009.09.001
11418588	Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.	J Biol Chem	2001 Aug 17	Rogers GW Jr	-
16030146	Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.	Proc Natl Acad Sci U S A	2005 Jul 26	Bordeleau ME	-
10801326	Wheat germ translation initiation factor eIF4B affects eIF4A and eIFiso4F helicase activity by increasing the ATP binding affinity of eIF4A.	Biochemistry	2000 May 16	Bi X	-
11922617	Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro.	Biochem Biophys Res Commun	2002 Apr 5	Kyono K	-
10748132	Wheat germ poly(A)-binding protein increases the ATPase and the RNA helicase activity of translation initiation factors eIF4A, eIF4B, and eIF-iso4F.	J Biol Chem	2000 Jun 9	Bi X	-
16014927	mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.	J Virol	2005 Aug	Feng P	-
23867391	Downregulation of EIF4A2 in non-small-cell lung cancer associates with poor prognosis.	Clin Lung Cancer	2013 Nov	Shaoyan X	doi: 10.1016/j.cllc.2013.04.011
23614532	Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex.	ACS Chem Biol	2013 Jul 19	Sadlish H	doi: 10.1021/cb400158t

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498746	EIF4A2-227	579	-	ENSP00000462571	109 (aa)	-	J3KSN7
ENST00000495049	EIF4A2-224	576	-	-	- (aa)	-	-
ENST00000466362	EIF4A2-214	545	-	-	- (aa)	-	-
ENST00000465792	EIF4A2-213	734	-	-	- (aa)	-	-
ENST00000465222	EIF4A2-211	676	-	-	- (aa)	-	-
ENST00000486805	EIF4A2-220	590	-	-	- (aa)	-	-
ENST00000465032	EIF4A2-210	578	-	-	- (aa)	-	-
ENST00000468362	EIF4A2-216	1356	-	-	- (aa)	-	-
ENST00000465267	EIF4A2-212	1054	-	-	- (aa)	-	-
ENST00000443963	EIF4A2-207	1729	-	ENSP00000402313	97 (aa)	-	F8WE11
ENST00000461021	EIF4A2-209	575	-	-	- (aa)	-	-
ENST00000425053	EIF4A2-202	1977	-	ENSP00000413529	362 (aa)	-	E7EQG2
ENST00000467585	EIF4A2-215	570	-	-	- (aa)	-	-
ENST00000440191	EIF4A2-205	1889	-	ENSP00000398370	408 (aa)	-	Q14240
ENST00000494445	EIF4A2-223	629	-	-	- (aa)	-	-
ENST00000426808	EIF4A2-203	1751	-	ENSP00000392686	96 (aa)	-	E9PBH4
ENST00000496382	EIF4A2-225	460	-	-	- (aa)	-	-
ENST00000492144	EIF4A2-222	993	-	-	- (aa)	-	-
ENST00000491473	EIF4A2-221	579	-	-	- (aa)	-	-
ENST00000485101	EIF4A2-219	5327	-	-	- (aa)	-	-
ENST00000445596	EIF4A2-208	600	-	ENSP00000415878	98 (aa)	-	E7EMV8
ENST00000497177	EIF4A2-226	849	-	-	- (aa)	-	-
ENST00000475409	EIF4A2-217	802	-	-	- (aa)	-	-
ENST00000429589	EIF4A2-204	1005	-	ENSP00000388237	96 (aa)	-	E9PBH4
ENST00000441007	EIF4A2-206	480	-	ENSP00000407504	57 (aa)	-	C9JUF0
ENST00000475653	EIF4A2-218	909	-	-	- (aa)	-	-
ENST00000323963	EIF4A2-201	1919	-	ENSP00000326381	407 (aa)	-	Q14240

Gene Model

Click here to download ENSG00000156976's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000156976	Adiponectin	7E-7	24105470

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000156976	rs266719	3	186783859	T	Adiponectin levels	24105470	[0.071-0.189] unit increase	0.13	EFO_0004502

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000156976's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000156976	EIF4A2	90	38.649	ENSG00000123136	DDX39A	92	40.909
ENSG00000156976	EIF4A2	93	33.019	ENSG00000111364	DDX55	94	30.978
ENSG00000156976	EIF4A2	90	30.481	ENSG00000118197	DDX59	64	35.000
ENSG00000156976	EIF4A2	90	30.904	ENSG00000107625	DDX50	50	31.536
ENSG00000156976	EIF4A2	88	30.247	ENSG00000184735	DDX53	51	30.247
ENSG00000156976	EIF4A2	99	90.148	ENSG00000161960	EIF4A1	100	94.017
ENSG00000156976	EIF4A2	76	34.783	ENSG00000152670	DDX4	62	30.084
ENSG00000156976	EIF4A2	93	31.667	ENSG00000215301	DDX3X	78	33.244
ENSG00000156976	EIF4A2	91	38.441	ENSG00000110367	DDX6	76	38.441
ENSG00000156976	EIF4A2	90	33.832	ENSG00000100201	DDX17	63	51.429
ENSG00000156976	EIF4A2	98	42.727	ENSG00000168872	DDX19A	93	40.483
ENSG00000156976	EIF4A2	87	39.571	ENSG00000109832	DDX25	96	38.611
ENSG00000156976	EIF4A2	89	31.611	ENSG00000088205	DDX18	79	30.645
ENSG00000156976	EIF4A2	90	32.464	ENSG00000165732	DDX21	51	32.976
ENSG00000156976	EIF4A2	83	37.755	ENSG00000136271	DDX56	96	32.203
ENSG00000156976	EIF4A2	98	44.545	ENSG00000157349	DDX19B	96	40.608
ENSG00000156976	EIF4A2	90	34.133	ENSG00000080007	DDX43	57	34.133
ENSG00000156976	EIF4A2	92	41.748	ENSG00000124228	DDX27	96	32.331
ENSG00000156976	EIF4A2	92	32.208	ENSG00000105671	DDX49	79	32.208
ENSG00000156976	EIF4A2	84	38.298	ENSG00000123064	DDX54	93	34.359
ENSG00000156976	EIF4A2	92	33.714	ENSG00000108654	DDX5	93	32.867
ENSG00000156976	EIF4A2	84	47.826	ENSG00000064703	DDX20	51	43.662
ENSG00000156976	EIF4A2	91	30.909	ENSG00000183258	DDX41	61	30.909
ENSG00000156976	EIF4A2	93	71.429	ENSG00000141543	EIF4A3	92	71.429
ENSG00000156976	EIF4A2	93	32.500	ENSG00000067048	DDX3Y	60	33.000
ENSG00000156976	EIF4A2	97	32.102	ENSG00000213782	DDX47	85	32.653
ENSG00000156976	EIF4A2	79	50.000	ENSG00000198563	DDX39B	91	36.257
ENSG00000156976	EIF4A2	90	30.539	ENSG00000278053	DDX52	59	33.521
ENSG00000156976	EIF4A2	92	30.900	ENSG00000174243	DDX23	53	30.864

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000156976	EIF4A2	100	95.413	ENSAPOG00000015061	eif4a2	100	94.647	Acanthochromis_polyacanthus
ENSG00000156976	EIF4A2	99	88.366	ENSAPOG00000016551	eif4a1b	99	88.366	Acanthochromis_polyacanthus
ENSG00000156976	EIF4A2	100	100.000	ENSAMEG00000000966	EIF4A2	100	100.000	Ailuropoda_melanoleuca
ENSG00000156976	EIF4A2	100	88.073	ENSACIG00000014917	-	87	86.452	Amphilophus_citrinellus
ENSG00000156976	EIF4A2	100	95.413	ENSACIG00000000989	eif4a2	98	95.477	Amphilophus_citrinellus
ENSG00000156976	EIF4A2	100	95.413	ENSAOCG00000024386	eif4a2	100	95.134	Amphiprion_ocellaris
ENSG00000156976	EIF4A2	99	89.109	ENSAOCG00000011063	eif4a1b	99	89.109	Amphiprion_ocellaris
ENSG00000156976	EIF4A2	100	95.413	ENSAPEG00000004260	eif4a2	100	95.134	Amphiprion_percula
ENSG00000156976	EIF4A2	99	89.109	ENSAPEG00000009660	eif4a1b	100	90.256	Amphiprion_percula
ENSG00000156976	EIF4A2	99	89.604	ENSATEG00000003064	eif4a1b	99	89.604	Anabas_testudineus
ENSG00000156976	EIF4A2	100	95.413	ENSATEG00000020546	eif4a2	100	95.134	Anabas_testudineus
ENSG00000156976	EIF4A2	100	98.039	ENSAPLG00000006751	EIF4A2	100	98.039	Anas_platyrhynchos
ENSG00000156976	EIF4A2	100	98.165	ENSACAG00000007682	EIF4A2	100	98.039	Anolis_carolinensis
ENSG00000156976	EIF4A2	100	100.000	ENSANAG00000027718	-	100	100.000	Aotus_nancymaae
ENSG00000156976	EIF4A2	72	73.630	ENSANAG00000029915	-	100	67.143	Aotus_nancymaae
ENSG00000156976	EIF4A2	60	95.122	ENSANAG00000022804	-	99	95.122	Aotus_nancymaae
ENSG00000156976	EIF4A2	100	95.413	ENSACLG00000010594	eif4a2	99	95.729	Astatotilapia_calliptera
ENSG00000156976	EIF4A2	99	89.109	ENSACLG00000013015	eif4a1b	99	89.109	Astatotilapia_calliptera
ENSG00000156976	EIF4A2	100	88.452	ENSAMXG00000030251	eif4a1a	100	88.452	Astyanax_mexicanus
ENSG00000156976	EIF4A2	97	83.797	ENSAMXG00000040730	eif4a1b	96	84.010	Astyanax_mexicanus
ENSG00000156976	EIF4A2	100	95.413	ENSAMXG00000019126	eif4a2	100	94.891	Astyanax_mexicanus
ENSG00000156976	EIF4A2	100	100.000	ENSBTAG00000014724	EIF4A2	100	100.000	Bos_taurus
ENSG00000156976	EIF4A2	100	97.248	ENSCJAG00000004019	-	100	94.608	Callithrix_jacchus
ENSG00000156976	EIF4A2	100	100.000	ENSCJAG00000032965	-	100	100.000	Callithrix_jacchus
ENSG00000156976	EIF4A2	100	100.000	ENSCAFG00000013659	EIF4A2	100	100.000	Canis_familiaris
ENSG00000156976	EIF4A2	66	86.134	ENSCAFG00020023734	-	90	85.932	Canis_lupus_dingo
ENSG00000156976	EIF4A2	100	100.000	ENSCAFG00020006146	EIF4A2	100	100.000	Canis_lupus_dingo
ENSG00000156976	EIF4A2	100	100.000	ENSCHIG00000012317	EIF4A2	100	100.000	Capra_hircus
ENSG00000156976	EIF4A2	100	100.000	ENSTSYG00000013050	EIF4A2	100	100.000	Carlito_syrichta
ENSG00000156976	EIF4A2	72	72.203	ENSTSYG00000031742	-	95	72.203	Carlito_syrichta
ENSG00000156976	EIF4A2	100	100.000	ENSCPOG00000011183	-	100	100.000	Cavia_porcellus
ENSG00000156976	EIF4A2	100	100.000	ENSCCAG00000036268	-	100	100.000	Cebus_capucinus
ENSG00000156976	EIF4A2	57	89.224	ENSCCAG00000022234	-	99	88.793	Cebus_capucinus
ENSG00000156976	EIF4A2	69	71.429	ENSCATG00000032833	-	100	71.071	Cercocebus_atys
ENSG00000156976	EIF4A2	100	100.000	ENSCATG00000039271	-	100	100.000	Cercocebus_atys
ENSG00000156976	EIF4A2	100	84.211	ENSCATG00000030154	-	100	69.533	Cercocebus_atys
ENSG00000156976	EIF4A2	52	87.368	ENSCATG00000033485	-	90	77.016	Cercocebus_atys
ENSG00000156976	EIF4A2	100	100.000	ENSCLAG00000014891	EIF4A2	100	99.171	Chinchilla_lanigera
ENSG00000156976	EIF4A2	100	100.000	ENSCSAG00000009233	EIF4A2	100	100.000	Chlorocebus_sabaeus
ENSG00000156976	EIF4A2	100	98.980	ENSCHOG00000014007	EIF4A2	100	79.607	Choloepus_hoffmanni
ENSG00000156976	EIF4A2	100	97.248	ENSCPBG00000000975	EIF4A2	100	98.649	Chrysemys_picta_bellii
ENSG00000156976	EIF4A2	100	100.000	ENSCANG00000036224	-	100	100.000	Colobus_angolensis_palliatus
ENSG00000156976	EIF4A2	69	89.643	ENSCANG00000034339	-	100	89.643	Colobus_angolensis_palliatus
ENSG00000156976	EIF4A2	100	100.000	ENSCGRG00001022442	Eif4a2	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000156976	EIF4A2	100	100.000	ENSCGRG00000004555	Eif4a2	100	100.000	Cricetulus_griseus_crigri
ENSG00000156976	EIF4A2	100	81.651	ENSCSEG00000017096	-	88	78.616	Cynoglossus_semilaevis
ENSG00000156976	EIF4A2	100	94.495	ENSCSEG00000017054	eif4a2	100	93.187	Cynoglossus_semilaevis
ENSG00000156976	EIF4A2	100	90.826	ENSCSEG00000014807	eif4a1b	98	91.409	Cynoglossus_semilaevis
ENSG00000156976	EIF4A2	100	96.330	ENSCVAG00000003186	eif4a2	100	95.377	Cyprinodon_variegatus
ENSG00000156976	EIF4A2	99	89.851	ENSCVAG00000019209	eif4a1b	99	89.851	Cyprinodon_variegatus
ENSG00000156976	EIF4A2	100	96.330	ENSDARG00000016477	eif4a2	100	95.864	Danio_rerio
ENSG00000156976	EIF4A2	100	90.826	ENSDARG00000003032	eif4a1b	99	90.864	Danio_rerio
ENSG00000156976	EIF4A2	100	88.943	ENSDARG00000092115	eif4a1a	100	88.943	Danio_rerio
ENSG00000156976	EIF4A2	100	85.321	ENSDNOG00000032305	-	100	71.499	Dasypus_novemcinctus
ENSG00000156976	EIF4A2	72	98.288	ENSDNOG00000040808	-	94	98.288	Dasypus_novemcinctus
ENSG00000156976	EIF4A2	98	77.638	ENSDNOG00000033741	-	99	77.638	Dasypus_novemcinctus
ENSG00000156976	EIF4A2	100	100.000	ENSDNOG00000011502	-	100	100.000	Dasypus_novemcinctus
ENSG00000156976	EIF4A2	100	100.000	ENSDORG00000028348	-	100	100.000	Dipodomys_ordii
ENSG00000156976	EIF4A2	100	95.918	ENSDORG00000024661	-	100	91.436	Dipodomys_ordii
ENSG00000156976	EIF4A2	100	99.754	ENSETEG00000018565	EIF4A2	100	99.754	Echinops_telfairi
ENSG00000156976	EIF4A2	100	90.826	ENSEBUG00000009705	eif4a1b	91	81.980	Eptatretus_burgeri
ENSG00000156976	EIF4A2	100	100.000	ENSEASG00005014096	EIF4A2	100	100.000	Equus_asinus_asinus
ENSG00000156976	EIF4A2	100	100.000	ENSECAG00000021223	EIF4A2	100	100.000	Equus_caballus
ENSG00000156976	EIF4A2	69	90.323	ENSEEUG00000008600	EIF4A2	100	90.323	Erinaceus_europaeus
ENSG00000156976	EIF4A2	100	94.660	ENSELUG00000023923	eif4a2	100	96.486	Esox_lucius
ENSG00000156976	EIF4A2	99	90.465	ENSELUG00000009963	eif4a1b	99	90.465	Esox_lucius
ENSG00000156976	EIF4A2	100	100.000	ENSFCAG00000013883	EIF4A2	100	100.000	Felis_catus
ENSG00000156976	EIF4A2	55	58.929	ENSFCAG00000031156	-	94	58.929	Felis_catus
ENSG00000156976	EIF4A2	100	97.794	ENSFALG00000008230	EIF4A2	100	97.794	Ficedula_albicollis
ENSG00000156976	EIF4A2	100	100.000	ENSFDAG00000006475	EIF4A2	100	100.000	Fukomys_damarensis
ENSG00000156976	EIF4A2	99	89.851	ENSFHEG00000000359	eif4a1b	88	89.851	Fundulus_heteroclitus
ENSG00000156976	EIF4A2	100	95.413	ENSFHEG00000016755	eif4a2	100	95.134	Fundulus_heteroclitus
ENSG00000156976	EIF4A2	97	91.139	ENSGMOG00000018350	eif4a1b	98	91.371	Gadus_morhua
ENSG00000156976	EIF4A2	100	93.873	ENSGMOG00000002930	eif4a2	100	93.873	Gadus_morhua
ENSG00000156976	EIF4A2	100	97.248	ENSGALG00000008684	EIF4A2	100	98.378	Gallus_gallus
ENSG00000156976	EIF4A2	99	89.851	ENSGAFG00000019309	eif4a1b	99	89.851	Gambusia_affinis
ENSG00000156976	EIF4A2	100	96.330	ENSGAFG00000007555	eif4a2	100	95.620	Gambusia_affinis
ENSG00000156976	EIF4A2	100	94.495	ENSGACG00000016054	eif4a2	100	93.154	Gasterosteus_aculeatus
ENSG00000156976	EIF4A2	99	89.877	ENSGACG00000020072	eif4a1b	100	91.026	Gasterosteus_aculeatus
ENSG00000156976	EIF4A2	100	97.794	ENSGAGG00000019478	EIF4A2	100	97.794	Gopherus_agassizii
ENSG00000156976	EIF4A2	100	100.000	ENSGGOG00000005867	EIF4A2	100	100.000	Gorilla_gorilla
ENSG00000156976	EIF4A2	100	86.735	ENSGGOG00000043141	-	100	80.590	Gorilla_gorilla
ENSG00000156976	EIF4A2	100	95.413	ENSHBUG00000018048	eif4a2	99	95.729	Haplochromis_burtoni
ENSG00000156976	EIF4A2	99	89.109	ENSHBUG00000004845	eif4a1b	99	89.109	Haplochromis_burtoni
ENSG00000156976	EIF4A2	100	95.918	ENSHGLG00000006433	-	100	85.258	Heterocephalus_glaber_female
ENSG00000156976	EIF4A2	100	100.000	ENSHGLG00000015574	EIF4A2	100	100.000	Heterocephalus_glaber_female
ENSG00000156976	EIF4A2	100	86.464	ENSHGLG00000007103	-	100	86.464	Heterocephalus_glaber_female
ENSG00000156976	EIF4A2	72	86.441	ENSHGLG00100005621	-	94	86.441	Heterocephalus_glaber_male
ENSG00000156976	EIF4A2	100	100.000	ENSHGLG00100017504	EIF4A2	100	100.000	Heterocephalus_glaber_male
ENSG00000156976	EIF4A2	100	78.177	ENSHGLG00100017196	-	100	78.177	Heterocephalus_glaber_male
ENSG00000156976	EIF4A2	78	71.250	ENSHGLG00100009811	-	99	71.250	Heterocephalus_glaber_male
ENSG00000156976	EIF4A2	65	91.667	ENSHGLG00100014415	-	99	91.667	Heterocephalus_glaber_male
ENSG00000156976	EIF4A2	100	87.156	ENSHCOG00000000636	eif4a1b	99	88.089	Hippocampus_comes
ENSG00000156976	EIF4A2	100	95.098	ENSHCOG00000020703	eif4a2	100	95.098	Hippocampus_comes
ENSG00000156976	EIF4A2	99	90.123	ENSIPUG00000005117	if4a1	99	90.123	Ictalurus_punctatus
ENSG00000156976	EIF4A2	100	95.413	ENSIPUG00000009463	EIF4A2	100	94.647	Ictalurus_punctatus
ENSG00000156976	EIF4A2	100	94.891	ENSIPUG00000012038	eif4a2	100	94.891	Ictalurus_punctatus
ENSG00000156976	EIF4A2	100	96.330	ENSSTOG00000031966	-	100	84.069	Ictidomys_tridecemlineatus
ENSG00000156976	EIF4A2	72	75.000	ENSSTOG00000033839	-	94	75.000	Ictidomys_tridecemlineatus
ENSG00000156976	EIF4A2	100	100.000	ENSSTOG00000012601	-	99	99.259	Ictidomys_tridecemlineatus
ENSG00000156976	EIF4A2	100	100.000	ENSJJAG00000021948	Eif4a2	100	99.755	Jaculus_jaculus
ENSG00000156976	EIF4A2	78	90.683	ENSJJAG00000018115	-	99	90.373	Jaculus_jaculus
ENSG00000156976	EIF4A2	99	90.347	ENSKMAG00000006928	eif4a1b	99	90.347	Kryptolebias_marmoratus
ENSG00000156976	EIF4A2	100	96.330	ENSKMAG00000004019	eif4a2	100	94.404	Kryptolebias_marmoratus
ENSG00000156976	EIF4A2	100	88.073	ENSLBEG00000018971	eif4a1b	99	88.366	Labrus_bergylta
ENSG00000156976	EIF4A2	100	92.661	ENSLBEG00000008635	eif4a2	99	91.484	Labrus_bergylta
ENSG00000156976	EIF4A2	100	88.971	ENSLACG00000003242	eif4a1a	99	89.435	Latimeria_chalumnae
ENSG00000156976	EIF4A2	98	91.250	ENSLACG00000004638	-	99	89.563	Latimeria_chalumnae
ENSG00000156976	EIF4A2	100	93.888	ENSLACG00000017818	eif4a2	100	93.888	Latimeria_chalumnae
ENSG00000156976	EIF4A2	100	97.324	ENSLOCG00000000847	eif4a2	100	97.324	Lepisosteus_oculatus
ENSG00000156976	EIF4A2	99	90.864	ENSLOCG00000014465	eif4a1b	99	90.864	Lepisosteus_oculatus
ENSG00000156976	EIF4A2	100	100.000	ENSLAFG00000003619	EIF4A2	98	100.000	Loxodonta_africana
ENSG00000156976	EIF4A2	69	71.429	ENSMFAG00000037886	-	100	71.071	Macaca_fascicularis
ENSG00000156976	EIF4A2	100	100.000	ENSMFAG00000044567	EIF4A2	100	100.000	Macaca_fascicularis
ENSG00000156976	EIF4A2	100	100.000	ENSMMUG00000003702	EIF4A2	100	100.000	Macaca_mulatta
ENSG00000156976	EIF4A2	76	78.641	ENSMMUG00000019847	-	97	78.641	Macaca_mulatta
ENSG00000156976	EIF4A2	78	71.519	ENSMNEG00000044822	-	100	71.519	Macaca_nemestrina
ENSG00000156976	EIF4A2	57	83.981	ENSMNEG00000043904	-	90	83.981	Macaca_nemestrina
ENSG00000156976	EIF4A2	100	100.000	ENSMNEG00000037282	-	100	100.000	Macaca_nemestrina
ENSG00000156976	EIF4A2	100	98.165	ENSMLEG00000018653	-	98	97.844	Mandrillus_leucophaeus
ENSG00000156976	EIF4A2	57	87.379	ENSMLEG00000042438	-	91	87.379	Mandrillus_leucophaeus
ENSG00000156976	EIF4A2	100	100.000	ENSMLEG00000030242	-	100	100.000	Mandrillus_leucophaeus
ENSG00000156976	EIF4A2	59	76.860	ENSMLEG00000043964	-	100	76.860	Mandrillus_leucophaeus
ENSG00000156976	EIF4A2	99	89.109	ENSMAMG00000000754	eif4a1b	99	89.109	Mastacembelus_armatus
ENSG00000156976	EIF4A2	100	95.413	ENSMAMG00000002729	eif4a2	100	95.134	Mastacembelus_armatus
ENSG00000156976	EIF4A2	100	95.413	ENSMZEG00005006771	eif4a2	100	94.647	Maylandia_zebra
ENSG00000156976	EIF4A2	99	89.109	ENSMZEG00005009716	eif4a1b	99	89.109	Maylandia_zebra
ENSG00000156976	EIF4A2	100	97.248	ENSMGAG00000009383	EIF4A2	100	92.714	Meleagris_gallopavo
ENSG00000156976	EIF4A2	100	100.000	ENSMAUG00000000531	Eif4a2	100	99.752	Mesocricetus_auratus
ENSG00000156976	EIF4A2	100	100.000	ENSMICG00000049007	-	100	100.000	Microcebus_murinus
ENSG00000156976	EIF4A2	63	90.234	ENSMICG00000029899	-	100	90.234	Microcebus_murinus
ENSG00000156976	EIF4A2	100	100.000	ENSMOCG00000021828	Eif4a2	100	100.000	Microtus_ochrogaster
ENSG00000156976	EIF4A2	100	94.495	ENSMMOG00000018299	eif4a2	100	92.683	Mola_mola
ENSG00000156976	EIF4A2	100	94.595	ENSMODG00000021284	EIF4A2	100	94.595	Monodelphis_domestica
ENSG00000156976	EIF4A2	100	95.413	ENSMALG00000007033	eif4a2	100	95.134	Monopterus_albus
ENSG00000156976	EIF4A2	72	90.508	ENSMALG00000000146	-	95	90.508	Monopterus_albus
ENSG00000156976	EIF4A2	100	100.000	ENSMUSG00000022884	Eif4a2	100	100.000	Mus_musculus
ENSG00000156976	EIF4A2	100	100.000	MGP_PahariEiJ_G0016317	Eif4a2	100	100.000	Mus_pahari
ENSG00000156976	EIF4A2	100	100.000	MGP_SPRETEiJ_G0021508	Eif4a2	100	100.000	Mus_spretus
ENSG00000156976	EIF4A2	100	100.000	ENSMPUG00000003326	EIF4A2	100	100.000	Mustela_putorius_furo
ENSG00000156976	EIF4A2	100	99.510	ENSMLUG00000016392	EIF4A2	100	99.510	Myotis_lucifugus
ENSG00000156976	EIF4A2	100	100.000	ENSNGAG00000000744	Eif4a2	100	100.000	Nannospalax_galili
ENSG00000156976	EIF4A2	63	87.209	ENSNBRG00000003384	eif4a1b	100	87.209	Neolamprologus_brichardi
ENSG00000156976	EIF4A2	100	95.413	ENSNBRG00000004471	eif4a2	100	94.647	Neolamprologus_brichardi
ENSG00000156976	EIF4A2	83	88.889	ENSNBRG00000003434	eif4a1b	87	86.131	Neolamprologus_brichardi
ENSG00000156976	EIF4A2	100	100.000	ENSNLEG00000006633	EIF4A2	100	99.509	Nomascus_leucogenys
ENSG00000156976	EIF4A2	100	99.083	ENSMEUG00000011737	EIF4A2	100	94.840	Notamacropus_eugenii
ENSG00000156976	EIF4A2	100	100.000	ENSOPRG00000004170	EIF4A2	100	98.526	Ochotona_princeps
ENSG00000156976	EIF4A2	71	80.756	ENSODEG00000006416	-	94	79.725	Octodon_degus
ENSG00000156976	EIF4A2	72	97.627	ENSODEG00000018638	-	95	97.627	Octodon_degus
ENSG00000156976	EIF4A2	72	95.932	ENSODEG00000019833	-	95	95.932	Octodon_degus
ENSG00000156976	EIF4A2	100	95.413	ENSONIG00000010685	eif4a2	100	94.647	Oreochromis_niloticus
ENSG00000156976	EIF4A2	99	89.356	ENSONIG00000000606	eif4a1b	99	89.356	Oreochromis_niloticus
ENSG00000156976	EIF4A2	100	100.000	ENSOCUG00000005011	EIF4A2	100	100.000	Oryctolagus_cuniculus
ENSG00000156976	EIF4A2	100	95.134	ENSORLG00000008838	eif4a2	100	95.134	Oryzias_latipes
ENSG00000156976	EIF4A2	99	90.594	ENSORLG00000010659	eif4a1b	99	90.594	Oryzias_latipes
ENSG00000156976	EIF4A2	99	90.594	ENSORLG00020014611	eif4a1b	99	90.594	Oryzias_latipes_hni
ENSG00000156976	EIF4A2	100	95.413	ENSORLG00020012834	eif4a2	100	95.377	Oryzias_latipes_hni
ENSG00000156976	EIF4A2	99	90.594	ENSORLG00015015733	eif4a1b	99	90.594	Oryzias_latipes_hsok
ENSG00000156976	EIF4A2	100	95.413	ENSORLG00015008563	eif4a2	100	95.377	Oryzias_latipes_hsok
ENSG00000156976	EIF4A2	99	90.347	ENSOMEG00000003369	eif4a1b	99	90.347	Oryzias_melastigma
ENSG00000156976	EIF4A2	100	95.413	ENSOMEG00000006138	eif4a2	99	96.859	Oryzias_melastigma
ENSG00000156976	EIF4A2	100	100.000	ENSOGAG00000010729	EIF4A2	100	100.000	Otolemur_garnettii
ENSG00000156976	EIF4A2	100	99.083	ENSOARG00000018462	-	100	97.789	Ovis_aries
ENSG00000156976	EIF4A2	100	100.000	ENSOARG00000020517	-	100	97.059	Ovis_aries
ENSG00000156976	EIF4A2	100	100.000	ENSPPAG00000014857	EIF4A2	100	100.000	Pan_paniscus
ENSG00000156976	EIF4A2	100	100.000	ENSPPRG00000007860	EIF4A2	100	100.000	Panthera_pardus
ENSG00000156976	EIF4A2	100	100.000	ENSPTIG00000011207	EIF4A2	100	100.000	Panthera_tigris_altaica
ENSG00000156976	EIF4A2	100	86.239	ENSPTRG00000049911	-	100	75.676	Pan_troglodytes
ENSG00000156976	EIF4A2	100	100.000	ENSPTRG00000015718	EIF4A2	100	100.000	Pan_troglodytes
ENSG00000156976	EIF4A2	100	100.000	ENSPANG00000014790	-	100	100.000	Papio_anubis
ENSG00000156976	EIF4A2	57	86.408	ENSPANG00000033611	-	91	86.408	Papio_anubis
ENSG00000156976	EIF4A2	86	83.761	ENSPANG00000017502	-	92	83.761	Papio_anubis
ENSG00000156976	EIF4A2	100	90.826	ENSPKIG00000001167	eif4a1b	100	90.418	Paramormyrops_kingsleyae
ENSG00000156976	EIF4A2	100	91.743	ENSPKIG00000001467	eif4a1b	99	91.358	Paramormyrops_kingsleyae
ENSG00000156976	EIF4A2	100	96.594	ENSPKIG00000022776	EIF4A2	100	96.594	Paramormyrops_kingsleyae
ENSG00000156976	EIF4A2	100	95.620	ENSPKIG00000013856	eif4a2	100	95.620	Paramormyrops_kingsleyae
ENSG00000156976	EIF4A2	100	98.165	ENSPSIG00000017404	EIF4A2	100	97.555	Pelodiscus_sinensis
ENSG00000156976	EIF4A2	100	92.661	ENSPMGG00000009346	eif4a2	100	87.436	Periophthalmus_magnuspinnatus
ENSG00000156976	EIF4A2	98	78.589	ENSPEMG00000009738	-	99	76.322	Peromyscus_maniculatus_bairdii
ENSG00000156976	EIF4A2	100	100.000	ENSPEMG00000021495	-	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000156976	EIF4A2	100	99.083	ENSPCIG00000013057	EIF4A2	100	99.017	Phascolarctos_cinereus
ENSG00000156976	EIF4A2	99	89.851	ENSPFOG00000012406	eif4a1b	99	89.851	Poecilia_formosa
ENSG00000156976	EIF4A2	100	94.686	ENSPFOG00000004507	eif4a2	100	94.686	Poecilia_formosa
ENSG00000156976	EIF4A2	100	96.330	ENSPLAG00000007805	eif4a2	100	95.377	Poecilia_latipinna
ENSG00000156976	EIF4A2	99	89.851	ENSPLAG00000018728	eif4a1b	99	89.851	Poecilia_latipinna
ENSG00000156976	EIF4A2	99	89.851	ENSPMEG00000002124	eif4a1b	99	89.851	Poecilia_mexicana
ENSG00000156976	EIF4A2	100	96.330	ENSPMEG00000018554	eif4a2	100	95.377	Poecilia_mexicana
ENSG00000156976	EIF4A2	100	96.330	ENSPREG00000006472	eif4a2	100	95.377	Poecilia_reticulata
ENSG00000156976	EIF4A2	100	88.073	ENSPREG00000003519	eif4a1b	100	90.769	Poecilia_reticulata
ENSG00000156976	EIF4A2	100	100.000	ENSPPYG00000014384	EIF4A2	100	100.000	Pongo_abelii
ENSG00000156976	EIF4A2	100	98.980	ENSPCAG00000010163	EIF4A2	100	88.943	Procavia_capensis
ENSG00000156976	EIF4A2	79	86.875	ENSPCOG00000023128	EIF4A2	95	86.875	Propithecus_coquereli
ENSG00000156976	EIF4A2	100	100.000	ENSPVAG00000013685	EIF4A2	100	88.452	Pteropus_vampyrus
ENSG00000156976	EIF4A2	99	89.109	ENSPNYG00000009758	eif4a1b	99	89.109	Pundamilia_nyererei
ENSG00000156976	EIF4A2	100	95.413	ENSPNYG00000001780	eif4a2	100	94.647	Pundamilia_nyererei
ENSG00000156976	EIF4A2	100	87.715	ENSPNAG00000027061	eif4a1a	100	87.715	Pygocentrus_nattereri
ENSG00000156976	EIF4A2	87	58.947	ENSPNAG00000012788	-	75	52.406	Pygocentrus_nattereri
ENSG00000156976	EIF4A2	100	89.216	ENSPNAG00000028563	eif4a1b	100	89.216	Pygocentrus_nattereri
ENSG00000156976	EIF4A2	100	91.176	ENSPNAG00000003445	eif4a2	98	89.196	Pygocentrus_nattereri
ENSG00000156976	EIF4A2	100	100.000	ENSRNOG00000001815	Eif4a2	100	100.000	Rattus_norvegicus
ENSG00000156976	EIF4A2	100	100.000	ENSRBIG00000033648	-	100	99.755	Rhinopithecus_bieti
ENSG00000156976	EIF4A2	100	100.000	ENSRROG00000033439	-	100	100.000	Rhinopithecus_roxellana
ENSG00000156976	EIF4A2	72	65.436	ENSSBOG00000024545	-	93	65.436	Saimiri_boliviensis_boliviensis
ENSG00000156976	EIF4A2	100	100.000	ENSSBOG00000020018	-	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000156976	EIF4A2	99	84.358	ENSSBOG00000028754	-	98	84.703	Saimiri_boliviensis_boliviensis
ENSG00000156976	EIF4A2	83	99.112	ENSSHAG00000017081	EIF4A2	100	99.112	Sarcophilus_harrisii
ENSG00000156976	EIF4A2	100	95.413	ENSSFOG00015013858	eif4a2	100	93.985	Scleropages_formosus
ENSG00000156976	EIF4A2	100	90.196	ENSSFOG00015013851	-	98	90.083	Scleropages_formosus
ENSG00000156976	EIF4A2	100	89.926	ENSSFOG00015000931	-	100	89.926	Scleropages_formosus
ENSG00000156976	EIF4A2	99	91.111	ENSSFOG00015022690	eif4a1b	100	92.308	Scleropages_formosus
ENSG00000156976	EIF4A2	100	95.377	ENSSFOG00015007526	EIF4A2	100	95.377	Scleropages_formosus
ENSG00000156976	EIF4A2	100	93.578	ENSSMAG00000008350	eif4a2	100	93.187	Scophthalmus_maximus
ENSG00000156976	EIF4A2	99	89.356	ENSSDUG00000004913	eif4a1b	99	89.356	Seriola_dumerili
ENSG00000156976	EIF4A2	100	95.413	ENSSDUG00000010103	eif4a2	100	95.134	Seriola_dumerili
ENSG00000156976	EIF4A2	100	95.413	ENSSLDG00000015202	eif4a2	100	95.134	Seriola_lalandi_dorsalis
ENSG00000156976	EIF4A2	99	89.356	ENSSLDG00000011941	eif4a1b	99	89.356	Seriola_lalandi_dorsalis
ENSG00000156976	EIF4A2	83	99.703	ENSSARG00000012922	EIF4A2	83	99.703	Sorex_araneus
ENSG00000156976	EIF4A2	100	96.814	ENSSPUG00000014154	EIF4A2	100	96.814	Sphenodon_punctatus
ENSG00000156976	EIF4A2	99	89.109	ENSSPAG00000002326	eif4a1b	99	89.109	Stegastes_partitus
ENSG00000156976	EIF4A2	100	95.413	ENSSPAG00000002382	eif4a2	100	94.891	Stegastes_partitus
ENSG00000156976	EIF4A2	100	100.000	ENSSSCG00000011803	EIF4A2	100	100.000	Sus_scrofa
ENSG00000156976	EIF4A2	91	57.303	ENSSSCG00000039746	-	74	61.538	Sus_scrofa
ENSG00000156976	EIF4A2	100	97.794	ENSTGUG00000010452	EIF4A2	100	97.794	Taeniopygia_guttata
ENSG00000156976	EIF4A2	100	94.495	ENSTRUG00000022264	eif4a2	100	92.910	Takifugu_rubripes
ENSG00000156976	EIF4A2	100	87.156	ENSTNIG00000007821	eif4a2	99	76.904	Tetraodon_nigroviridis
ENSG00000156976	EIF4A2	100	100.000	ENSTBEG00000002268	EIF4A2	100	99.748	Tupaia_belangeri
ENSG00000156976	EIF4A2	100	99.083	ENSTTRG00000016835	EIF4A2	100	86.241	Tursiops_truncatus
ENSG00000156976	EIF4A2	100	100.000	ENSUAMG00000015946	EIF4A2	98	100.000	Ursus_americanus
ENSG00000156976	EIF4A2	100	100.000	ENSUMAG00000004240	EIF4A2	100	100.000	Ursus_maritimus
ENSG00000156976	EIF4A2	100	100.000	ENSVPAG00000003871	EIF4A2	100	84.709	Vicugna_pacos
ENSG00000156976	EIF4A2	100	100.000	ENSVVUG00000013242	EIF4A2	100	99.755	Vulpes_vulpes
ENSG00000156976	EIF4A2	100	98.280	ENSXETG00000019390	eif4a2	100	98.280	Xenopus_tropicalis
ENSG00000156976	EIF4A2	100	96.330	ENSXCOG00000007417	eif4a2	99	96.482	Xiphophorus_couchianus
ENSG00000156976	EIF4A2	100	88.073	ENSXCOG00000003747	eif4a1b	99	82.398	Xiphophorus_couchianus
ENSG00000156976	EIF4A2	100	96.330	ENSXMAG00000004590	eif4a2	100	95.377	Xiphophorus_maculatus
ENSG00000156976	EIF4A2	99	89.851	ENSXMAG00000008167	eif4a1b	99	89.851	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003743	translation initiation factor activity	-	IEA	Function
GO:0004004	ATP-dependent RNA helicase activity	-	IEA	Function
GO:0004386	helicase activity	8521730.	TAS	Function
GO:0005515	protein binding	11922617.17229681.25277244.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005829	cytosol	-	TAS	Component
GO:0006413	translational initiation	-	TAS	Process
GO:0006446	regulation of translational initiation	8521730.	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016281	eukaryotic translation initiation factor 4F complex	8521730.	TAS	Component
GO:0016887	ATPase activity	11922617.	IDA	Function
GO:0048471	perinuclear region of cytoplasm	11922617.	IDA	Component
GO:1900260	negative regulation of RNA-directed 5'-3' RNA polymerase activity	11922617.	IDA	Process
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	Process